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The Institute of Human Genetics (Institut de Génétique Humaine, IGH) is a major CNRS unit dedicated to excellence in fundamental research and pathology. The principal research interests of the IGH are genome dynamics, developmental genetics, epigenetics, and molecular and cellular pathology.

Laboratory's News

TODAY: 01-12-2015

  14h00 IGH : salle de Conférence (1er étage) 14h00 Long non-coding RNAs controlling X chromosome activity in mammals
Claire Rougeulle (U. Paris-Diderot, France)

TOMORROW: 02-12-2015

  14h30 IGH : salle de Conférence (1er étage) 14h30 Pervasive transcription, lessons from budding yeast
Antonin Morillon (Institut Curie, France)


Communiqué de presse national

Génétique : un « code origines » pour l'ADN

A partir de cellules souches de souris (dont le génome est très proche du nôtre), l'équipe de Marcel Méchali (dont principalement Christelle Cayrou) à l'IGH, et les bioinformaticiens Jacques van Helden et Benoit Ballester du laboratoire TAGC ont recherché les caractéristiques des origines de réplication. [Lire la suite]

Seminar Series on Molecular Bases of Human Diseases

Amphitheater Genopolys, at 11:30, from October 16th to May 19th

Seminar Series on Genome Dynamics 2015-2016

Amphitheater Genopolys, at 11:30, from October 2nd to January 29th

Talents du CNRS - Médailles d'argent 2015

En 2015, le CNRS a décerné la médaille d'argent à 17 chercheurs reconnus sur le plan national et international pour l'originalité, la qualité et l'importance de leurs travaux.
Parmi eux, Monsef Benkirane, Directeur de l'IGH.

Seminars of the month @ IGH

  • 01-12-2015 (14h00) "Long non-coding RNAs controlling X chromosome activity in mammals"
    Claire Rougeulle (U. Paris-Diderot, France)
  • 02-12-2015 (14h30) "Pervasive transcription, lessons from budding yeast"
    Antonin Morillon (Institut Curie, France)
  • 03-12-2015 (14h00) "Cell types, cell states and epigenetic memory: classical models revisited by single cell methods"
    Amos Tanay (Weizmann Institute, Israel)
  • 04-12-2015 (11h00) "Transparent Publishing - how to share reproducible data"
    Bernd Pulverer (Editor in Chief of EMBO J, Germany)
  • 11-12-2015 (11h00) "Dissecting Polycomb activity at CpG islands"
    Rob KLOSE (Oxford University, UK)
  • 16-12-2015 (11h30) "A dangerous game: DNA breaks and meiotic chromosome dynamics"
    Scott KEENEY (Howard Hughes Medical Institute, New York, USA)

Some recent papers

  • Cayrou C, Ballester B, Peiffer I, Fenouil R, Coulombe P, Andrau JC, van Helden J, Méchali M. "The chromatin environment shapes DNA replication origin organization and defines origin classes" (2015), Genome Res: PubMed
  • Cavalli, G. "PRC1 proteins orchestrate three-dimensional genome architecture" (2015), Nat Genet: 47(10):1105-6 PubMed
  • Traver S, Coulombe P, Peiffer I, Hutchins JR, Kitzmann M, Latreille D, Méchali M "MCM9 Is Required for Mammalian DNA Mismatch Repair" (2015), Mol Cell: 59(5):831-839 PubMed
  • Barckmann,B., Pierson,S., Dufourt, J., Papin, C., Armenise, C., Port, F., Grentzinger, T., Chambeyron, S., Baronian, G., Desvignes, JP., Curk, T., Simonelig, M. "Aubergine iCLIP Reveals piRNA-Dependent Decay of mRNAs Involved in Germ Cell Development in the Early Embryo" (2015), Cell Rep: 12(7):1205-1216 PubMed
  • Kermi, C., Prieto, S., van der Laan, S., Tsanov, N., Recolin, B., Uro-Coste, E., Delisle, M-B., and Maiorano, D. "Rad18 is a maternal limiting factor that suppresses the UV-dependent DNA damge checkpoint in Xenopus embryos" (2015), Developmental Cell : 34(3):364-372 PubMed
  • Reynaud E, Lahaye LL, Boulanger A, Petrova IM, Marquilly C, Flandre A, Martianez T, Privat M, Noordermeer JN, Fradkin LG, Dura JM "Guidance of Drosophila Mushroom Body Axons Depends upon DRL-Wnt Receptor Cleavage in the Brain Dorsomedial Lineage Precursors" (2015), Cell Rep: 11(8):1293-304 PubMed
  • Gonzalez I, Munita R, Agirre E, Dittmer TA, Gysling K, Misteli T, Luco RF. "A lncRNA regulates alternative splicing via establishment of a splicing-specific chromatin signature" (2015), Nat Struct Mol Biol: 22, 5, 370-376 PubMed
  • Fragkos M, Ganier O, Coulombe P, Méchali M "DNA replication origin activation in space and time" (2015), Nat Rev Mol Cell Biol: 16(6):360-74 PubMed
  • Ide, S., Dejardin, J. "End-targeting proteomics of isolated chromatin segments of a mammalian ribosomal RNA gene promoter" (2015), Nat. Commun.: 6, 6674 PubMed
  • Borde V, de Massy B "Meiosis: early DNA double-strand breaks pave the way for inter-homolog repair" (2015), Dev Cell: 32(6):663-4 PubMed
  • Sexton, T., Cavalli, G. "The Role of Chromosome Domains in Shaping the Functional Genome" (2015), CELL: 160, 6, 1049–1059 PubMed
  • Marzec, P., Armenise, C., Perot, G., Roumelioti, F.M., Basyuk, E., Gagos, S., Chibon, F., Dejardin, J. "Nuclear-Receptor-Mediated Telomere Insertion Leads to Genome Instability in ALT Cancer" (2015), CELL: 160, 5, 913-927 PubMed
  • Saksouk N, Barth TK, Ziegler-Birling C, Olova N, Nowak A, Rey E, Mateos-Langerak J, Urbach S, Reik W, Torres-Padilla ME, Imhof A, Déjardin J. "Redundant Mechanisms to Form Silent Chromatin at Pericentromeric Regions Rely on BEND3 and DNA Methylation" (2014), Mol Cell: 56(4):580-94 PubMed
  • Stadelmayer B, Micas G, Gamot A, Martin P, Malirat N, Koval S, Raffel R, Sobhian B, Severac D, Rialle S, Parrinello H, Cuvier O, Benkirane M "Integrator complex regulates NELF-mediated RNA polymerase II pause/release and processivity at coding genes" (2014), Nat Commun: 5:5531 PubMed
  • de Massy B. "Human genetics. Hidden features of human hotspots" (2014), Science: 346(6211):808-9 PubMed
  • Cole F, Baudat F, Grey C, Keeney S, de Massy B, Jasin M. "Mouse tetrad analysis provides insights into recombination mechanisms and hotspot evolutionary dynamics" (2014), Nat Genet.: 46, 10, 1072-1080 PubMed
  • Yoshida K, Bacal J, Desmarais D, Padioleau I, Tsaponina O, Chabes A, Pantesco V, Dubois E, Parrinello H, Skrzypczak M, Ginalski K, Lengronne A, Pasero P "The histone deacetylases sir2 and rpd3 act on ribosomal DNA to control the replication program in budding yeast." (2014), Mol Cell.: 54(4):691-697 PubMed
  • Gonzalez I, Mateos-Langerak J, Thomas A, Cheutin T, Cavalli G. "Identification of Regulators of the Three-Dimensional Polycomb Organization by a Microscopy-Based Genome-wide RNAi Screen" (2014), Mol Cell: 54(3):485-99 PubMed
  • Moran, Y., Fredman, D., Praher, D., Li Z. L., Meng Wee,L., Rentzsch, F., Zamore,P.D., Technau, U., Seitz H. "Cnidarian microRNAs frequently regulate targets by cleavage" (2014), Genome Research: 24(4):651-63 PubMed
  • Laguette,N., Bregnard, C., Hue, P., Basbous, J., Yatim, A., Larroque, M., Kirchhoff, F., Constantinou, A., Sobhian, B., Benkirane, M. "Premature Activation of the SLX4 Complex by Vpr Promotes G2/M Arrest and Escape from Innate Immune Sensing" (2014), CELL: 156, 1-2, 134-145 PubMed

Last minute IGH NEWS

Today 01-12-2015


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1 Thesis

{Next Thesis} : Biogenesis and function of H3K9me3 at telomeres of mouse embryonic fibroblasts
04-12-2015, Sophie KAN

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Web Site ICTE2016: International Congress on Transposable Elements
16-04-2016, Saint-Malo, France

IGH papers 1476 Publications

... the 2 last ones

Cayrou C, Ballester B, Peiffer I, Fenouil R, Coulombe P, Andrau JC, van Helden J, Méchali M.. The chromatin environment shapes DNA replication origin organization and defines origin classes (2015), Genome Res.
Royo H, Seitz H, ElInati E, Peters AH, Stadler MB, Turner JM. Silencing of X-Linked MicroRNAs by Meiotic Sex Chromosome Inactivation (2015), PLoS Genet.

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