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L'Institut de Génétique Humaine (IGH) est une unité propre de recherche du CNRS (UPR 1142) qui a pour objectif de réaliser une recherche fondamentale d'excellence et de conduire celle-ci jusqu'à ses retombées dans le domaine de la pathologie. Les principaux thèmes de recherche concernent la dynamique du génome et de la chromatine, la génétique du développement, le contrôle épigénétique, et les pathologies moléculaires et cellulaires.


Actualités du laboratoire



Nadine Laguette - ERC starting Grant

Molecular Basis of the Cross-Talk between Chronic Inflammation and Cancer





Série de séminaires en Dynamique du Génome

Amphithéâtre Genopolys, 11h30, du 6 octobre 2014 au 3 avril 2015






Les séminaires du mois à l'Institut


  • 16-01-2015 (11h30) "Seminar series on Genome Dynamics: G-quadruplexes and their regulatory roles in biology"
    Daniela RHODES (Director, Nanyang Institute of Structural Biology, Singapore)
  • 23-01-2015 (11h30) "Seminar series on Genome Dynamics: Chromosomal DNA replication: Towards a molecular understanding of mechanism and regulation"
    John DIFFLEY (Cancer Research London Research Institute, UK)
  • 30-01-2015 (11h30) "Human proteins that bind methylated DNA: biological roles and links with DNA replication"
    Pierre-Antoine DEFOSSEZ (UMR 7216 CNRS - Univ. Paris 7 - Epigenetics and Cell Fate)


Quelques publications récentes


  • Saksouk N, Barth TK, Ziegler-Birling C, Olova N, Nowak A, Rey E, Mateos-Langerak J, Urbach S, Reik W, Torres-Padilla ME, Imhof A, Déjardin J. "Redundant Mechanisms to Form Silent Chromatin at Pericentromeric Regions Rely on BEND3 and DNA Methylation" (2014), Mol Cell: 56(4):580-94 PubMed
  • Stadelmayer B, Micas G, Gamot A, Martin P, Malirat N, Koval S, Raffel R, Sobhian B, Severac D, Rialle S, Parrinello H, Cuvier O, Benkirane M "Integrator complex regulates NELF-mediated RNA polymerase II pause/release and processivity at coding genes" (2014), Nat Commun: 5:5531 PubMed
  • de Massy B. "Human genetics. Hidden features of human hotspots" (2014), Science: 346(6211):808-9 PubMed
  • Cole F, Baudat F, Grey C, Keeney S, de Massy B, Jasin M. "Mouse tetrad analysis provides insights into recombination mechanisms and hotspot evolutionary dynamics" (2014), Nat Genet.: 46, 10, 1072-1080 PubMed
  • Yoshida K, Bacal J, Desmarais D, Padioleau I, Tsaponina O, Chabes A, Pantesco V, Dubois E, Parrinello H, Skrzypczak M, Ginalski K, Lengronne A, Pasero P "The histone deacetylases sir2 and rpd3 act on ribosomal DNA to control the replication program in budding yeast." (2014), Mol Cell.: 54(4):691-697 PubMed
  • Gonzalez I, Mateos-Langerak J, Thomas A, Cheutin T, Cavalli G. "Identification of Regulators of the Three-Dimensional Polycomb Organization by a Microscopy-Based Genome-wide RNAi Screen" (2014), Mol Cell: 54(3):485-99 PubMed
  • Moran, Y., Fredman, D., Praher, D., Li Z. L., Meng Wee,L., Rentzsch, F., Zamore,P.D., Technau, U., Seitz H. "Cnidarian microRNAs frequently regulate targets by cleavage" (2014), Genome Research: 24(4):651-63 PubMed
  • Laguette,N., Bregnard, C., Hue, P., Basbous, J., Yatim, A., Larroque, M., Kirchhoff, F., Constantinou, A., Bijan, S., Benkirane, M. "Premature Activation of the SLX4 Complex by Vpr Promotes G2/M Arrest and Escape from Innate Immune Sensing" (2014), CELL: 156, 1-2, 134-145 PubMed
  • Van der Laan, S., Crozet, C., Tsanov, N., and Maiorano, D "High Dub3 expression in mouse ESC couples the G1/S checkpoint to pluripotency" (2013), Molecular Cell: 52, 3, 366-379 PubMed
  • Bétous R., Pillaire, M-J, Pierini, L., Van der Laan, S., Recolin B., Ohl-Séguy, E., Guo, C., Niimi, N., Gruz, P., Nohmi, T. Friedberg, E., Cazaux, C., Maiorano, D* and Hoffmann J-S*. * corresponding authors "DNA polymerase k-dependent DNA synthesis at stalled replication forks is important for Chk1 activation" (2013), EMBO Journal: 32(15):2172-85 PubMed
  • Lossaint G, Larroque M, Ribeyre C, Bec N, Larroque C, Décaillet C, Gari K, Constantinou A. "FANCD2 Binds MCM Proteins and Controls Replisome Function upon Activation of S Phase Checkpoint Signaling." (2013), Mol Cell.: 51(5):678-690 PubMed
  • Iovino N, Ciabrelli F, Cavalli G. "PRC2 Controls Drosophila Oocyte Cell Fate by Repressing Cell Cycle Genes." (2013), Dev Cell: 26(4):431-9 PubMed
  • Berkhout B, Lever A, Wainberg M, Fassati A, Borrow P, Fujii M "Monsef Benkirane awarded 2013 Ming K. Jeang Foundation Retrovirology Prize: Landmark HIV-1 research honoured" (2013), Retrovirology: 10, 1, 28 PubMed
  • Cavalli, G., Mistelli, T. "Functional implications of genome topology" (2013), Nat. Struct. Mol. Biol: 20, 3, 290-299 PubMed

Dernière minuteActualité IGH

Aujourd'hui 27-01-2015

2013

Emplois - Stages3 Opportunité(s) d'emplois / de stages

 

Actualités Infos / Archives


iGHazette - Accès local

Rendez-vousSéminaires et Congrés à venir

----- @IGH

Seminar series on Genome Dynamics: Chromosome Dynamics from Bacteria to Mammalian Cells
27-03-2015, Nancy KLECKNER (Harvard University, Molecular & Cellular Biology, Cambridge, USA)

Seminar series on Genome Dynamics: Stress, transposons and evolution
03-04-2015, Sergio PIMPINELLI (Dipartimento di Genetica e Biologia Molecolare, Università di Roma «La Sapienza» Roma, Italy)

A memory found?
30-04-2015, Scott WADDELL (- Centre for Neural Circuits & Behaviour, OXFORD, UK)

An evolutionary perspective on human germline mutation
26-06-2015, Molly PRZEWORSKI (Biological Science, Columbia University, USA)

Publications de l'IGH 1435 Publications

... dont les 2 dernières

Xochelli A, Agathangelidis A, Kavakiotis I, Minga E, Sutton LA, Baliakas P, Chouvarda I, Giudicelli V, Vlahavas I, Maglaveras N, Bonello L, Trentin L, Tedeschi A, Panagiotidis P, Geisler C, Langerak AW, Pospisilova S, Jelinek DF, Oscier D, Chiorazzi N, Darzentas N, Davi F, Ghia P, Rosenquist R, Hadzidimitriou A, Belessi C, Lefranc MP, Stamatopoulos K. Immunoglobulin heavy variable (IGHV) genes and alleles: new entities, new names and implications for research and prognostication in chronic lymphocytic leukaemia (2015), Immunogenetics.
Lefranc MP, Giudicelli V, Duroux P, Jabado-Michaloud J, Folch G, Aouinti S, Carillon E, Duvergey H, Houles A, Paysan-Lafosse T, Hadi-Saljoqi S, Sasorith S, Lefranc G, Kossida S.. IMGT®, the international ImMunoGeneTics information system® 25 years on (2015), Nucleic Acids Res..

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  INSTITUT de GENETIQUE HUMAINE
  CNRS UPR 1142
  Montpellier, France