Publications
Toxic R-loops: Cause or consequence of replication stress?
Maintien de l'intégrité du génome au cours de la réplicationSamira Kemiha, Jérôme Poli, Yea-Lih Lin, Armelle Lengronne, Philippe Pasero
Chromatin-associated MRN complex protects highly transcribing genes from genomic instability
Régulation des gènesKader Salifou, Callum Burnard, Poornima Basavarajaiah, Marion Helsmoortel, Victor Mac, David Depierre, Giuseppa Grasso, Céline Franckhauser, Emmanuelle Beyne, Xavier Contreras, Jérôme Dejardin, Sylvie Rouquier, Olivier Cuvier, Rosemary Kiernan
Nucleic Acid Immunity and DNA Damage Response: New Friends and Old Foes.
Bases Moléculaires de l’Inflammation associée au cancerTaffoni C, Steer A, Marines J, Chamma H, Vila IK, Laguette N
Discovery of candidate DNA methylation cancer driver genes.
Modifications épigénétiques et instabilité génomique dans les cellules B normales et tumoralesPan H, Renaud L, Chaligne R, Bloehdorn J, Tausch E, Mertens D, Fink AM, Fischer K, Zhang C, Betel D, Gnirke A, Imielinski M, Moreaux J, Hallek M, Meissner A, Stilgenbauer S, Wu CJ, Elemento O, Landau DA
Understanding 3D genome organization by multidisciplinary methods
Chromatine et Biologie CellulaireIvana Jerkovic´ & Giacomo Cavalli
Histone marks are drivers of the splicing changes necessary for an epithelial-to-mesenchymal transition
Composante Epigénétique de l'Epissage AlternatifAlexandre Segelle, Yaiza Nunez-Alvarez, Andrew J Oldfield, Kimberly M Webb, Philipp Voigt, Reini F Luco
A cell-to-patient machine learning transfer approach uncovers novel basal-like breast cancer prognostic markers amongst alternative splice variants
Composante Epigénétique de l'Epissage AlternatifJean-Philippe Villemin, Claudio Lorenzi, Marie-Sarah Cabrillac, Andrew Oldfield, William Ritchie & Reini F. Luco
Translesion Synthesis or Repair by Specialized DNA Polymerases Limits Excessive Genomic Instability upon Replication Stress.
Surveillance et Stabilité du GénomeMaiorano D, El Etri J, Franchet C, Hoffmann JS
Axonal chemokine-like Orion induces astrocyte infiltration and engulfment during mushroom body neuronal remodeling
Neurogénétique et MémoireAna Boulanger, Camille Thinat, Stephan Züchner, Lee G. Fradkin, Hugues Lortat-Jacob & Jean-Maurice Dura
TopBP1 assembles nuclear condensates to switch on ATR signaling.
Instabilité Génétique et CancerFrattini C, Promonet A, Alghoul E, Vidal-Eychenie S, Lamarque M, Blanchard MP, Urbach S, Basbous J, Constantinou A
Exon junction complex dependent mRNA localization is linked to centrosome organization during ciliogenesis
Biologie cellulaire de l'ARNOh Sung Kwon, Rahul Mishra, Adham Safieddine, Emeline Coleno, Quentin Alasseur, Marion Faucourt, Isabelle Barbosa, Edouard Bertrand, Nathalie Spassky & Hervé Le Hir
A choreography of centrosomal mRNAs reveals a conserved localization mechanism involving active polysome transport
Biologie cellulaire de l'ARNAdham Safieddine, Emeline Coleno, Soha Salloum, Arthur Imbert, Abdel-Meneem Traboulsi, Oh Sung Kwon, Frederic Lionneton, Virginie Georget, Marie-Cécile Robert, Thierry Gostan, Charles-Henri Lecellier, Racha Chouaib, Xavier Pichon, Hervé Le Hir, Kazem Zibara, Florian Mueller, Thomas Walter, Marion Peter & Edouard Bertrand
Regulation of the conserved 3'-5' exoribonuclease EXOSC10/Rrp6 during cell division, development and cancer.
Biologie des Cellules de MammifèresStuparević I, Novačić A, Rahmouni AR, Fernandez A, Lamb N, Primig M
Splicing-associated chromatin signatures: a combinatorial and position-dependent role for histone marks in splicing definition.
Composante Epigénétique de l'Epissage AlternatifAgirre E, Oldfield AJ, Bellora N, Segelle A, Luco RF
Anti-prion Drugs Targeting the Protein Folding Activity of the Ribosome Reduce PABPN1 Aggregation.
Régulation des ARNm et DéveloppementBamia A, Sinane M, Naït-Saïdi R, Dhiab J, Keruzoré M, Nguyen PH, Bertho A, Soubigou F, Halliez S, Blondel M, Trollet C, Simonelig M, Friocourt G, Béringue V, Bihel F, Voisset C
Sting orchestrates the crosstalk between polyunsaturated fatty acids metabolism and inflammatory responses
Bases Moléculaires de l’Inflammation associée au cancerIsabelle K. Vila, Hanane Chamma, Alizée Steer, Clara Taffoni, Line S. Reinert, Evgenia Turtoi, Mathilde Saccas, Johanna Marines, Lei Jin, Xavier Bonnefont, Soren R. Paludan, Dimitrios Vlachakis, Andrei Turtoi, Nadine Laguette
Quantitative imaging of transcription in living Drosophila embryos reveals the impact of core promoter motifs on promoter state dynamics. Nat. Comm, in revision.
Biologie cellulaire de l'ARNPimmett, L., Dejean, M., Fernandez, C., Trullo, A., Bertrand, E., Radulescu, O., and M. Lagha.