Projects MARCEL MECHALI

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DNA REPLICATION ORIGINS AND THE 3D GENOME 01/01/2020 - 31/12/2024

A recent intriguing observation of our group was a specific organization of DNA replication origins along the Topologically Associated domains (Akerman[...]

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Replication and Genome Dynamics

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GENETIC AND EPIGENETIC NATURE OF DNA REPLICATION ORIGINS 01/01/2011 - 31/12/2022

In contrast to bacterial or Saccharomyces cerevisiae, origins in multicellular organisms do not share a strict consensus genetic sequence. The availability[...]

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Replication and Genome Dynamics

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DNA REPLICATION ORIGINS AND CELL IDENTITY 01/01/2000 - 31/12/2022

We found that the positions of DNA replication origins is associated with the organization of chromosomal domains, and that this positioning may define[...]

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Replication and Genome Dynamics

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