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Director: Giacomo CAVALLI
Associate director: Philippe PASERO

The Institute of Human Genetics (Institut de Génétique Humaine, IGH) is a major CNRS unit dedicated to excellence in fundamental research and pathology. The principal research interests of the IGH are genome dynamics, developmental genetics, epigenetics, and molecular and cellular pathology.


Laboratory's News

 






Seminars of the month @ IGH


  • 02-07-2014 (10h00) "postdoc interview: Functional interactions between Shox2 and Hox genes during the regional growth of the mouse limb"
    Stanley NEUFELD


Some recent papers


  • Yoshida K, Bacal J, Desmarais D, Padioleau I, Tsaponina O, Chabes A, Pantesco V, Dubois E, Parrinello H, Skrzypczak M, Ginalski K, Lengronne A, Pasero P "The histone deacetylases sir2 and rpd3 act on ribosomal DNA to control the replication program in budding yeast." (2014), Mol Cell.: 54(4):691-697
  • Gonzalez I, Mateos-Langerak J, Thomas A, Cheutin T, Cavalli G. "Identification of Regulators of the Three-Dimensional Polycomb Organization by a Microscopy-Based Genome-wide RNAi Screen" (2014), Mol Cell: 54(3):485-99
  • Moran, Y., Fredman, D., Praher, D., Li Z. L., Meng Wee,L., Rentzsch, F., Zamore,P.D., Technau, U., Seitz H. "Cnidarian microRNAs frequently regulate targets by cleavage" (2014), Genome Research: 24(4):651-63
  • Laguette,N., Bregnard, C., Hue, P., Basbous, J., Yatim, A., Larroque, M., Kirchhoff, F., Constantinou, A., Bijan, S., Benkirane, M. "Premature Activation of the SLX4 Complex by Vpr Promotes G2/M Arrest and Escape from Innate Immune Sensing" (2014), CELL: 156, 1-2, 134-145
  • Joly, W,, Chartier,A., Rojas-Rios, P., Busseau,I., Simonelig, M. "The CCR4 Deadenylase Acts with Nanos and Pumilio in the Fine-Tuning of Mei-P26 Expression to Promote Germline Stem Cell Self-Renewal" (2013), Stem Cell Reports: Volume 1, Issue 5, 411-424
  • Van der Laan, S., Crozet, C., Tsanov, N., and Maiorano, D "High Dub3 expression in mouse ESC couples the G1/S checkpoint to pluripotency" (2013), Molecular Cell: 52, 3, 366-379
  • Wu H, Mathioudakis N, Diagouraga B, Dong A, Dombrovski L, Baudat F, Cusack S, de Massy B, Kadlec J. "Molecular Basis for the Regulation of the H3K4 Methyltransferase Activity of PRDM9." (2013), Cell Rep: 14, 11, 794-806
  • Bétous R., Pillaire, M-J, Pierini, L., Van der Laan, S., Recolin B., Ohl-Séguy, E., Guo, C., Niimi, N., Gruz, P., Nohmi, T. Friedberg, E., Cazaux, C., Maiorano, D* and Hoffmann J-S*. * corresponding authors "DNA polymerase k-dependent DNA synthesis at stalled replication forks is important for Chk1 activation" (2013), EMBO Journal: 32(15):2172-85
  • Lossaint G, Larroque M, Ribeyre C, Bec N, Larroque C, Décaillet C, Gari K, Constantinou A. "FANCD2 Binds MCM Proteins and Controls Replisome Function upon Activation of S Phase Checkpoint Signaling." (2013), Mol Cell.: 51(5):678-690
  • Iovino N, Ciabrelli F, Cavalli G. "PRC2 Controls Drosophila Oocyte Cell Fate by Repressing Cell Cycle Genes." (2013), Dev Cell: 26(4):431-9
  • Cribier, A., Descours, B., Chaves Valadeo, AL., Laguette, N., Benkirane , M. "Phosphorylation of SAMHD1 by CyclinA2/CDK1 regulates its restriction activity towards HIV-1" (2013), CELL Reports: 3, 4, 1036-1043
  • Berkhout B, Lever A, Wainberg M, Fassati A, Borrow P, Fujii M "Monsef Benkirane awarded 2013 Ming K. Jeang Foundation Retrovirology Prize: Landmark HIV-1 research honoured" (2013), Retrovirology: 10, 1, 28
  • Cavalli, G., Mistelli, T. "Functional implications of genome topology" (2013), Nat. Struct. Mol. Biol: 20, 3, 290-299

Last minute IGH NEWS

Today 23-07-2014

2013

Opportunities3 job / training period opportunities

 

All NewsNews / Archives

  • Two post-doctoral positions: Role of the piRNA pathway in gene regulation
    (Published: 06-07-2014)

  • iGHazette - Staff only

    Don't missNext seminars & congresses

    IGH papers 1415 Publications

    ... the 2 last ones

    Simonelig M. piRNAs, master regulators of gene expression (2014), Cell Res.
    Jemaà M, Morin N, Cavelier P, Cau J, Strub JM, Delsert C.. Adult somatic progenitor cells and hematopoiesis in oyster (2014), J Exp Biol..

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      INSTITUTE of HUMAN GENETICS
      CNRS UPR 1142
      Montpellier, France