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Director: Giacomo CAVALLI
Associate director: Philippe PASERO

The Institute of Human Genetics (Institut de Génétique Humaine, IGH) is a major CNRS unit dedicated to excellence in fundamental research and pathology. The principal research interests of the IGH are genome dynamics, developmental genetics, epigenetics, and molecular and cellular pathology.


Laboratory's News

 


Seminar Series on Genome Dynamics 2014-2015

Amphitheater Genopolys, at 11:30, from October 6th to April 3rd







Seminars of the month @ IGH


  • 04-11-2014 (10h30) "3D organization of the genome: fundamental principles and practical applications"
    Elzo DE WIT (Hubrecht Institute for Developmental Biology and Stem Cell Research - Utrecht (THE NETHERLANDS))
  • 06-11-2014 (11h30) "Seminar series on Genome Dynamics: Noncoding RNAs: with a viral twist"
    Joan STEITZ (Yale University/HHMI, New Haven, USA)
  • 06-11-2014 (17h00) "Women & Science"
    Joan STEITZ (Yale University/HHMI, New Haven, USA)
  • 07-11-2014 (11h30) "Seminar series on Genome Dynamics: Long-range gene regulation in the 3D genome: technologies and insight"
    Wouter de LAAT (Hubrecht Institute, Urtrecht, The Netherlands)
  • 10-11-2014 (10h30) "Transcriptional and epigenetic regulation by short RNAs"
    Germano CECERE (Columbia University Medical Center - New York, NY (USA))
  • 12-11-2014 (10h30) "Genome defense by germline small RNAs"
    Ramesh PILLAI (European Molecular Biology Laboratory - Grenoble (FRANCE))
  • 14-11-2014 (11h30) "BLESS, Genome-wide high-resolution DNA double-strand break mapping"
    Magdalena Skrzypczak (Laboratory of Bioinformatics and Systems Biology CeNT University of Warsaw)


Some recent papers


  • Stadelmayer B, Micas G, Gamot A, Martin P, Malirat N, Koval S, Raffel R, Sobhian B, Severac D, Rialle S, Parrinello H, Cuvier O, Benkirane M "Integrator complex regulates NELF-mediated RNA polymerase II pause/release and processivity at coding genes" (2014), Nat Commun: 5:5531
  • de Massy B. "Human genetics. Hidden features of human hotspots" (2014), Science: 346(6211):808-9
  • Cole F, Baudat F, Grey C, Keeney S, de Massy B, Jasin M. "Mouse tetrad analysis provides insights into recombination mechanisms and hotspot evolutionary dynamics" (2014), Nat Genet.: 46, 10, 1072-1080
  • Yoshida K, Bacal J, Desmarais D, Padioleau I, Tsaponina O, Chabes A, Pantesco V, Dubois E, Parrinello H, Skrzypczak M, Ginalski K, Lengronne A, Pasero P "The histone deacetylases sir2 and rpd3 act on ribosomal DNA to control the replication program in budding yeast." (2014), Mol Cell.: 54(4):691-697
  • Gonzalez I, Mateos-Langerak J, Thomas A, Cheutin T, Cavalli G. "Identification of Regulators of the Three-Dimensional Polycomb Organization by a Microscopy-Based Genome-wide RNAi Screen" (2014), Mol Cell: 54(3):485-99
  • Moran, Y., Fredman, D., Praher, D., Li Z. L., Meng Wee,L., Rentzsch, F., Zamore,P.D., Technau, U., Seitz H. "Cnidarian microRNAs frequently regulate targets by cleavage" (2014), Genome Research: 24(4):651-63
  • Laguette,N., Bregnard, C., Hue, P., Basbous, J., Yatim, A., Larroque, M., Kirchhoff, F., Constantinou, A., Bijan, S., Benkirane, M. "Premature Activation of the SLX4 Complex by Vpr Promotes G2/M Arrest and Escape from Innate Immune Sensing" (2014), CELL: 156, 1-2, 134-145
  • Van der Laan, S., Crozet, C., Tsanov, N., and Maiorano, D "High Dub3 expression in mouse ESC couples the G1/S checkpoint to pluripotency" (2013), Molecular Cell: 52, 3, 366-379
  • Bétous R., Pillaire, M-J, Pierini, L., Van der Laan, S., Recolin B., Ohl-Séguy, E., Guo, C., Niimi, N., Gruz, P., Nohmi, T. Friedberg, E., Cazaux, C., Maiorano, D* and Hoffmann J-S*. * corresponding authors "DNA polymerase k-dependent DNA synthesis at stalled replication forks is important for Chk1 activation" (2013), EMBO Journal: 32(15):2172-85
  • Lossaint G, Larroque M, Ribeyre C, Bec N, Larroque C, Décaillet C, Gari K, Constantinou A. "FANCD2 Binds MCM Proteins and Controls Replisome Function upon Activation of S Phase Checkpoint Signaling." (2013), Mol Cell.: 51(5):678-690
  • Iovino N, Ciabrelli F, Cavalli G. "PRC2 Controls Drosophila Oocyte Cell Fate by Repressing Cell Cycle Genes." (2013), Dev Cell: 26(4):431-9
  • Berkhout B, Lever A, Wainberg M, Fassati A, Borrow P, Fujii M "Monsef Benkirane awarded 2013 Ming K. Jeang Foundation Retrovirology Prize: Landmark HIV-1 research honoured" (2013), Retrovirology: 10, 1, 28
  • Cavalli, G., Mistelli, T. "Functional implications of genome topology" (2013), Nat. Struct. Mol. Biol: 20, 3, 290-299

Last minute IGH NEWS

Today 23-11-2014

2013

Opportunities2 job / training period opportunities

 

All NewsNews / Archives

  • Two post-doctoral positions: Role of the piRNA pathway in gene regulation
    (Published: 06-07-2014)

  • iGHazette - Staff only

    Don't missNext seminars & congresses

    ----- @IGH

    Novel players in the regulation of chromatin function
    19-12-2014, Robert SCHNEIDER (IGBMC Strasbourg )

    IGH papers 1431 Publications

    ... the 2 last ones

    Stadelmayer B, Micas G, Gamot A, Martin P, Malirat N, Koval S, Raffel R, Sobhian B, Severac D, Rialle S, Parrinello H, Cuvier O, Benkirane M. Integrator complex regulates NELF-mediated RNA polymerase II pause/release and processivity at coding genes (2014), Nat Commun.
    Lengronne A, Pasero P.. Closing the MCM cycle at replication termination sites (2014), EMBO Rep.

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      INSTITUTE of HUMAN GENETICS
      CNRS UPR 1142
      Montpellier, France