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Recent publications :
Cayrou C, Coulombe P, Vigneron A, Stanojcic S, Ganier O, Peiffer I, Rivals E, Puy A, Laurent-Chabalier S, Desprat R, and Mechali M. (2011)
Genome-scale analysis of metazoan replication origins reveals their organization in specific but flexible sites defined by conserved features.
Genome Reseach. 21, 1438-1449 PDF
Nishiyama A, Frappier L, and Mechali M. (2011)
MCM-BP regulates unloading of the MCM2-7 helicase in late S phase.
Genes and Dev. 25, 165-175 PDF
Mechali, M. (2010)
Eukaryotic DNA replication origins: many choices for appropriate answers.
Nature reviews Molecular Cell Biology, 11, 728-738 PDF
Cayrou C, Coulombe P, and Mechali M. (2010)
Programming DNA replication origins and chromosome organization.
Chromosome Research, 18, 137-145 PDF
Lutzmann M, and Mechali M. (2009)
How to load a replicative helicase onto chromatin : a more and more complex matter during evolution.
Cell Cycle 8, 1309-1313 PDF
Lutzmann M, and Mechali M. (2008)
MCM9 binds Cdt1 and is required for the assembly of prereplication complexes.
Mol Cell 31:190-200 PDF
Ganier O, and Mechali M. (2008)
New cell or new cycle ?
Genes Dev. 22, 2908-2913 PDF
Lutzmann M, and Mechali M. (2008)
The cell cycle : now live and in color.
Cell 132:341-343 PDF
Cuvier O, Stanojcic S, Lemaître J-M, and Mechali M. (2008)
A Topoisomerase II-dependent mechanism for resetting replicons at the S-M phase transition.
Genes and Dev 22:860-865 PDF
Stanojcic S, Montel N, Cucchi-Mouillot P, Bocquet S, Lemaître J-M, and Mechali M. (2008)
In Xenopus egg extracts DNA replication initiates preferentially at or near asymmetric AT sequences.
Mol Cell Biol 28:5265-74 PDF
Krasinska L, Besnard E, Cot E, Dohet C, Mechali M, Lemaître J-M, and Fisher D. (2008)
Cdk1 and Cdk2 activity levels determine the efficiency of replication origin firing in Xenopus.
EMBO J. 27:758-769 PDF
Auziol C, Mechali M, and Maiorano D. (2007)
Geminin is cleaved by caspase-3 during apoptosis in Xenopus egg extracts.
Biochem Biophys Res. 361:276-280 PDF
Lemaître J-M, Gregoire D, and Mechali M. (2007)
Replication, development and totipotency.
Med Sci (Paris) 23, 3, 245-247 PDF
Lutzmann M, Maiorano D, and Mechali M. (2006)
A Cdt1-geminin complex licenses chromatin for DNA replication and prevents rereplication during S phase.
EMBO Journal 25:5764-74 PDF
Cuvier O, Lutzmann M, and Mechali M. (2006)
ORC is necessary at the interphase-to-mitosis transition to recruit cdc2 kinase and disassemble RPA foci.
Curr Biol 16:516-523 PDF
Gregoire D, Brodolin K, and Mechali M. (2006)
Hox B domain induction silences replication origins within the locus and specifies a single origin at its boundary.
EMBO Rep 7:812-816 PDF
Maiorano D, Lutzmann M, and Mechali M. (2006)
MCM proteins and DNA replication.
Curr Opin Cell Biol 18:130-136 PDF
Gregoire D, and Mechali M. (2006)
DNA replication during animal development and its relevance to gene expression.
In DNA replication and human diseases, CSHL Press, Ed. M. DePamphilis, 217-231 PDF
Lemaitre JM, Danis E, Vassetzky Y, Pasero P, and Mechali M. (2005)
Mitotic remodeling of the replicon and chromatin structure.
Cell 123:787-801 PDF
Lutzmann M, Maiorano D and Mechali M. (2005)
Identification of full genes and proteins of MCM9, a novel, vertebrate-specific member of the MCM2-8 protein family.
Gene 362:51-56 PDF
Maiorano D, Cuvier O, Danis E and Mechali M. (2005)
MCM8 is an MCM2-7-related protein that functions as a DNA Helicase during replication elongation and not initiation.
Cell 120:315-28 PDF
Maiorano D, Krasinska L, Lutzmann M and Mechali M. (2005)
Recombinant Cdt1 induces rereplication of G2 nuclei in Xenopus egg extracts .
Current Biology 15:146-53 PDF
Francon P, Lemaitre JM, Dreyer C, Maiorano D, Cuvier O, Mechali M. (2004)
A hypophosphorylated form of RPA34 is a specific component of pre-replication centers.
J Cell Sci. 117:4909-20 Abstract PDF
Thepaut M, Maiorano D, Guichou JF, Auge MT,Dumas C, Mechali M, Padilla A. (2004)
Crystal structure of the coiled-coil dimerization motif of geminin: structural and functional insights on DNA replication regulation.
J Mol Biol. 342:275-87 Abstract
Lemaitre JM, Bocquet S, Terret ME, Namdar M, Ait-Ahmed O, Kearsey S, Verlhac MH, Mechali M. (2004)
The regulation ofcompetence to replicate in meiosis by Cdc6 is conserved during evolution.
MolReprod Dev. 69:94-100. Abstract PDF
Danis E, Brodolin K, Menut S, Maiorano D, Girard-Reydet C, Mechali M. (2004)
Specification of a DNA replication origin by a transcription complex.
Nat. Cell. Biol. 6:721-30. Abstract PDF
Girard-Reydet C, Gregoire D, Vassetzky Y, Mechali M. (2004)
DNA replication initiates at domains overlapping with nuclear matrix attachment regions in the xenopus and mouse c-myc promoter.
Gene. 332:129-38. Abstract PDF
Maiorano D, Rul W, Mechali M. (2004)
Cell cycle regulation of the licensing activity of Cdt1 in Xenopus laevis.
Exp Cell Res.295:138-49. Abstract PDF
Fisher D, Mechali M. (2003)
Vertebrate HoxB gene expression requires DNA replication.
EMBO J. 22, 3737-48. Abstract PDF
Cohen S, Mechali M. (2002)
Formation of extrachromosomal circles from telomeric DNA in Xenopus laevis.
EMBO Rep. 3, 1168-74. Abstract PDF
Demeret C, Bocquet S, Lemaitre JM, Francon P, Mechali M. (2002)
Expression of ISWI and its binding to chromatin during the cell cycle and early development.
J Struct Biol. 140, 57-66. Abstract PDF
Lemaitre JM, Bocquet S, Mechali M.(2002)
Competence to replicate in the unfertilized egg is conferred by Cdc6 during meiotic maturation. Nature. 419, 18-22. Abstract PDF Supplementary Data
Maiorano D, Mechali M.(2002)
Many roads lead to the origin
Nat Cell Biol. 4, E58-9 PDF
Mechali M. (2001)
DNA replication origins: from sequence specificity to epigenetics.
Nature Reviews. Genetics 2, 640-645 PDF
Demeret C, Vassetzky Y, Mechali M. (2001)
Chromatin remodelling and DNA replication: from nucleosomes to loop domains.
Oncogene. 20:3086-3093. PDF
Vassetzky, Y., Hair, A., and Mechali, M. (2000)
Dynamics of Chromatin Domains during Xenopus Development.
Genes and Dev., 14, 1541-1552.
Maiorano D, Moreau J, Mechali M. (2000)
XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis.
Nature 404, 622-5.Abstract PDF
Maiorano D, Lemaitre JM, Mechali M. (2000)
Stepwise regulated chromatin assembly of MCM2-7 proteins.
J Biol Chem. 275, 8426-8431. Abstract PDF
Cohen, S. Menut, S. ,and Mechali, M. (1999)
Regulated Formation of extrachromosomal DNA circle molecules during the early development in Xenopus Laevis
Mol. Cell. Biol. 19, 6682-6689. Abstract
Menut, S., Lemaitre, J.M., Hair, A., and Mechali, M. (1999)
DNA Replication and Chromatin Assembly using Xenopus Egg Extracts. In Advances in Molecular Biology:A comparative Methods Approach to the Study of Ooocytes and Embryos, p. 196-226, Oxford University Press. PDF
Francon, P., Maiorano, D., and Méchali, M. (1999)
DNA replication in Eukaryotes : Questioning the origins .
Minireview FEBS Letters , 452, 87-91. Abstract