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The Institute of Human Genetics (Institut de Génétique Humaine, IGH) is a major CNRS unit dedicated to excellence in fundamental research and pathology. The principal research interests of the IGH are genome dynamics, developmental genetics, epigenetics, and molecular and cellular pathology.


Laboratory's News

TOMORROW: 24-03-2017

  11h30 Amphithéâtre GENOPOLYS 11h30 Seminar series on Genetics and Development: Control of the stem cell genome: chromatin remodelling and genome stability
Allison BARDIN (Institut Curie Paris, France)

 


Découverte d'un marqueur du réservoir du VIH.

Des chercheurs français (dont l'équipe de Monsef Benkirane de l'IGH) ont identifié un marqueur qui permet de différencier les cellules « dormantes » infectées par le VIH des cellules saines. Cette découverte permettra d'isoler et d'analyser ces cellules réservoirs qui, en hébergeant silencieusement le virus, sont responsables de la persistance du virus même chez les patients sous traitements antirétroviraux, dont la charge virale est indétectable. Ces travaux s'inscrivent dans le cadre du programme stratégique de l'ANRS « Réservoirs du VIH ». Ils sont issus d'une collaboration entre le CNRS, l'Université de Montpellier, l'Inserm, l'Institut Pasteur, l'hôpital Henri-Mondor AP-HP de Créteil, l'hôpital Gui de Chauliac (CHU de Montpellier) et le VRI (Institut de recherche vaccinale), et font l'objet d'une publication dans la revue Nature le 15 mars 2017 : Descours, B. et al. Nature http://dx.doi.org/10.1038/nature21710 (2017). Un brevet, en propriété CNRS, a été déposé sur l'utilisation diagnostique et thérapeutique du marqueur identifié.
Illistration © Fabrice Hyber

[ Communiqué de presse ]




IGH Seminar Series on Genetics and Development

Genopolys Amphitheater, from March to June '17




Seminar Series on Molecular Bases of Human Diseases 2017

Amphitheater Genopolys, at 11:30, from April 4th to June 30th, 2017










Seminar Series on Genome Dynamics 2016-2017

Amphitheater Genopolys, at 11:30, from November 25th to June 16th











Seminars of the month @ IGH


  • 10-03-2017 (11h30) "Seminar series on Genetics and Development: Coordination of the organ growth in Drosophila"
    Pierre LEOPOLD (Institut de Biologie Valrose Nice, France)
  • 24-03-2017 (11h30) "Seminar series on Genetics and Development: Control of the stem cell genome: chromatin remodelling and genome stability"
    Allison BARDIN (Institut Curie Paris, France)
  • 31-03-2017 (11h30) "Seminar series on genome Dynamics: Epigenetics and functional intratumour heterogeneity"
    Paola Scaffidi (The Francis Crick Institute, London, UK)


Some recent papers


  • Descours B, Petitjean G, López-Zaragoza JL, Bruel T, Raffel R, Psomas C, Reynes J, Lacabaratz C, Levy Y, Schwartz O, Lelievre JD, Benkirane M. "CD32a is a marker of a CD4 T-cell HIV reservoir harbouring replication-competent proviruses" (2017), NATURE: PubMed
  • Rodríguez-Martínez, M., Pinzón, N., Ghommidh, C., Beyne, E., Seitz, H., Cayrou, C., Méchali, M. "The gastrula transition reorganizes replication origin selection in Caenorhabditis elegans " (2017), Nature Structural & Molecular Biology: 24(3):290-299 PubMed
  • Viziteu E, Klein B, Basbous J, Lin YL, Hirtz C, Gourzones C, Tiers L, Bruyer A, Vincent L, Grandmougin C, Seckinger A, Goldschmidt H, Constantinou A, Pasero P, Hose D, Moreaux J. "RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma" (2017), Leukemia: PubMed
  • Pinzon, N., Li, B., Martinez, L., Sergeeva, A., Presumey, J., Apparailly, F., Seitz, H "The number of biologically relevant microRNA targets has been largely over-estimated" (2017), Genome Res: 27, 2, 234-245 PubMed
  • Luco RF "Retrotransposons jump into alternative-splicing regulation via a long noncoding RNA" (2016), Nat Struct Mol Biol: 23(11):952-954 PubMed
  • Stanzione M, Baumann M, Papanikos F, Dereli I, Lange J, Ramlal A, Tränkner D, Shibuya H, de Massy B, Watanabe Y, Jasin M, Keeney S, Tóth A "Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice" (2016), Nat Cell Biol.: 18, 11, 1208-1220 PubMed
  • Bonev B, Cavalli G. "Organization and function of the 3D genome" (2016), Nat Rev Genet: 17(11):661-678 PubMed
  • Loubière, V., Delest, A., Thomas, A., Bonev, B., Schuettengruber, B., Sati, S., Martinez AM., Cavalli, G. "Coordinate redeployment of PRC1 proteins suppresses tumor formation during Drosophila development" (2016), Nature Genetics: 48, 11, 1436-1442 PubMed
  • Bregnard, C, Guerra, J, Dejardin, S, Passalacqua, F, Benkirane, M, Laguette, N "Upregulated LINE-1 Activity in the Fanconi Anemia Cancer Susceptibility Syndrome Leads to Spontaneous Pro-inflammatory Cytokine Production" (2016), EBioMedicine: 8, 184-194 PubMed
  • Ribeyre C, Zellweger R, Chauvin M, Bec N, Larroque C, Lopes M, Constantinou A "Nascent DNA Proteomics Reveals a Chromatin Remodeler Required for Topoisomerase I Loading at Replication Forks" (2016), Cell Rep: 15, 2, 300-309 PubMed
  • Robert T, Nore A, Brun C, Maffre C, Crimi B, Bourbon HM, de Massy B "The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation" (2016), SCIENCE: 351(6276):943-9 PubMed

Last minute IGH NEWS

Today 23-03-2017

2014

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iGHazette - Staff only

Don't missNext seminars & congresses

----- @IGH

Seminar series on Molecular Bases of Human Diseases: Cellular responses to DNA double strand breaks: Molecular mechanisms and clinical utility
07-04-2017, Roland KANAAR (Erasmus MC, University Medical Center Rotterdam NL)

Seminar Series on Genome Dynamics: The seemingly unending complexity of nucleic-acid dependent AAA+ ATPases: some assembly required
14-04-2017, James BERGER (Johns Hopkins School of Medicine, Baltimore, USA)

Seminar series on Molecular Bases of Human Diseases: DNA damage induced signaling and transcription
21-04-2017, Wim VERMEULEN (Erasmus MC, Dept. of Molecular Genetics, Rotterdam, NL)

Seminar series on Molecular Bases of Human Diseases: Clinical proteomics in diagnostics, research and discovery
28-04-2017, Marc BAUMANN (Meilahti Clinical Proteomics Core Facility, University of Helsinki Finland)

Seminar series on Genetics and Development: It takes two to tango: exploring sense/antisense double-stranded RNAs
05-05-2017, Michael PRIMIG (Institut de Recherches en Santé-Environnement-Travail, Rennes, France)

Seminar series on Genetics and Development: Transposable element insertion polymorphisms and hybrid sterility in Paramecium
12-05-2017, Eric MEYER (Institut de Biologie ENS, Paris, France)

Seminar series on Genetics and Development: The cohesin ring and other meiotic protens in human fertility
19-05-2017, Reiner VEITIA (Institut Jacques Monod, Paris, France)

Seminar series on Molecular Bases of Human Diseases: Fluorescent nanodiamonds as non-photobleachable responsive probes
23-05-2017, Petr CIGLER (Synthetic Nanochemistry, Institute of Organic Chemistry & Biochemistry, Prague, Czech republic)

Seminar series on Molecular Bases of Human Diseases: Mechanisms that restrict mammalian DNA over-replication
26-05-2017, Juan MENDEZ (Centro Nacional de Investigaciones Oncológicas, Madrid, Spain)

Seminar series on Genetics and Development: Adult neural stem cell pools homeostasis: single cell and population analysis in the zebrafish telencephalon
02-06-2017, Laure BALLY-CUIF (Institut Pasteur,Paris, France)

Seminar series on Genetics and Development: How cells read and write the tubulin code
06-06-2017, Antonina ROLL-MECAK (NIH Bethesda, USA)

Seminar series on Molecular Bases of Human Diseases: Mobile elements, polydactyl proteins and the species-specifi city of human biology
09-06-2017, Didier TRONO (Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland)

The mutations behind Evolution
14-06-2017, Virginie Courtier-Orgogozo (Institut Jacques Monod - CNRS UMR7592 - Université Paris Diderot)

Seminar series on genome Dynamics: Chromatin regulators in cell differentiation and cancer
16-06-2017, Luciano Di Croce (CRG Centre for Genomic Regulation, Barcelona, Spain)

Seminar series on Molecular Bases of Human Diseases: Living well with our microbiota: implication for HIV care
30-06-2017, Jean-Pierre ROUTY (Experimental Medicine, McGill University, Montreal, Quebec, Canada)

IGH papers 1539 Publications

... the 2 last ones

Hodroj D, Recolin B, Serhal K, Martinez S, Tsanov N, Abou Merhi R, Maiorano D. An ATR-dependent function for the Ddx19 RNA helicase in nuclear R-loop metabolism (2017), EMBO J..
Descours B, Petitjean G, López-Zaragoza JL, Bruel T, Raffel R, Psomas C, Reynes J, Lacabaratz C, Levy Y, Schwartz O, Lelievre JD, Benkirane M.. CD32a is a marker of a CD4 T-cell HIV reservoir harbouring replication-competent proviruses (2017), NATURE.

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