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Deputy director:

The Institute of Human Genetics (Institut de Génétique Humaine, IGH) is a major CNRS unit dedicated to excellence in fundamental research and pathology. The principal research interests of the IGH are genome dynamics, developmental genetics, epigenetics, and molecular and cellular pathology.

Laboratory's News

TODAY: 25-09-2017

  11h30 Amphithéâtre GENOPOLYS 11h30 The role of Mre11 in elimination of Topoisomerase II cleavage complex
Shunichi TAKEDA (Kyoto University, Medical School )


Seminars of the month @ IGH

  • 22-09-2017 (11h00) "Mapping genomic regulatory architecture and interpreting non-coding variation with capture HiC"
    Mikhail SPIVAKOV (Babraham Institute - Regulatory Genomics Group - Cambridge UK)
  • 25-09-2017 (11h30) "The role of Mre11 in elimination of Topoisomerase II cleavage complex"
    Shunichi TAKEDA (Kyoto University, Medical School )

Some recent papers

  • Lin, YL., Pasero, P. "Transcription-Replication Conflicts: Orientation Matters" (2017), CELL: 170(4):603-604 PubMed
  • Schuettengruber, B., Bourbon, HM., Di Croce, L., Cavalli, G. "Genome Regulation by Polycomb and Trithorax: 70 Years and Counting" (2017), CELL: Vol 171, Issue1, 34-57
  • Morchikh, M., Cribier, A., Raffel, R., Amraoui, S., Cau, J., Severac, D., Dubois, E., Schwartz, O., Bennasser, Y., Benkirane, M. "HEXIM1 and NEAT1 lncRNA form a multi subunit complex that regulates DNA-mediated innate immune response" (2017), Mol. Cell: 37, 3, 387-399 PubMed
  • Rahmoun M, Lavery R, Laurent-Chaballier S, Bellora N, Philip GK, Rossitto M, Symon A, Pailhoux E, Cammas F, Chung J, Bagheri-Fam S, Murphy M, Bardwell V, Zarkower D, Boizet-Bonhoure B, Clair P, Harley VR, Poulat F. "In mammalian foetal testes, SOX9 regulates expression of its target genes by binding to genomic regions with conserved signatures" (2017), Nucleic Acids Res.: PubMed
  • Akkouche, A., Mugat, B., Barckmann, B., Varela-Chavez, C., Li, B., Raffel, R., Pelisson, A., Chambeyron, S. "Piwi Is Required during Drosophila Embryogenesis to License Dual-Strand piRNA Clusters for Transposon Repression in Adult Ovaries" (2017), Molecular Cell: 66, 3, 411-419 PubMed
  • Ciabrelli F, Comoglio F, Fellous S, Bonev B, Ninova M, Szabo Q, Xuéreb A, Klopp C, Aravin A, Paro R, Bantignies F, Cavalli G "Stable Polycomb-dependent transgenerational inheritance of chromatin states in Drosophila" (2017), Nat. Genet.: PubMed
  • Descours B, Petitjean G, López-Zaragoza JL, Bruel T, Raffel R, Psomas C, Reynes J, Lacabaratz C, Levy Y, Schwartz O, Lelievre JD, Benkirane M. "CD32a is a marker of a CD4 T-cell HIV reservoir harbouring replication-competent proviruses" (2017), NATURE: 546(7660):686 PubMed
  • Hodroj D, Recolin B, Serhal K, Martinez S, Tsanov N, Abou Merhi R, Maiorano D "An ATR-dependent function for the Ddx19 RNA helicase in nuclear R-loop metabolism" (2017), EMBO J.: 36(9):1182-1198 PubMed
  • Grey C, Clément JA, Buard J, Leblanc B, Gut I, Gut M, Duret L, de Massy B. "In vivo binding of PRDM9 reveals interactions with noncanonical genomic sites" (2017), Genome Res.: 27(4):580-590 PubMed
  • Rodríguez-Martínez, M., Pinzón, N., Ghommidh, C., Beyne, E., Seitz, H., Cayrou, C., Méchali, M. "The gastrula transition reorganizes replication origin selection in Caenorhabditis elegans " (2017), Nature Structural & Molecular Biology: 24(3):290-299 PubMed
  • Viziteu E, Klein B, Basbous J, Lin YL, Hirtz C, Gourzones C, Tiers L, Bruyer A, Vincent L, Grandmougin C, Seckinger A, Goldschmidt H, Constantinou A, Pasero P, Hose D, Moreaux J. "RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma" (2017), Leukemia: PubMed
  • Pinzon, N., Li, B., Martinez, L., Sergeeva, A., Presumey, J., Apparailly, F., Seitz, H "microRNA target prediction programs predict many false positives" (2017), Genome Res: 27, 2, 234-245 PubMed

Last minute IGH NEWS

Today 25-09-2017


Opportunities2 job / training period opportunities


All NewsNews / Archives

iGHazette - Staff only

Don't missNext seminars & congresses

----- @IGH

Trans-generational transmission of environmental information
27-10-2017, Ben Lehner (Centre for Genomic Regulation Barcelona)

----- @Int'l

Web Site France-Japan Epigenetics Workshop-2017
06-11-2017, Paris, France

Web Site The CRISPR revolution: from bacterial immunity to functional genomics
16-11-2017, Montpellier, France

Web Site EMBO Conference “Nuclear Structure and Dynamics”
04-10-2017, L'Isle sur la Sorgue, France

IGH papers 1563 Publications

... the 2 last ones

Schuettengruber, B., Bourbon, HM., Di Croce, L., Cavalli, G.. Genome Regulation by Polycomb and Trithorax: 70 Years and Counting (2017), CELL.
Romero-Soriano V, Modolo L, Lopez-Maestre H, Mugat B, Pessia E, Chambeyron S, Vieira C, Garcia Guerreiro MP. Transposable Element Misregulation Is Linked to the Divergence between Parental piRNA Pathways in Drosophila Hybrids (2017), Genome Biol Evol..

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