The Institute of Human Genetics is working at the forefront of the scientific response to COVID-19
During the developing COVID-19 pandemic the Institute of Human Genetics and its researchers are playing their part in tackling the virus.
The IGH is dedicated to excellence in fundamental research and pathology. The principal research interests of the IGH are genome dynamics, developmental genetics, epigenetics, and molecular and cellular pathology.
Papers
Splicing-associated chromatin signatures: a combinatorial and position-dependent role for histone ma...
Agirre E, Oldfield AJ, Bellora N, Segelle A, Luco RF
2021 - Nat Commun, 12(1):682
33514745
TopBP1 assembles nuclear condensates to switch on ATR signaling.
Frattini C, Promonet A, Alghoul E, Vidal-Eychenie S, Lamarque M, Blanchard MP, Urbach S, Basbous J, ...
2021 - Mol Cell
33503405More informations
Htt is a repressor of Abl activity required for APP-induced axonal growth
Claire Marquilly,Germain U. Busto,Brittany S. Leger,Ana Boulanger,Edward Giniger,James A. Walker,Lee...
2021 - PLOS GENETICS
More informationsInteractions between gut microbiota and skeletal muscle.
Gizard F, Fernandez A, De Vadder F
2021 - Nutr Metab Insights, 13:1178638820980490
33402830More informations
A Role for the Mre11-Rad50-Xrs2 Complex in Gene Expression and Chromosome Organization
Romain Forey, Antoine Barthe, Mireille Tittel-Elmer, Maxime Wery, Marie-Bénédicte Barrault, Cécil...
2020 - Molecular cell
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A predictable conserved DNA base composition signature defines human core DNA replication origins.
Akerman I, Kasaai B, Bazarova A, Sang PB, Peiffer I, Artufel M, Derelle R, Smith G, Rodriguez-Martin...
2020 - Nat Commun, 11(1):4826
32958757
Tubulin modifying enzymes as target for the treatment of tau-related diseases
Krzysztof Rogowski, Khaled Hached, Carole Crozet, Siem Van Der Laan
2020 - Pharmacology & Therapeutics
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Functions of PIWI Proteins in Gene Regulation: New Arrows Added to the piRNA Quiver
Anne Ramat, Martine Simonelig
2020 - Trends in Genetics
The Mi-2 nucleosome remodeler and the Rpd3 histone deacetylase are involved in piRNA-guided heteroch...
Bruno Mugat, Simon Nicot, Carolina Varela-Chavez, Christophe Jourdan, Kaoru Sato, Eugenia Basyuk, Fr...
2020 - Nature Communications volume
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Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation
J. Guerra, A.-L. Valadao, D. Vlachakis, K. Polak, I. K. Vila, C. Taffoni, T. Prabakaran, A. S. Marri...
2020 - Science Advances, 10.1126/sciadv.aax3333
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NF90 modulates processing of a subset of human pri-miRNAs
Grasso G, Higuchi T, Mac V, Barbier J, Helsmoortel M, Lorenzo C, Sanchez G, Bello M, Ritchie W, Saka...
2020 - Nucleic Acids Research
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4D Genome Rewiring during Oncogene-Induced and Replicative Senescence
Sati, S., Bonev, B., Szabo, Q., Jost, D., Bensadoun, P., Serra, F., Loubiere...
2020 - Mol Cell, 10.1016/j.molcel.2020.03.007
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