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The Institute of Human Genetics (Institut de Génétique Humaine, IGH) is a major CNRS unit dedicated to excellence in fundamental research and pathology. The principal research interests of the IGH are genome dynamics, developmental genetics, epigenetics, and molecular and cellular pathology.

Laboratory's News


Diag2Tec lauréat iLAB 2016 création-développement

Lauréate du 18e concours national d'aide à la création d'entreprises innovantes, dans la catégorie "création-développement" Diag2Tec est une spin-off issue de l'Institut de Génétique Humaine et du CHU de Montpellier (P Pasero - J Moreaux).

Diag2Tec est une société spécialisée dans le développement d'outils pour une médecine de précision dans les hémopathies malignes (CEO Pierre Vidal).

Seminars of the month @ IGH

  • 12-07-2016 (14h00) "Through the looking glass: witnessing host-virus interplay in zebrafish"
    Christelle Langevin (Fish infection and Immunity team, INRA, Jouy en Josas)
  • 22-07-2016 (11h30) "Seminar series on Genetics & Development: Building neural circuits interconnecting the left and right sides of the central nervous system: molecular mechanisms of midline crossing"
    Valérie Castellani (INMG - Université de lyon1)

Some recent papers

  • Ribeyre C, Zellweger R, Chauvin M, Bec N, Larroque C, Lopes M, Constantinou A "Nascent DNA Proteomics Reveals a Chromatin Remodeler Required for Topoisomerase I Loading at Replication Forks" (2016), Cell Rep: 15, 2, 300-309 PubMed
  • Robert T, Nore A, Brun C, Maffre C, Crimi B, Bourbon HM, de Massy B "The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation" (2016), SCIENCE: 351(6276):943-9 PubMed
  • Menolfi D, Delamarre A, Lengronne A, Pasero P, Branzei D. "Essential Roles of the Smc5/6 Complex in Replication through Natural Pausing Sites and Endogenous DNA Damage Tolerance" (2015), Mol. Cell: 60(6):835-46 PubMed
  • Rojas-Rios, P., Chartier, A., Pierson, S., Severac, D., Dantec, C., Busseau, I., Simonelig, M. "Translational Control of Autophagy by Orb in the Drosophila Germline" (2015), Developmental Cell: 35, 5, 622-631 PubMed
  • Cayrou C, Ballester B, Peiffer I, Fenouil R, Coulombe P, Andrau JC, van Helden J, Méchali M. "The chromatin environment shapes DNA replication origin organization and defines origin classes" (2015), Genome Res: 25(12):1873-85 PubMed
  • Cavalli, G. "PRC1 proteins orchestrate three-dimensional genome architecture" (2015), Nat Genet: 47(10):1105-6 PubMed
  • Traver S, Coulombe P, Peiffer I, Hutchins JR, Kitzmann M, Latreille D, Méchali M "MCM9 Is Required for Mammalian DNA Mismatch Repair" (2015), Mol Cell: 59(5):831-839 PubMed
  • Barckmann,B., Pierson,S., Dufourt, J., Papin, C., Armenise, C., Port, F., Grentzinger, T., Chambeyron, S., Baronian, G., Desvignes, JP., Curk, T., Simonelig, M. "Aubergine iCLIP Reveals piRNA-Dependent Decay of mRNAs Involved in Germ Cell Development in the Early Embryo" (2015), Cell Rep: 12(7):1205-1216 PubMed
  • Kermi, C., Prieto, S., van der Laan, S., Tsanov, N., Recolin, B., Uro-Coste, E., Delisle, M-B., and Maiorano, D. "Rad18 is a maternal limiting factor that suppresses the UV-dependent DNA damge checkpoint in Xenopus embryos" (2015), Developmental Cell : 34(3):364-372 PubMed
  • Reynaud E, Lahaye LL, Boulanger A, Petrova IM, Marquilly C, Flandre A, Martianez T, Privat M, Noordermeer JN, Fradkin LG, Dura JM "Guidance of Drosophila Mushroom Body Axons Depends upon DRL-Wnt Receptor Cleavage in the Brain Dorsomedial Lineage Precursors" (2015), Cell Rep: 11(8):1293-304 PubMed
  • Gonzalez I, Munita R, Agirre E, Dittmer TA, Gysling K, Misteli T, Luco RF. "A lncRNA regulates alternative splicing via establishment of a splicing-specific chromatin signature" (2015), Nat Struct Mol Biol: 22, 5, 370-376 PubMed
  • Fragkos M, Ganier O, Coulombe P, Méchali M "DNA replication origin activation in space and time" (2015), Nat Rev Mol Cell Biol: 16(6):360-74 PubMed
  • Ide, S., Dejardin, J. "End-targeting proteomics of isolated chromatin segments of a mammalian ribosomal RNA gene promoter" (2015), Nat. Commun.: 6, 6674 PubMed
  • Borde V, de Massy B "Meiosis: early DNA double-strand breaks pave the way for inter-homolog repair" (2015), Dev Cell: 32(6):663-4 PubMed
  • Sexton, T., Cavalli, G. "The Role of Chromosome Domains in Shaping the Functional Genome" (2015), CELL: 160, 6, 1049–1059 PubMed
  • Marzec, P., Armenise, C., Perot, G., Roumelioti, F.M., Basyuk, E., Gagos, S., Chibon, F., Dejardin, J. "Nuclear-Receptor-Mediated Telomere Insertion Leads to Genome Instability in ALT Cancer" (2015), CELL: 160, 5, 913-927 PubMed

Last minute IGH NEWS

Today 25-07-2016


Opportunities1 job / training period opportunities


All NewsNews / Archives

iGHazette - Staff only

Don't missNext seminars & congresses

----- @Int'l

Web Site Architecture and Plasticity of the Cell Nucleus
29-11-2016, ENSA Paris-Val de Seine, Fr.

Web Site The Students and Postdocs Meiosis Workshop
19-09-2016, Montpellier, Fr.

Web Site XXIIIème Colloque de l'Association des Cytogénéticiens de Langue Française
20-09-2016, Montpellier, France

IGH papers 1508 Publications

... the 2 last ones

Psomas, C, Younas, M, Reynes, C, Cezar, R, Portalès, P, Tuaillon, E, Guigues, A, Merle, C, Atoui, N, Fernandez, C, Le Moing, V, Barbuat, C, Marin, G, Nagot, N, Sotto, A, Eliaou, JF, Sabatier, R, Reynes, J, Cordeau P . One of the immune activation profiles observed in HIV-1-infected adults with suppressed viremia is linked to metabolic syndrome: The ACTIVIH study (2016), EBioMedicine.
Bregnard, C, Guerra, J, Dejardin, S, Passalacqua, F, Benkirane, M, Laguette, N. Upregulated LINE-1 Activity in the Fanconi Anemia Cancer Susceptibility Syndrome Leads to Spontaneous Pro-inflammatory Cytokine Production (2016), EBioMedicine.

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