English version Version Française
 About CNRS Life Sciences Other CNRS web sites
  Group Genetic Instability and Cancer
  Home > Research > Scientific Groups

Genetic Instability and Cancer

(Department Molecular Bases of Human Diseases)


Leader: Angelos CONSTANTINOU


From the earliest stages of tumour genesis, deregulated oncogenes induce the formation of DNA lesions during the process of DNA replication. Replication-associated defects can result from chemical alterations in the DNA template, from nucleotide pool imbalance and/or from conflicts between the replication and transcription machineries. Stalled replication forks and DNA lesions induce a variety of surveillance pathways collectively known as the DNA damage response.

We study how cells respond to replication impediments. Our goal is to unveil novel mechanisms that allow DNA replication to overcome obstacles. We believe that these mechanisms are key determinants of tumour growth and resistance to chemotherapies. In recent years, our main focus has been on the molecular function of proteins implicated in Fanconi anaemia, a genetic disorder characterised by congenital abnormalities, bone marrow failure and cancer proneness. FANC proteins are necessary to coordinate the action of molecular machines involved in the rescue of stalled replication forks and in DNA repair. We explore novel mechanisms implicated in the signalling of damaged replication intermediates, and we use proteomic approaches to understand the biology of the replication machinery under stressful conditions.



Group's News


Opportunities Postdoctoral position: molecular basis of DNA replication checkpoint signalling

We are seeking to appoint a Postdoctoral Research Associate from October 2016 to study DNA replication checkpoint signalling. Our research objective is to unveil key mechanisms that promote DNA replication under stressful conditions. These mechanisms make a significant contribution to the resistance of cancer cells to radio and chemotherapies.

The candidate will exploit complementary biochemical, cell biological and targeted genome editing approaches to study how combinatorial posttranslational modifications promote the self-organisation of ATR signalling complexes in response to DNA replication obstacles.

The Institute of Human Genetics provides a highly dynamic scientific life supported by first class expertise and facilities dedicated to the study fundamental biological processes. It is located in the University and Hospital area of Montpellier, a culturally vibrant city on the south coast of France

The position is funded for three years. Candidates must hold a Ph.D. or M.D., should have excellent interpersonal and analytical skills, and have a proven track record in molecular biology and biochemistry.

Please submit a CV accompanied by a statement of research interests until July 31, and arrange for two/three letters of recommendation to be sent directly to Angelos.Constantinou@igh.cnrs.fr.

IGH-Institute of Human Genetics
141 rue de la Cardonille
Tel: 33 (0) 34 35 98 14
E-mail: Angelos.Constantinou@igh.cnrs.fr

Expected starting date: October 2017


Group's publications of the year (2016):

Alsafadi S, Houy A, Battistella A, Popova T, Wassef M, Henry E, Tirode F, Constantinou A, Piperno-Neumann S, Roman-Roman S, Dutertre M, Stern MH.
Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage
(2016), Nat Commun : 7, 10615
Ribeyre C, Zellweger R, Chauvin M, Bec N, Larroque C, Lopes M, Constantinou A.
Nascent DNA Proteomics Reveals a Chromatin Remodeler Required for Topoisomerase I Loading at Replication Forks
(2016), Cell Rep : 15, 2, 300-309


All the publications of the group


Name / First name Room Phone status


BASBOUS Jihane 038-039 9815 CR (CNRS) E-mail    Photo  
CONSTANTINOU Angelos 038-039 9814/9907 DR (INSERM) E-mail    Photo  
RIBEYRE Cyril 038-039 9815 CR (CNRS) E-mail    Photo  

   Engineer & Administrative

VIDAL-EYCHENIE Sophie 038-039 9815 TECH (CNRS) E-mail    Photo  


GERUS-DURAND Marie 038-039 9815 (CNRS) E-mail    Photo  
OVEJERO MERINO Sara 038-039 9815 (CNRS) E-mail    Photo  

   PhD students

KUMBHAR Ramhari 038-039 9815 (Univ.Montp) E-mail    Photo  


ZADDAM Walid 038-039 9815 E-mail    Photo  

Genetic Instability and Cancer Group

Home pageSmart printContactCoordinatesCopyrightsPersonnal AccessWebmail  Mailing Lists



Institute of Human Genetics



the Institute Servers


  CNRS UPR 1142
  Montpellier, France