English version Version Française
 About CNRS Life Sciences Other CNRS web sites
 
 

Director:
Deputy director:

The Institute of Human Genetics (Institut de Génétique Humaine, IGH) is a major CNRS unit dedicated to excellence in fundamental research and pathology. The principal research interests of the IGH are genome dynamics, developmental genetics, epigenetics, and molecular and cellular pathology.


Laboratory's News

 


IAS 2017, "rendez-vous à Paris!"

Paris accueillera en 2017 la Conférence internationale sur la Pathogenèse du VIH, le Traitement et la Prévention. L'ANRS, partenaire local, participera aux côtés de l'IAS (International AIDS Society) à l'organisation de cet événement.
Rendez-vous à Paris en 2017.





Seminars of the month @ IGH


  • 04-09-2015 (11h30) "Genome instability, stem cell defect and cancer in Fanconi anemia"
    Jean SOULIER (Institut Universitaire d’Hématologie (IUH) - Paris)
  • 09-09-2015 (11h30) "Transcription termination and the control of pervasive transcription "
    Domenico LIBRI (INSTITUT JACQUES MONOD - Paris)
  • 17-09-2015 (11h30) "Postdoc interview"
    Andrew Oldfield, PhD (Epigenetics and Stem Cell Biology Laboratory National Institutes of Health, NIEHS, NC, USA)


Some recent papers


  • Traver S, Coulombe P, Peiffer I, Hutchins JR, Kitzmann M, Latreille D, Méchali M "MCM9 Is Required for Mammalian DNA Mismatch Repair" (2015), Mol Cell: pii: S1097-2765(15)00568-7. doi: 10.1016/j.molcel.2015.07.010 PubMed
  • Barckmann,B., Pierson,S., Dufourt, J., Papin, C., Armenise, C., Port, F., Grentzinger, T., Chambeyron, S., Baronian, G., Desvignes, JP., Curk, T., Simonelig, M. "Aubergine iCLIP Reveals piRNA-Dependent Decay of mRNAs Involved in Germ Cell Development in the Early Embryo" (2015), Cell Rep: 12(7):1205-1216 PubMed
  • Kermi, C., Prieto, S., van der Laan, S., Tsanov, N., Recolin, B., Uro-Coste, E., Delisle, M-B., and Maiorano, D. "Rad18 is a maternal limiting factor that suppresses the UV-dependent DNA damge checkpoint in Xenopus embryos" (2015), Developmental Cell : 34(3):364-372 PubMed
  • Reynaud E, Lahaye LL, Boulanger A, Petrova IM, Marquilly C, Flandre A, Martianez T, Privat M, Noordermeer JN, Fradkin LG, Dura JM "Guidance of Drosophila Mushroom Body Axons Depends upon DRL-Wnt Receptor Cleavage in the Brain Dorsomedial Lineage Precursors" (2015), Cell Rep: 11(8):1293-304 PubMed
  • Gonzalez I, Munita R, Agirre E, Dittmer TA, Gysling K, Misteli T, Luco RF. "A lncRNA regulates alternative splicing via establishment of a splicing-specific chromatin signature" (2015), Nat Struct Mol Biol: 22, 5, 370-376 PubMed
  • Fragkos M, Ganier O, Coulombe P, Méchali M "DNA replication origin activation in space and time" (2015), Nat Rev Mol Cell Biol: 16(6):360-74 PubMed
  • Ide, S., Dejardin, J. "End-targeting proteomics of isolated chromatin segments of a mammalian ribosomal RNA gene promoter" (2015), Nat. Commun.: 6, 6674 PubMed
  • Borde V, de Massy B "Meiosis: early DNA double-strand breaks pave the way for inter-homolog repair" (2015), Dev Cell: 32(6):663-4 PubMed
  • Sexton, T., Cavalli, G. "The Role of Chromosome Domains in Shaping the Functional Genome" (2015), CELL: 160, 6, 1049–1059 PubMed
  • Marzec, P., Armenise, C., Perot, G., Roumelioti, F.M., Basyuk, E., Gagos, S., Chibon, F., Dejardin, J. "Nuclear-Receptor-Mediated Telomere Insertion Leads to Genome Instability in ALT Cancer" (2015), CELL: 160, 5, 913-927 PubMed
  • Saksouk N, Barth TK, Ziegler-Birling C, Olova N, Nowak A, Rey E, Mateos-Langerak J, Urbach S, Reik W, Torres-Padilla ME, Imhof A, Déjardin J. "Redundant Mechanisms to Form Silent Chromatin at Pericentromeric Regions Rely on BEND3 and DNA Methylation" (2014), Mol Cell: 56(4):580-94 PubMed
  • Stadelmayer B, Micas G, Gamot A, Martin P, Malirat N, Koval S, Raffel R, Sobhian B, Severac D, Rialle S, Parrinello H, Cuvier O, Benkirane M "Integrator complex regulates NELF-mediated RNA polymerase II pause/release and processivity at coding genes" (2014), Nat Commun: 5:5531 PubMed
  • de Massy B. "Human genetics. Hidden features of human hotspots" (2014), Science: 346(6211):808-9 PubMed
  • Cole F, Baudat F, Grey C, Keeney S, de Massy B, Jasin M. "Mouse tetrad analysis provides insights into recombination mechanisms and hotspot evolutionary dynamics" (2014), Nat Genet.: 46, 10, 1072-1080 PubMed
  • Yoshida K, Bacal J, Desmarais D, Padioleau I, Tsaponina O, Chabes A, Pantesco V, Dubois E, Parrinello H, Skrzypczak M, Ginalski K, Lengronne A, Pasero P "The histone deacetylases sir2 and rpd3 act on ribosomal DNA to control the replication program in budding yeast." (2014), Mol Cell.: 54(4):691-697 PubMed
  • Gonzalez I, Mateos-Langerak J, Thomas A, Cheutin T, Cavalli G. "Identification of Regulators of the Three-Dimensional Polycomb Organization by a Microscopy-Based Genome-wide RNAi Screen" (2014), Mol Cell: 54(3):485-99 PubMed
  • Moran, Y., Fredman, D., Praher, D., Li Z. L., Meng Wee,L., Rentzsch, F., Zamore,P.D., Technau, U., Seitz H. "Cnidarian microRNAs frequently regulate targets by cleavage" (2014), Genome Research: 24(4):651-63 PubMed
  • Laguette,N., Bregnard, C., Hue, P., Basbous, J., Yatim, A., Larroque, M., Kirchhoff, F., Constantinou, A., Sobhian, B., Benkirane, M. "Premature Activation of the SLX4 Complex by Vpr Promotes G2/M Arrest and Escape from Innate Immune Sensing" (2014), CELL: 156, 1-2, 134-145 PubMed

Last minute IGH NEWS

Today 02-09-2015

2014

Opportunities2 job / training period opportunities

 

All NewsNews / Archives


iGHazette - Staff only

Don't missNext seminars & congresses

----- @IGH

RNAi-mediated assembly of heterochromatin - a kiss to remember
02-10-2015, Marc BÜHLER (Friedrich Miescher Institute for Biomedicalm Research; Basel, Switzerland)

----- @Int'l

Web Site 26th Ion Channel Meeting
13-09-2015, Sète, France

Web Site ICTE2016: International Congress on Transposable Elements
16-04-2016, Saint-Malo, France

Web Site 29th French Drosophila Conference
13-10-2015, La Grande-Motte, France

IGH papers 1467 Publications

... the 2 last ones

Traver S, Coulombe P, Peiffer I, Hutchins JR, Kitzmann M, Latreille D, Méchali M. MCM9 Is Required for Mammalian DNA Mismatch Repair (2015), Mol Cell.
Le Goff E, Martinand-Mari C, Martin M, Feuillard J, Boublik Y, Godefroy N, Mangeat P, Baghdiguian S, Cavalli G. Enhancer of zeste acts as a major developmental regulator of Ciona intestinalis embryogenesis (2015), Biol Open.

Home pageSmart printContactCoordinatesCopyrightsPersonnal AccessWebmail  Mailing Lists

 

 

CNRS
Institute of Human Genetics
  

Directories

Search

the Institute Servers



the CNRS WEB



  INSTITUTE of HUMAN GENETICS
  CNRS UPR 1142
  Montpellier, France