The implication of CCR5 and CXCR4 in HIV infection and inflammatory diseases
The chemokines are soluble, small molecular weight (8-14 kDa) proteins that bind to their cognate G-protein coupled receptors (GPCRs), chemokine receptors, to elicit cellular responses, usually migration or chemotaxis. Chemokines were shown to be involved, among other biological functions, in angiogenesis, haematopoiesis, embryonic development, and metastasis. Two chemokine receptors, CCR5 and CXCR4, have attracted substantial interest due to their roles in HIV-1 infection as viral entry, together with CD4. We have demonstrated that HIV-induced signaling through CCR5 or CXCR4 plays an important role in viral production, and protein G1?-mediated ERK1/2 activation is involved in the regulation of viral reverse transcription.
One of my research projects is to study the mechanism of how ERK1/2 regulates the completion of reverse transcription in HIV-1 infection. Meanwhile, I will also focus on the identification of Chinese herbal extracts which may have therapeutic effects on CCR5- and CXCR4-implicated pathologies.
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A Tribute to Angelos Constantinou
from
10/03/2025
until 13/03/2025
Village Club de Carry-Le-Rouet, France