L'Institut de Génétique Humaine se mobilise pour apporter une réponse scientifique à COVID-19
en offrant son expertise et ses installations pour lutter contre la pandémie.
L'IGH a pour objectif de réaliser une recherche fondamentale d'excellence et de conduire celle-ci jusqu'à ses retombées dans le domaine de la pathologie.
Publications
A predictable conserved DNA base composition signature defines human core DNA replication origins.
Akerman I, Kasaai B, Bazarova A, Sang PB, Peiffer I, Artufel M, Derelle R, Smith G, Rodriguez-Martin...
2020 - Nat Commun, 11(1):4826
32958757
Tubulin modifying enzymes as target for the treatment of tau-related diseases
Krzysztof Rogowski, Khaled Hached, Carole Crozet, Siem Van Der Laan
2020 - Pharmacology & Therapeutics
Plus d'informations
Functions of PIWI Proteins in Gene Regulation: New Arrows Added to the piRNA Quiver
Anne Ramat, Martine Simonelig
2020 - Trends in Genetics
The Mi-2 nucleosome remodeler and the Rpd3 histone deacetylase are involved in piRNA-guided heteroch...
Bruno Mugat, Simon Nicot, Carolina Varela-Chavez, Christophe Jourdan, Kaoru Sato, Eugenia Basyuk, Fr...
2020 - Nature Communications volume
Plus d'informations
Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation
J. Guerra, A.-L. Valadao, D. Vlachakis, K. Polak, I. K. Vila, C. Taffoni, T. Prabakaran, A. S. Marri...
2020 - Science Advances, 10.1126/sciadv.aax3333
Plus d'informations
NF90 modulates processing of a subset of human pri-miRNAs
Grasso G, Higuchi T, Mac V, Barbier J, Helsmoortel M, Lorenzo C, Sanchez G, Bello M, Ritchie W, Saka...
2020 - Nucleic Acids Research
Plus d'informations
4D Genome Rewiring during Oncogene-Induced and Replicative Senescence
Sati, S., Bonev, B., Szabo, Q., Jost, D., Bensadoun, P., Serra, F., Loubiere...
2020 - Mol Cell, 10.1016/j.molcel.2020.03.007
Plus d'informations
The PIWI protein Aubergine recruits eIF3 to activate translation in the germ plasm.
Ramat A, Garcia-Silva MR, Jahan C, Naït-Saïdi R, Dufourt J, Garret C, Chartier A...
2020 - Cell Research (2020)., 10.1038/s41422-020-0294-9
Widespread activation of developmental gene expression characterized by PRC1-dependent chromatin loo...
Loubiere V, Papadopoulos GL, Szabo Q, Martinez AM, Cavalli G
2020 - Sci Adv, 6(2):eaax4001
31950077MRX Increases Chromatin Accessibility at Stalled Replication Forks to Promote Nascent DNA Resection ...
Delamarre A, Barthe A, de la Roche Saint-André C, Luciano P, Forey R, Padioleau I, Skrzypczak M, Gi...
2019 - Mol Cell, 77(2):395-410.e3
31759824
MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53- Dependent...
Malik Lutzmann, Florence Bernex, Cindy da Costa de Jesus, Dana Hodroj, Caroline Marty, Isabelle Plo,...
2019 - Cell Reports, 10.1016/j.celrep.2019.07.095
In utero exposure to acetaminophen and ibuprofen leads to intergenerational accelerated reproductive...
Rossitto M, Ollivier M, Déjardin S, Pruvost A, Brun C, Marchive C, Nguyen AL, Ghettas A, Keime C, d...
2019 - Communications Biology vol 2, 310 (2019)