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The Institute of Human Genetics (Institut de Génétique Humaine, IGH) is a major CNRS unit dedicated to excellence in fundamental research and pathology. The principal research interests of the IGH are genome dynamics, developmental genetics, epigenetics, and molecular and cellular pathology.


Laboratory's News

TOMORROW: 20-11-2017

  14h00 IGH : salle de Conférence (1er étage) 14h00 Mechanisms of gene activation in animal development
Adam KLOSIN (MPI of Molecular Cell Biology and Genetics, Dresden, Germany)

 


Epigenetics & Chromosomal Topology in Differentiation & Disease

Les 14 et 15 décembre 2017, à Génopolys, organisé par le Pôle BioSanté Rabelais, avec entre autre la présence de chercheur de l’IGH : G. Cavalli, B. de Massy, M. Méchali









Just published in Cell

The 3D organization of the genome has emerged recently as intimately linked to its biological function, yet its relation to cell fate during development not understood. Bonev et al. (Cavalli's team) used ultrahigh resolution Hi-C maps to characterize changes in 3D nuclear architecture during mouse neural development and identified multiple factors that influence the dynamics of chromatin interactions. The drawing represents an artistic view of a mouse embryo, hands grasping each other symbolizing chromatin contacts and multiple scales of compaction associated with the chromatin fiber. Hi-C contacts maps are shown in the background.
Copyright: Adrien Méchali
Bonev, B., Mendelson Cohen, N., Szabo, Q., Fritsch, L., Papadopoulos, G., Lubling, Y., Xu, X., Hugnot, JP., Tanay, A., Cavalli, G. "Multi-scale 3D genome rewiring during mouse neural development." (2017), CELL: 171(3):557-572




FANCI/D2 regulate the dynamics of splicing factors

Moriel-Carretero et al.(Constantinou's lab) show that the Fanconi anemia proteins FANCI and FANCD2 associate with the splicing factor SF3B1 and that DNA replication stress induces the FANCI-dependent release of SF3B1 from nuclear speckles. FANCI and FANCD2 prevent accumulation of postcatalytic intron lariats, suggesting that they help coordinate DNA replication and transcription.
Journal of Cell Biology - DOI: 10.1083/jcb.201702136




Seminar Series on Genome Dynamics 2017-2018

Amphitheater Genopolys, at 11:30, from October 27th to May 25th











Seminars of the month @ IGH


  • 10-11-2017 (14h00) "In the context of the Workshop in Epigenetics organized for the Master 2 students of the parcours Genetique-Epigenetique: Genome 3D Dynamics and Function"
    Peter FRASER (The Babraham Institute Cambridge, UK)
  • 13-11-2017 (11h30) "In the context of the Workshop in Epigenetics organized for the Master 2 students of the parcours Genetique-Epigenetique: Bridging the gap from the bench to the bedside. Applied and collaborative RD, views and personal experience"
    Gerard Mathis (CisBio Bioassays)
  • 16-11-2017 (10h00) "Importance of T Follicular Helper cells in microbial infections"
    Jérôme ESTAQUIER (Maladies infectieuses et immunitaires Université de Laval, Québec, Canada)
  • 20-11-2017 (14h00) "Mechanisms of gene activation in animal development"
    Adam KLOSIN (MPI of Molecular Cell Biology and Genetics, Dresden, Germany)


Some recent papers


  • Aillaud, C., Bosc, C., Peris, L., Bosson, A., Heemeryck, P.,Van Dijk, J., Le Friec, J., Boulan, B., Vossier, F., Sanman, L.E., Syed, S., Amara, N., Couté, Y., Lafanechère, L., Denarier, E., Delphin, C., Pelletier, L., Humbert, S., Bogyo, M., Andrieux*, A., Rogowski*, K., Moutin*, M.J. "Vasohibins/SVBP are tubulin carboxypeptidases (TCP) that regulate neuron differentiation" (2017), SCIENCE: DOI: 10.1126/science.aao4165
  • Dufourt J, Bontonou G, Chartier A, Jahan C, Meunier AC, Pierson S, Harrison PF, Papin C, Beilharz TH, Simonelig M "piRNAs and Aubergine cooperate with Wispy poly(A) polymerase to stabilize mRNAs in the germ plasm" (2017), Nat Commun: 8(1):1305 PubMed
  • Bonev, B., Mendelson Cohen, N., Szabo, Q., Fritsch, L., Papadopoulos, G., Lubling, Y., Xu, X., Hugnot, JP., Tanay, A., Cavalli, G. "Multi-scale 3D genome rewiring during mouse neural development." (2017), CELL: 171(3):557-572 PubMed
  • Rojas-Ríos P, Chartier A, Pierson S, Simonelig M "Aubergine and piRNAs promote germline stem cell self-renewal by repressing the proto-oncogene Cbl." (2017), EMBO J.: 36, 21, 3194-3211 PubMed
  • Schuettengruber, B., Bourbon, HM., Di Croce, L., Cavalli, G. "Genome Regulation by Polycomb and Trithorax: 70 Years and Counting" (2017), CELL: 171, 1, 34-57 PubMed
  • Lin, YL., Pasero, P. "Transcription-Replication Conflicts: Orientation Matters" (2017), CELL: 170(4):603-604 PubMed
  • Morchikh, M., Cribier, A., Raffel, R., Amraoui, S., Cau, J., Severac, D., Dubois, E., Schwartz, O., Bennasser, Y., Benkirane, M. "HEXIM1 and NEAT1 lncRNA form a multi subunit complex that regulates DNA-mediated innate immune response" (2017), Mol. Cell: 37, 3, 387-399 PubMed
  • Rahmoun M, Lavery R, Laurent-Chaballier S, Bellora N, Philip GK, Rossitto M, Symon A, Pailhoux E, Cammas F, Chung J, Bagheri-Fam S, Murphy M, Bardwell V, Zarkower D, Boizet-Bonhoure B, Clair P, Harley VR, Poulat F. "In mammalian foetal testes, SOX9 regulates expression of its target genes by binding to genomic regions with conserved signatures" (2017), Nucleic Acids Res.: PubMed
  • Akkouche, A., Mugat, B., Barckmann, B., Varela-Chavez, C., Li, B., Raffel, R., Pelisson, A., Chambeyron, S. "Piwi Is Required during Drosophila Embryogenesis to License Dual-Strand piRNA Clusters for Transposon Repression in Adult Ovaries" (2017), Molecular Cell: 66, 3, 411-419 PubMed
  • Ciabrelli F, Comoglio F, Fellous S, Bonev B, Ninova M, Szabo Q, Xuéreb A, Klopp C, Aravin A, Paro R, Bantignies F, Cavalli G "Stable Polycomb-dependent transgenerational inheritance of chromatin states in Drosophila" (2017), Nat. Genet.: 49(6):876-886 PubMed
  • Descours B, Petitjean G, López-Zaragoza JL, Bruel T, Raffel R, Psomas C, Reynes J, Lacabaratz C, Levy Y, Schwartz O, Lelievre JD, Benkirane M. "CD32a is a marker of a CD4 T-cell HIV reservoir harbouring replication-competent proviruses" (2017), NATURE: 546(7660):686 PubMed
  • Hodroj D, Recolin B, Serhal K, Martinez S, Tsanov N, Abou Merhi R, Maiorano D "An ATR-dependent function for the Ddx19 RNA helicase in nuclear R-loop metabolism" (2017), EMBO J.: 36(9):1182-1198 PubMed
  • Grey C, Clément JA, Buard J, Leblanc B, Gut I, Gut M, Duret L, de Massy B. "In vivo binding of PRDM9 reveals interactions with noncanonical genomic sites" (2017), Genome Res.: 27(4):580-590 PubMed
  • Rodríguez-Martínez, M., Pinzón, N., Ghommidh, C., Beyne, E., Seitz, H., Cayrou, C., Méchali, M. "The gastrula transition reorganizes replication origin selection in Caenorhabditis elegans " (2017), Nature Structural & Molecular Biology: 24(3):290-299 PubMed
  • Viziteu E, Klein B, Basbous J, Lin YL, Hirtz C, Gourzones C, Tiers L, Bruyer A, Vincent L, Grandmougin C, Seckinger A, Goldschmidt H, Constantinou A, Pasero P, Hose D, Moreaux J. "RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma" (2017), Leukemia: 31, 10, 2104-2113 PubMed
  • Pinzon, N., Li, B., Martinez, L., Sergeeva, A., Presumey, J., Apparailly, F., Seitz, H "microRNA target prediction programs predict many false positives" (2017), Genome Res: 27, 2, 234-245 PubMed

Last minute IGH NEWS

Today 19-11-2017

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{Next Thesis} : Genome-wide analysis of replication/transcription interference and genetic instability
24-11-2017, Ismaël PADIOLEAU

IGH papers 1573 Publications

... the 2 last ones

Aillaud, C., Bosc, C., Peris, L., Bosson, A., Heemeryck, P.,Van Dijk, J., Le Friec, J., Boulan, B., Vossier, F., Sanman, L.E., Syed, S., Amara, N., Couté, Y., Lafanechère, L., Denarier, E., Delphin, C., Pelletier, L., Humbert, S., Bogyo, M., Andrieux*, A., Rogowski*, K., Moutin*, M.J.. Vasohibins/SVBP are tubulin carboxypeptidases (TCP) that regulate neuron differentiation (2017), SCIENCE.
Dufourt J, Bontonou G, Chartier A, Jahan C, Meunier AC, Pierson S, Harrison PF, Papin C, Beilharz TH, Simonelig M. piRNAs and Aubergine cooperate with Wispy poly(A) polymerase to stabilize mRNAs in the germ plasm (2017), Nat Commun.

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