Chromatin and cell biology

Genome dynamics

• Team
• Projects
• Members
• Publications
• Theses and hdr
• Alumni

https://www.igh.cnrs.fr/uploads/media/60a28b2617dde/thumbnail-img-1846.jpg

The genome is more than a linear string of genes. It has secondary, tertiary and quaternary higher-order structures. Strings of genes organize in chromosomal domains that are characterized by one of relatively few different types of chromatin, either repressive or activating. In the 3D space, each of the elements in one domain makes frequent contacts with other elements in the same domain. These entities have been called physical- or topologically associated- domains (TADs).
At a chromosome level, individual TADs form contacts with other TADs, preferentially of the same type, in order to build ordered 3D architectures that are called chromosome territories. Finally, different chromosomes organize non randomly in the nuclear space.
Therefore, the eukaryotic genome is highly organized in 3D and this regulation can be transmitted or modulated during the life of cells and organisms.
This sophisticated chromosomal choreography involves thousands of different players – DNA sequences, RNAs and proteins – but rather than combining in infinite numbers of ways, these components organize a relatively limited number of types of chromatin, either active or repressive. In particular, two main groups of genome regulatory components are proteins of the Polycomb Group (PcG) and of the trithorax Group (trxG). PcG proteins are maintain the memory of silent states of gene expression through cell physiology and multiple cell divisions, while trxG members maintain active chromatin states
These proteins are able to recognize regulatory states of their target genes and to maintain these states even after disappearance of the primary transcriptional regulators that have induced them in the first place. Remarkably, these states can also be transmitted to a fraction of the progeny over multiple generations. In our lab, we aim at understanding the principle governing 3D genome organization, its functional implications, and the molecular mechanisms by which PcG and trxG proteins regulate their target genes, convey inheritance of chromatin states and orchestrate development.
To reach this goal, we employ a variety of complementary approaches and techniques in the areas of molecular, cellular and developmental biology, genomics and bioinformatics.

Frederic BANTIGNIES
Project leader
Researcher
0434359997

Giacomo CAVALLI
Researcher
0434359970

Thierry CHEUTIN
Researcher
0434359997

Marco DI STEFANO
Researcher
0434359968

Max FITZ-JAMES
Researcher
0434359968

Ivana JERKOVIC
Researcher
0434359997

Anne-Marie MARTINEZ
Project leader
Researcher
0434359969

Flora PALDI
Researcher
0434359968

Gonzalo SABARIS
Researcher
0434359968

Bernd SCHUTTENGRUBER
Researcher
0434359997

Nazli AKILLI
PhD Student
0434359997

Victoria PARRENO
PhD Student
0434359968

Ana-Maria POPMIHAYLOVA
PhD Student
0434359968

Hadrien REBOUL
PhD Student
0434359997

Michael SZALAY
PhD Student
0434359997

Solène DUFAU
ITA
0434359997

Lauriane FRITSCH
ITA
0434359968

Publications of the team

Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes.

Published the 01/10/2022 - Cell , 185(20):3689-3704.e21

Ringel AR, Szabo Q, Chiariello AM, Chudzik K, Schöpflin R, Rothe P, Mattei AL, Zehnder T, Harnett D, Laupert V, Bianco S, Hetzel S, Glaser J, Phan MHQ, Schindler M, Ibrahim DM, Paliou C, Esposito A, Prada-Medina CA, Haas SA, Giere P, Vingron M, Wittler L, Meissner A, Nicodemi M, Cavalli G, Bantignies F, Mundlos S, Robson MI

A shared ancient enhancer element differentially regulates the bric-a-brac tandem gene duplicates in the developing Drosophila leg.

Published the 17/03/2022 - PLoS Genet , 18(3):e1010083 35294439

Bourbon HG, Benetah MH, Guillou E, Mojica-Vazquez LH, Baanannou A, Bernat-Fabre S, Loubiere V, Bantignies F, Cavalli G, Boube M

Comprehensive characterization of the epigenetic landscape in Multiple Myeloma.

Published the 25/02/2022 - Theranostics , 12(4):1715-1729 35198065

Alaterre E, Ovejero S, Herviou L, de Boussac H, Papadopoulos G, Kulis M, Boireau S, Robert N, Requirand G, Bruyer A, Cartron G, Vincent L, Martinez AM, Martin-Subero JI, Cavalli G, Moreaux J

HiCmapTools: a tool to access HiC contact maps.

Published the 12/02/2022 - BMC Bioinformatics , 23(1):64 35144531

Chang JM, Weng YF, Chang WT, Lin FA, Cavalli G

SETDB1/NSD-dependent H3K9me3/H3K36me3 dual heterochromatin maintains gene expression profiles by bookmarking poised enhancers.

Published the 27/01/2022 - Mol Cell , 82(4):816-832.e12 35081363

Barral A, Pozo G, Ducrot L, Papadopoulos GL, Sauzet S, Oldfield AJ, Cavalli G, Déjardin J

Mechanisms of Polycomb group protein function in cancer.

Published the 21/01/2022 - Cell Res , 32(3):231-253 35046519

Parreno V, Martinez AM, Cavalli G

Molecular mechanisms of transgenerational epigenetic inheritance.

Published the 06/01/2022 - Nat Rev Genet 34983971

Fitz-James MH, Cavalli G

Clinical Correlations of Polycomb Repressive Complex 2 in Different Tumor Types.

Published the 03/07/2021 - Cancers (Basel) , 13(13) 34202528

Erokhin M, Chetverina O, Győrffy B, Tatarskiy VV, Mogila V, Shtil AA, Roninson IB, Moreaux J, Georgiev P, Cavalli G, Chetverina D

Understanding 3D genome organization by multidisciplinary methods

Published the 05/05/2021 - Nature Reviews Molecular Cell Biology

Ivana Jerkovic´ & Giacomo Cavalli

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Published the 19/11/2020 - 32894860

Published the 28/10/2020 - 33126754

Regulation of single-cell genome organization into TADs and chromatin nanodomains

Published the 18/10/2020 - Nature Genetics , 52, 1151–1157. (2020)

Szabo, Q., Donjon, A., Jerkovic, I., Papadopoulos, G.L., Cheutin, T., Bonev, B., Nora, E., Bruneau, B.G., Bantignies, F., and Cavalli, G.

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Published the 21/08/2020 - 32820407

4D Genome Rewiring during Oncogene-Induced and Replicative Senescence

Published the 26/03/2020 - Molecular Cell , 10.1016/j.molcel.2020.03.007

Sati, S., Bonev, B., Szabo, Q., Jost, D., Bensadoun, P., Serra, F., Loubiere...

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Published the 23/03/2020 - 32203508

Widespread activation of developmental gene expression characterized by PRC1-dependent chromatin looping.

Published the 18/01/2020 - Sci Adv , 6(2):eaax4001 31950077

Loubiere V, Papadopoulos GL, Szabo Q, Martinez AM, Cavalli G

+ Chromatin and cell biology

Widespread activation of developmental gene expression characterized by PRC1-dependent chromatin looping.

Published the 18/01/2020 - Sci Adv , 6(2):eaax4001 31950077

Loubiere V, Papadopoulos GL, Szabo Q, Martinez AM, Cavalli G

+ Chromatin and cell biology

Global chromatin conformation differences in the Drosophila dosage compensated chromosome X.

Published the 27/11/2019 - Nat Commun , 10(1):5355 31767860

Pal K, Forcato M, Jost D, Sexton T, Vaillant C, Salviato E, Mazza EMC, Lugli E, Cavalli G, Ferrari F

+ Chromatin and cell biology

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Global chromatin conformation differences in the Drosophila dosage compensated chromosome X.

Published the 27/11/2019 - Nat Commun , 10(1):5355 31767860

Pal K, Forcato M, Jost D, Sexton T, Vaillant C, Salviato E, Mazza EMC, Lugli E, Cavalli G, Ferrari F

+ Chromatin and cell biology

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The multiscale effects of polycomb mechanisms on 3D chromatin folding.

Published the 09/11/2019 - Crit Rev Biochem Mol Biol , 54(5):399-417 31698957

Cheutin T, Cavalli G

+ Chromatin and cell biology

The multiscale effects of polycomb mechanisms on 3D chromatin folding.

Published the 09/11/2019 - Crit Rev Biochem Mol Biol , 54(5):399-417 31698957

Cheutin T, Cavalli G

+ Chromatin and cell biology

Higher-Order Chromosomal Structures Mediate Genome Function.

Published the 07/11/2019 - J Mol Biol 31689436

Jerković I, Szabo Q, Bantignies F, Cavalli G

+ Chromatin and cell biology

Higher-Order Chromosomal Structures Mediate Genome Function.

Published the 07/11/2019 - J Mol Biol 31689436

Jerković I, Szabo Q, Bantignies F, Cavalli G

+ Chromatin and cell biology

Advances in epigenetics link genetics to the environment and disease

Published the 24/07/2019 - Nature , 10.1038/s41586-019-1411-0

Giacomo Cavalli and Edith Heard

+ Chromatin and cell biology

Advances in epigenetics link genetics to the environment and disease

Published the 24/07/2019 - Nature , 10.1038/s41586-019-1411-0

Giacomo Cavalli and Edith Heard

+ Chromatin and cell biology

Principles of genome folding into topologically associating domains.

Published the 17/04/2019 - Sci Adv , 5(4):eaaw1668 30989119

Szabo Q, Bantignies F, Cavalli G

Microscopy-Based Chromosome Conformation Capture Enables Simultaneous Visualization of Genome Organization and Transcription in Intact Organisms.

Published the 24/02/2019 - Mol Cell 30795893

Cardozo Gizzi AM, Cattoni DI, Fiche JB, Espinola SM, Gurgo J, Messina O, Houbron C, Ogiyama Y, Papadopoulos GL, Cavalli G, Lagha M, Nollmann M

Cell Fate and Developmental Regulation Dynamics by Polycomb Proteins and 3D Genome Architecture.

Published the 23/02/2019 - Bioessays , 41(3):e1800222 30793782

Loubiere V, Martinez AM, Cavalli G

EZH2 is overexpressed in transitional preplasmablasts and is involved in human plasma cell differentiation.

Published the 14/02/2019 - Leukemia 30755708

Herviou L, Jourdan M, Martinez AM, Cavalli G, Moreaux J

+ Maintenance of genome integrity during DNA replication

PRC2 targeting is a therapeutic strategy for EZ score defined high-risk multiple myeloma patients and overcome resistance to IMiDs.

Published the 05/10/2018 - Clin Epigenetics , 10(1):121 30285865

Herviou L, Kassambara A, Boireau S, Robert N, Requirand G, Müller-Tidow C, Vincent L, Seckinger A, Goldschmidt H, Cartron G, Hose D, Cavalli G, Moreaux J

+ Maintenance of genome integrity during DNA replication

Challenges and guidelines toward 4D nucleome data and model standards.

Published the 29/09/2018 - Nat Genet , 50(10):1352-1358 30262815

Marti-Renom MA, Almouzni G, Bickmore WA, Bystricky K, Cavalli G, Fraser P, Gasser SM, Giorgetti L, Heard E, Nicodemi M, Nollmann M, Orozco M, Pombo A, Torres-Padilla ME

Loss of PRC1 induces higher-order opening of Hox loci independently of transcription during Drosophila embryogenesis.

Published the 27/09/2018 - Nat Commun , 9(1):3898 30254245

Cheutin T, Cavalli G

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[EZH2 is therapeutic target for personalized treatment in multiple myeloma].

Published the 26/07/2018 - Bull Cancer , 105(9):804-819 30041976

Herviou L, Cavalli G, Moreaux J

+ Maintenance of genome integrity during DNA replication

Polycomb-Dependent Chromatin Looping Contributes to Gene Silencing during Drosophila Development.

Published the 17/07/2018 - Mol Cell , 71(1):73-88.e5 30008320

Ogiyama Y, Schuettengruber B, Papadopoulos GL, Chang JM, Cavalli G

TADs are 3D structural units of higher-order chromosome organization in Drosophila.

Published the 06/03/2018 - Sci Adv , 4(2):eaar8082 29503869

Szabo Q, Jost D, Chang JM, Cattoni DI, Papadopoulos GL, Bonev B, Sexton T, Gurgo J, Jacquier C, Nollmann M, Bantignies F, Cavalli G

Technical Review: A Hitchhiker's Guide to Chromosome Conformation Capture.

Published the 03/01/2018 - Methods Mol Biol , 1675:233-246 29052195

Grob S, Cavalli G

Multi-scale 3D genome rewiring during mouse neural development.

Published the 01/01/2017 - CELL , 171(3):557-572 29053968

Bonev, B., Mendelson Cohen, N., Szabo, Q., Fritsch, L., Papadopoulos, G., Lubling, Y., Xu, X., Hugnot, JP., Tanay, A., Cavalli, G.

Genome Regulation by Polycomb and Trithorax: 70 Years and Counting

Published the 01/01/2017 - CELL , 171, 1, 34-57 28938122

Schuettengruber, B., Bourbon, HM., Di Croce, L., Cavalli, G.

Chromosome topology guides the Drosophila Dosage Compensation Complex for target gene activation

Published the 01/01/2017 - EMBO Rep. 28794204

Schauer T, Ghavi-Helm Y, Sexton T, Albig C, Regnard C, Cavalli G, Furlong EE, Becker PB.

Stable Polycomb-dependent transgenerational inheritance of chromatin states in Drosophila

Published the 01/01/2017 - Nat. Genet. , 49(6):876-886 28436983

Ciabrelli F, Comoglio F, Fellous S, Bonev B, Ninova M, Szabo Q, Xuéreb A, Klopp C, Aravin A, Paro R, Bantignies F, Cavalli G

Three-Dimensional Genome Organization and Function in Drosophila

Published the 01/01/2017 - Genetics , 205, 1, 5-24 28049701

Schwartz YB, Cavalli G.

Chromosome conformation capture technologies and their impact in understanding genome function

Published the 01/01/2017 - Chromosoma , 126(1):33-44 27130552

Sati S, Cavalli G.

Single-cell absolute contact probability detection reveals chromosomes are organized by multiple low-frequency yet specific interactions

Published the 01/01/2017 - Nat Commun. , 8(1):1753. 29170434

Cattoni DI, Gizzi AMC, Georgieva M, Di Stefano M, Valeri A, Chamousset D, Houbron C, Déjardin S, Fiche JB, González I, Chang JM, Sexton T, Marti-Renom MA, Bantignies F, Cavalli G, Nollmann M.

Organization and function of the 3D genome

Published the 01/01/2016 - Nat Rev Genet , 17(11):661-678 27739532

Bonev B, Cavalli G.

Chromosome Conformation Capture on Chip (4C): Data Processing

Published the 01/01/2016 - Methods Mol Biol , 1480:243-61 27659990

Leblanc B, Comet I, Bantignies F, Cavalli G.

Following the Motion of Polycomb Bodies in Living Drosophila Embryos

Published the 01/01/2016 - Methods Mol. Biol. , 1480:283-8 27659993

Cheutin T, Cavalli G.

Coordinate redeployment of PRC1 proteins suppresses tumor formation during Drosophila development

Published the 01/01/2016 - Nature Genetics , 48, 11, 1436-1442 27643538

Loubière, V., Delest, A., Thomas, A., Bonev, B., Schuettengruber, B., Sati, S., Martinez AM., Cavalli, G.

Regulation of Genome Architecture and Function by Polycomb Proteins

Published the 01/01/2016 - Trends Cell Biol. , 26, 7, 511-525 27198635

Entrevan M, Schuettengruber B, Cavalli G

EZH2 in normal hematopoiesis and hematological malignancies

Published the 01/01/2016 - Oncotarget , 7, 3, 284-296 26497210

Herviou L, Cavalli G, Cartron G, Klein B, Moreaux J.

+ Maintenance of genome integrity during DNA replication

PRC1 proteins orchestrate three-dimensional genome architecture

Published the 01/01/2015 - Nat Genet , 47(10):1105-6 26417860

Cavalli, G.

Enhancer of zeste acts as a major developmental regulator of Ciona intestinalis embryogenesis

Published the 01/01/2015 - Biol Open , 4(9):1109-21 26276097

Le Goff E, Martinand-Mari C, Martin M, Feuillard J, Boublik Y, Godefroy N, Mangeat P, Baghdiguian S, Cavalli G

Distinct polymer physics principles govern chromatin dynamics in mouse and Drosophila topological domains

Published the 01/01/2015 - BMC Genomics , 16(1):607

Ea V, Sexton T, Gostan T, Herviou L, Baudement MO, Zhang Y, Berlivet S, Le Lay-Taha MN, Cathala G, Lesne A, Victor JM, Fan Y, Cavalli G, Forné T.

Histone H3 Serine 28 Is Essential for Efficient Polycomb-Mediated Gene Repression in Drosophila

Published the 01/01/2015 - Cell Rep , 11(9):1437-45 26004180

Yung PY, Stuetzer A, Fischle W, Martinez AM, Cavalli G

The Role of Chromosome Domains in Shaping the Functional Genome

Published the 01/01/2015 - CELL , 160, 6, 1049–1059

Sexton, T., Cavalli, G.

Developmental determinants in non-communicable chronic diseases and ageing

Published the 01/01/2015 - Thorax , 70(6):595-7 25616486

Bousquet J, Anto JM, Berkouk K, Gergen P, Pinto Antunes J, Augé P, Camuzat T, Bringer J, Mercier J, Best N, Bourret R, Akdis M, Arshad SH, Bedbrook A, Berr C, Bush A, Cavalli G, Charles MA, Clavel-Chapelon F, Gillman M, Gold DR, Goldberg M, Holloway JW, Iozzo P, Jacquemin S, Jeandel C, Kauffmann F, Keil T, Koppelman GH, Krauss-Etschmann S, Kuh D, Lehmann S, Lodrup Carlsen KC, Maier D, Méchali M, Melén E, Moatti JP, Momas I, Nérin P, Postma DS, Ritchie K, Robine JM, Samolinski B, Siroux V, Slagboom PE, Smit HA, Sunyer J, Valenta R, Van de Perre P, Verdier JM, Vrijheid M, Wickman M, Yiallouros P, Zins M.

+ Replication and Genome Dynamics

Chromatin driven behavior of topologically associating domains

Published the 01/01/2015 - J Mol Biol. , 427(3):608-625 25280896

Ciabrelli F, Cavalli G.

Cooperativity, Specificity, and Evolutionary Stability of Polycomb Targeting in Drosophila

Published the 01/01/2014 - Cell Rep , 9(1):219-33 25284790

Schuettengruber B, Oded Elkayam N, Sexton T, Entrevan M, Stern S, Thomas A, Yaffe E, Parrinello H, Tanay A, Cavalli G.

Topological organization of Drosophila hox genes using DNA fluorescent in situ hybridization

Published the 01/01/2014 - Methods Mol Biol. , 1196:103-20 25151160

Bantignies, F., Cavalli, G.

Modeling epigenome folding: formation and dynamics of topologically associated chromatin domains

Published the 01/01/2014 - Nucleic Acids Res. , 42(15):9553-61 25092923

Jost D, Carrivain P, Cavalli G, Vaillant C.

Identification of Regulators of the Three-Dimensional Polycomb Organization by a Microscopy-Based Genome-wide RNAi Screen

Published the 01/01/2014 - Mol Cell , 54(3):485-99 24703951

Gonzalez I, Mateos-Langerak J, Thomas A, Cheutin T, Cavalli G.

A RING to Rule Them All: RING1 as Silencer and Activator

Published the 01/01/2014 - Dev. Cell , 28(1):1-2 24434133

Cavalli, G.

Polycomb silencing: from linear chromatin domains to 3D chromosome folding

Published the 01/01/2014 - Curr Opin Genet Dev , 25C, 30-37 24434548

Cheutin T, Cavalli G

Chromosomes: now in 3D!

Published the 01/01/2014 - Nat Rev Mol Cell Biol. , 15(1):6 24281191

Cavalli, G.

Three-dimensional genome organization: a lesson from the Polycomb-Group proteins

Published the 01/01/2013 - Biol Aujourdhui , 207(1):19-31 23694722

Bantignies, F.

PRC2 Controls Drosophila Oocyte Cell Fate by Repressing Cell Cycle Genes.

Published the 01/01/2013 - Dev Cell , 26(4):431-9 23932903

Iovino N, Ciabrelli F, Cavalli G.

The 3D Genome Shapes Up For Pluripotency.

Published the 01/01/2013 - Cell Stem Cell. , 13(1):3-4. doi: 10.1016/j.stem.2013.06.013. 23827701

Sexton T, Cavalli G.

Functional implications of genome topology

Published the 01/01/2013 - Nat. Struct. Mol. Biol , 20, 3, 290-299 23463314

Cavalli, G., Mistelli, T.

Polycomb domain formation depends on short and long distance regulatory cues.

Published the 01/01/2013 - PLoS One , ;8(2):e56531. doi: 10.1371/journal.pone.0056531 23437158

Schuettengruber B, Cavalli G.

Chromosomal domains: epigenetic contexts and functional implications of genomic compartmentalization.

Published the 01/01/2013 - Curr Opin Genet Dev. , 23, 2, 197-203.doi:pii: S0959-437X(12)00154-2 23414654

Tanay A, Cavalli G.

Progressive polycomb assembly on H3K27me3 compartments generates polycomb bodies with developmentally regulated motion

Published the 01/01/2012 - PLoS Genet. , 8(1):e1002465. doi: 10.1371/journal.pgen.1002465 22275876

Cheutin T, Cavalli G.

Polycomb: a paradigm for genome organization from one to three dimensions.

Published the 01/01/2012 - Curr Opin Cell Biol. , 24(3):405-14 22336329

Delest A, Sexton T, Cavalli G.

Three-Dimensional Folding and Functional Organization Principles of the Drosophila Genome.

Published the 01/01/2012 - CELL , 148(3):458-72 22265598

Sexton T, Yaffe E, Kenigsberg E, Bantignies F, Leblanc B, Hoichman M, Parrinello H, Tanay A, Cavalli G.

Molecular biology. EZH2 goes solo

Published the 01/01/2012 - SCIENCE , 338, 6113,1430-1431.doi: 10.1126/science.1232332

Cavalli, G.

Trithorax group proteins: switching genes on and keeping them active.

Published the 01/01/2011 - Nat Rev Mol Cell Biol. , 12(12):799-814. doi: 10.1038/nrm3230. 22108599

Schuettengruber B, Martinez AM, Iovino N, Cavalli G.

Rolling ES Cells Down the Waddington Landscape with Oct4 and Sox2

Published the 01/01/2011 - CELL , 145, 6, 815-817 21663785

Iovino, N., Cavalli, G.

Polycomb group proteins: repression in 3D.

Published the 01/01/2011 - Trends Genet. , 27(11):454-64 21794944

Bantignies F, Cavalli G.

Editorial Review

Published the 01/01/2011 - Curr. Opin. Cell Biol , 23(3):255-7 21592757

Hetzer, M., Cavalli, G

Chromatin folding : from linear chromosomes to the 4D nucleus.

Published the 01/01/2011 - Cold Spring Harb Symp Quant Biol. , 75, 461-473 21447815

Cheutin, T., Bantignies, F., Leblanc, B., Cavalli, G.

From linear genes to Epigenetic inheritance of three dimensional Epigenomes.

Published the 01/01/2011 - J. Mol. Biol , 409, 1, 54-61 21392507

Cavalli, G.

A chromatin insulator driving three-dimensional Polycomb response element (PRE) contacts and Polycomb association with the chromatin fiber.

Published the 01/01/2011 - Proc Natl Acad Sci U S A , 108(6):2294-9 21262819

Comet, I., Schuettengruber, B., Sexton, T., Cavalli, G

Polycomb-dependent Regulatory Contacts between Distant Hox Loci in Drosophila,

Published the 01/01/2011 - CELL , 144, 214-226

Bantignies, F., Roure, V., Comet, I., Leblanc, B., Schuttengruber, B., Bonnet, J., Tixier, V., Mas, A., Cavalli, G.

The DUBle life of polycomb complexes

Published the 01/01/2010 - Dev Cell , 18 6, 878-80 20627069

Schuettengruber, B., Cavalli, G

Uncovering a tumor-suppressor function for Drosophila polycomb group genes.

Published the 01/01/2010 - Cell Cycle , 9, 2, 215-216 20046098

Martinez, AM., Cavalli, G

Recruitment of polycomb group complexes and their role in the dynamic regulation of cell fate choice.

Published the 01/01/2009 - DEVELOPMENT , 136, 21, 3531-3542 19820181

Schuettengruber B, Cavalli G.

Genomic interactions: Chromatin loops and gene meeting points in transcriptional regulation

Published the 01/01/2009 - Semin. Cell Dev. Biol. , 20, 7, 849-855 19559093

Sexton, T., Bantignies, F., Cavalli, G.

Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling

Published the 01/01/2009 - Nature Genet. , 41(10):1076-82 19749760

Martinez, AM., Schuettengruber, B., Sakr, S., Janic, A., Gonzalez, C., and Cavalli, G.

Functional Anatomy of Polycomb and Trithorax Chromatin Landscapes in Drosophila Embryos

Published the 01/01/2009 - PLoS Biol , 7, 1, e13. 19143474

Schuettengruber B, Ganapathi M, Leblanc B, Portoso M, Jaschek R, Tolhuis B, van Lohuizen M, Tanay A, Cavalli G.

Epigenetics and the control of multicellularity. Workshop on Chromatin at the Nexus of Cell Division and Differentiation.

Published the 01/01/2009 - EMBO Rep. , 10, 1, 25-29 19039326

Reuter G, Cavalli G.

Chapter 2 polycomb group proteins and long-range gene regulation.

Published the 01/01/2008 - Adv Genet. , 61, 45-66 18282502

Mateos-Langerak J, Cavalli G

The Role of RNAi and Noncoding RNAs in Polycomb Mediated Control of Gene Expression and Genomic Programming.

Published the 01/01/2008 -

Portoso, M, and Cavalli, G.

Idefix insulator activity can be modulated by nearby regulatory elements.

Published the 01/01/2007 - Nucleic Acids Res. , 35(8):2661-70 17426135

Brasset E, Bantignies F, Court F, Cheresiz S, Conte C, Vaury C.

Polycomb response elements mediate the formation of chromosome higher-order structures in the bithorax complex.

Published the 01/01/2007 - Nat Cell Biol. , 9(10):1167-74 17828248

Lanzuolo C, Roure V, Dekker J, Bantignies F, Orlando V.

Visualizing macromolecules with fluoronanogold: from photon microscopy to electron tomography.

Published the 01/01/2007 - Methods Cell. Biol. , 79, 559-574 17327174

Cheutin, T., Sauvage, C., Tchélidzé, P., O

Chromosome kissing

Published the 01/01/2007 - Curr Opin Genet Dev. , 17, 443-450 17933509

Cavalli, G.

Genome Regulation by Polycomb and Trithorax Proteins.

Published the 01/01/2007 - Cell , 128, 4, 735-745 17320510

Schuettengruber B, Chourrout D, Vervoort M, Leblanc B, Cavalli G.

Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions.

Published the 01/01/2007 - Nat Rev Genet , 8, 2, 104-115 17230197

Lanctot C, Cheutin T, Cremer M, Cavalli G, Cremer T

Polycomb controls the cell fate.

Published the 01/01/2006 - Med Sci (Paris) , 22, 12, 1033-1035. 17156722

Negre N, Cavalli G.

Mapping the distribution of chromatin proteins by ChIP on chip.

Published the 01/01/2006 - Methods Enzymol. , 410, 316-341 16938558

Negre N, Lavrov S, Hennetin J, Bellis M, Cavalli G.

From genetics to epigenetics: the tale of Polycomb group and trithorax group genes.

Published the 01/01/2006 - Chromosome Res. , 14, 363-375. Review. 16821133

Grimaud C, Negre N, Cavalli G.

PRE-Mediated Bypass of Two Su(Hw) Insulators Targets PcG Proteins to a Downstream Promoter.

Published the 01/01/2006 - Dev Cell. , 11(1):117-24 16824958

Comet I, Savitskaya E, Schuettengruber B, Negre N, Lavrov S, Parshikov A, Juge F, Gracheva E, Georgiev P, Cavalli G.

Chromosomal Distribution of PcG Proteins during Drosophila Development.

Published the 01/01/2006 - PLoS Biol , 4, e170 16613483

Negre N, Hennetin J, Sun LV, Lavrov S, Bellis M, White KP, Cavalli G.

The role of polycomb group proteins in cell cycle regulation during development.

Published the 01/01/2006 - Cell Cycle , 5, 1189-1197 16721063

Martinez AM, Cavalli G.

Polycomb group-dependent Cyclin A repression in Drosophila.

Published the 01/01/2006 - Genes Dev , 20, 501-5 13 16481477

Martinez AM, Colomb S, Dejardin J, Bantignies F, Cavalli G.

RNAi components are required for nuclear clustering of Polycomb group response elements.

Published the 01/01/2006 - Cell , 124, 957-971 16530043

Grimaud C, Bantignies F, Pal-Bhadra M, Ghana P, Bhadra U, Cavalli G.

Chromatin and epigenetics in development: blending cellular memory with cell fate plasticity.

Published the 01/01/2006 - Development , 133, 2089-2094 16672331

Cavalli G.

Cellular memory and dynamic regulation of polycomb group proteins.

Published the 01/01/2006 - Curr Opin Cell Biol. , 18, 275-283 16650749

Bantignies F, Cavalli G.

Epigenetic inheritance of chromatin states mediated by Polycomb- and trithorax group proteins in Drosophila

Published the 01/01/2005 - Prog Mol Subcell Biol , 38: 31-64

Déjardin, J., and Cavalli, G.

Recruitment of Drosophila Polycomb Group proteins to chromatin by DSP1

Published the 01/01/2005 - Nature , 434: 533-538

Déjardin, J., Rappailles, A., Cuvier, O., Grimaud, C., Decoville, M., Locker, D., and Cavalli, G.

+ Replication and Genome Dynamics

Recruitment of Drosophila Polycomb group proteins to chromatin by DSP1

Published the 01/01/2005 - Med Sci , 21(8-9):689-91

Dejardin J, Cavalli G.

The epigenome network of excellence.

Published the 01/01/2005 - PLoS Biol , 2(5): e177

Akhtar A, Cavalli G

Dissection of a natural RNA silencing process in the Drosophila melanogaster germ line

Published the 01/01/2004 - Mol Cell Biol , 24, 6742-6750 15254241

Aravin, A. A., Klenov, M. S., Vagin, V. V., Bantignies, F., Cavalli, G., and Gvozdev, V. A.

Chromatin inheritance upon Zeste-mediated Brahma recruitment at a minimal cellular memory module

Published the 01/01/2004 - EMBO J , 23, 857-868. 14963490

Déjardin, J., and Cavalli, G.

Interaction between GAF and Mod(mdg4) proteins promotes insulator bypass in Drosophila

Published the 01/01/2004 - Proc Natl Acad Sci USA , 101, 14806-14811. Epub 2004 Oct 01. 15465920

Melnikova, L., Juge, F., Gruzdeva, N., Mazur, A., Cavalli, G., and Georgiev, P.

Combined immunostaining and FISH analysis of polytene chromosomes

Published the 01/01/2004 - Methods Mol Biol. , 247, 289-303 14707354

Lavrov, S., Déjardin, J., and Cavalli, G.

SNR1 is an essential subunit in a subset of drosophila brm complexes, targeting specific functions during development

Published the 01/01/2003 - Developmental Biology , 253, 291-308 12645932

Zraly, C. B., Marenda, D. R., Nanchal, R., Cavalli, G., Muchardt, C., and Dingwal, A.K.

Protein-DNA interaction mapping using genomic tiling path microarrays in Drosophila

Published the 01/01/2003 - Proc Natl Acad Sci USA , 100, 9428-9433 12876199

Sun, L. V., Chen, L., Greil, F., Nègre, N., Li, T. R., Cavalli, G., Zhao, H., Van Steensel, B., and White, K.

Inheritance of Polycomb-dependent chromosomal interactions in Drosophila

Published the 01/01/2003 - Genes and Development , 17, 2406-2420 14522946

Bantignies, F., Grimaud, C., Lavrov, S., Gabut, M., and Cavalli, G.

Chromatin as a eukaryotic template of genetic information

Published the 01/01/2002 - Current Opinion in Cell Biology , 14(3), 269-278. 12067648

Cavalli, G.

The MYST Domain Acetyltransferase Chameau Functions in Epigenetic Mechanisms of Transcriptional Repression

Published the 01/01/2002 - Current Biology , 12(9), 762-766 12007422

Grienenberger, A., Miotto, B., Sagnier, T., Cavalli, G., Schramke, V., Geli, V., Mariol, M. C., Berenger, H., Graba, Y., and Pradel, J.

Epigenetic Inheritance of active chromatin after removal of the main transactivator

Published the 01/01/1999 - Science , 286, 955-958 10542150

Cavalli, G., Paro, R.

Mapping DNA target sites of chromatin-associated proteins by formaldehyde cross-linking in Drosophila embryos.

Published the 01/01/1999 - Chromosome Structural Analysis: A Practical Approach. , p 20-37

Cavalli, G., Orlando, V., and Paro, R.

The Drosophila Fab-7 chromosomal element conveys epigenetic inheritance during mitosis and meiosis

Published the 01/01/1998 - Cell , 93, 505-518 9604927

11) Cavalli, G., and Paro, R.

Thèses et hdr

Study of the three-dimensional folding of chromatin into topological domains 27/11/2019

Defended by Quentin Szabo on 27/11/2019 under the supervision of Frédéric Bantignies and Giacomo Cavalli

Dynamic role of PRC1 during normal development and tumorigenesis in Drosophila melanogaster 16/11/2018

Defended by Vincent Loubière on 16/11/2018 under the supervision of Anne/Marie Martinez and Giacomo Cavalli

Characterization of Polycomb group protein binding site diversity in Drosophila 29/09/2017

by Marianne Entrevan on 29/09/2017 under the supervision of Giacomo Cavalli and Bernd Schuttengruber

Stable transgenerational inheritance of alternative chromatin states in Drosophila melanogaster 16/12/2015

Defended by Filippo Ciabrelli on 16/12/2015 under the supervision of Giacomo Cavalli

Histone H3 Serine 28 is essential for efficient Polycomb/mediated gene repression in Drosophila 09/02/2015

Defended by Yuk Kwong Yung on 09/02/2015 under the supervision of Giacomo Cavalli

 

Dynamic and differential targeting of Polycomb complexes during Drosophila melanogaster development 30/11/2012

Anna Delest, 30/11/2012

Differential function of Polycomb group proteins during Drosophila development 24/11/2011

Soutenue par Samy Sakr le 24/10/2011

Genomic and structural study of chromatin in Drosophila 24/10/2011

Benjamin Leblanc, 23/06/2011

The cell nucleus and gene regulation by Polycomb group proteins 28/10/2010

Bernd Stadelmayer 28/10/2010

Role of Polycomb and trithorax group proteins in the nuclear organization of homeotic genes in Drosophila melanogaster 10/12/2008

Virginie Roure 10/12/2008

Molecular studies of functional interactions between Polycomb group protein-dependent repression and gipsy insulators in Drosophila 20/11/2007

Itys Comet 20/11/2007

Search for Polycomb Group (PcG) Protein Target Genes in Drosophila 28/11/2005

Nicolas Nègre 28/11/2005

Sequences and factors required for epigenetic memory of chromatin states 27/05/2004

Jérôme Déjardin 27/05/2004

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