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The Institute of Human Genetics (Institut de Génétique Humaine, IGH) is a major CNRS unit dedicated to excellence in fundamental research and pathology. The principal research interests of the IGH are genome dynamics, developmental genetics, epigenetics, and molecular and cellular pathology.


Laboratory's News

TOMORROW: 30-09-2016

  11h30 IGH : salle de Conférence (1er étage) 11h30 BRCA1 and BRCA2 tumour suppressors prevent replication stress and genome instability
Madalena Tarsounas (Oxford Institute for Radiation Oncology, Cancer Research, UK )

 


A new epigenetic mechanism mediating tumor suppression by Polycomb proteins

The Cavalli lab shows that a complex of Polycomb group proteins has a tumor suppressor activity that depends on its specific binding to hundreds of genes involved in the control of proliferation, cell signaling and polarity. This activity was discovered in Drosophila, but the same chromosomal binding pattern is observed in differentiated human cells, suggesting that this phenomenon might be conserved in some human tumors. This study, published in the journal Nature Genetics, opens new perspectives in the field of carcinogenesis.
Read more.





Seminars of the month @ IGH


  • 13-09-2016 (11h30) "Functions of ATR and RPA in Suppression of Genomic Instability"
    LEE ZOU (Harvard Medical School and Massachusetts General Hospital Cancer Center, USA)
  • 16-09-2016 (11h30) "Mechanistic, functional and evolutionary lessons from budding yeasts meiotic recombination landscapes"
    Bertrand LLORENTE (CRCM - Marseille)
  • 27-09-2016 (11h30) "Spatio-temporal replication program of the human genome and its impact on genome organization and evolution"
    Chunlong CHEN (Institut Curie, PARIS)
  • 30-09-2016 (11h30) "BRCA1 and BRCA2 tumour suppressors prevent replication stress and genome instability"
    Madalena Tarsounas (Oxford Institute for Radiation Oncology, Cancer Research, UK )


Some recent papers


  • Loubière, V., Delest, A., Thomas, A., Bonev, B., Schuettengruber, B., Sati, S., Martinez AM., Cavalli, G. "Coordinate redeployment of PRC1 proteins suppresses tumor formation during Drosophila development" (2016), Nature Genetics: doi:10.1038/ng.3671 PubMed
  • Bregnard, C, Guerra, J, Dejardin, S, Passalacqua, F, Benkirane, M, Laguette, N "Upregulated LINE-1 Activity in the Fanconi Anemia Cancer Susceptibility Syndrome Leads to Spontaneous Pro-inflammatory Cytokine Production" (2016), EBioMedicine: 8, 184-194 PubMed
  • Ribeyre C, Zellweger R, Chauvin M, Bec N, Larroque C, Lopes M, Constantinou A "Nascent DNA Proteomics Reveals a Chromatin Remodeler Required for Topoisomerase I Loading at Replication Forks" (2016), Cell Rep: 15, 2, 300-309 PubMed
  • Robert T, Nore A, Brun C, Maffre C, Crimi B, Bourbon HM, de Massy B "The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation" (2016), SCIENCE: 351(6276):943-9 PubMed

Last minute IGH NEWS

Today 29-09-2016

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Don't missNext seminars & congresses

----- @IGH

Epigenetic mechanisms in nerve regeneration
07-10-2016, Valeria CAVALLI (https://hopecenter.wustl.edu/?faculty=valeria-cavalli-phd)

Probing host-virus interactions in the gut microbiome by proximity ligation (chromosome capture) assay
11-10-2016, Romain KOSZUL (Institut Pasteur, PARIS)

Generation of Neural Diversity
14-10-2016, Claude DESPLAN (NYU Biology, Washington, USA)

Seminar series on Genome Dynamics: Splicing-dependent mRNA quality control in Drosophila
25-11-2016, Klaus Forsterman (LMU, Gene Center Munich, Genzentrum & Dept. Biochemie, Munich, Germany)

Seminar series on genome Dynamics: New vision of heredity to promote the Inclusive Evolutionary Synthesis
16-12-2016, Etienne DANCHIN (Evolution and biological diversity laboratory Ecole Nationale de Formation Agronomique Toulouse)

----- @Int'l

Web Site Architecture and Plasticity of the Cell Nucleus
29-11-2016, ENSA Paris-Val de Seine, Fr.

Web Site Transcription-Replication Crosstalk and Genome Instability
14-11-2016, Roscoff, France

IGH papers 1513 Publications

... the 2 last ones

Aigner A, Buesen R, Gant T, Gooderham N, Greim H, Hackermüller J, Hubesch B, Laffont M, Marczylo E, Meister G, Petrick JS, Rasoulpour RJ, Sauer UG, Schmidt K, Seitz H, Slack F, Sukata T, van der Vies SM, Verhaert J, Witwer KW, Poole A. Advancing the use of noncoding RNA in regulatory toxicology: Report of an ECETOC workshop (2016), Regul Toxicol Pharmacol..
Leblanc B, Comet I, Bantignies F, Cavalli G.. Chromosome Conformation Capture on Chip (4C): Data Processing (2016), Methods Mol Biol.

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  INSTITUTE of HUMAN GENETICS
  CNRS UPR 1142
  Montpellier, France