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The Institute of Human Genetics (Institut de Génétique Humaine, IGH) is a major CNRS unit dedicated to excellence in fundamental research and pathology. The principal research interests of the IGH are genome dynamics, developmental genetics, epigenetics, and molecular and cellular pathology.


Laboratory's News

TODAY: 23-05-2017

  11h30 Amphithéâtre GENOPOLYS 11h30 Seminar series on Molecular Bases of Human Diseases: Fluorescent nanodiamonds as non-photobleachable responsive probes
Petr CIGLER (Synthetic Nanochemistry, Institute of Organic Chemistry & Biochemistry, Prague, Czech republic)

 


We are more than our DNA...

The lab of Giacomo Cavalli at the Institute of Human Genetics of Montpellier (CNRS and University of Montpellier), in collaboration with researchers at INRA, ETH and Caltech has demonstrated the existence of transgenerational epigenetic inheritance (TEI) in Drosophila. By transiently modifying the 3D organization of chromosomes and the function of Polycomb proteins, whose function is essential in development, the Cavalli lab has obtained fly lines characterized by different eye colors in the presence of the same DNA sequence. These differences depend on a variable degree of Polycomb-dependent gene silencing that can be stably but reversibly transmitted through a large number of generations. This epigenetic inheritance applies to transgenic as well as natural populations and can be modulated by environmental conditions, such as growth temperature. These results have been published in the journal Nature Genetics on April 24, 2017. Read the article at Ciabrelli et al. Nature Genetics, doi:10.1038/ng.3848
Artwork (c) Elisa Cavalli

[Press release]




Découverte d'un marqueur du réservoir du VIH.

Des chercheurs français (dont l'équipe de Monsef Benkirane de l'IGH) ont identifié un marqueur qui permet de différencier les cellules « dormantes » infectées par le VIH des cellules saines. Cette découverte permettra d'isoler et d'analyser ces cellules réservoirs qui, en hébergeant silencieusement le virus, sont responsables de la persistance du virus même chez les patients sous traitements antirétroviraux, dont la charge virale est indétectable. Ces travaux s'inscrivent dans le cadre du programme stratégique de l'ANRS « Réservoirs du VIH ». Ils sont issus d'une collaboration entre le CNRS, l'Université de Montpellier, l'Inserm, l'Institut Pasteur, l'hôpital Henri-Mondor AP-HP de Créteil, l'hôpital Gui de Chauliac (CHU de Montpellier) et le VRI (Institut de recherche vaccinale), et font l'objet d'une publication dans la revue Nature le 15 mars 2017 : Descours, B. et al. Nature http://dx.doi.org/10.1038/nature21710 (2017). Un brevet, en propriété CNRS, a été déposé sur l'utilisation diagnostique et thérapeutique du marqueur identifié.
Illustration © Fabrice Hyber

[ Communiqué de presse ]




IGH Seminar Series on Genetics and Development

Genopolys Amphitheater, from March to June '17




Seminar Series on Molecular Bases of Human Diseases 2017

Amphitheater Genopolys, at 11:30, from April 4th to June 30th, 2017











Seminars of the month @ IGH


  • 05-05-2017 (11h30) "Seminar series on Genetics and Development: It takes two to tango: exploring sense/antisense double-stranded RNAs"
    Michael PRIMIG (Institut de Recherches en Santé-Environnement-Travail, Rennes, France)
  • 12-05-2017 (14h00) "Chromosome mis-segregation in spermatocytes and the paternal age effect: 15 is the new 40"
    Francesca COLE (University of Texas, MD Anderson Cancer Center)
  • 12-05-2017 (11h30) "Seminar series on Genetics and Development: Transposable element insertion polymorphisms and hybrid sterility in Paramecium"
    Eric MEYER (Institut de Biologie ENS, Paris, France)
  • 15-05-2017 (14h30) "Interview post-doc: Genomic Analysis of Smchd1 function by PAR-CLIP, ATAC-seq, and in situ Hi-C"
    Natasha Jansz
  • 19-05-2017 (11h30) "Seminar series on Genetics and Development: The cohesin ring and other meiotic protens in human fertility"
    Reiner VEITIA (Institut Jacques Monod, Paris, France)
  • 23-05-2017 (11h30) "Seminar series on Molecular Bases of Human Diseases: Fluorescent nanodiamonds as non-photobleachable responsive probes"
    Petr CIGLER (Synthetic Nanochemistry, Institute of Organic Chemistry & Biochemistry, Prague, Czech republic)
  • 26-05-2017 (11h30) "Seminar series on Molecular Bases of Human Diseases: Mechanisms that restrict mammalian DNA over-replication"
    Juan MENDEZ (Centro Nacional de Investigaciones Oncológicas, Madrid, Spain)


Some recent papers


  • Akkouche, A., Mugat, B., Barckmann, B., Varela-Chavez, C., Li, B., Raffel, R., Pelisson, A., Chambeyron, S. "Piwi Is Required during Drosophila Embryogenesis to License Dual-Strand piRNA Clusters for Transposon Repression in Adult Ovaries" (2017), Molecular Cell: 66, 3, 411-419 PubMed
  • Ciabrelli F, Comoglio F, Fellous S, Bonev B, Ninova M, Szabo Q, Xuéreb A, Klopp C, Aravin A, Paro R, Bantignies F, Cavalli G "Stable Polycomb-dependent transgenerational inheritance of chromatin states in Drosophila" (2017), Nat. Genet.: PubMed
  • Descours B, Petitjean G, López-Zaragoza JL, Bruel T, Raffel R, Psomas C, Reynes J, Lacabaratz C, Levy Y, Schwartz O, Lelievre JD, Benkirane M. "CD32a is a marker of a CD4 T-cell HIV reservoir harbouring replication-competent proviruses" (2017), NATURE: 543(7646):564-567 PubMed
  • Hodroj D, Recolin B, Serhal K, Martinez S, Tsanov N, Abou Merhi R, Maiorano D "An ATR-dependent function for the Ddx19 RNA helicase in nuclear R-loop metabolism" (2017), EMBO J.: PubMed
  • Grey C, Clément JA, Buard J, Leblanc B, Gut I, Gut M, Duret L, de Massy B. "In vivo binding of PRDM9 reveals interactions with noncanonical genomic sites" (2017), Genome Res.: 27(4):580-590 PubMed
  • Rodríguez-Martínez, M., Pinzón, N., Ghommidh, C., Beyne, E., Seitz, H., Cayrou, C., Méchali, M. "The gastrula transition reorganizes replication origin selection in Caenorhabditis elegans " (2017), Nature Structural & Molecular Biology: 24(3):290-299 PubMed
  • Viziteu E, Klein B, Basbous J, Lin YL, Hirtz C, Gourzones C, Tiers L, Bruyer A, Vincent L, Grandmougin C, Seckinger A, Goldschmidt H, Constantinou A, Pasero P, Hose D, Moreaux J. "RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma" (2017), Leukemia: PubMed
  • Pinzon, N., Li, B., Martinez, L., Sergeeva, A., Presumey, J., Apparailly, F., Seitz, H "The number of biologically relevant microRNA targets has been largely over-estimated" (2017), Genome Res: 27, 2, 234-245 PubMed
  • Luco RF "Retrotransposons jump into alternative-splicing regulation via a long noncoding RNA" (2016), Nat Struct Mol Biol: 23(11):952-954 PubMed
  • Stanzione M, Baumann M, Papanikos F, Dereli I, Lange J, Ramlal A, Tränkner D, Shibuya H, de Massy B, Watanabe Y, Jasin M, Keeney S, Tóth A "Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice" (2016), Nat Cell Biol.: 18, 11, 1208-1220 PubMed
  • Bonev B, Cavalli G. "Organization and function of the 3D genome" (2016), Nat Rev Genet: 17(11):661-678 PubMed
  • Loubière, V., Delest, A., Thomas, A., Bonev, B., Schuettengruber, B., Sati, S., Martinez AM., Cavalli, G. "Coordinate redeployment of PRC1 proteins suppresses tumor formation during Drosophila development" (2016), Nature Genetics: 48, 11, 1436-1442 PubMed
  • Bregnard, C, Guerra, J, Dejardin, S, Passalacqua, F, Benkirane, M, Laguette, N "Upregulated LINE-1 Activity in the Fanconi Anemia Cancer Susceptibility Syndrome Leads to Spontaneous Pro-inflammatory Cytokine Production" (2016), EBioMedicine: 8, 184-194 PubMed
  • Ribeyre C, Zellweger R, Chauvin M, Bec N, Larroque C, Lopes M, Constantinou A "Nascent DNA Proteomics Reveals a Chromatin Remodeler Required for Topoisomerase I Loading at Replication Forks" (2016), Cell Rep: 15, 2, 300-309 PubMed
  • Robert T, Nore A, Brun C, Maffre C, Crimi B, Bourbon HM, de Massy B "The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation" (2016), SCIENCE: 351(6276):943-9 PubMed

Last minute IGH NEWS

Today 23-05-2017

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Don't missNext seminars & congresses

----- @IGH

Seminar series on Genetics and Development: Adult neural stem cell pools homeostasis: single cell and population analysis in the zebrafish telencephalon
02-06-2017, Laure BALLY-CUIF (Institut Pasteur,Paris, France)

Seminar series on Genetics and Development: How cells read and write the tubulin code
06-06-2017, Antonina ROLL-MECAK (NIH Bethesda, USA)

Seminar series on Molecular Bases of Human Diseases: Living well with our microbiota: implication for HIV care
30-06-2017, Jean-Pierre ROUTY (Experimental Medicine, McGill University, Montreal, Quebec, Canada)

----- @Int'l

Web Site EMBO Conference “Nuclear Structure and Dynamics”
04-10-2017, L'Isle sur la Sorgue, France

IGH papers 1547 Publications

... the 2 last ones

Wong JJ, Gao D, Nguyen TV, Kwok CT, van Geldermalsen M, Middleton R, Pinello N, Thoeng A, Nagarajah R, Holst J, Ritchie W, Rasko JEJ. Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment (2017), Nat Commun.
Rahmoun M, Lavery R, Laurent-Chaballier S, Bellora N, Philip GK, Rossitto M, Symon A, Pailhoux E, Cammas F, Chung J, Bagheri-Fam S, Murphy M, Bardwell V, Zarkower D, Boizet-Bonhoure B, Clair P, Harley VR, Poulat F.. In mammalian foetal testes, SOX9 regulates expression of its target genes by binding to genomic regions with conserved signatures (2017), .

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  INSTITUTE of HUMAN GENETICS
  UMR9002 CNRS-UM
  Montpellier, France