L'Institut de Génétique Humaine se mobilise pour apporter une réponse scientifique à COVID-19
en offrant son expertise et ses installations pour lutter contre la pandémie.
L'IGH a pour objectif de réaliser une recherche fondamentale d'excellence et de conduire celle-ci jusqu'à ses retombées dans le domaine de la pathologie.
Publications
A Role for the Mre11-Rad50-Xrs2 Complex in Gene Expression and Chromosome Organization
Romain Forey, Antoine Barthe, Mireille Tittel-Elmer, Maxime Wery, Marie-Bénédicte Barrault, Cécil...
2020 - Molecular cell
Plus d'informations
A predictable conserved DNA base composition signature defines human core DNA replication origins.
Akerman I, Kasaai B, Bazarova A, Sang PB, Peiffer I, Artufel M, Derelle R, Smith G, Rodriguez-Martin...
2020 - Nat Commun, 11(1):4826
32958757
Tubulin modifying enzymes as target for the treatment of tau-related diseases
Krzysztof Rogowski, Khaled Hached, Carole Crozet, Siem Van Der Laan
2020 - Pharmacology & Therapeutics
Plus d'informations
Functions of PIWI Proteins in Gene Regulation: New Arrows Added to the piRNA Quiver
Anne Ramat, Martine Simonelig
2020 - Trends in Genetics
The Mi-2 nucleosome remodeler and the Rpd3 histone deacetylase are involved in piRNA-guided heteroch...
Bruno Mugat, Simon Nicot, Carolina Varela-Chavez, Christophe Jourdan, Kaoru Sato, Eugenia Basyuk, Fr...
2020 - Nature Communications volume
Plus d'informations
Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation
J. Guerra, A.-L. Valadao, D. Vlachakis, K. Polak, I. K. Vila, C. Taffoni, T. Prabakaran, A. S. Marri...
2020 - Science Advances, 10.1126/sciadv.aax3333
Plus d'informations
NF90 modulates processing of a subset of human pri-miRNAs
Grasso G, Higuchi T, Mac V, Barbier J, Helsmoortel M, Lorenzo C, Sanchez G, Bello M, Ritchie W, Saka...
2020 - Nucleic Acids Research
Plus d'informations
4D Genome Rewiring during Oncogene-Induced and Replicative Senescence
Sati, S., Bonev, B., Szabo, Q., Jost, D., Bensadoun, P., Serra, F., Loubiere...
2020 - Mol Cell, 10.1016/j.molcel.2020.03.007
Plus d'informations
The PIWI protein Aubergine recruits eIF3 to activate translation in the germ plasm.
Ramat A, Garcia-Silva MR, Jahan C, Naït-Saïdi R, Dufourt J, Garret C, Chartier A...
2020 - Cell Research (2020)., 10.1038/s41422-020-0294-9
Widespread activation of developmental gene expression characterized by PRC1-dependent chromatin loo...
Loubiere V, Papadopoulos GL, Szabo Q, Martinez AM, Cavalli G
2020 - Sci Adv, 6(2):eaax4001
31950077MRX Increases Chromatin Accessibility at Stalled Replication Forks to Promote Nascent DNA Resection ...
Delamarre A, Barthe A, de la Roche Saint-André C, Luciano P, Forey R, Padioleau I, Skrzypczak M, Gi...
2019 - Mol Cell, 77(2):395-410.e3
31759824
MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53- Dependent...
Malik Lutzmann, Florence Bernex, Cindy da Costa de Jesus, Dana Hodroj, Caroline Marty, Isabelle Plo,...
2019 - Cell Reports, 10.1016/j.celrep.2019.07.095