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Postdoc ad#1:
The Dejardin lab is seeking an outstanding postdoctoral candidate to explore potential mechanisms underlying epiallele metastability in mammals in the context of our ERC research project.

Metastable epialleles are alleles that are variably expressed in genetically identical individuals. These epialleles are established during early development by epigenetic modifications in a process influenced by stress and the environment. The epiallele’s state can subsequently be maintained throughout development and adult life. All known examples of epialleles involve the insertion of a transposable element, whose variable methylation among individuals correlates with local gene expression. However, the mechanisms underlying interindividual metastability are unknown. We have purified and established the proteome of one such transposable element and found that it has the potential to contact multiple chromosomal regions, that we suspect alter such transposable element silencing capacity.

The successful candidate will explore this mechanism by using cutting-edge chromosome conformation methods, genetics and mouse models, chromatin proteomics and biochemistry. Our research group is located in the Institute of Human Genetics which provides a scientifically rich environment and opportunities for young scientists to thrive. IGH is equipped or has an easy access to cutting-edge sequencing/proteomics and imaging facilities.

The successful candidate should have a strong background in epigenetics and chromatin regulation.

Experience in high-throughput genomics (ChIP-seq/RNA-seq/Hi-C/Capture Hi-C), in mouse genetics and in chromatin biochemistry would be a plus. Experience in long read DNA sequencing would be a plus.

Candidates shortly expecting to be awarded a PhD degree in this field are strongly encouraged to apply.

Gauchier, M, van Mierlo, G, Vermeulen, M and Dejardin J. (2020). Purification and Enrichment of Specific Chromatin Loci. Nature Methods 17(4):380-389. doi: 10.1038/s41592-020-0765-4.
Gauchier et al, (2019). SETDB1-dependent Heterochromatin Stimulates Alternative Lengthening of Telomeres. Science Advances. May 8;5(5):eaav3673. doi: 10.1126/sciadv.aav3673.

Postdoc ad#2:
The Dejardin lab is seeking an outstanding postdoctoral candidate to explore a novel mechanism of transposon silencing in mammalian somatic cells at the interface of fundamental epigenetics and immunity in the context of our ERC research project.

Transposable elements represent a large fraction of mammalian genomes and their activity must be tightly restricted to maintain genome stability and cellular identity. Our lab is particularly interested the chromatin control of retrotransposons in somatic cells. Several mechanisms, involving DNA methylation, histone methylation or small RNA targeting have extensively been described. Our recent chromatin proteomics efforts identified a number of novel pathways, including innate immune sensors on such transposons (Gauchier et al, in prep). The goal of this project is to understand the mechanistic details of these unexpected associations, with far reaching implications in the fields of epigenetics and immunity and inflammation.

The successful candidate will explore this mechanism by using cutting-edge genomics, develop mouse knock-out cell lines and possibly animals, and chromatin biochemistry. Our research group is located in the Institute of Human Genetics which provides a scientifically rich environment and opportunities for young scientists to thrive. IGH is equipped or has an easy access to cutting-edge sequencing/proteomics and imaging facilities.

The successful candidate should have a strong background in chromatin regulation and/or RNA biochemistry. Experience in high-throughput genomics and in enzyme biochemistry would be a plus.

Candidates shortly expecting to be awarded a PhD degree in this field are strongly encouraged to apply.

Recent papers from the lab

-Gauchier, M, van Mierlo, G, Vermeulen, M and Dejardin J. (2020). Purification and Enrichment of Specific Chromatin Loci. Nature Methods 17(4):380-389. doi: 10.1038/s41592-020-0765-4.

-Barral, A and Dejardin, J. (2020). Telomeric chromatin and TERRA. J Mol Biol. 10;432(15):4244-4256. doi: 10.1016/j.jmb.2020.03.003

-Gauchier et al, (2019). SETDB1-dependent Heterochromatin Stimulates Alternative Lengthening of Telomeres. Science Advances. May 8;5(5):eaav3673. doi: 10.1126/sciadv.aav3673.