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The Institute of Human Genetics (Institut de Génétique Humaine, IGH) is a major CNRS unit dedicated to excellence in fundamental research and pathology. The principal research interests of the IGH are genome dynamics, developmental genetics, epigenetics, and molecular and cellular pathology.

Laboratory's News


IGH Seminar Series on Genetics and Development

Genopolys, at 11:30, from March 25th to June 3rd, 2016

Seminars of the month @ IGH

  • 13-05-2016 (11h30) "SEMINAR SERIES on GENETICS and DEVELOPMENT: Regulation of miRNA function and metabolism in culture mammalian cells and mouse retina"
    Witold FILIPOWICZ (Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland)
  • 18-05-2016 (13h00) "The importance of professionally editing manuscripts before submission"
    Julian Venables (julian.venables@science-sense.com)

  • 19-05-2016 (11h30) "Seminar series on Molecular Bases of Human diseases: The Road to Utopia: Challenges in linking literature and research data"
    Terri ATTWOOD (Life Sciences and School of Computer ScienceThe University of Manchester, UK)
  • 20-05-2016 (11h30) "Seminar series on Genetics & Development: What can gonadal sex reversal in the mouse tell us about human disorders of sex development?"
    Andy GREENFIELD (MRC Harwell, Mammalian Genetics Unit, Oxford, UK)
  • 23-05-2016 (17h30) "Epigenetics: bridging together development, inheritance and evolution, from Waddington to today"
    Francesca MERLIN (Institut d’Histoire et de Philosophie des Sciences et des Techniques (CNRS, Univ. Paris, ENS), Paris)
  • 24-05-2016 (11h30) "The interplay between meiotic chromosome structure and recombination biochemistry"
    Michael Lichten (NIH, USA)

Some recent papers

  • Ribeyre C, Zellweger R, Chauvin M, Bec N, Larroque C, Lopes M, Constantinou A "Nascent DNA Proteomics Reveals a Chromatin Remodeler Required for Topoisomerase I Loading at Replication Forks" (2016), Cell Rep: 15, 2, 300-309 PubMed
  • Robert T, Nore A, Brun C, Maffre C, Crimi B, Bourbon HM, de Massy B "The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation" (2016), SCIENCE: 351(6276):943-9 PubMed
  • Menolfi D, Delamarre A, Lengronne A, Pasero P, Branzei D. "Essential Roles of the Smc5/6 Complex in Replication through Natural Pausing Sites and Endogenous DNA Damage Tolerance" (2015), Mol. Cell: 60(6):835-46 PubMed
  • Rojas-Rios, P., Chartier, A., Pierson, S., Severac, D., Dantec, C., Busseau, I., Simonelig, M. "Translational Control of Autophagy by Orb in the Drosophila Germline" (2015), Developmental Cell: 35, 5, 622-631 PubMed
  • Cayrou C, Ballester B, Peiffer I, Fenouil R, Coulombe P, Andrau JC, van Helden J, Méchali M. "The chromatin environment shapes DNA replication origin organization and defines origin classes" (2015), Genome Res: 25(12):1873-85 PubMed
  • Cavalli, G. "PRC1 proteins orchestrate three-dimensional genome architecture" (2015), Nat Genet: 47(10):1105-6 PubMed
  • Traver S, Coulombe P, Peiffer I, Hutchins JR, Kitzmann M, Latreille D, Méchali M "MCM9 Is Required for Mammalian DNA Mismatch Repair" (2015), Mol Cell: 59(5):831-839 PubMed
  • Barckmann,B., Pierson,S., Dufourt, J., Papin, C., Armenise, C., Port, F., Grentzinger, T., Chambeyron, S., Baronian, G., Desvignes, JP., Curk, T., Simonelig, M. "Aubergine iCLIP Reveals piRNA-Dependent Decay of mRNAs Involved in Germ Cell Development in the Early Embryo" (2015), Cell Rep: 12(7):1205-1216 PubMed
  • Kermi, C., Prieto, S., van der Laan, S., Tsanov, N., Recolin, B., Uro-Coste, E., Delisle, M-B., and Maiorano, D. "Rad18 is a maternal limiting factor that suppresses the UV-dependent DNA damge checkpoint in Xenopus embryos" (2015), Developmental Cell : 34(3):364-372 PubMed
  • Reynaud E, Lahaye LL, Boulanger A, Petrova IM, Marquilly C, Flandre A, Martianez T, Privat M, Noordermeer JN, Fradkin LG, Dura JM "Guidance of Drosophila Mushroom Body Axons Depends upon DRL-Wnt Receptor Cleavage in the Brain Dorsomedial Lineage Precursors" (2015), Cell Rep: 11(8):1293-304 PubMed
  • Gonzalez I, Munita R, Agirre E, Dittmer TA, Gysling K, Misteli T, Luco RF. "A lncRNA regulates alternative splicing via establishment of a splicing-specific chromatin signature" (2015), Nat Struct Mol Biol: 22, 5, 370-376 PubMed
  • Fragkos M, Ganier O, Coulombe P, Méchali M "DNA replication origin activation in space and time" (2015), Nat Rev Mol Cell Biol: 16(6):360-74 PubMed
  • Ide, S., Dejardin, J. "End-targeting proteomics of isolated chromatin segments of a mammalian ribosomal RNA gene promoter" (2015), Nat. Commun.: 6, 6674 PubMed
  • Borde V, de Massy B "Meiosis: early DNA double-strand breaks pave the way for inter-homolog repair" (2015), Dev Cell: 32(6):663-4 PubMed
  • Sexton, T., Cavalli, G. "The Role of Chromosome Domains in Shaping the Functional Genome" (2015), CELL: 160, 6, 1049–1059 PubMed
  • Marzec, P., Armenise, C., Perot, G., Roumelioti, F.M., Basyuk, E., Gagos, S., Chibon, F., Dejardin, J. "Nuclear-Receptor-Mediated Telomere Insertion Leads to Genome Instability in ALT Cancer" (2015), CELL: 160, 5, 913-927 PubMed

Last minute IGH NEWS

Today 28-05-2016


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Don't missNext seminars & congresses

----- @IGH

Seminar series on Genetics & Development: Building neural circuits interconnecting the left and right sides of the central nervous system: molecular mechanisms of midline crossing
03-06-2016, Valérie Castellani (INMG - Université de lyon1)

----- @Int'l

Web Site Architecture and Plasticity of the Cell Nucleus
29-11-2016, ENSA Paris-Val de Seine, Fr.

Web Site Les bases génétiques des maladies rares ( Journée Scientifique Mireille CLAUSTRES)
28-06-2016, Montpellier, Fr.

Web Site The Students and Postdocs Meiosis Workshop
19-09-2016, Montpellier, Fr.

IGH papers 1504 Publications

... the 2 last ones

Entrevan M, Schuettengruber B, Cavalli G. Regulation of Genome Architecture and Function by Polycomb Proteins (2016), Trends Cell Biol. .
Ogrunc M, Martinez-Zamudio RI, Sadoun PB, Dore G, Schwerer H, Pasero P, Lemaitre JM, Dejean A, Bischof O. USP1 Regulates Cellular Senescence by Controlling Genomic Integrity (2016), Cell Rep.

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Institute of Human Genetics



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