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Director: Giacomo CAVALLI
Associate director: Philippe PASERO

The Institute of Human Genetics (Institut de Génétique Humaine, IGH) is a major CNRS unit dedicated to excellence in fundamental research and pathology. The principal research interests of the IGH are genome dynamics, developmental genetics, epigenetics, and molecular and cellular pathology.

Laboratory's News


« Le sida reste une épidémie majeure »

Le Sidaction qui démarre aujourd'hui nous le rappelle : l'épidémie reste majeure. Le point sur le VIH avec Monsef Benkirane, directeur de recherche CNRS à l'IGH de Montpellier, qui vient de recevoir le prix Liliane Bettencourt 2013 pour ses travaux.

7th IGH Seminar Series on Genetics and Development

Genopolys or IGH, at 11:30, from April 11th, 2014 to June 13th, 2014

January 2014, Monsef Benkirane is awarded the 2013 Liliane Bettencourt Prize for Life Sciences.

Here, Monsef Benkirane tells Naturejobs how the viral reservoir stands as a major obstacle to a cure for HIV, and how the prize will help him to develop much needed models to replicate the behaviour of the virus.
[NatureJobs 2014] French movie of the Fondation Bettencourt Schueller

Seminar Series on Molecular Bases of Human Diseases 2014

Amphitheater Genopolys, at 11:30, from January 15th to June 13th, 2014

Seminars of the month @ IGH

  • 04-04-2014 (11h30) "Changes in chromatin remodeling during hormone-dependent gene activation in Breast Cancer"
    Roser ZAURIN (CRG - Barcelona)
  • 08-04-2014 (10h00) "Regulation of neocentromere formation in fission yeast"
    Yuki Ogiyama (Osaka University)

  • 11-04-2014 (12h00) "Seminar Series on Genetics & Development: Regulation of gene expression at the neuromuscular junction by electrical activity"
    Laurent SCHAEFFER (Laboratoire Biologie Moléculaire de la Cellule, ENS, Lyon, France)
  • 11-04-2014 (10h30) "Signalling and mechanics at the human mitotic centromere and kinetochore"
    Jason SWEDLOW (Centre for Gene Regulation & Expression College of Life Sciences University of Dundee)
  • 18-04-2014 (11h30) "Seminar series on Genetics & Development: Conserved roles of lincRNAs in vertebrate development"
    Alena SHKUMATAVA (Institut Curie - Unité de Génétique et Biologie du Développement - PARIS)
  • 25-04-2014 (11h30) "Seminar series on Genetics & Development: Small RNA-directed DNA elimination in Tetrahymena"
    Kazufumi MOCHIZUKI (IMBA (Institute of Molecular Biotechnology of the Austrian Academy of Sciences) Vienna, Austria)
  • 25-04-2014 (14h00) "Seminar series on Molecular bases of Human Diseases: What Is the Future of the HIV Epidemic If Drug Resistance against a New Antiviral Compound could not Occur?"
    Mark WAINBERG (Centre SIDA McGill, Institut Lady David, Montréal, Canada)

Some recent papers

  • Gonzalez I, Mateos-Langerak J, Thomas A, Cheutin T, Cavalli G. "Identification of Regulators of the Three-Dimensional Polycomb Organization by a Microscopy-Based Genome-wide RNAi Screen" (2014), Mol Cell: pii: S1097-2765(14)00209-3. doi: 10.1016/j.molcel.2014.03.004.
  • Moran, Y., Fredman, D., Praher, D., Li Z. L., Meng Wee,L., Rentzsch, F., Zamore,P.D., Technau, U., Seitz H. "Cnidarian microRNAs frequently regulate targets by cleavage" (2014), Genome Research: 24(4):651-63
  • Laguette,N., Bregnard, C., Hue, P., Basbous, J., Yatim, A., Larroque, M., Kirchhoff, F., Constantinou, A., Bijan, S., Benkirane, M. "Premature Activation of the SLX4 Complex by Vpr Promotes G2/M Arrest and Escape from Innate Immune Sensing" (2014), CELL: 156, 1-2, 134-145
  • Joly, W,, Chartier,A., Rojas-Rios, P., Busseau,I., Simonelig, M. "The CCR4 Deadenylase Acts with Nanos and Pumilio in the Fine-Tuning of Mei-P26 Expression to Promote Germline Stem Cell Self-Renewal" (2013), Stem Cell Reports: Volume 1, Issue 5, 411-424
  • Van der Laan, S., Crozet, C., Tsanov, N., and Maiorano, D "High Dub3 expression in mouse ESC couples the G1/S checkpoint to pluripotency" (2013), Molecular Cell: 52, 3, 366-379
  • Wu H, Mathioudakis N, Diagouraga B, Dong A, Dombrovski L, Baudat F, Cusack S, de Massy B, Kadlec J. "Molecular Basis for the Regulation of the H3K4 Methyltransferase Activity of PRDM9." (2013), Cell Rep: 14, 11, 794-806
  • Bétous R., Pillaire, M-J, Pierini, L., Van der Laan, S., Recolin B., Ohl-Séguy, E., Guo, C., Niimi, N., Gruz, P., Nohmi, T. Friedberg, E., Cazaux, C., Maiorano, D* and Hoffmann J-S*. * corresponding authors "DNA polymerase k-dependent DNA synthesis at stalled replication forks is important for Chk1 activation" (2013), EMBO Journal: 32(15):2172-85
  • Lossaint G, Larroque M, Ribeyre C, Bec N, Larroque C, Décaillet C, Gari K, Constantinou A. "FANCD2 Binds MCM Proteins and Controls Replisome Function upon Activation of S Phase Checkpoint Signaling." (2013), Mol Cell.: 51(5):678-690
  • Iovino N, Ciabrelli F, Cavalli G. "PRC2 Controls Drosophila Oocyte Cell Fate by Repressing Cell Cycle Genes." (2013), Dev Cell: 26(4):431-9
  • Cribier, A., Descours, B., Chaves Valadeo, AL., Laguette, N., Benkirane , M. "Phosphorylation of SAMHD1 by CyclinA2/CDK1 regulates its restriction activity towards HIV-1" (2013), CELL Reports: 3, 4, 1036-1043;
  • Berkhout B, Lever A, Wainberg M, Fassati A, Borrow P, Fujii M "Monsef Benkirane awarded 2013 Ming K. Jeang Foundation Retrovirology Prize: Landmark HIV-1 research honoured" (2013), Retrovirology: 10, 1, 28
  • Cavalli, G., Mistelli, T. "Functional implications of genome topology" (2013), Nat. Struct. Mol. Biol: 20, 3, 290-299

Last minute IGH NEWS

Today 21-04-2014


Opportunities4 job / training period opportunities


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iGHazette - Staff only

Don't missNext seminars & congresses

----- @IGH

Seminar series on Molecular bases of Human Diseases: DNA damage and repair: key factors for aging and cancer
23-05-2014, Jan HOEIJMAKERS (Department of Genetics Erasmus University Medical Center - Rotterdam - The Netherlands)

Seminar series on Molecular bases of Human Diseases: Spatial and temporal limits of genome integrity maintenance
13-06-2014, Jiri LUKAS (Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Denmark)

13-06-2014, Claudia LUKAS (Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Denmark)

----- @Int'l

Web Site Chromatin Meets South
16-06-2014, Genopolys, Montpellier (FR)

IGH papers 1402 Publications

... the 2 last ones

Recolin B, van der Laan S, Tsanov N, Maiorano D.. Molecular mechanisms of DNA replication checkpoint activation (2014), Genes (Basel).
Rouquier, S., Pillaire, MJ., Cazaux, C., Giorgi, D.. Expression of the microtubule-associated protein MAP9/ASAP and its partners AURKA and PLK1 in colorectal and breast cancers (2014), Disease Markers.

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Institute of Human Genetics



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