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Director: Giacomo CAVALLI
Associate director: Philippe PASERO

The Institute of Human Genetics (Institut de Génétique Humaine, IGH) is a major CNRS unit dedicated to excellence in fundamental research and pathology. The principal research interests of the IGH are genome dynamics, developmental genetics, epigenetics, and molecular and cellular pathology.


Laboratory's News

TOMORROW: 24-09-2014

  14h30 Amphithéâtre GENOPOLYS 14h30 Les débuts de la génétique en France
Simone GILGENKRANTZ (Professeur émérite de génétique humaine, Université Henri Poincaré - Nancy 1)

 
















IGH supports




http://sciencesenmarche.org

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Seminars of the month @ IGH


  • 05-09-2014 (11h30) "Differential roles of double-strand break resection enzymes between yeast and vertebrates"
    Shunichi TAKEDA (Department of Radiation Genetics Kyoto University)
  • 12-09-2014 (11h30) "The NF-kB signaling pathway: from molecules to pathologies"
    Alain ISRAEL (Institut Pasteur Paris)
  • 24-09-2014 (14h30) "Les débuts de la génétique en France "
    Simone GILGENKRANTZ (Professeur émérite de génétique humaine, Université Henri Poincaré - Nancy 1)


Some recent papers


  • Cole F, Baudat F, Grey C, Keeney S, de Massy B, Jasin M. "Mouse tetrad analysis provides insights into recombination mechanisms and hotspot evolutionary dynamics" (2014), Nat Genet.: in press
  • Yoshida K, Bacal J, Desmarais D, Padioleau I, Tsaponina O, Chabes A, Pantesco V, Dubois E, Parrinello H, Skrzypczak M, Ginalski K, Lengronne A, Pasero P "The histone deacetylases sir2 and rpd3 act on ribosomal DNA to control the replication program in budding yeast." (2014), Mol Cell.: 54(4):691-697
  • Gonzalez I, Mateos-Langerak J, Thomas A, Cheutin T, Cavalli G. "Identification of Regulators of the Three-Dimensional Polycomb Organization by a Microscopy-Based Genome-wide RNAi Screen" (2014), Mol Cell: 54(3):485-99
  • Moran, Y., Fredman, D., Praher, D., Li Z. L., Meng Wee,L., Rentzsch, F., Zamore,P.D., Technau, U., Seitz H. "Cnidarian microRNAs frequently regulate targets by cleavage" (2014), Genome Research: 24(4):651-63
  • Laguette,N., Bregnard, C., Hue, P., Basbous, J., Yatim, A., Larroque, M., Kirchhoff, F., Constantinou, A., Bijan, S., Benkirane, M. "Premature Activation of the SLX4 Complex by Vpr Promotes G2/M Arrest and Escape from Innate Immune Sensing" (2014), CELL: 156, 1-2, 134-145
  • Van der Laan, S., Crozet, C., Tsanov, N., and Maiorano, D "High Dub3 expression in mouse ESC couples the G1/S checkpoint to pluripotency" (2013), Molecular Cell: 52, 3, 366-379
  • Bétous R., Pillaire, M-J, Pierini, L., Van der Laan, S., Recolin B., Ohl-Séguy, E., Guo, C., Niimi, N., Gruz, P., Nohmi, T. Friedberg, E., Cazaux, C., Maiorano, D* and Hoffmann J-S*. * corresponding authors "DNA polymerase k-dependent DNA synthesis at stalled replication forks is important for Chk1 activation" (2013), EMBO Journal: 32(15):2172-85
  • Lossaint G, Larroque M, Ribeyre C, Bec N, Larroque C, Décaillet C, Gari K, Constantinou A. "FANCD2 Binds MCM Proteins and Controls Replisome Function upon Activation of S Phase Checkpoint Signaling." (2013), Mol Cell.: 51(5):678-690
  • Iovino N, Ciabrelli F, Cavalli G. "PRC2 Controls Drosophila Oocyte Cell Fate by Repressing Cell Cycle Genes." (2013), Dev Cell: 26(4):431-9
  • Berkhout B, Lever A, Wainberg M, Fassati A, Borrow P, Fujii M "Monsef Benkirane awarded 2013 Ming K. Jeang Foundation Retrovirology Prize: Landmark HIV-1 research honoured" (2013), Retrovirology: 10, 1, 28
  • Cavalli, G., Mistelli, T. "Functional implications of genome topology" (2013), Nat. Struct. Mol. Biol: 20, 3, 290-299

Last minute IGH NEWS

Today 23-09-2014

2013

Opportunities3 job / training period opportunities

 

All NewsNews / Archives

  • Two post-doctoral positions: Role of the piRNA pathway in gene regulation
    (Published: 06-07-2014)

  • iGHazette - Staff only

    Don't missNext seminars & congresses

    ----- @IGH

    Post-doc interview : A new role for polyadenylation in mRNA processing
    03-10-2014, Lisa MUNIZ (Wellcome Trust Centre for Cell Biology, University of Edinburgh)

    Genome stability and DNA replication: novel molecular and structural insights using a vertebrate cell free system
    24-10-2014, Vincenzo COSTANZO ( IFOM - FIRC INSTITUTE OF MOLECULAR ONCOLOGY, Milan, Italy)

    Post-doc interview: Cdc14 phosphatases in the regulation of the cell division cycle in human cells
    31-10-2014, Sara OVEJERO (Centro de Investigación del Cáncer Universidad de Salamanca-CSIC)

    BLESS, Genome-wide high-resolution DNA double-strand break mapping
    14-11-2014, Magdalena Skrzypczak (Laboratory of Bioinformatics and Systems Biology CeNT University of Warsaw)

    IGH papers 1420 Publications

    ... the 2 last ones

    Ducroux A, Benhenda S, Rivière L, Semmes OJ, Benkirane M, Neuveut C.. The Tudor Domain Protein Spindlin1 Is Involved in Intrinsic Antiviral Defense against Incoming Hepatitis B Virus and Herpes Simplex Virus Type 1 (2014), PLoS Pathog.
    Moniot B, Ujjan S, Champagne J, Hirai H, Aritake K, Nagata K, Dubois E, Nidelet S, Nakamura M, Urade Y, Poulat F, Boizet-Bonhoure B. Prostaglandin D2 acts through the Dp2 receptor to influence male germ cell differentiation in the foetal mouse testis (2014), Development.

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      INSTITUTE of HUMAN GENETICS
      CNRS UPR 1142
      Montpellier, France