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A Role for the Mre11-Rad50-Xrs2 Complex in Gene Expression and Chromosome Organization

Romain Forey, Antoine Barthe, Mireille Tittel-Elmer, Maxime Wery, Marie-Bénédicte Barrault, Cécile Ducrot, Andrew Seeber, Nils Krietenstein, Ugo Szachnowski, Magdalena Skrzypczak, Krzysztof Ginalski, Maga Rowicka, Jennifer A.Cobb, Oliver J.Rando, Julie Soutourina, Michel Werner, Karine Dubrana, Susan M.Gasser, Jérôme Poli

2020 - Molecular cell

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Regulation of single-cell genome organization into TADs and chromatin nanodomains

Szabo, Q., Donjon, A., Jerkovic, I., Papadopoulos, G.L., Cheutin, T., Bonev, B., Nora, E., Bruneau, B.G., Bantignies, F., and Cavalli, G.

2020 - Nature Genetics 52, 1151–1157. (2020)

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Metformin partially reverses the inhibitory effect of co-culture with ER-/PR-/HER2+ breast cancer cells on biomarkers of monocyte antitumor activity

Dahmani Z., Addou-Klouche L, Gizard F., Dahou S, Messaoud A, Chahinez Djebri N, Benaissti M.I, Mostefaoui M, Terbeche H, Nouari W, Miliani M, Lefranc . , Fernandez A, Lamb N J. and Aribi M.

2020 - PLOS ONE

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PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment.

Imai Y, Biot M, Clément J, Teragaki M, Urbach S, Robert T, Baudat F, Grey C, de Massy B

2020 - Elife, 9

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Re-assessment of the involvement of Snord115 in the serotonin 2C receptor pathway in a genetically relevant mouse model.

Hebras J, Marty V, Personnaz J, Mercier P, Krogh N, Nielsen H, Aguirrebengoa M, Seitz H, Pradere JP, Guiard BP, Cavaille J

2020 - Elife, 9

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A predictable conserved DNA base composition signature defines human core DNA replication origins.

Akerman I, Kasaai B, Bazarova A, Sang PB, Peiffer I, Artufel M, Derelle R, Smith G, Rodriguez-Martinez M, Romano M, Kinet S, Tino P, Theillet C, Taylor N, Ballester B, Méchali M

2020 - Nat Commun, 11(1):4826

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Tubulin modifying enzymes as target for the treatment of tau-related diseases

Krzysztof Rogowski, Khaled Hached, Carole Crozet, Siem Van Der Laan

2020 - Pharmacology & Therapeutics

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Functions of PIWI Proteins in Gene Regulation: New Arrows Added to the piRNA Quiver

Anne Ramat, Martine Simonelig

2020 - Trends in Genetics

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Reading the epigenetic code for exchanging DNA.

Biot M, de Massy B

2020 - Elife, 9

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iMOKA: ?-mer based software to analyze large collections of sequencing data

Claudio Lorenzi, Sylvain Barriere, Jean-Philippe Villemin, Laureline Dejardin Bretones, Alban Mancheron, William Ritchie

2020 - Genome Biology

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Animal Models for the Study of Nucleic Acid Immunity: Novel Tools and New Perspectives

Isabelle K Vila , Maxence Fretaud , Dimitrios Vlachakis, Nadine Laguette, Christelle Langevin

2020 - Journal of Molecular Biology

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Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites

Promonet A, Padioleau I, Liu Y, Sanz L, Biernacka A, Schmitz AL, Skrzypczak M, Sarrazin A, Mettling C, Rowicka M, Ginalski K, Chedin F, Chen CL, Lin YL, Pasero P.

2020 - Nature communications

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SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation

Patricia Richard, Shuang Feng, Yueh-Lin Tsai, Wencheng Li, Paola Rinchetti, Ubayed Muhith, Juan Irizarry-Cole, Katharine Stolz, Lionel A Sanz, Stella Hartono, Mainul Hoque, Saba Tadesse, Hervé Seitz, Francesco Lotti, Michio Hirano, Frédéric Chédin, Bin Tian, James L Manley

2020 - Autophagy

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TALC: Transcription Aware Long Read Correction

Lucile Broseus, Aubin Thomas, Andrew J Oldfield, Dany Severac, Emeric Dubois, William Ritchie

2020 - Bioinformatics

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The Mi-2 nucleosome remodeler and the Rpd3 histone deacetylase are involved in piRNA-guided heterochromatin formation

Bruno Mugat, Simon Nicot, Carolina Varela-Chavez, Christophe Jourdan, Kaoru Sato, Eugenia Basyuk, François Juge, Mikiko C. Siomi, Alain Pélisson & Séverine Chambeyron

2020 - Nature Communications volume

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Chromatin-associated MRN complex protects highly transcribing genes from genomic instability

Kader Salifou, Callum Burnard, Poornima Basavarajaiah, Marion Helsmoortel, Victor Mac, David Depierre, Giuseppa Grasso, Céline Franckhauser, Emmanuelle Beyne, Xavier Contreras, Jérôme Dejardin, Sylvie Rouquier, Olivier Cuvier and Rosemary Kiernan

2020 - Biorxiv

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Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation

J. Guerra, A.-L. Valadao, D. Vlachakis, K. Polak, I. K. Vila, C. Taffoni, T. Prabakaran, A. S. Marriott, R. Kaczmarek, A. Houel, B. Auzemery,S. Déjardin,P. Boudinot, B. Nawrot, N. J. Jones, S. R. Paludan, S. Kossida, C. Langevin,* and N. Laguette

2020 - Science Advances, 10.1126/sciadv.aax3333

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NF90 modulates processing of a subset of human pri-miRNAs

Grasso G, Higuchi T, Mac V, Barbier J, Helsmoortel M, Lorenzo C, Sanchez G, Bello M, Ritchie W, Sakamoto S, and Kiernan R.

2020 - Nucleic Acids Research

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Homologous recombination and Mus81 promote replication completion in response to replication fork blockage

Benjamin Pardo, María Moriel‐Carretero, Thibaud Vicat, Andrés Aguilera and Philippe Pasero

2020 - EMBO Rep (2020) e49367, 10.15252/embr.201949367

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4D Genome Rewiring during Oncogene-Induced and Replicative Senescence

Sati, S., Bonev, B., Szabo, Q., Jost, D., Bensadoun, P., Serra, F., Loubiere...

2020 - Mol Cell, 10.1016/j.molcel.2020.03.007

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