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Director: Giacomo CAVALLI
Associate director: Philippe PASERO
The Institute of Human Genetics (Institut de Génétique Humaine, IGH) is a major CNRS unit dedicated to excellence in fundamental research and pathology. The principal research interests of the IGH are genome dynamics, developmental genetics, epigenetics, and molecular and cellular pathology.

Laboratory's
News


Talents du CNRS - Médailles d'argent 2012
Bernard de Massy, directeur de recherche, a reçu la médaille d'argent du CNRS*, le 16 avril 2013 dans l'amphithéâtre de la délégation régionale du CNRS à Montpellier.
*La médaille d'argent du CNRS distingue un chercheur pour l'originalité, la qualité et l'importance de ses travaux, reconnus sur le plan national et international.
Monsef Benkirane awarded 2013 Ming K. Jeang Foundation Retrovirology Prize: Landmark HIV-1 research honoured
Dr. Monsef Benkirane, from the IGH: Laboratoire de Virologie Moléculaire in Montpellier, France, has been announced as the recipient of the 2013 Retrovirology Prize. This bi-annual prize covers all aspects of the Retrovirology field and celebrates groundbreaking research from retrovirologists aged between 45 and 60. Monsef is among the brightest young "stars" in HIV-1 biology. At 45 years of age, he is the youngest recipient of the Retrovirology prize [...].
From Retrovirology 2013, 10:38 (5 April 2013)
Bernard de Massy awarded by ERC
At the end of the year 2012, the European Research Council (ERC) has awarded three researchers from CNRS Montpellier, including Bernard de Massy, director of research at IGH in category "Confirmed Researcher".
The 2013 talents of the CNRS
In Languedoc-Roussillon, five scientists are distinguished by the CNRS, the bronze medal for Armelle Cau-Lengronne (Pasero team).
6th IGH Seminar Series on Genetics and Development

Seminars of the month @ IGH
- 03-05-2013 (11h30) "Patterning the visual system. Stochastic vs. deterministic choices"
Claude DESPLAN (Dept of Biology - New York University - USA)
- 17-05-2013 (11h30) "The role of mRNA localisation and translational regulation in synaptic plasticity at the Drosophila neuromuscular junction"
Ilan DAVIS (Dept Biochemistry - University of Oxford - UK)
- 24-05-2013 (11h30) "Ubiquitin conjugation: a timing mechanism for nuclear functions"
Catherine DARGEMONT (Institut Jacques Monod - PARIS)

Some recent papers
- Méchali M, Yoshida K, Coulombe P, Pasero P. "Genetic and epigenetic determinants of DNA replication origins, position and activation" (2013), Curr Opin Genet Dev.: 23, 2, 124-131. pii: S0959-437X(13)00028-2. doi: 10.1016/j.gde.2013.02.010.
- Cribier, A., Descours, B., Chaves Valadeo, AL., Laguette, N., Benkirane , M. "Phosphorylation of SAMHD1 by CyclinA2/CDK1 regulates its restriction activity towards HIV-1" (2013), CELL Reports: 3, 4, 1036-1043; doi:pii: S2211-1247(13)00124-1. 10.1016/j.celrep.2013.03.017
- Berkhout B, Lever A, Wainberg M, Fassati A, Borrow P, Fujii M "Monsef Benkirane awarded 2013 Ming K. Jeang Foundation Retrovirology Prize: Landmark HIV-1 research honoured" (2013), Retrovirology: 10, 1, 28
- Tittel-Elmer M, Lengronne A, Davidson MB, Bacal J, François P, Hohl M, Petrini JH, Pasero P, Cobb JA. "Cohesin Association to Replication Sites Depends on Rad50 and Promotes Fork Restart." (2012), Mol Cell.: 48, 1, 98-108. doi: 10.1016/j.molcel.2012.07.004
- Yatim, A., Benne, C., Sobhian, B., Laurent-Chabalier, S., Deas, O., Judde, JG., Lelievre, JD., Levy, Y., Benkirane, M. "NOTCH1 Nuclear Interactome Reveals Key Regulators of Its Transcriptional Activity and Oncogenic Function" (2012), Molecular Cell: 48(3):445-58, http://dx.doi.org/10.1016/j.molcel.2012.08.022
- Wagschal, A., Rousset, E., Basavarajaiah, P., Contreras, X. , Harwig, A., Laurent-Chabalier, S. , Nakamura, M., Chen, X., Zhang, K., Meziane, O., Boyer, F., Parrinello, H., Berkhout, B., Terzian, C., Benkirane, M., Kiernan, R. "Microprocessor, Setx, Xrn2 and Rrp6 Co-Operate to Induce Premature Termination of Transcription by RNAPII" (2012), CELL: 150, 1147-1157, http://dx.doi.org/10.1016/J.cell.2012.08.004
- Grentzinger T, Armenise C, Brun C, Mugat B, Serrano V, Pelisson A, Chambeyron S. "piRNA-mediated transgenerational inheritance of an acquired trait" (2012), Genome Res.: 22, 10, 1877-1888
- Poli J, Tsaponina O, Crabbé L, Keszthelyi A, Pantesco V, Chabes A, Lengronne A, Pasero P. "dNTP pools determine fork progression and origin usage under replication stress." (2012), EMBO J. : 31, 4, 883-894, doi: 10.1038/emboj.2011.470.
- Sexton T, Yaffe E, Kenigsberg E, Bantignies F, Leblanc B, Hoichman M, Parrinello H, Tanay A, Cavalli G. "Three-Dimensional Folding and Functional Organization Principles of the Drosophila Genome." (2012), CELL: 148(3):458-72
- Laguette N, Rahm N, Sobhian B, Chable-Bessia C, Münch J, Snoeck, Sauter D, Switzer WM, Heneine W, Kirchhoff F, Delsuc F, Telenti A and Benkirane M. "Evolutionary and Functional Analyses of the Interaction between the Myeloid Restriction Factor SAMHD1 and the Lentiviral Vpx Protein" (2012), Cell Host & Microbe: 11(2):205-17, doi:10.1016/j.chom.2012.01.007
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IGH NEWS
Today 22-05-2013

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----- @IGHCytoplasmic interaction of the tumor suppressor protein hSNF5 with Dynamin-2 controls endocytosis 07-06-2013, Tatiana ALFONSO PEREZ (Cabimer, Séville ) Transgenerational epigenetic inheritance of Paramecium mating types through co-optation of the scnRNA pathway 28-06-2013, Eric MEYER (Institut de Biologie de l'Ecole Normale SupéŽrieure CNRS UMR8197 - INSERM U1024 PARIS)
----- @Int'l
XVIIIe Congrès National sur les Eléments Transposables
01-07-2013, Montpellier, France
EMBO Conference: Nuclear structure and dynamics
02-10-2013, L'Isle-sur-la-Sorgue, France
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... the 2 last ones
Ishmukhametova A, Chen JM, Bernard R, de Massy B, Baudat F, Boyer A, Méchin D, Thorel D, Chabrol B, Vincent MC, Van Kien PK, Claustres M, Tuffery-Giraud S.. Dissecting the Structure and Mechanism of a Complex Duplication-Triplication Rearrangement in the DMD Gene (2013), Hum Mutat..
Yeeles JT, Poli J, Marians KJ, Pasero P.. Rescuing stalled or damaged replication forks (2013), Cold Spring Harb Perspect Biol..
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