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L'Institut de Génétique Humaine (IGH) est une unité mixte de recherche du CNRS-Université de Montpellier (UMR9002) qui a pour objectif de réaliser une recherche fondamentale d'excellence et de conduire celle-ci jusqu'à ses retombées dans le domaine de la pathologie. Les principaux thèmes de recherche concernent la dynamique du génome et de la chromatine, la génétique du développement, le contrôle épigénétique, et les pathologies moléculaires et cellulaires.


Actualités du laboratoire



Série de séminaires en Génétique et Développement

Amphithéâtre Genopolys, de Mars à Juin 2017




Série de séminaires en Bases Moléculaires de Pathologies Humaines 2017

Amphithéâtre Genopolys, 11h30, du 04 avril au 30 juin 2017










A paraitre

Marta Rodríguez-Martínez, Natalia Pinzón, Charles Ghommidh, Emmanuelle Beyne, Hervé Seitz, Christelle Cayrou, and Marcel Méchali (2017) The gastrula transition reorganizes replication origin selection in Caenorhabditis elegans. Nature Structural & Molecular Biology, in press.




Série de séminaires en Dynamique du Génome

Amphithéâtre Genopolys, 11h30, du 25 novembre 2016 au 16 juin 2017











Les séminaires du mois à l'Institut


  • 03-02-2017 (11h30) "Seminar Series on Genome Dynamics: Biogenesis and turnover of small RNAs in health and disease"
    Javier F. Caceres (MRC Human Genetics Unit - Institute of Genetics and Molecular Medicine (IGMM) - University of Edinburgh, UK)


Quelques publications récentes


  • Rodríguez-Martínez, M., Pinzón, N., Ghommidh, C., Beyne, E., Seitz, H., Cayrou, C., Méchali, M. "The gastrula transition reorganizes replication origin selection in Caenorhabditis elegans " (2017), Nature Structural & Molecular Biology: PubMed
  • Pinzon, N., Li, B., Martinez, L., Sergeeva, A., Presumey, J., Apparailly, F., Seitz, H "The number of biologically relevant microRNA targets has been largely over-estimated" (2017), Genome Res: 27, 2, 234-245 PubMed
  • Luco RF "Retrotransposons jump into alternative-splicing regulation via a long noncoding RNA" (2016), Nat Struct Mol Biol: 23(11):952-954 PubMed
  • Stanzione M, Baumann M, Papanikos F, Dereli I, Lange J, Ramlal A, Tränkner D, Shibuya H, de Massy B, Watanabe Y, Jasin M, Keeney S, Tóth A "Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice" (2016), Nat Cell Biol.: 18, 11, 1208-1220 PubMed
  • Bonev B, Cavalli G. "Organization and function of the 3D genome" (2016), Nat Rev Genet: 17(11):661-678 PubMed
  • Loubière, V., Delest, A., Thomas, A., Bonev, B., Schuettengruber, B., Sati, S., Martinez AM., Cavalli, G. "Coordinate redeployment of PRC1 proteins suppresses tumor formation during Drosophila development" (2016), Nature Genetics: 48, 11, 1436-1442 PubMed
  • Bregnard, C, Guerra, J, Dejardin, S, Passalacqua, F, Benkirane, M, Laguette, N "Upregulated LINE-1 Activity in the Fanconi Anemia Cancer Susceptibility Syndrome Leads to Spontaneous Pro-inflammatory Cytokine Production" (2016), EBioMedicine: 8, 184-194 PubMed
  • Ribeyre C, Zellweger R, Chauvin M, Bec N, Larroque C, Lopes M, Constantinou A "Nascent DNA Proteomics Reveals a Chromatin Remodeler Required for Topoisomerase I Loading at Replication Forks" (2016), Cell Rep: 15, 2, 300-309 PubMed
  • Robert T, Nore A, Brun C, Maffre C, Crimi B, Bourbon HM, de Massy B "The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation" (2016), SCIENCE: 351(6276):943-9 PubMed

Dernière minuteActualité IGH

Aujourd'hui 21-02-2017

2014

Emplois - Stages2 Opportunité(s) d'emplois / de stages

 

Actualités Infos / Archives


iGHazette - Accès local

Rendez-vousSéminaires et Congrés à venir

----- @IGH

Seminar series on Genetics and Development: Coordination of the organ growth in Drosophila
10-03-2017, Pierre LEOPOLD (Institut de Biologie Valrose Nice, France)

Seminar series on Genetics and Development: Control of the stem cell genome: chromatin remodelling and genome stability
24-03-2017, Allison BARDIN (Institut Curie Paris, France)

Seminar series on genome Dynamics: Epigenetics and functional intratumour heterogeneity
31-03-2017, Paola Scaffidi (The Francis Crick Institute, London, UK)

Seminar series on Molecular Bases of Human Diseases: Cellular responses to DNA double strand breaks: Molecular mechanisms and clinical utility
07-04-2017, Roland KANAAR (Erasmus MC, University Medical Center Rotterdam NL)

Seminar Series on Genome Dynamics: A simplified topoisomerase related to the meiotic DNA break machinery gets complicated
14-04-2017, James BERGER (Johns Hopkins School of Medicine, Baltimore, USA)

Seminar series on Molecular Bases of Human Diseases: DNA damage induced signaling and transcription
21-04-2017, Wim VERMEULEN (Erasmus MC, Dept. of Molecular Genetics, Rotterdam, NL)

Seminar series on Molecular Bases of Human Diseases: Clinical proteomics in diagnostics, research and discovery
28-04-2017, Marc BAUMANN (Meilahti Clinical Proteomics Core Facility, University of Helsinki Finland)

Seminar series on Genetics and Development: It takes two to tango: exploring sense/antisense double-stranded RNAs
05-05-2017, Michael PRIMIG (Institut de Recherches en Santé-Environnement-Travail, Rennes, France)

Seminar series on Genetics and Development: Transposable element insertion polymorphisms and hybrid sterility in Paramecium
12-05-2017, Eric MEYER (Institut de Biologie ENS, Paris, France)

Seminar series on Genetics and Development: The cohesin ring and other meiotic protens in human fertility
19-05-2017, Reiner VEITIA (Institut Jacques Monod, Paris, France)

Seminar series on Molecular Bases of Human Diseases: Fluorescent nanodiamonds as non-photobleachable responsive probes
23-05-2017, Petr CIGLER (Synthetic Nanochemistry, Institute of Organic Chemistry & Biochemistry, Prague, Czech republic)

Seminar series on Molecular Bases of Human Diseases: Mechanisms that restrict mammalian DNA over-replication
26-05-2017, Juan MENDEZ (Centro Nacional de Investigaciones Oncológicas, Madrid, Spain)

Seminar series on Genetics and Development: Adult neural stem cell pools homeostasis: single cell and population analysis in the zebrafish telencephalon
02-06-2017, Laure BALLY-CUIF (Institut Pasteur,Paris, France)

Seminar series on Genetics and Development: How cells read and write the tubulin code
06-06-2017, Antonina ROLL-MECAK (NIH Bethesda, USA)

Seminar series on Molecular Bases of Human Diseases: Mobile elements, polydactyl proteins and the species-specifi city of human biology
09-06-2017, Didier TRONO (Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland)

Seminar series on genome Dynamics: Chromatin regulators in cell differentiation and cancer
16-06-2017, Luciano Di Croce (CRG Centre for Genomic Regulation, Barcelona, Spain)

Seminar series on Molecular Bases of Human Diseases: Living well with our microbiota: implication for HIV care
30-06-2017, Jean-Pierre ROUTY (Experimental Medicine, McGill University, Montreal, Quebec, Canada)

Publications de l'IGH 1534 Publications

... dont les 2 dernières

Rodríguez-Martínez, M., Pinzón, N., Ghommidh, C., Beyne, E., Seitz, H., Cayrou, C., Méchali, M.. The gastrula transition reorganizes replication origin selection in Caenorhabditis elegans (2017), Nature Structural & Molecular Biology.
Kermi, C., Lo Furno, E., Maiorano, D. Regulation of DNA Replication in Early Embryonic Cleavages (2017), Genes.

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  INSTITUT de GENETIQUE HUMAINE
  UMR9002 CNRS-UM
  Montpellier, France