Replication and Genome Dynamics

Marcel Méchali


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Institute of Human Genetics, CNRS, UPR 1142
141 rue de la Cardonille, 34396 Montpellier Cedex
France

Tel : 33 (0)4 34 35 99 17,
Fax: 33 (0)4 34 35 99 20,
Marcel Mechali : contact

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At each division, chromosomes should be duplicated and also maintain the memory of the specific transcription programs that have been previously established. DNA replication is an precisely regulated process that starts from dozen of thousands of sites that are dispersed along the genome and are called DNA replication origins (Méchali, 2010).Errors in this process can cause loss or gain of genetic material that will lead to genome instability, a hallmark of cancer cells. Our objectives are to characterize the genetic and epigenetic nature of replication origins, to understand how they are integrated to chromatin domains and transcriptional controls, and to identify new factors involved in initiation of DNA replication. 


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Last modification: 01/2014
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