Armelle LENGRONNE "chercheure d'avenir"

Le prix "Chercheur d'avenir 2011" décerné par la région Languedoc-Roussillon a été attribué à 38 lauréats, dont Armelle Lengronne (équipe Pasero) pour son projet "Organisation des chromosomes et stabilité du patrimoine génétique".
Ils recevront une aide financière de la région Languedoc-Roussillon entre 20 000 et 100 000 euros sur trois ans pour mener à bien leur projet de recherche.

Interview of Giacomo Cavalli and Amos Tanay

Epigenesys's podcast about the paper "Three-Dimensional Folding and Functional Organization Principles of the Drosophila Genome." Sexton T. et al. Cell 2012.

High-resolution mapping of the 3D organization of chromosomes

[Interview of Giacomo Cavalli by TVSud (in french)]

In collaboration with researchers from the Weizmann Institute in Israel, a team from the Institut de Génétique Humaine (CNRS) has, for the first time, revealed the detailed three-dimensional architecture of chromosomes: Giacomo Cavalli and his colleagues have achieved high-resolution mapping of the different contacts that exist within and between chromosomes. They performed this feat using a new very high-throughput technique improved by the Montpellier team. This major research work should shed new light on the impact of 3D chromosome organization on genome expression and on the onset of diseases such as cancer. It is published in the journal Cell of 3 February 2012... Read more.

The cover of this issue was designed by Cyril Sarrauste de Menthière

Seminar series on Genome Dynamics

The seminars take place on Fridays, in the IGH 1st floor room, at 11:30 from Decmeber 2011 to March 2012 (7 seminars).
The programme is available on the poster.

Seminars of the month @ IGH

• 09-02-2012 "Screening genes and chemical suppressors of miRNA silencing pathway in Drosophila"
  Caroline Jacquier-Labroche

  Candidature Post-doctorat

• 10-02-2012 "Genome stability: from worms to human disease"
  Simon BOULTON (Clare Hall, Cancer Research, UK)

• 15-02-2012 "Identification of new pathophysiological mechanisms in multiple myeloma and therapeutic applications"
  Jérome Moreaux (Institut de Recherche en Biothérapies, INSERM Unité 1400, Hôpital Saint-Eloi, CHU de Montpellier)

Some recent papers

• Sexton T, Yaffe E, Kenigsberg E, Bantignies F, Leblanc B, Hoichman M, Parrinello H, Tanay A, Cavalli G. "Three-Dimensional Folding and Functional Organization Principles of the Drosophila Genome." (2012), CELL: 148(3):458-72

• Laguette N, Rahm N, Sobhian B, Chable-Bessia C, Münch J, Snoeck, Sauter D, Switzer WM, Heneine W, Kirchhoff F, Delsuc F, Telenti A and Benkirane M. "Evolutionary and Functional Analyses of the Interaction between the Myeloid Restriction Factor SAMHD1 and the Lentiviral Vpx Protein" (2012), Cell Host & Microbe: 11, 1-3, doi:10.1016/j.chom.2012.01.007

• Schuettengruber B, Martinez AM, Iovino N, Cavalli G. "Trithorax group proteins: switching genes on and keeping them active." (2011), Nat Rev Mol Cell Biol.: 12(12):799-814. doi: 10.1038/nrm3230.

• Grey C, Barthès P, Chauveau-Le Friec G, Langa F, Baudat F, de Massy B. "Mouse PRDM9 DNA-Binding Specificity Determines Sites of Histone H3 Lysine 4 Trimethylation for Initiation of Meiotic Recombination." (2011), PLoS Biol: 9(10):e1001176

• Lichten, M., de Massy, B. "The Impressionistic Landscape of Meiotic Recombination" (2011), CELL: Vol. 147, Issue 2, pp. 267-270

• Ganier O, Bocquet S, Peiffer I, Brochard V, Arnaud P, Puy A, Jouneau A, Feil R, Renard JP, and Méchali M "Synergic reprogramming of mammalian cells by combined exposure to mitotic Xenopus egg extracts and transcription factors." (2011), Proc. Natl. Acad. Sci. USA: 108(42):17331-6

• Cayrou C, Coulombe P, Vigneron A, Stanojcic S, Ganier O, Peiffer I, Rivals E, Puy A, Laurent-Chabalier S, Desprat R, Méchali M. "Genome-scale analysis of metazoan replication origins reveals their organization in specific but flexible sites defined by conserved features." (2011), Genome Res. : 21, 9, 1438-1449

• Laguette, N., Sobhian, B., Casartelli, N., Ringeard, M., Chable-Bessia, C., Ségéral, E., Emiliani, S., Schwartz, O., Benkirane, M "SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx." (2011), NATURE: 474(7353):654-7 - http://dx.doi.org/10.1038/nature10117

• Bennasser, Y., Chable-Bessia, C., Triboulet, R., Gibbings, D., Gwizdek, C., Dargemont, C., Kremer, EJ., Voinnet, O., Benkirane, M. "Competition for XPO5 binding between Dicer mRNA, pre-miRNA and viral RNA regulates human Dicer levels" (2011), Nature Structural & Molecular Biology: 18(3):323-7

• Nishiyama A, Frappier L, Méchali M. "MCM-BP regulates unloading of the MCM2-7 helicase in late S phase." (2011), Genes Dev.: 25(2):165-75

• Bantignies, F., Roure, V., Comet, I., Leblanc, B., Schuttengruber, B., Bonnet, J., Tixier, V., Mas, A., Cavalli, G. "Polycomb-dependent Regulatory Contacts between Distant Hox Loci in Drosophila," (2011), CELL: 144, 214-226

• Boulanger, A., Clouet-Redt, C., Farge, M., Flandre, A., Guignard, T., Fernando, C., Juge, F. & Dura, JM. "ftz-f1 and Hr39 opposing roles on EcR expression during Drosophila mushroom body neuron remodeling" (2011), Nature Neuroscience: 14(1) : 37-44. voir Nature Neuroscience News and Views, Vol. 14 N°1