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Prospects and challenges of multi-omics data integration in toxicology.

Canzler S, Schor J, Busch W, Schubert K, Rolle-Kampczyk UE, Seitz H, Kamp H, von Bergen M, Buesen R, Hackermüller J

2020 - Arch Toxicol

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Widespread activation of developmental gene expression characterized by PRC1-dependent chromatin looping.

Loubiere V, Papadopoulos GL, Szabo Q, Martinez AM, Cavalli G

2020 - Sci Adv, 6(2):eaax4001

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Dihydropyrimidinase protects from DNA replication stress caused by cytotoxic metabolites.

Basbous J, Aze A, Chaloin L, Lebdy R, Hodroj D, Ribeyre C, Larroque M, Shepard C, Kim B, Pruvost A, Moreaux J, Maiorano D, Mechali M, Constantinou A

2019 - Nucleic Acids Res

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Evolutionary Divergence of Enzymatic Mechanisms for Tubulin Detyrosination.

van der Laan S, Lévêque MF, Marcellin G, Vezenkov L, Lannay Y, Dubra G, Bompard G, Ovejero S, Urbach S, Burgess A, Amblard M, Sterkers Y, Bastien P, Rogowski K

2019 - Cell Rep, 29(12):4159-4171.e6

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Global chromatin conformation differences in the Drosophila dosage compensated chromosome X.

Pal K, Forcato M, Jost D, Sexton T, Vaillant C, Salviato E, Mazza EMC, Lugli E, Cavalli G, Ferrari F

2019 - Nat Commun, 10(1):5355

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MRX Increases Chromatin Accessibility at Stalled Replication Forks to Promote Nascent DNA Resection and Cohesin Loading.

Delamarre A, Barthe A, de la Roche Saint-André C, Luciano P, Forey R, Padioleau I, Skrzypczak M, Ginalski K, Géli V, Pasero P, Lengronne A

2019 - Mol Cell, 77(2):395-410.e3

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The multiscale effects of polycomb mechanisms on 3D chromatin folding.

Cheutin T, Cavalli G

2019 - Crit Rev Biochem Mol Biol, 54(5):399-417

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Higher-Order Chromosomal Structures Mediate Genome Function.

Jerković I, Szabo Q, Bantignies F, Cavalli G

2019 - J Mol Biol

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Dietary Apigenin in the Prevention of Endothelial Cell Dysfunction.

Lamb NJ, Gizard F

2019 - J Cardiovasc Pharmacol, 74(6):513-515

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MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53- Dependent Myeloid Tumors

Malik Lutzmann, Florence Bernex, Cindy da Costa de Jesus, Dana Hodroj, Caroline Marty, Isabelle Plo, William Vainchenker, Marie Tosolini, Luc Forichon, Caroline Bret, Sophie Queille, Candice Marchive, Jean-Sébastien Hoffmann, Marcel Méchali

2019 - Cell Reports, 10.1016/j.celrep.2019.07.095

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In utero exposure to acetaminophen and ibuprofen leads to intergenerational accelerated reproductive aging in female mice

Rossitto M, Ollivier M, Déjardin S, Pruvost A, Brun C, Marchive C, Nguyen AL, Ghettas A, Keime C, de Massy B, Poulat F, Philibert Pand Boizet-Bonhoure B

2019 - Communications Biology vol 2, 310 (2019)

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Advances in epigenetics link genetics to the environment and disease

Giacomo Cavalli and Edith Heard

2019 - Nature, 10.1038/s41586-019-1411-0

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Diversification of small RNA amplification mechanisms for targeting transposon-related sequences in ciliates.

Mutazono M, Noto T, Mochizuki K.

2019 - Proc Natl Acad Sci USA

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Combination of metformin with sodium selenite induces a functional phenotypic switch of human GM-CSF monocyte-derived macrophages.

Meziane W, Mekkaoui Z, Hai I, Kacimi K, Djilali K, Touil-Boukoffa C, Lefranc G, Fernandez A, Lamb N, Mennechet F, Aribi M

2019 - Int Immunopharmacol, 73:212-224

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SETDB1-dependent heterochromatin stimulates alternative lengthening of telomeres

Gauchier M, Kan S, Barral A, Sauzet S, Agirre E, Bonnell E, Saksouk N, Barth TK, Ide S, Urbach S, Wellinger RJ, Luco RF, Imhof A and Déjardin J 

2019 - Science Advances, 10.1126/sciadv.aav3673

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Metazoan DNA replication origins

Ganier O., Prorok P, Akerman I. , and Méchali M.

2019 - Curr. Opinion in Cell Biol.

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Involvement of G-quadruplex regions in mammalian replication origin activity

Prorok P., Artufel, M., Aze, A., Coulombe, P., Peifer I., Lacroix L., Guédin A., Mergny J.L., Damaschke J., Schepers, A., Ballester, B., and Méchali, M.

2019 - Nature Com.

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OBI1, an ORC ubiquitin ligase promoting DNA replication origin firing

Coulombe P, Nassar J, Peiffer I, Stanojcic S, Sterkers Y, Delamarre A, Bocquet S. and Méchali M.

2019 - Nature Com.

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Mouse ANKRD31 Regulates Spatiotemporal Patterning of Meiotic Recombination Initiation and Ensures Recombination between X and Y Sex Chromosomes.

Papanikos F, Clément JAJ, Testa E, Ravindranathan R, Grey C, Dereli I, Bondarieva A, Valerio-Cabrera S, Stanzione M, Schleiffer A, Jansa P, Lustyk D, Fei JF, Adams IR, Forejt J, Barchi M, de Massy B, Toth A

2019 - Mol Cell

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Inhibition of Ataxia-Telangiectasia Mutated and RAD3-related (ATR) overcomes oxaliplatin resistance and promotes anti-tumor immunity in colorectal cancer.

Combes E, Andrade AF, Tosi D, Michaud HA, Coquel F, Garambois V, Desigaud D, Jarlier M, Coquelle A, Pasero P, Bonnefoy N, Moreaux J, Martineau P, Del Rio M, Beijersbergen RL, Vezzio-Vie N, Gongora C

2019 - Cancer Res

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