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L'Institut de Génétique Humaine (IGH) est une unité propre de recherche du CNRS (UPR 1142) qui a pour objectif de réaliser une recherche fondamentale d'excellence et de conduire celle-ci jusqu'à ses retombées dans le domaine de la pathologie. Les principaux thèmes de recherche concernent la dynamique du génome et de la chromatine, la génétique du développement, le contrôle épigénétique, et les pathologies moléculaires et cellulaires.


Actualités du laboratoire



8ème série de séminaires en Génétique et Développement

Genopolys ou IGH, à 11h30, du 6 mars 2015 au 3 juillet 2015






Série de séminaires en Dynamique du Génome

Amphithéâtre Genopolys, 11h30, du 6 octobre 2014 au 3 avril 2015






Les séminaires du mois à l'Institut


  • 06-03-2015 (11h30) "Seminar series on Genetics & Development : Small RNA Biology of Germ Cells"
    René KETTING (Institute of Molecular Biology, Mainz, Germany)
  • 13-03-2015 (11h30) "Seminar series on Genetics & Development :Nutrients, growth and survival"
    Marco MILAN
  • 16-03-2015 (11h30) "Chromatin dynamics in proliferating and senescent cells"
    Armelle Corpet
  • 20-03-2015 (11h30) "Seminar series on Genetics & Development : Genome Biology of redundant Drosophila Sox proteins"
    Steve RUSSELL (Department of Genetics & Cambridge Systems Biology Centre, Cambridge, UK)
  • 27-03-2015 (11h30) "Seminar series on Genome Dynamics: Chromosome Dynamics from Bacteria to Mammalian Cells"
    Nancy KLECKNER (Harvard University, Molecular & Cellular Biology, Cambridge, USA)


Quelques publications récentes


  • Sexton, T., Cavalli, G. "The Role of Chromosome Domains in Shaping the Functional Genome" (2015), CELL: 160, 6, 1049–1059 PubMed
  • Marzec, P., Armenise, C., Perot, G., Roumelioti, F.M., Basyuk, E., Gagos, S., Chibon, F., Dejardin, J. "Nuclear-Receptor-Mediated Telomere Insertion Leads to Genome Instability in ALT Cancer" (2015), CELL: 160, 5, 913-927 PubMed
  • Saksouk N, Barth TK, Ziegler-Birling C, Olova N, Nowak A, Rey E, Mateos-Langerak J, Urbach S, Reik W, Torres-Padilla ME, Imhof A, Déjardin J. "Redundant Mechanisms to Form Silent Chromatin at Pericentromeric Regions Rely on BEND3 and DNA Methylation" (2014), Mol Cell: 56(4):580-94 PubMed
  • Stadelmayer B, Micas G, Gamot A, Martin P, Malirat N, Koval S, Raffel R, Sobhian B, Severac D, Rialle S, Parrinello H, Cuvier O, Benkirane M "Integrator complex regulates NELF-mediated RNA polymerase II pause/release and processivity at coding genes" (2014), Nat Commun: 5:5531 PubMed
  • de Massy B. "Human genetics. Hidden features of human hotspots" (2014), Science: 346(6211):808-9 PubMed
  • Cole F, Baudat F, Grey C, Keeney S, de Massy B, Jasin M. "Mouse tetrad analysis provides insights into recombination mechanisms and hotspot evolutionary dynamics" (2014), Nat Genet.: 46, 10, 1072-1080 PubMed
  • Yoshida K, Bacal J, Desmarais D, Padioleau I, Tsaponina O, Chabes A, Pantesco V, Dubois E, Parrinello H, Skrzypczak M, Ginalski K, Lengronne A, Pasero P "The histone deacetylases sir2 and rpd3 act on ribosomal DNA to control the replication program in budding yeast." (2014), Mol Cell.: 54(4):691-697 PubMed
  • Gonzalez I, Mateos-Langerak J, Thomas A, Cheutin T, Cavalli G. "Identification of Regulators of the Three-Dimensional Polycomb Organization by a Microscopy-Based Genome-wide RNAi Screen" (2014), Mol Cell: 54(3):485-99 PubMed
  • Moran, Y., Fredman, D., Praher, D., Li Z. L., Meng Wee,L., Rentzsch, F., Zamore,P.D., Technau, U., Seitz H. "Cnidarian microRNAs frequently regulate targets by cleavage" (2014), Genome Research: 24(4):651-63 PubMed
  • Laguette,N., Bregnard, C., Hue, P., Basbous, J., Yatim, A., Larroque, M., Kirchhoff, F., Constantinou, A., Sobhian, B., Benkirane, M. "Premature Activation of the SLX4 Complex by Vpr Promotes G2/M Arrest and Escape from Innate Immune Sensing" (2014), CELL: 156, 1-2, 134-145 PubMed
  • Van der Laan, S., Crozet, C., Tsanov, N., and Maiorano, D "High Dub3 expression in mouse ESC couples the G1/S checkpoint to pluripotency" (2013), Molecular Cell: 52, 3, 366-379 PubMed
  • Bétous R., Pillaire, M-J, Pierini, L., Van der Laan, S., Recolin B., Ohl-Séguy, E., Guo, C., Niimi, N., Gruz, P., Nohmi, T. Friedberg, E., Cazaux, C., Maiorano, D* and Hoffmann J-S*. * corresponding authors "DNA polymerase k-dependent DNA synthesis at stalled replication forks is important for Chk1 activation" (2013), EMBO Journal: 32(15):2172-85 PubMed
  • Lossaint G, Larroque M, Ribeyre C, Bec N, Larroque C, Décaillet C, Gari K, Constantinou A. "FANCD2 Binds MCM Proteins and Controls Replisome Function upon Activation of S Phase Checkpoint Signaling." (2013), Mol Cell.: 51(5):678-690 PubMed
  • Iovino N, Ciabrelli F, Cavalli G. "PRC2 Controls Drosophila Oocyte Cell Fate by Repressing Cell Cycle Genes." (2013), Dev Cell: 26(4):431-9 PubMed
  • Berkhout B, Lever A, Wainberg M, Fassati A, Borrow P, Fujii M "Monsef Benkirane awarded 2013 Ming K. Jeang Foundation Retrovirology Prize: Landmark HIV-1 research honoured" (2013), Retrovirology: 10, 1, 28 PubMed
  • Cavalli, G., Mistelli, T. "Functional implications of genome topology" (2013), Nat. Struct. Mol. Biol: 20, 3, 290-299 PubMed

Dernière minuteActualité IGH

Aujourd'hui 28-03-2015

2014

Emplois - Stages4 Opportunité(s) d'emplois / de stages

 

Actualités Infos / Archives


iGHazette - Accès local

Rendez-vousSéminaires et Congrés à venir

----- @IGH

Seminar series on Genetics & Development : Transcriptomic chronology of skeletal muscle stem cells identifies SoxF genes as novel regulators of satellite cell renewal
24-04-2015, Frédéric RELAIX (Faculté de Médecine U 955, Créteil, France)

Seminar series on Genetics & Development : A memory found?
30-04-2015, Scott WADDELL (- Centre for Neural Circuits & Behaviour, OXFORD, UK)

An evolutionary perspective on human germline mutation
26-06-2015, Molly PRZEWORSKI (Biological Science, Columbia University, USA)

Seminar series on Genetics & Development : Regulation of E-cadherin and epithelial-mesenchymal plasticity by Protein Phosphatase-6
03-07-2015, David BRAUTIGAN (University if Virginia School of Medicine, Charlottesville, USA)

----- @Int'l

Site Web Chromatin Meets South 2015
04-06-2015, Marseille, Fr.

Publications de l'IGH 1446 Publications

... dont les 2 dernières

Tsanov, N., Kermi, C., Delgado, J., Serrano, L., Maiorano D. . Regulation of translesion DNA synthesis by PCNA monoubiquitylation and beyond (2015), IN Function of Translesion DNA polymerases in Genome Stability -Editors: Domenico Maiorano & Jean-Sébastien Hoffmann. Editions Research Signpost .
Vanacker JM, Maiorano D.. Checking the cycle by ERRβ splice variants (2015), Cell Cycle.

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  INSTITUT de GENETIQUE HUMAINE
  CNRS UPR 1142
  Montpellier, France