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ERCUniversité MontpellierCNRSIGH

 


A postdoctoral position funded by the ERC is available in the group “Meiosis and Recombination”.

Our group is interested in the mechanism and regulation of meiotic recombination using mouse as a model system and taking advantage of a large variety of experimental approaches.
The research project will aim to understand molecular mechanisms mediating and regulating interactions between homologous chromosomes during meiotic prophase.
Ambitious and pioneering approaches at the molecular and cytological levels will be developed to address these questions.
Qualification: We are seeking a highly qualified and motivated postdoc with strong skills in molecular and cellular biology, with previous research experience and knowledge in chromosome and genome biology, validated by high quality firstauthor publications.
Application: Please submit a CV, a statement of research interest, and names of at least two references as a single pdf file before January 15th 2021 to: Bernard de Massy (Cette adresse e-mail est protégée contre les robots spammeurs. Vous devez activer le JavaScript pour la visualiser.), starting date: early 2021.
Team web site: https://www.igh.cnrs.fr/en/research/departments/genome-dynamics/5-meiosisand-recombination

Un contrat d’ingénieur.e financé par l’ERC est ouvert au sein de l’équipe “Méiose et recombinaison” dirigée par Bernard de Massy.

L’ingénieur.e optimisera des protocoles de préparation de cellules méiotiques de souris pour produire et caractériser ces cellules aux niveaux moléculaire et cellulaire.
Les techniques utilisées seront: culture cellulaire, tri cellulaire, immuno-cytochimie, hybridation in situ, microscopie, analyses moléculaires et modification génétique par CrispR/Cas9.
Ce travail sera en lien avec le projet de recherche d’un.e chercheur.e ou postdoc.
Compétences: Connaissances et expertises en biologie cellulaire.
Expérience en culture cellulaire indispensable. Expérience en tri cellulaire et/ou microscopie souhaitable.
Bon niveau en anglais. Travail en équipe. Rigueur, organisation, motivation et autonomie.
Candidature: Merci d’adresser un CV, et les coordonnées de réferences dans un fichier pdf unique avant le 15 Janvier 2021: Bernard de Massy (Cette adresse e-mail est protégée contre les robots spammeurs. Vous devez activer le JavaScript pour la visualiser.), début de contrat: début 2021. Durée: 2 ans voire plus.
Site web de l’équipe: https://www.igh.cnrs.fr/fr/recherche/departements/dynamique-dugenome/5-meiose-et-recombinaison

 

ERCIGH

 


Postdoc ad#1:
The Dejardin lab is seeking an outstanding postdoctoral candidate to explore potential mechanisms underlying epiallele metastability in mammals in the context of our ERC research project.

Metastable epialleles are alleles that are variably expressed in genetically identical individuals. These epialleles are established during early development by epigenetic modifications in a process influenced by stress and the environment. The epiallele’s state can subsequently be maintained throughout development and adult life. All known examples of epialleles involve the insertion of a transposable element, whose variable methylation among individuals correlates with local gene expression. However, the mechanisms underlying interindividual metastability are unknown. We have purified and established the proteome of one such transposable element and found that it has the potential to contact multiple chromosomal regions, that we suspect alter such transposable element silencing capacity.

The successful candidate will explore this mechanism by using cutting-edge chromosome conformation methods, genetics and mouse models, chromatin proteomics and biochemistry. Our research group is located in the Institute of Human Genetics which provides a scientifically rich environment and opportunities for young scientists to thrive. IGH is equipped or has an easy access to cutting-edge sequencing/proteomics and imaging facilities.

The successful candidate should have a strong background in epigenetics and chromatin regulation.

Experience in high-throughput genomics (ChIP-seq/RNA-seq/Hi-C/Capture Hi-C), in mouse genetics and in chromatin biochemistry would be a plus. Experience in long read DNA sequencing would be a plus.

Candidates shortly expecting to be awarded a PhD degree in this field are strongly encouraged to apply.

Gauchier, M, van Mierlo, G, Vermeulen, M and Dejardin J. (2020). Purification and Enrichment of Specific Chromatin Loci. Nature Methods 17(4):380-389. doi: 10.1038/s41592-020-0765-4.
Gauchier et al, (2019). SETDB1-dependent Heterochromatin Stimulates Alternative Lengthening of Telomeres. Science Advances. May 8;5(5):eaav3673. doi: 10.1126/sciadv.aav3673.

Postdoc ad#2:
The Dejardin lab is seeking an outstanding postdoctoral candidate to explore a novel mechanism of transposon silencing in mammalian somatic cells at the interface of fundamental epigenetics and immunity in the context of our ERC research project.

Transposable elements represent a large fraction of mammalian genomes and their activity must be tightly restricted to maintain genome stability and cellular identity. Our lab is particularly interested the chromatin control of retrotransposons in somatic cells. Several mechanisms, involving DNA methylation, histone methylation or small RNA targeting have extensively been described. Our recent chromatin proteomics efforts identified a number of novel pathways, including innate immune sensors on such transposons (Gauchier et al, in prep). The goal of this project is to understand the mechanistic details of these unexpected associations, with far reaching implications in the fields of epigenetics and immunity and inflammation.

The successful candidate will explore this mechanism by using cutting-edge genomics, develop mouse knock-out cell lines and possibly animals, and chromatin biochemistry. Our research group is located in the Institute of Human Genetics which provides a scientifically rich environment and opportunities for young scientists to thrive. IGH is equipped or has an easy access to cutting-edge sequencing/proteomics and imaging facilities.

The successful candidate should have a strong background in chromatin regulation and/or RNA biochemistry. Experience in high-throughput genomics and in enzyme biochemistry would be a plus.

Candidates shortly expecting to be awarded a PhD degree in this field are strongly encouraged to apply.

Recent papers from the lab

-Gauchier, M, van Mierlo, G, Vermeulen, M and Dejardin J. (2020). Purification and Enrichment of Specific Chromatin Loci. Nature Methods 17(4):380-389. doi: 10.1038/s41592-020-0765-4.

-Barral, A and Dejardin, J. (2020). Telomeric chromatin and TERRA. J Mol Biol. 10;432(15):4244-4256. doi: 10.1016/j.jmb.2020.03.003

-Gauchier et al, (2019). SETDB1-dependent Heterochromatin Stimulates Alternative Lengthening of Telomeres. Science Advances. May 8;5(5):eaav3673. doi: 10.1126/sciadv.aav3673.