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Chromatin and cell biology.

(Department Genome Dynamics)


Leader: Giacomo CAVALLI


In eukaryotes, chromatin is essential for heredity. Chromatin architectures are sometimes epistatic over the DNA and impart different heritable functions to the same DNA sequence or the same function to unrelated DNA sequences. In higher eukaryotes, memory of cell fates can be maintained by regulatory proteins classified in the Polycomb Group (PcG) and the trithorax Group (trxG). PcG proteins are maintain silent states of gene expression, while trxG members maintain active chromatin states. These proteins are able to recognize regulatory states of their target genes and to maintain these states even after disappearance of the primary transcriptional regulators that have induced them in the first place. Remarkably, these states can also be transmitted to a fraction of the progeny over multiple generations. In our lab, we aim at understanding the molecular mechanisms by which PcG and trxG proteins regulate their target genes, convey inheritance of chromatin states and orchestrate development. To reach this goal, we employ a variety of complementary approaches and techniques in the areas of molecular, cellular and developmental biology, genomics and bioinformatics.


Keywords: Chromatin, chromosome, nuclear organization, development, Polycomb, trithorax, Drosophila


Group's News


News A new epigenetic mechanism mediating tumor suppression by Polycomb proteins

The Cavalli lab shows that a complex of Polycomb group proteins has a tumor suppressor activity that depends on its specific binding to hundreds of genes involved in the control of proliferation, cell signaling and polarity. This activity was discovered in Drosophila, but the same chromosomal binding pattern is observed in differentiated human cells, suggesting that this phenomenon might be conserved in some human tumors. This study, published in the journal Nature Genetics, opens new perspectives in the field of carcinogenesis.
Read more.

News Poste Ingénieur de Recherche - Campagne FSEP mobilité interne automne 2015

Un poste d'Ingénieur de recherche est disponible au sein de notre équipe.

La fonction FSEP n° B53005  d’Ingénieur en biologie, au sein de notre équipe a été affichée sur le site web national prévu à cet effet ( pour plus de détails, voir : http://web-rh.dsi.cnrs.fr/afip/owa/consult.accueil. Chercher DR13, BAP A, corps IR).  
IMPORTANT- Cette fonction ne peut être pourvue que par un agent CNRS (fonctionnaire titulaire et CDI)

Rappel de la Mission :
Conception, développement et expérimentation de nouvelles technologies dans le cadre des recherches de l'équipe Cavalli. En particulier, l'agent étudiera la régulation épigénétique du génome, de sa structure et de sa fonction, et du rôle des protéines Polycomb dans cette régulation avec des techniques à haut débit ainsi que des techniques moléculaires et de biologie cellulaire. Se rajoutera à cette activité, celle de lab manager concernant le 30% du temps total.

Date butoir de réception des candidatures : 13/1/2016 - Date butoir pour effectuer les entretiens : 14/1/2016

Svp Envoyer vos candidatures via email à giacomo.cavalli@igh.cnrs.fr

Read more


Group's publications of the year (2016):

Bonev B, Cavalli G..
Organization and function of the 3D genome
(2016), Nat Rev Genet : 17(11):661-678
Cheutin T, Cavalli G..
Following the Motion of Polycomb Bodies in Living Drosophila Embryos
(2016), Methods Mol. Biol. : 1480:283-8
Entrevan M, Schuettengruber B, Cavalli G.
Regulation of Genome Architecture and Function by Polycomb Proteins
(2016), Trends Cell Biol. : 26, 7, 511-525
Herviou L, Cavalli G, Cartron G, Klein B, Moreaux J..
EZH2 in normal hematopoiesis and hematological malignancies
(2016), Oncotarget : 7, 3, 284-296
Leblanc B, Comet I, Bantignies F, Cavalli G..
Chromosome Conformation Capture on Chip (4C): Data Processing
(2016), Methods Mol Biol : 1480:243-61
Loubière, V., Delest, A., Thomas, A., Bonev, B., Schuettengruber, B., Sati, S., Martinez AM., Cavalli, G..
Coordinate redeployment of PRC1 proteins suppresses tumor formation during Drosophila development
(2016), Nature Genetics : 48, 11, 1436-1442
Sati S, Cavalli G..
Chromosome conformation capture technologies and their impact in understanding genome function
(2016), Chromosoma : in press


All the publications of the group


Name / First name Room Phone status


BANTIGNIES Frederic 106-107 9997 DR (CNRS) E-mail    Photo  
CAVALLI Giacomo 103 9970 DR (CNRS) E-mail    Photo  
CHEUTIN Thierry 106-107 9997 CR (CNRS) E-mail    Photo  
MARTINEZ Anne-Marie 200 9969 PU (Univ.Montp.2) E-mail    Photo  
SCHUTTENGRUBER Bernd 106-107 9997 CR (INSERM) E-mail    Photo  

   Engineer & Administrative

FRITSCH Lauriane 104-105 9968 IE (CNRS) E-mail    Photo  
THOMAS Aubin front of 122 9997 IE (CNRS) E-mail    Photo  


BONEV Boyan 104-105 9968 (CNRS) E-mail    Photo  
CIABRELLI Filippo 106-107 9997 (CNRS) E-mail    Photo  
GROB Stefan 106-107 9997 (CNRS) E-mail    Photo  
OGIYAMA Yuki 104-105 9968 E-mail    Photo  
PAPADOPOULOS Giorgio Lucio 104-105 9968 (CNRS) E-mail   
SATI Satish 104-105 9968 (Univ.Montp) E-mail    Photo  

   PhD students

ENTREVAN Marianne 106-107 9997 (Univ.Montp) E-mail    Photo  
LOUBIERE Vincent 104-105 9968 (Univ.Montp.1) E-mail    Photo  
PULICANI Sylvain 170 9564 (Univ.Montp) E-mail    Photo  
SZABO Quentin 106 9997 (Univ.Montp) E-mail    Photo  


RAUTURIER Charles 104-105 9968 (CNRS) E-mail    Photo  

Chromatin and cell biology. Group

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