Toxic R-loops: Cause or consequence of replication stress?
Samira Kemiha, Jérôme Poli, Yea-Lih Lin, Armelle Lengronne, Philippe Pasero
Maintenance of genome integrity during DNA replication
Molecular bases of human diseases
The human body is made of 3.7x1013 cells, which contain about two meters of DNA each. As our cells undergo a total of 1016 divisions in a life time, they synthesize therefore more than 2x1016 meters of DNA, which represents 130,000 times the distance from Earth to the sun! This daunting task is executed by micro-machines called replisomes, containing hundreds of proteins. Replisomes assemble at replication origins and generate DNA structures called replication forks. As they progress along the chromosomes, replisomes often encounter obstacles such as DNA lesions or transcription complexes, leading to replication fork arrest. Stalled forks are fragile structures that can give rise to chromosome breaks and trigger genomic instability if they are not rapidly restarted. Fork stalling occurs even more frequently in cancer cells due to the deregulation of oncogenic pathways. Oncogene-induced replication stress (RS) promotes genomic instability and is therefore the driving force of tumorigenesis. However, RS represents also the Achilles’ heel of cancer cells as it interferes with cell proliferation and sensitizes them to chemotherapeutic agents. Understanding how normal and cancer cells respond to replication stress represents therefore a major challenge in cancer biology.
Our group investigates the cellular responses to replication stress in budding yeast and in human cell lines. Owing to the small size of its genome and the power of molecular genetics, budding yeast is an invaluable model organism to study the RS response and to characterize novel mechanisms that are conserved in human cells and are relevant to cancer biology. This is achieved through the use of powerful technologies to monitor the progression, arrest and recovery of replication forks. These methods include single-molecule approaches such as DNA combing and DNA fiber spreading, chromosome-based assays such as pulsed-field gel electrophoresis and NGS-based assays such as ChIP-seq, BrdU-IP-seq, DRIP-seq and BLESS. Together, these methods provide a comprehensive view of the replication stress response in yeast and human cells, from individual DNA molecules to whole genomes.
To further investigate the links between replication stress and cancer, we have recently teamed up with the group of Jérôme Moreaux (Hematology Department of the University Hospital of Montpellier) who is an expert of the pathophysiology of malignant plasma cells and in particular of Multiple Myeloma (MM).
PUBLICATIONS OF THE TEAM
A Role for the Mre11-Rad50-Xrs2 Complex in Gene Expression and Chromosome Organization
Forey R, Barthe A, Tittel-Elmer M, Wery M, Barrault MB, Ducrot C, Seeber A, Krietenstein N, Szachnowski U, Skrzypczak M, Ginalski K, Rowicka M, Cobb J, Rando OJ, Soutourina J, Dubrana K, Gasser SM, Morillon A, Pasero P, Lengronne A and Poli J
Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites
Promonet A, Padioleau I, Liu Y, Sanz L, Biernacka A, Schmitz AL, Skrzypczak M, Sarrazin A, Mettling C, Rowicka M, Ginalski K, Chedin F, Chen CL, Lin YL, Pasero P
Homologous recombination and Mus81 promote replication completion in response to replication fork blockage
Benjamin Pardo, María Moriel‐Carretero, Thibaud Vicat, Andrés Aguilera and Philippe Pasero
Mec1 Is Activated at the Onset of Normal S Phase by Low-dNTP Pools Impeding DNA Replication
Romain Forey, Ana Poveda, Sushma Sharma, Antoine Barthe, Ismael Padioleau, Claire Renard, Robin Lambert, Magdalena Skrzypczak, Krzysztof Ginalski, Armelle Lengronne, Andrei Chabes, Benjamin Pardo, Philippe Pasero
MRX Increases Chromatin Accessibility at Stalled Replication Forks to Promote Nascent DNA Resection and Cohesin Loading.
Delamarre A, Barthe A, de la Roche Saint-André C, Luciano P, Forey R, Padioleau I, Skrzypczak M, Ginalski K, Géli V, Pasero P, Lengronne A
Inhibition of Ataxia-Telangiectasia Mutated and RAD3-related (ATR) overcomes oxaliplatin resistance and promotes anti-tumor immunity in colorectal cancer.
Combes E, Andrade AF, Tosi D, Michaud HA, Coquel F, Garambois V, Desigaud D, Jarlier M, Coquelle A, Pasero P, Bonnefoy N, Moreaux J, Martineau P, Del Rio M, Beijersbergen RL, Vezzio-Vie N, Gongora C
Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner.
Bianco JN, Bergoglio V, Lin YL, Pillaire MJ, Schmitz AL, Gilhodes J, Lusque A, Mazières J, Lacroix-Triki M, Roumeliotis TI, Choudhary J, Moreaux J, Hoffmann JS, Tourrière H, Pasero P
EZH2 is overexpressed in transitional preplasmablasts and is involved in human plasma cell differentiation.
Herviou L, Jourdan M, Martinez AM, Cavalli G, Moreaux J
DDR Inc., one business, two associates.
Moriel-Carretero M, Pasero P, Pardo B
Myeloid-derived suppressor cells induce multiple myeloma cell survival by activating the AMPK pathway.
De Veirman K, Menu E, Maes K, De Beule N, De Smedt E, Maes A, Vlummens P, Fostier K, Kassambara A, Moreaux J, Van Ginderachter JA, De Bruyne E, Vanderkerken K, Van Valckenborgh E
i-BLESS is an ultra-sensitive method for detection of DNA double-strand breaks.
Biernacka A, Zhu Y, Skrzypczak M, Forey R, Pardo B, Grzelak M, Nde J, Mitra A, Kudlicki A, Crosetto N, Pasero P, Rowicka M, Ginalski K
SAMHD1 and the innate immune response to cytosolic DNA during DNA replication.
Coquel F, Neumayer C, Lin YL, Pasero P
PRC2 targeting is a therapeutic strategy for EZ score defined high-risk multiple myeloma patients and overcome resistance to IMiDs.
Herviou L, Kassambara A, Boireau S, Robert N, Requirand G, Müller-Tidow C, Vincent L, Seckinger A, Goldschmidt H, Cartron G, Hose D, Cavalli G, Moreaux J
Mrc1 and Rad9 cooperate to regulate initiation and elongation of DNA replication in response to DNA damage.
Bacal J, Moriel-Carretero M, Pardo B, Barthe A, Sharma S, Chabes A, Lengronne A, Pasero P
DDK Has a Primary Role in Processing Stalled Replication Forks to Initiate Downstream Checkpoint Signaling.
Sasi NK, Coquel F, Lin YL, MacKeigan JP, Pasero P, Weinreich M
Physiological and druggable skipping of immunoglobulin variable exons in plasma cells.
Ashi MO, Srour N, Lambert JM, Marchalot A, Martin O, Le Noir S, Pinaud E, Ayala MV, Sirac C, Saulière J, Moreaux J, Cogné M, Delpy L
[EZH2 is therapeutic target for personalized treatment in multiple myeloma].
Herviou L, Cavalli G, Moreaux J
SAMHD1 acts at stalled replication forks to prevent interferon induction.
Coquel F, Silva MJ, Técher H, Zadorozhny K, Sharma S, Nieminuszczy J, Mettling C, Dardillac E, Barthe A, Schmitz AL, Promonet A, Cribier A, Sarrazin A, Niedzwiedz W, Lopez B, Costanzo V, Krejci L, Chabes A, Benkirane M, Lin YL, Pasero P
DNMTi/HDACi combined epigenetic targeted treatment induces reprogramming of myeloma cells in the direction of normal plasma cells.
Bruyer A, Maes K, Herviou L, Kassambara A, Seckinger A, Cartron G, Rème T, Robert N, Requirand G, Boireau S, Müller-Tidow C, Veyrune JL, Vincent L, Bouhya S, Goldschmidt H, Vanderkerken K, Hose D, Klein B, De Bruyne E, Moreaux J
Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations.
Cohen S, Puget N, Lin YL, Clouaire T, Aguirrebengoa M, Rocher V, Pasero P, Canitrot Y, Legube G
Dbf4 recruitment by forkhead transcription factors defines an upstream rate-limiting step in determining origin firing timing.
Fang D, Lengronne A, Shi D, Forey R, Skrzypczak M, Ginalski K, Yan C, Wang X, Cao Q, Pasero P, Lou H
Loss of RASSF4 Expression in Multiple Myeloma Promotes RAS-Driven Malignant Progression.
De Smedt E, Maes K, Verhulst S, Lui H, Kassambara A, Maes A, Robert N, Heirman C, Cakana A, Hose D, Breckpot K, van Grunsven LA, De Veirman K, Menu E, Vanderkerken K, Moreaux J, De Bruyne E
CD24, CD27, CD36 and CD302 gene expression for outcome prediction in patients with multiple myeloma.
Alaterre E, Raimbault S, Goldschmidt H, Bouhya S, Requirand G, Robert N, Boireau S, Seckinger A, Hose D, Klein B, Moreaux J
Nucleases Acting at Stalled Forks: How to Reboot the Replication Program with a Few Shortcuts
Pasero P, Vindigni A.
Signaling Pathways of Replication Stress in Yeast
Pardo B, Crabbé L, Pasero P
Nuclear DNA replication and repair in parasites of the genus Leishmania: Exploiting differences to develop innovative therapeutic approaches
Uzcanga G, Lara E, Gutiérrez F, Beaty D, Beske T, Teran R, Navarro JC, Pasero P, Benítez W, Poveda A
RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma
Viziteu E, Klein B, Basbous J, Lin YL, Hirtz C, Gourzones C, Tiers L, Bruyer A, Vincent L, Grandmougin C, Seckinger A, Goldschmidt H, Constantinou A, Pasero P, Hose D, Moreaux J.
Global miRNA expression analysis identifies novel key regulators of plasma cell differentiation and malignant plasma cell.
Kassambara A, Jourdan M, Bruyer A, Robert N, Pantesco V, Elemento O, Klein B, Moreaux J.
Hypoxia favors the generation of human plasma cells
Schoenhals M, Jourdan M, Bruyer A, Kassambara A, Klein B, Moreaux J.
Characterization of human FCRL4-positive B cells
Jourdan M, Robert N, Cren M, Thibaut C, Duperray C, Kassambara A, Cogné M, Tarte K, Klein B, Moreaux J.
Transcription-Replication Conflicts: Orientation Matters
Lin, YL., Pasero, P.
Automated and simplified identification of normal and abnormal plasma cells in Multiple Myeloma by flow cytometry
Alaterre E, Raimbault S, Garcia JM, Rème T, Requirand G, Klein B, Moreaux J.
Extracellular S100A9 Protein in Bone Marrow Supports Multiple Myeloma Survival by Stimulating Angiogenesis and Cytokine Secretion.
De Veirman K, De Beule N, Maes K, Menu E, De Bruyne E, De Raeve H, Fostier K, Moreaux J, Kassambara A, Hose D, Heusschen R, Eriksson H, Vanderkerken K, Van Valckenborgh E.
Identifying high-risk adult AML patients: epigenetic and genetic risk factors and their implications for therapy
Bret C, Viziteu E, Kassambara A, Moreaux J.
Inhibiting the anaphase promoting complex/cyclosome induces a metaphase arrest and cell death in multiple myeloma cells
Lub S, Maes A, Maes K, De Veirman K, De Bruyne E, Menu E, Fostier K, Kassambara A, Moreaux J, Hose D, Leleu X, King RW, Vanderkerken K, Van Valckenborgh E.
Mec1, INO80, and the PAF1 complex cooperate to limit transcription replication conflicts through RNAPII removal during replication stress
Poli J, Gerhold CB, Tosi A, Hustedt N, Seeber A, Sack R, Herzog F, Pasero P, Shimada K, Hopfner KP, Gasser SM.
RECQ helicases are deregulated in hematological malignancies in association with a prognostic value
Viziteu E, Kassambara A, Pasero P, Klein B, Moreaux J.
Chetomin, targeting HIF-1α/p300 complex, exhibits antitumour activity in multiple myeloma
Viziteu E, Grandmougin C, Goldschmidt H, Seckinger A, Hose D, Klein B, Moreaux J.
Differential effects of lenalidomide during plasma cell differentiation
Jourdan M, Cren M, Schafer P, Robert N, Duperray C, Vincent L, Ceballos P, Cartron G, Rossi JF, Moreaux J, Chopra R, Klein B
USP1 Regulates Cellular Senescence by Controlling Genomic Integrity
Ogrunc M, Martinez-Zamudio RI, Sadoun PB, Dore G, Schwerer H, Pasero P, Lemaitre JM, Dejean A, Bischof O
Forced KLF4 expression increases the generation of mature plasma cells and uncovers a network linked with plasma cell stage
Schoenhals M, Jourdan M, Seckinger A, Pantesco V, Hose D, Kassambara A, Moreaux J, Klein B.
Phosphorylation of CMG helicase and Tof1 is required for programmed fork arrest
Bastia D, Srivastava P, Zaman S, Choudhury M, Mohanty BK, Bacal J, Langston LD, Pasero P, O'Donnell ME
RPA Mediates Recruitment of MRX to Forks and Double-Strand Breaks to Hold Sister Chromatids Together
Seeber A, Hegnauer AM, Hustedt N, Deshpande I, Poli J, Eglinger J, Pasero P, Gut H, Shinohara M, Hopfner KP, Shimada K, Gasser SM.
Drug metabolism and clearance system in tumor cells of patients with multiple myeloma
Hassen W, Kassambara A, Reme T, Sahota S, Seckinger A, Vincent L, Cartron G, Moreaux J, Hose D, Klein B
In vivo treatment with epigenetic modulating agents induces transcriptional alterations associated with prognosis and immunomodulation in multiple myeloma
Maes K, De Smedt E, Kassambara A, Hose D, Seckinger A, Van Valckenborgh E, Menu E, Klein B, Vanderkerken K, Moreaux J, De Bruyne E
Expression and role of RIP140/NRIP1 in chronic lymphocytic leukemia
Lapierre M, Castet-Nicolas A, Gitenay D, Jalaguier S, Teyssier C, Bret C, Cartron G, Moreaux J, Cavaillès V. J Hematol Oncol. 2015 Mar 4;8(1):20.
miRNAs in multiple myeloma - a survival relevant complex regulator of gene expression
Seckinger A, Meißner T, Moreaux J, Benes V, Hillengass J, Castoldi M, Zimmermann J, Ho AD, Jauch A, Goldschmidt H, Klein B, Hose D.
Essential Roles of the Smc5/6 Complex in Replication through Natural Pausing Sites and Endogenous DNA Damage Tolerance
Menolfi D, Delamarre A, Lengronne A, Pasero P, Branzei D.
New histone supply regulates replication fork speed and PCNA unloading
Mejlvang J, Feng Y, Alabert C, Neelsen KJ, Jasencakova Z, Zhao X, Lees M, Sandelin A, Pasero P, Lopes M, Groth A.
Domain within the helicase subunit Mcm4 integrates multiple kinase signals to control DNA replication initiation and fork progression
Sheu YJ, Kinney JB, Lengronne A, Pasero P, Stillman B.
The causes of replication stress and their consequences on genome stability and cell fate
Magdalou I, Lopez BS, Pasero P, Lambert SA
The histone deacetylases sir2 and rpd3 act on ribosomal DNA to control the replication program in budding yeast.
Yoshida K, Bacal J, Desmarais D, Padioleau I, Tsaponina O, Chabes A, Pantesco V, Dubois E, Parrinello H, Skrzypczak M, Ginalski K, Lengronne A, Pasero P
Closing the MCM cycle at replication termination sites
Lengronne A, Pasero P.
Caught in the Act: R-Loops Are Cleaved by Structure-Specific Endonucleases to Generate DSBs
Lin YL, Pasero P.
Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing
Crosetto N, Mitra A, Silva MJ, Bienko M, Dojer N, Wang Q, Karaca E, Chiarle R, Skrzypczak M, Ginalski K, Pasero P, Rowicka M, Dikic I
Rescuing stalled or damaged replication forks
Yeeles JT, Poli J, Marians KJ, Pasero P.
DNA repair pathways in human multiple myeloma: Role in oncogenesis and potential targets for treatment.
Gourzones-Dmitriev C, Kassambara A, Sahota S, Rème T, Moreaux J, Bourquard P, Hose D, Pasero P, Constantinou A, Klein B.
Time to Be Versatile: Regulation of the Replication Timing Program in Budding Yeast
Yoshida K, Poveda A, Pasero P.
DNA polymerase η modulates replication fork progression and DNA damage responses in platinum-treated human cells
Sokol AM, Cruet-Hennequart S, Pasero P, Carty MP.
DNA replication stress response involving PLK1, CDC6, POLQ, RAD51 and CLASPIN upregulation prognoses the outcome of early/mid-stage non-small cell lung cancer patients
Allera-Moreau C, Rouquette I, Lepage B, Oumouhou N, Walschaerts M, Leconte E, Schilling V, Gordien K, Brouchet L, Delisle MB, Mazieres J, Hoffmann JS, Pasero P, Cazaux C.
Histone h3 lysine 56 acetylation and the response to DNA replication fork damage.
Wurtele H, Kaiser GS, Bacal J, St-Hilaire E, Lee EH, Tsao S, Dorn J, Maddox P, Lisby M, Pasero P, Verreault A.
dNTP pools determine fork progression and origin usage under replication stress.
Poli J, Tsaponina O, Crabbé L, Keszthelyi A, Pantesco V, Chabes A, Lengronne A, Pasero P.
Analysis of DNA replication profiles in budding yeast and mammalian cells using DNA combing
Bianco JN, Poli J, Saksouk J, Bacal J, Silva MJ, Yoshida K, Lin YL, Tourrière H, Lengronne A, Pasero P.
Cohesin Association to Replication Sites Depends on Rad50 and Promotes Fork Restart.
Tittel-Elmer M, Lengronne A, Davidson MB, Bacal J, François P, Hohl M, Petrini JH, Pasero P, Cobb JA.
Interference between DNA replication and transcription as a cause of genomic instability
Lin YL, Pasero P.
New Topoisomerase I mutations are associated with resistance to camptothecin
Gongora, C., Vezzio-Vie, N., Tuduri, S., Denis, V., Causse, A., Auzanneau, C., Collod-Beroud, G., Coquelle, A., Pasero, P., Pourquier, P., Martineau, P., Del Rio, M
Does interference between replication and transcription contribute to genomic instability in cancer cells?
Tuduri, S., Crabbe, L., Tourrière, H., Coquelle, A., Pasero, P.
Defining replication origin efficiency using DNA fiber assays.
Tuduri, S., Tourrière, H., Pasero, P.
The Smc5/6 complex is required for dissolution of DNA-mediated sister chromatid linkages
Bermúdez-López, M., Ceschia, A., de Piccoli, G., Colomina, N., Pasero, P., Aragón, L., Torres-Rosell, J.
Exo1 competes with repair synthesis, converts NER intermediates to long ssDNA gaps, and promotes checkpoint activation.
Giannattasio M, Follonier C, Tourrière H, Puddu F, Lazzaro F, Pasero P, Lopes M, Plevani P, Muzi-Falconi M
Analysis of replication profiles reveals key role of RFC-Ctf18 in yeast replication stress response.
Crabbe, L., Thomas, A., Pantesco, V., De Vos, J., Pasero, P. and Lengronne, A.
Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription
Tuduri, S., Crabbé, L., Conti, C., Tourrière, H., Holtgreve-Grez, H., Jauch, A., Pantesco, V., De Vos, J., Thomas, A., Theillet, C., Pommier, Y., Tazi, J., Coquelle, A., Pasero, P
RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells
Piwko, W., Olma, MH., Held, M., Bianco, JN., Pedrioli, PG., Hofmann, K., Pasero, P., Gerlich, DW., Peter, M
Transcription and replication: Breaking the rules of the road causes genomic instability
Poveda, AM., Le Clech, M., Pasero, P.
Differential regulation of homologous recombination at DNA breaks and replication forks by the Mrc1 branch of the S-phase checkpoint.
Alabert C, Bianco JN, Pasero P
The MRX complex stabilizes the replisome independently of the S phase checkpoint during replication stress.
Tittel-Elmer M, Alabert C, Pasero P, Cobb JA.
Specific function of phosphoinositide 3-kinase beta in the control of DNA replication.
Marqués, M., Kumar, A., Poveda, AM., Zuluaga, S., Hernández, C., Jackson, S., Pasero, P., Carrera, AC.
Single-molecule analysis of DNA replication in yeast and in human cells.
Alabert, C., Poveda, A. and Pasero, P
Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription.
Tuduri S, Crabbé L, Conti C, Tourrière H, Holtgreve-Grez H, Jauch A, Pantesco V, De Vos J, Thomas A, Theillet C, Pommier Y, Tazi J, Coquelle A, Pasero P.
Involvement of a chromatin remodeling complex in damage tolerance during DNA replication
Falbo, K.B., Alabert, C., Katou, Y., Wu, S., Han, J., Wehr, T., Xiao, J., He, X., Zhang, Z., Shi, Y., Shirahige, K., Pasero, P., Shen, X.
Defining replication origin efficiency using DNA fiber assays
Tuduri, S., Tourrière, H., Pasero, P
A journey into the nucleus. Conference on Nuclear Structure and Dynamics.
Solovei, I., Pasero, P., Visa, N.
Rtt101 and Mms1 in budding yeast form a CUL4(DDB1)-like ubiquitin ligase that promotes replication through damaged DNA
Zaidi, IW., Rabut, G., Poveda, A., Scheel, H., Malmström, J., Ulrich, H., Hofmann, K., Pasero, P., Peter, M., Luke, B.
Maintenance of fork integrity at damaged DNA and natural pause sites.
Tourriere, H., Pasero Ph.
Anaphase onset before complete DNA replication with intact checkpoint responses
Torres-Rosell J, De Piccoli G, Cordon-Preciado V, Farmer S, Jarmuz A, Machin F, Pasero P, Lisby M, Haber JE, Aragon L.
Upregulation of error-prone DNA polymerases beta and kappa slows down fork progression without activating the replication checkpoint
Pillaire MJ, Betous R, Conti C, Czaplicki J, Pasero P, Bensimon A, Cazaux C, Hoffmann JS.
Phosphorylation of Slx4 by Mec1 and Tel1 regulates the single-strand annealing mode of DNA repair in budding yeast
Flott, S., Alabert, C., Toh, GW., Toth, R., Sugawara, N., Campbell, DG., Haber, JE., Pasero, P., Rouse, J.
The cullin Rtt101p promotes replication fork progression through damaged DNA and natural pause sites.
Luke, B, Versini, G, Jaquenoud, M, Zaidi, IW, Kurz, T, Pintard, L, Pasero, P, Peter, M.
An essential role for Orc6 in DNA replication through maintenance of pre-replicative complexes
Semple JW, Da-Silva LF, Jervis EJ, Ah-Kee J, Al-Attar H, Kummer L, Heikkila JJ, Pasero P, Duncker BP.
Mrc1 and tof1 promote replication fork progression and recovery independently of Rad53
Tourriere, H., Versini, G., Cordon-Preciado, V., Alabert, C., Pasero, P.
PUBLICATIONS COMMUNES
MRX Increases Chromatin Accessibility at Stalled Replication Forks to Promote Nascent DNA Resection and Cohesin Loading.
Delamarre A, Barthe A, de la Roche Saint-André C, Luciano P, Forey R, Padioleau I, Skrzypczak M, Ginalski K, Géli V, Pasero P, Lengronne A
2019 - Mol Cell
, 77(2):395-410.e3 31759824 
Service porteur :
Maintenance of genome integrity during DNA replication
EZH2 in normal hematopoiesis and hematological malignancies
Herviou L, Cavalli G, Cartron G, Klein B, Moreaux J.
2016 - Oncotarget
, 7, 3, 284-296 26497210
Service porteur :
Chromatin and cell biology
DNA repair in diffuse large B-cell lymphoma: a molecular portrait
Bret C, Klein B, Cartron G, Schved JF, Constantinou A, Pasero P, Moreaux J.
2015 - Br J Haematol.
, 169(2):296-9 25369781
Service porteur :
Genetic Instability and Cancer
SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage
Clifford R, Louis T, Robbe P, Ackroyd S, Burns A, Timbs AT, Colopy GW, Dreau H, Sigaux F, Judde JG, Rotger M, Telenti A, Lin YL, Pasero P, Maelfait J, Titsias M, Cohen DR, Henderson SJ, Ross M, Bentley D, Hillmen P, Pettitt A, Rehwinkel J, Knight SJ, Taylor JC, Crow YJ, Benkirane M, Schuh A.
2014 - BLOOD
, 123(7):1021-31 24335234
Service porteur :
Laboratory of Molecular Virology
A DNA repair pathway score predicts survival in human multiple myeloma: the potential for therapeutic strategy
Kassambara A, Gourzones-Dmitriev C, Sahota S, Rème T, Moreaux J, Goldschmidt H, Constantinou A, Pasero P, Hose D, Klein B
2014 - Oncotarget
, 5(9):2487-98 24809299
Service porteur :
Genetic Instability and Cancer
Genetic and epigenetic determinants of DNA replication origins, position and activation
Méchali M, Yoshida K, Coulombe P, Pasero P.
2013 - Curr Opin Genet Dev.
, 23, 2, 124-131. 23541525
Service porteur :
Replication and Genome Dynamics
A DNA replication signature of progression and negative outcome in colorectal cancer
Pillaire, M.J., Selves, J., Gordien, K., Gouraud, P.A., Gentil, C., Danjoux, M., Do, C., Negre, V., Bieth, A., Guimbaud, R., Trouche, D., Pasero, P., Méchali, M., Hoffmann, JS, and Cazaux, C
2010 - Oncogen
, 29, 6, 876-887 19901968
Service porteur :
Replication and Genome Dynamics
