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Directeur : Giacomo CAVALLI
Directeur-adjoint : Philippe PASERO

L'Institut de Génétique Humaine (IGH) est une unité propre de recherche du CNRS (UPR 1142) qui a pour objectif de réaliser une recherche fondamentale d'excellence et de conduire celle-ci jusqu'à ses retombées dans le domaine de la pathologie. Les principaux thèmes de recherche concernent la dynamique du génome et de la chromatine, la génétique du développement, le contrôle épigénétique, et les pathologies moléculaires et cellulaires.


Actualités du laboratoire

AUJOURD'HUI : 19-12-2014

  11h30 IGH : salle de Conférence (1er étage) 11h30 Novel players in the regulation of chromatin function
Robert SCHNEIDER (IGBMC Strasbourg )



Nadine Laguette - ERC starting Grant

Molecular Basis of the Cross-Talk between Chronic Inflammation and Cancer





Série de séminaires en Dynamique du Génome

Amphithéâtre Genopolys, 11h30, du 6 octobre 2014 au 3 avril 2015






Les séminaires du mois à l'Institut


  • 02-12-2014 (14h00) "Protein sequence databases: use and pitfalls"
    Marie-Claude Blatter (Swiss Institute of Bioinformatics Geneva, Switzerland )

  • 10-12-2014 (11h30) "Replication fork remodeling upon DNA replication stress in human cells"
    Massimo LOPES (Institute of Molecular Cancer Research University of Zuerich - Switzerland)
  • 19-12-2014 (11h30) "Novel players in the regulation of chromatin function "
    Robert SCHNEIDER (IGBMC Strasbourg )


Quelques publications récentes


  • Saksouk N, Barth TK, Ziegler-Birling C, Olova N, Nowak A, Rey E, Mateos-Langerak J, Urbach S, Reik W, Torres-Padilla ME, Imhof A, Déjardin J. "Redundant Mechanisms to Form Silent Chromatin at Pericentromeric Regions Rely on BEND3 and DNA Methylation" (2014), Mol Cell: 56(4):580-94 PubMed
  • Stadelmayer B, Micas G, Gamot A, Martin P, Malirat N, Koval S, Raffel R, Sobhian B, Severac D, Rialle S, Parrinello H, Cuvier O, Benkirane M "Integrator complex regulates NELF-mediated RNA polymerase II pause/release and processivity at coding genes" (2014), Nat Commun: 5:5531 PubMed
  • de Massy B. "Human genetics. Hidden features of human hotspots" (2014), Science: 346(6211):808-9 PubMed
  • Cole F, Baudat F, Grey C, Keeney S, de Massy B, Jasin M. "Mouse tetrad analysis provides insights into recombination mechanisms and hotspot evolutionary dynamics" (2014), Nat Genet.: 46, 10, 1072-1080 PubMed
  • Yoshida K, Bacal J, Desmarais D, Padioleau I, Tsaponina O, Chabes A, Pantesco V, Dubois E, Parrinello H, Skrzypczak M, Ginalski K, Lengronne A, Pasero P "The histone deacetylases sir2 and rpd3 act on ribosomal DNA to control the replication program in budding yeast." (2014), Mol Cell.: 54(4):691-697 PubMed
  • Gonzalez I, Mateos-Langerak J, Thomas A, Cheutin T, Cavalli G. "Identification of Regulators of the Three-Dimensional Polycomb Organization by a Microscopy-Based Genome-wide RNAi Screen" (2014), Mol Cell: 54(3):485-99 PubMed
  • Moran, Y., Fredman, D., Praher, D., Li Z. L., Meng Wee,L., Rentzsch, F., Zamore,P.D., Technau, U., Seitz H. "Cnidarian microRNAs frequently regulate targets by cleavage" (2014), Genome Research: 24(4):651-63 PubMed
  • Laguette,N., Bregnard, C., Hue, P., Basbous, J., Yatim, A., Larroque, M., Kirchhoff, F., Constantinou, A., Bijan, S., Benkirane, M. "Premature Activation of the SLX4 Complex by Vpr Promotes G2/M Arrest and Escape from Innate Immune Sensing" (2014), CELL: 156, 1-2, 134-145 PubMed
  • Van der Laan, S., Crozet, C., Tsanov, N., and Maiorano, D "High Dub3 expression in mouse ESC couples the G1/S checkpoint to pluripotency" (2013), Molecular Cell: 52, 3, 366-379 PubMed
  • Bétous R., Pillaire, M-J, Pierini, L., Van der Laan, S., Recolin B., Ohl-Séguy, E., Guo, C., Niimi, N., Gruz, P., Nohmi, T. Friedberg, E., Cazaux, C., Maiorano, D* and Hoffmann J-S*. * corresponding authors "DNA polymerase k-dependent DNA synthesis at stalled replication forks is important for Chk1 activation" (2013), EMBO Journal: 32(15):2172-85 PubMed
  • Lossaint G, Larroque M, Ribeyre C, Bec N, Larroque C, Décaillet C, Gari K, Constantinou A. "FANCD2 Binds MCM Proteins and Controls Replisome Function upon Activation of S Phase Checkpoint Signaling." (2013), Mol Cell.: 51(5):678-690 PubMed
  • Iovino N, Ciabrelli F, Cavalli G. "PRC2 Controls Drosophila Oocyte Cell Fate by Repressing Cell Cycle Genes." (2013), Dev Cell: 26(4):431-9 PubMed
  • Berkhout B, Lever A, Wainberg M, Fassati A, Borrow P, Fujii M "Monsef Benkirane awarded 2013 Ming K. Jeang Foundation Retrovirology Prize: Landmark HIV-1 research honoured" (2013), Retrovirology: 10, 1, 28 PubMed
  • Cavalli, G., Mistelli, T. "Functional implications of genome topology" (2013), Nat. Struct. Mol. Biol: 20, 3, 290-299 PubMed

Dernière minuteActualité IGH

Aujourd'hui 19-12-2014

2013

Emplois - Stages4 Opportunité(s) d'emplois / de stages

 

Actualités Infos / Archives


iGHazette - Accès local

Rendez-vousSéminaires et Congrés à venir

----- @IGH

Seminar series on Genome Dynamics: G-quadruplexes and their regulatory roles in biology
16-01-2015, Daniela RHODES (Director, Nanyang Institute of Structural Biology, Singapore)

Seminar series on Genome Dynamics: Chromosomal DNA replication: Towards a molecular understanding of mechanism and regulation
23-01-2015, John DIFFLEY (Cancer Research London Research Institute, UK)

Seminar series on Genome Dynamics: Chromosome Dynamics from Bacteria to Mammalian Cells
27-03-2015, Nancy KLECKNER (Harvard University, Molecular & Cellular Biology, Cambridge, USA)

Seminar series on Genome Dynamics: Stress, transposons and evolution
03-04-2015, Sergio PIMPINELLI (Dipartimento di Genetica e Biologia Molecolare, Università di Roma «La Sapienza» Roma, Italy)

Publications de l'IGH 1433 Publications

... dont les 2 dernières

Rossitto M, Ujjan S, Poulat F, Boizet-Bonhoure B. The multiples roles of the Prostaglandin D2 signaling pathway in reproduction (2015), Reproduction.
Saksouk N, Barth TK, Ziegler-Birling C, Olova N, Nowak A, Rey E, Mateos-Langerak J, Urbach S, Reik W, Torres-Padilla ME, Imhof A, Déjardin J.. Redundant Mechanisms to Form Silent Chromatin at Pericentromeric Regions Rely on BEND3 and DNA Methylation (2014), Mol Cell.

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  INSTITUT de GENETIQUE HUMAINE
  CNRS UPR 1142
  Montpellier, France