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The Institute of Human Genetics (Institut de Génétique Humaine, IGH) is a major CNRS unit dedicated to excellence in fundamental research and pathology. The principal research interests of the IGH are genome dynamics, developmental genetics, epigenetics, and molecular and cellular pathology.


Laboratory's News

 


Seminar Series on Genome Dynamics 2016-2017

Amphitheater Genopolys, at 11:30, from November 25th to April 14th










Prix L'Oréal-UNESCO pour les Femmes et la Science 2016

La Fondation L’Oréal a organisé le 12 octobre dernier, la remise des Bourses en présence d’Hervé Navellou, Directeur Général de L’Oréal France, du Professeur Bernard Meunier, Président de l’Académie des sciences et Daniel Janicot, Président de la Commission nationale française pour l’UNESCO.
Parmi les 30 lauréates Maria MORIEL CARRETERO, de l'équipe Pasero.




A new epigenetic mechanism mediating tumor suppression by Polycomb proteins

The Cavalli lab shows that a complex of Polycomb group proteins has a tumor suppressor activity that depends on its specific binding to hundreds of genes involved in the control of proliferation, cell signaling and polarity. This activity was discovered in Drosophila, but the same chromosomal binding pattern is observed in differentiated human cells, suggesting that this phenomenon might be conserved in some human tumors. This study, published in the journal Nature Genetics, opens new perspectives in the field of carcinogenesis.
Read more.





Seminars of the month @ IGH


  • 14-12-2016 (11h00) "Ribonucleotides in human genome-origins and impact on DNA repair "
    Barbara Van LOON (Norwegian University of Science and Technology)
  • 15-12-2016 (10h00) "post-doc interview : The role of pendolino in epigenetic regulation of Drosophila telomere capping"
    Marta Marzullo (Department of Biology and Biotechnologies C.Darwin Sapienza, University of Rome)
  • 16-12-2016 (11h30) "Seminar series on genome Dynamics: New vision of heredity to promote the Inclusive Evolutionary Synthesis"
    Etienne DANCHIN (Evolution and biological diversity laboratory Ecole Nationale de Formation Agronomique Toulouse)


Some recent papers


  • Pinzon, N., Li, B., Martinez, L., Sergeeva, A., Presumey, J., Apparailly, F., Seitz, H "The number of biologically relevant microRNA targets has been largely over-estimated" (2016), Genome Res:
  • Luco RF "Retrotransposons jump into alternative-splicing regulation via a long noncoding RNA" (2016), Nat Struct Mol Biol: 23(11):952-954 PubMed
  • Stanzione M, Baumann M, Papanikos F, Dereli I, Lange J, Ramlal A, Tränkner D, Shibuya H, de Massy B, Watanabe Y, Jasin M, Keeney S, Tóth A "Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice" (2016), Nat Cell Biol.: 18, 11, 1208-1220 PubMed
  • Bonev B, Cavalli G. "Organization and function of the 3D genome" (2016), Nat Rev Genet: 17(11):661-678 PubMed
  • Loubière, V., Delest, A., Thomas, A., Bonev, B., Schuettengruber, B., Sati, S., Martinez AM., Cavalli, G. "Coordinate redeployment of PRC1 proteins suppresses tumor formation during Drosophila development" (2016), Nature Genetics: 48, 11, 1436-1442 PubMed
  • Bregnard, C, Guerra, J, Dejardin, S, Passalacqua, F, Benkirane, M, Laguette, N "Upregulated LINE-1 Activity in the Fanconi Anemia Cancer Susceptibility Syndrome Leads to Spontaneous Pro-inflammatory Cytokine Production" (2016), EBioMedicine: 8, 184-194 PubMed
  • Ribeyre C, Zellweger R, Chauvin M, Bec N, Larroque C, Lopes M, Constantinou A "Nascent DNA Proteomics Reveals a Chromatin Remodeler Required for Topoisomerase I Loading at Replication Forks" (2016), Cell Rep: 15, 2, 300-309 PubMed
  • Robert T, Nore A, Brun C, Maffre C, Crimi B, Bourbon HM, de Massy B "The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation" (2016), SCIENCE: 351(6276):943-9 PubMed

Last minute IGH NEWS

Today 06-12-2016

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5 Thesis

{Next Thesis} : Risks of in utero analgesics and non steroidal anti-inflammatory exposure on the early development and maturation of the male reproductive organs in mice
09-12-2016, Moïra ROSSITTO

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Web Site Recombination and Epigenetics
30-01-2017, Université Paris-Diderot, Paris

IGH papers 1524 Publications

... the 2 last ones

Younas M, Carrat F, Finge S, Desaint C, Launay O, Corbeau P; ANRS HB03 VIHVAC-B Trial Group. Immune activation, smoking, and vaccine response (2017), AIDS.
Chartier A, Joly W, Simonelig M.. Measurement of mRNA Poly(A) Tail Lengths in Drosophila Female Germ Cells and Germ-Line Stem Cells (2017), Methods Mol Biol..

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  INSTITUTE of HUMAN GENETICS
  CNRS UPR 1142
  Montpellier, France