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TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks
Nat Commun 2022
Meiosis and recombination
Mitosis without DNA replication in mammalian somatic cells
BioRXiv 2020
Replication and Genome Dynamics
Emerging roles and functional mechanisms of PIWI-interacting RNAs.
Nat Rev Mol Cell Biol 2022
mRNA Regulation and Development
Activating translation with phase separation
Science 2022
mRNA Regulation and Development
TRIM28-dependent SUMOylation protects the adult ovary from activation of the testicular pathway
Nature communications 2022
Development and Pathology of the gonad
Histone marks are drivers of the splicing changes necessary for an epithelial-to-mesenchymal transition
Cell Reports 2022
Chromatin and Splicing
Understanding 3D genome organization by multidisciplinary methods
Nature Reviews Molecular Cell Biology 2021
Chromatin and cell biology
Chromatin-associated MRN complex protects highly transcribing genes from genomic instability
Science Advances 2021
Gene regulation
Axonal chemokine-like Orion induces astrocyte infiltration and engulfment during mushroom body neuronal remodeling
Nature Communications 2021
Neurogenetics and memory
TopBP1 assembles nuclear condensates to switch on ATR signaling.
Molecular Cell. 2021
Genetic Instability and Cancer
Exon junction complex dependent mRNA localization is linked to centrosome organization during ciliogenesis
Nature Communications 2021
Cell Biology of RNA
A choreography of centrosomal mRNAs reveals a conserved localization mechanism involving active polysome transport
Nature Communications 2021
Cell Biology of RNA
Regulation of single-cell genome organization into TADs and chromatin nanodomains
Nature Genetics 2020
Chromatin and cell biology
A predictable conserved DNA base composition signature defines human core DNA replication origins.
Nat Commun 2020
Replication and Genome Dynamics
Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites
Nature Communications 2020
Maintenance of genome integrity during DNA replication
The Mi-2 nucleosome remodeler and the Rpd3 histone deacetylase are involved in piRNA-guided heterochromatin formation
Nature Communications volume 2020
Non-coding RNA, epigenetics and genome stability
Homologous recombination and Mus81 promote replication completion in response to replication fork blockage
EMBO 2020
Maintenance of genome integrity during DNA replication
4D Genome Rewiring during Oncogene-Induced and Replicative Senescence
Molecular Cell 2020
Chromatin and cell biology
Exploring histone loading on HIV DNA reveals a dynamic nucleosome positioning between unintegrated and integrated viral genome.
Proc Natl Acad Sci U S A 2020
Laboratory of Molecular Virology
Mec1 Is Activated at the Onset of Normal S Phase by Low-dNTP Pools Impeding DNA Replication
Molecular Cell 2020
Maintenance of genome integrity during DNA replication
SETDB1-dependent heterochromatin stimulates alternative lengthening of telomeres
Science Advances 2019
Chromatin and Splicing
Angiotensin II induces reactive oxygen species, DNA damage, and T cell apoptosis in severe COVID-19.
J Allergy Clin Immunol 2022
Homing, immune activation and infection
Targeting Cellular Iron Homeostasis with Ironomycin in Diffuse Large B-cell Lymphoma.
Cancer Res 2022
Epigenome modifications and genomic instability in normal and malignant B cells
PIM2 kinase has a pivotal role in plasmablast generation and plasma cell survival, opening up novel treatment options in myeloma.
Blood 2022
Epigenome modifications and genomic instability in normal and malignant B cells
Faithful to the Marseille tradition: Unique and intriguing-that's how Marseillevirus packs its DNA.
Molecular Cell 2022
Laboratory of Molecular Virology
Condensates, the place to hide self-immunostimulatory RNA.
Molecular Cell 2022
Laboratory of Molecular Virology
Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair
Molecular Cell 2023
Genetic Instability and Cancer
STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses
Cell Metabolism 2022
Molecular Basis of Inflammation
A rationalized definition of general tumor suppressor microRNAs excludes miR-34a
Nucleic Acids Research 2022
Systemic impact of small regulatory RNAs
Activation of the ubiquitin-proteasome system contributes to oculopharyngeal muscular dystrophy through muscle atrophy.
PLoS Genet 2022
mRNA Regulation and Development
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The Institute of Human Genetics is dedicated to excellence in fundamental research and pathology. The principal research interests of the IGH are genome dynamics, developmental genetics, epigenetics, and molecular and cellular pathology
3
DEPARTMENTS
26
RESEARCH TEAMS
1446
PUBLICATIONS
12
ERC LAUREATES
(7 Adv, 2 StG, 2 COG & 1PoC)
54
PHD THESES AND HDR DEFENCES
Headlines
Giacomo Cavalli elected to the Academy of Sciences
Small regulatory RNAs Workshop
Mini-Symposium on Small regulatory RNAs: from biogenesis to function
Research departments
Molecular Bases of Human Diseases
High quality research in the fields of immunology and cancer
Genome Dynamics
Research on understanding the multiple activities of the genome in various model systems
Genetics, Cell Biology and Development
Understand genetic information translated into the production of many different cell types
Last publications
All publications
3-O sulfation of syndecan-1 mediated by the sulfotransferase...
Matrix Biol 2023
Epigenome modifications and genomic instability in normal and malignant B cells
Mechanisms of action of monoclonal antibodies in oncology...
Front Immunol. 2023
IMGT® - the international ImMunoGeneTics information system®
Editorial: Transcriptional control in normal and malignant...
Front Immunol 2023
Epigenome modifications and genomic instability in normal and malignant B cells
The BLM helicase is a new therapeutic target in multiple...
Front Immunol 2022
Epigenome modifications and genomic instability in normal and malignant B cells
Replication gap suppression depends on the double-strand...
nature communications 2022
Genetic Instability and Cancer
LAIR1, an ITIM-Containing Receptor Involved in Immune...
Int J Mol Sci 2022
Epigenome modifications and genomic instability in normal and malignant B cells
Chromatin-associated YTHDC1 coordinates heat-induced...
Cell Reports 2022
Gene regulation
Programmed DNA elimination: New metazoan models....
Curr Biol 2022
Epigenetic Chromatin Regulation
The Polyvalent Role of NF90 in RNA Biology...
International Journal of Molecular Sciences 2022
Gene regulation
Targeting the β(2) -adrenergic receptor increases...
J Pathol 2022
Epigenome modifications and genomic instability in normal and malignant B cells
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CMB2023
Ciliate Molecular Biology Meeting 2023, June 26 - 29, La Panacée, Montpellier
from 26/06/2023 until 29/06/2023 - 17:00
La Panacée, Montpellier
Epigenetic Chromatin Regulation
22/06/2023 11:00
Amphitheater of Genopolys
Seminars
Non-canonical functions of DNA methylation during epigenetic reprogramming in mammals
Biology of distal regulatory elements
31/05/2023 11:00 IGH Seminar room 1st floor
Initiation of meiotic recombination in zebrafish
Meiosis and recombination
26/06/2023 14:00 IGH Seminar room 1st floor
All seminars
Congresses
Ciliate Molecular Biology Meeting 2023
Epigenetic Chromatin Regulation
26/06/2023 until 29/06/2023 - 17:00 La Panacée, Montpellier
"InteRNAt" summer school on small regulatory RNAs (microRNA, siRNA, piRNA)
Systemic impact of small regulatory RNAs
16/10/2023 until 20/10/2023 12:00 - 15:30 « Le Lazaret » (223 Rue du Pasteur Lucien Benoît, 34200 Sète)
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