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Séminaires

Orateur: Wolfgang J. MILLER (Medical University of Vienna, Austria)
IGH seminar room

Seminar Wolfgang Miller - March 5th
Wolfgang J. MILLER is an Assistant Professor and the group leader of the Laboratories of Genome Dynamics at the Medical University of Vienna, Austria. He has been working on the evolutionary dynamics of genomic parasites in Drosophila since more than 30 years, first on P element evolution in Drosophila and discovered the first case of “molecular domestication” of a TE, i.e., the functional transition from a selfish element in a new host gene now serving novel host functions. More recently, he has...

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Contact IGH Severine CHAMBEYRON

ARN non codants, épigénétique et stabilité génomique

Orateur: Dario Lupianez (Centro Andaluz de Biología del Desarrollo, Sevilla, Spain)
Genopolys amphitheater

Seminar of Dario Lupianez - March 1st
Dario Lupianez, whose laboratory is based in Seville, will be giving a seminar entitled "Genomes in 3D: implications for development and evolution". Dario did his thesis in Raphael Jimenez's laboratory on a very specific model of sex determination: the mole. In 2012, he joined Stefan Mundlos' laboratory for a post-doc where his main research topic was chromatin architecture and disease. In 2017-2023, he joined the Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Centre for Molecular...

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Contact IGH Francis POULAT

Développement et Pathologie de la Gonade

Orateur: Dominique Weil (IBPS, Paris)
IGH, Seminar room

What drives the dynamics of RNA storage in P-bodies?
P-bodies (PBs) are cytoplasmic membraneless organelles containing untranslated mRNAs, whose functions are poorly understood. In two extreme scenarios, they could either ensure cellular functions by gathering together specific proteins and RNAs in a timely manner, or they could be an epiphenomenon due to intrinsic molecular features of their components. We tackled this issue by purifying human PBs at different phases of the cell cycle. We observed widespread changes in their RNA content: some were...

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Contact IGH Edouard BERTRAND

Biologie cellulaire de l'ARN

Orateur: Germano CECERE (Institut Pasteur, Paris, France)
Genopolys amphitheater

Small RNAs In Epigenetic Inheritance
Heritable traits have long revolved around genomic DNA, yet emerging research redefines our understanding of inheritance. In our laboratory, we embark on a captivating journey into the world of small RNAs and their role in epigenetic inheritance, employing the model organism Caenorhabditis elegans. During my talk, I will unveil the profound influence of small RNAs in trait inheritance. I will present a compelling case study demonstrating how small RNAs gradually reduce fertility across successive...

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Contact IGH Giacomo CAVALLI

Chromatine et Biologie Cellulaire

Orateur: Jan Rehwinkel, PhD
Genopolys amphitheater

Nucleic Acid Sensing by Innate Immune Receptors- A journey from MDA5 to cGAS

Jan is a Professor in the Medical Sciences Division at the University of Oxford. His  research focuses on the molecular biology of the activation and regulation of innate immune receptors that survey the cytosol, including the role of nucleic acid sensing in inflammatory diseases and in cancer. Jan is also interested in the molecular mechanisms underlying host-pathogen interactions. His work lies at the intersection of immunology, virology and molecular biology.

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Contact IGH Yea-Lih LIN

Orateur: Bennett Van Houten (UPMC-Hillman Cancer Center, PA, USA)
Genopolys, Room Rotonde

A new single molecule approach to study DNA repair protein dynamics: seeing is believing
This seminar will present a new rapid and robust method for single molecule analysis of DNA binding proteins from nuclear extracts (SMADNE) of human cells expressing a fluorescently tagged protein of interest (Schaich et al., Nucleic Acids Res. 2023 Apr 24;51(7):e39). SMADNE when combined with the LUMICKS C-trap provides unprecedented observations of DNA repair protein dynamics on damaged DNA. Over the last 18 months our group has been able to analyze the dwell times of 30 proteins or protein variants...

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Contact IGH Jihane BASBOUS

Instabilité Génétique et Cancer

Orateur: Patrick Lomonte (Univ Lyon, Université Claude Bernard Lyon 1)
IGH seminars room

Epigenetic control of herpes simplex virus 1 latency
The establishment of latent herpes simplex virus 1 (HSV-1) infection involves an intricate interplay of cellular and molecular processes. On the epigenetic front, this entails viral chromatinization and the interaction between latent episomal viral genomes and the cell's nucleus. Promyelocytic leukemia nuclear bodies (PML NBs) are nuclear membrane-less organelles responding to interferon stimuli, and playing a major role in the transcriptional regulation of HSV-1 latent genomes through an intrinsic...

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Contact IGH Jerome DEJARDIN

Biologie des Séquences Répétées

Orateur: Lise Dauban
IGH Seminar Room

Séminaire Lise Dauban
Mammalian genomes contain hundreds of lamina-associated domains (LADs), which are large, often megabase-sized heterochromatin domains that are anchored to the nuclear lamina (NL). Even though LADs play a key role in the spatial organization of the genome and potently repress gene activity, it is not yet understood how their interactions with the NL are encoded in their DNA. Here, we investigated the principles that govern LAD-NL interactions by taking a "LAD scrambling" approach. This approach relies...

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Contact IGH Charlene BOUMENDIL

Architecture nucléaire dans les contextes physiologiques et pathologiques

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Orateur: Dr. Marlene Oeffinger (Institut de recherches cliniques de Montréal)
Seminar room of Genopolys

Heterogeneity of RNA machines

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Contact IGH Edouard BERTRAND

Orateur: Dr. Daniel Zenklusen (Département de biochimie et médicine moléculaire, Université de Montréal)
Seminar room of Genopolys

Investigating spatio-temporal dynamics of RNA metabolism, one molecule at the time

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Contact IGH Edouard BERTRAND