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Update: 30-05-2016

Meiosis and recombination

(Department Genome Dynamics)

 

Leader: Bernard DE MASSY

 

In sexually reproducing species, meiosis allows the proper transmission of the genetic information at each generation through various steps which lead to the formation of haploid gametes from diploid cells. In most species, the proper segregation of chromosomes at the first meiotic division requires the establishment of connections resulting from reciprocal homologous exchanges or crossing over. Crossing over also generate new allele combinations and thus increase the genetic diversity. Our group is addressing several aspects of the mechanism and regulation of meiotic recombination using the mouse as a model system. Meiotic recombination events are initiated by the formation of DNA double-strand breaks catalyzed by Spo11 protein. About 300 DSBs take place at the beginning of meiotic prophase in mouse meiotic cells. We are looking for proteins involved in this process. In parallel, one puzzling question is to understand what determines the distribution of meiotic recombination events in the genome. Initiation is known to occur in highly localized, non random regions, and most often intergenic. We are investigating the various components that might contribute to initiation sites specification (DNA sequence, chromatin, higher order feature, trans acting factors…). DSBs are known to be repaired according to two major pathways, one leading to crossing over, one to non crossover. We are investigating how these DSB repair pathways are regulated.


"The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation" T. Robert et al., Science 2016: Vol. 351, Issue 6276, pp. 943-949

[ Abstract | Full Text | Reprint ]

 

 

 

 

Group's publications of the year (2016):

Grey C, Espeut J, Ametsitsi R, Kumar R, Luksza M, Brun C, Verlhac MH, Suja JÁ, de Massy B.
SKAP, an outer kinetochore protein, is required for mouse germ cell development
(2016), Reproduction : 151, 3, 239-251
Robert T, Nore A, Brun C, Maffre C, Crimi B, Bourbon HM, de Massy B.
The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation
(2016), SCIENCE : 351(6276):943-9
Robert T, Vrielynck N, Mézard C, de Massy B, Grelon M.
A new light on the meiotic DSB catalytic complex
(2016), Semin Cell Dev Biol. : 54, 165-176

 

All the publications of the group

Staff:


Name / First name Room Phone status

   Researcher

BAUDAT Frédéric 035-036 9911 CR (CNRS) E-mail    Photo  
DE MASSY Bernard 033-034 et 014 9972 et 9992 DR (CNRS) E-mail    Photo  
GREY corinne 035-036 9911 CR (CNRS) E-mail    Photo  
ROBERT Thomas 033-034 9972 CR (CNRS) E-mail    Photo  

   Engineer & Administrative

BRUN Christine 035-036 9911 AI (CNRS) E-mail    Photo  

   Post-Doc

CLEMENT Julie 033-034 9972 (CNRS) E-mail    Photo  
OLIVER VELASCO Cecilia 033-034 9972 (CNRS) E-mail    Photo  

   PhD students

DIAGOURAGA Boubou 033-034 9972 (CNRS) E-mail    Photo  
DUNOYER DE SEGONZAC Denis 035-036 9911 (CNRS) E-mail    Photo  
IMAI Yukiko 035-036 9911 (CNRS) E-mail    Photo  
NORE Alexandre 036 9972 (Univ.Montp.2) E-mail    Photo  

   Fixed-term contract

CRIMI Barbara 033-034 9972 IE (CNRS) E-mail    Photo  

   Student

BIOT Mathilde S35-S36 9911 (Univ.Montp) E-mail    Photo  

Meiosis and recombination Group

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  INSTITUTE of HUMAN GENETICS
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  Montpellier, France