Neurogenetics and memory

  • Drosophila adult brain developmental molecular genetics

    Drosophila adult brain developmental molecular genetics is a youg science which is gaining momentum. We can raisonably foresee that the gene cascades at work during brain development will be conserved in mammals. In Drosophila, recent techniques are now available and allow to work efficiently on this topic. Mushroom bodies (MB) may be considered as the mamalian hippocampus analogue are an excellent model in order to study brain development. Each MB neuroblast generates, in a sequential fashion, three distinct classes of neurons. First the γ then the α'β' and finally the αβ neurons appear during development. MB are essential for several forms of learning and memory. We have introduced in the laboratory a memory paradigm based on male courtship behavior (in collaboration with M.L. Parmentier and Y. Grau, IGF). Therefore we are able to correlate a developing brain structure and its fonction.


    Jean-Maurice Dura
    Dura Jean-Maurice
    Ana Boulanger
    Boulanger Ana


    Nuclear receptors and Drosophila neuronal remodelling

    Boulanger A, Dura JM.

    2015 - Biochim Biophys Acta, 1849(2):187-195

    Request for full article24882358

    Guidance of Drosophila Mushroom Body Axons Depends upon DRL-Wnt Receptor Cleavage in the Brain Dorsomedial Lineage Precursors

    Reynaud E, Lahaye LL, Boulanger A, Petrova IM, Marquilly C, Flandre A, Martianez T, Privat M, Noordermeer JN, Fradkin LG, Dura JM

    2015 - Cell Rep, 11(8):1293-304

    Request for full article25981040

    The Drosophila Amyloid Precusor Protein is a conserved neuronal modulator of Wnt PCP signaling

    Soldano A., Okray Z., Janovska P., Tmejova K., Reynaud E., Claeys A., Yan J., Atak Z. K., De Strooper B., Dura J.-M., Bryja V., Hasssan B. A.

    2013 - PLoS Biology , 11(5):e1001562

    Request for full article23690751

    Ecdysone signaling at metamorphosis triggers apoptosis of Drosophila abdominal muscles

    Zirin J, Cheng D, Dhanyasi N, Cho J, Dura JM, Vijayraghavan K, Perrimon N.

    2013 - Dev Biol., 383, 2, 375-384

    Request for full article24051228
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