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Update: 06-12-2016

Genetic Instability and Cancer

(Department Molecular Bases of Human Diseases)

 

Leader: Angelos CONSTANTINOU

 

From the earliest stages of tumour genesis, deregulated oncogenes induce the formation of DNA lesions during the process of DNA replication. Replication-associated defects can result from chemical alterations in the DNA template, from nucleotide pool imbalance and/or from conflicts between the replication and transcription machineries. Stalled replication forks and DNA lesions induce a variety of surveillance pathways collectively known as the DNA damage response.

We study how cells respond to replication impediments. Our goal is to unveil novel mechanisms that allow DNA replication to overcome obstacles. We believe that these mechanisms are key determinants of tumour growth and resistance to chemotherapies. In recent years, our main focus has been on the molecular function of proteins implicated in Fanconi anaemia, a genetic disorder characterised by congenital abnormalities, bone marrow failure and cancer proneness. FANC proteins are necessary to coordinate the action of molecular machines involved in the rescue of stalled replication forks and in DNA repair. We explore novel mechanisms implicated in the signalling of damaged replication intermediates, and we use proteomic approaches to understand the biology of the replication machinery under stressful conditions.

 

 

 

 

Group's publications of the year (2016):

Alsafadi S, Houy A, Battistella A, Popova T, Wassef M, Henry E, Tirode F, Constantinou A, Piperno-Neumann S, Roman-Roman S, Dutertre M, Stern MH.
Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage
(2016), Nat Commun : 7, 10615
Ribeyre C, Zellweger R, Chauvin M, Bec N, Larroque C, Lopes M, Constantinou A.
Nascent DNA Proteomics Reveals a Chromatin Remodeler Required for Topoisomerase I Loading at Replication Forks
(2016), Cell Rep : 15, 2, 300-309

 

All the publications of the group

Staff:


Name / First name Room Phone status

   Researcher

BASBOUS Jihane 038-039 9815 CR (CNRS) E-mail    Photo  
CONSTANTINOU Angelos 038-039 9814/9907 DR (INSERM) E-mail    Photo  
RIBEYRE Cyril 038-039 9815 CR (CNRS) E-mail    Photo  

   Engineer & Administrative

VIDAL-EYCHENIE Sophie 038-039 9815 TECH (CNRS) E-mail    Photo  

   Post-Doc

GERUS-DURAND Marie 038-039 9815 (CNRS) E-mail    Photo  
OVEJERO MERINO Sara 038-039 9815 (CNRS) E-mail    Photo  

   Fixed-term contract

BAPTISTE Julie 038-039 9815 IE (CNRS) E-mail    Photo  

Genetic Instability and Cancer Group

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  INSTITUTE of HUMAN GENETICS
  CNRS UPR 1142
  Montpellier, France