Gene regulation

  • All organisms must regulate the expression of their genes to achieve the silencing of certain genes, and the activation of others during development and homeostasis. Disregulation of gene expression frequently has dire consequences, and can lead to pathologies such as cancer. The regulation of gene expression occurs at different levels, all of which depend on a multitude of factors. Chromatin is a primary regulator of gene expression. Physical compaction of the genome into chromatin controls accessability to the transcription machinery. Studies performed over recent years have revealed the enormous complexity involved in modifying chromatin to regulate gene expression.


    Members

    Rosemary Kiernan
    Kiernan Rosemary
    Sylvie Rouquier
    Rouquier Sylvie
    Céline Franckhauser
    Franckhauser Céline
    Giuseppa Grasso
    Grasso Giuseppa
    Mouna Kammoun
    Kammoun Mouna

    Publications

    NF90 modulates processing of a subset of human pri-miRNAs

    Grasso G, Higuchi T, Mac V, Barbier J, Helsmoortel M, Lorenzo C, Sanchez G, Bello M, Ritchie W, Sakamoto S, and Kiernan R.

    2020 - Nucleic Acids Research

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    Chromatin-associated MRN complex protects highly transcribing genes from genomic instability

    Kader Salifou, Callum Burnard, Poornima Basavarajaiah, Marion Helsmoortel, Victor Mac, David Depierre, Giuseppa Grasso, Céline Franckhauser, Emmanuelle Beyne, Xavier Contreras, Jérôme Dejardin, Sylvie Rouquier, Olivier Cuvier and Rosemary Kiernan

    2020 - Biorxiv

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    [Nuclear RNA surveillance complexes control HIV-1 transcription].

    Salifou K, Kiernan R, Contreras X

    2019 - Med Sci (Paris), 35(2):113-115

    Request for full article30774074

    An NF90/NF110-mediated feedback amplification loop regulates dicer expression and controls ovarian carcinoma progression.

    Barbier J, Chen X, Sanchez G, Cai M, Helsmoortel M, Higuchi T, Giraud P, Contreras X, Yuan G, Feng Z, Nait-Saidi R, Deas O, Bluy L, Judde JG, Rouquier S, Ritchie W, Sakamoto S, Xie D, Kiernan R

    2018 - Cell Res, 28(5):556-571

    Request for full article29563539
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    Publications of the team

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