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Director: Giacomo CAVALLI
Associate director: Philippe PASERO

The Institute of Human Genetics (Institut de Génétique Humaine, IGH) is a major CNRS unit dedicated to excellence in fundamental research and pathology. The principal research interests of the IGH are genome dynamics, developmental genetics, epigenetics, and molecular and cellular pathology.

Laboratory's News

TOMORROW: 03-10-2014

  11h30 IGH : salle de Conférence (1er étage) 11h30 Post-doc interview : A new role for polyadenylation in mRNA processing
Lisa MUNIZ (Wellcome Trust Centre for Cell Biology, University of Edinburgh)


Seminar Series on Genome Dynamics 2014-2015

Amphitheater Genopolys, at 11:30, from October 6th to April 3rd

IGH supports


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Seminars of the month @ IGH

  • 03-10-2014 (11h30) "Post-doc interview : A new role for polyadenylation in mRNA processing"
    Lisa MUNIZ (Wellcome Trust Centre for Cell Biology, University of Edinburgh)
  • 06-10-2014 (11h30) "Seminar Series on Genome Dynamics: New insights into mammalian gene regulation and immune responsiveness"
    Karen ADELMAN (National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA)
  • 24-10-2014 (11h30) "Genome stability and DNA replication: novel molecular and structural insights using a vertebrate cell free system"
  • 31-10-2014 (11h30) "Post-doc interview: Cdc14 phosphatases in the regulation of the cell division cycle in human cells"
    Sara OVEJERO (Centro de Investigación del Cáncer Universidad de Salamanca-CSIC)

Some recent papers

  • Cole F, Baudat F, Grey C, Keeney S, de Massy B, Jasin M. "Mouse tetrad analysis provides insights into recombination mechanisms and hotspot evolutionary dynamics" (2014), Nat Genet.: 46, 10, 1072-1080
  • Yoshida K, Bacal J, Desmarais D, Padioleau I, Tsaponina O, Chabes A, Pantesco V, Dubois E, Parrinello H, Skrzypczak M, Ginalski K, Lengronne A, Pasero P "The histone deacetylases sir2 and rpd3 act on ribosomal DNA to control the replication program in budding yeast." (2014), Mol Cell.: 54(4):691-697
  • Gonzalez I, Mateos-Langerak J, Thomas A, Cheutin T, Cavalli G. "Identification of Regulators of the Three-Dimensional Polycomb Organization by a Microscopy-Based Genome-wide RNAi Screen" (2014), Mol Cell: 54(3):485-99
  • Moran, Y., Fredman, D., Praher, D., Li Z. L., Meng Wee,L., Rentzsch, F., Zamore,P.D., Technau, U., Seitz H. "Cnidarian microRNAs frequently regulate targets by cleavage" (2014), Genome Research: 24(4):651-63
  • Laguette,N., Bregnard, C., Hue, P., Basbous, J., Yatim, A., Larroque, M., Kirchhoff, F., Constantinou, A., Bijan, S., Benkirane, M. "Premature Activation of the SLX4 Complex by Vpr Promotes G2/M Arrest and Escape from Innate Immune Sensing" (2014), CELL: 156, 1-2, 134-145
  • Van der Laan, S., Crozet, C., Tsanov, N., and Maiorano, D "High Dub3 expression in mouse ESC couples the G1/S checkpoint to pluripotency" (2013), Molecular Cell: 52, 3, 366-379
  • Bétous R., Pillaire, M-J, Pierini, L., Van der Laan, S., Recolin B., Ohl-Séguy, E., Guo, C., Niimi, N., Gruz, P., Nohmi, T. Friedberg, E., Cazaux, C., Maiorano, D* and Hoffmann J-S*. * corresponding authors "DNA polymerase k-dependent DNA synthesis at stalled replication forks is important for Chk1 activation" (2013), EMBO Journal: 32(15):2172-85
  • Lossaint G, Larroque M, Ribeyre C, Bec N, Larroque C, Décaillet C, Gari K, Constantinou A. "FANCD2 Binds MCM Proteins and Controls Replisome Function upon Activation of S Phase Checkpoint Signaling." (2013), Mol Cell.: 51(5):678-690
  • Iovino N, Ciabrelli F, Cavalli G. "PRC2 Controls Drosophila Oocyte Cell Fate by Repressing Cell Cycle Genes." (2013), Dev Cell: 26(4):431-9
  • Berkhout B, Lever A, Wainberg M, Fassati A, Borrow P, Fujii M "Monsef Benkirane awarded 2013 Ming K. Jeang Foundation Retrovirology Prize: Landmark HIV-1 research honoured" (2013), Retrovirology: 10, 1, 28
  • Cavalli, G., Mistelli, T. "Functional implications of genome topology" (2013), Nat. Struct. Mol. Biol: 20, 3, 290-299

Last minute IGH NEWS

Today 02-10-2014


Opportunities3 job / training period opportunities


All NewsNews / Archives

  • Two post-doctoral positions: Role of the piRNA pathway in gene regulation
    (Published: 06-07-2014)

  • iGHazette - Staff only

    Don't missNext seminars & congresses

    ----- @IGH

    Seminar series on Genome Dynamics: Noncoding RNAs: with a viral twist
    06-11-2014, Joan STEITZ (Yale University/HHMI, New Haven, USA)

    Seminar series on Genome Dynamics: Long-range gene regulation in the 3D genome: technologies and insight
    07-11-2014, Wouter de LAAT (Hubrecht Institute, Urtrecht, The Netherlands)

    BLESS, Genome-wide high-resolution DNA double-strand break mapping
    14-11-2014, Magdalena Skrzypczak (Laboratory of Bioinformatics and Systems Biology CeNT University of Warsaw)

    IGH papers 1421 Publications

    ... the 2 last ones

    Duquenne C, Psomas C, Gimenez S, Guigues A, Carles MJ, Barbuat C, Lavigne JP, Sotto A, Reynes J, Guglielmi P, Mettling C, François V, Corbeau P. The Two Human CXCR4 Isoforms Display Different HIV Receptor Activities: Consequences for the Emergence of X4 Strains (2014), J. Immunol..
    Ducroux A, Benhenda S, Rivière L, Semmes OJ, Benkirane M, Neuveut C.. The Tudor Domain Protein Spindlin1 Is Involved in Intrinsic Antiviral Defense against Incoming Hepatitis B Virus and Herpes Simplex Virus Type 1 (2014), PLoS Pathog.

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