Tubulin code

  • Microtubules (MTs) are essential cytoskeletal elements composed of alpha- and beta-Tubulin heterodimers. They are involved in a range of cellular functions including cell division, maintenance of cell shape, intracellular transport as well as cell motility. The mechanisms that allow MTs to perform such a diverse range of functions are poorly understood, but it is clear that each specific MT function requires the recruitment of a particular set of MT-associated proteins (MAPs). Strikingly, many MAPs interact with the C-terminal tails of Tubulins, which are known to protrude from the MT surface and to undergo several unusual post-translational modifications (Westermann and Weber, 2003). Such Tubulin C-terminal modifications include the removal of the very C-terminal tyrosine from alpha-Tubulin and two so-called poly-modifications, namely poly-glutamylation and poly-glycylation, which consist in the addition of side chains of either glutamate or glycine residues to the C-terminal tails of both alpha- and beta-Tubulin. The combination of the different Tubulin C-terminal modifications together with the fact that the side chains generated by the poly-modifications vary in length provides a high potential for encoding patterns on the MT surface that might recruit specific MAPs and allow the functional adaptation of MTs. In addition, since all these modifications have been shown to be reversible, they permit rapid changes in the MT properties.

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    Khaled Hached
    Hached Khaled
    Francois Juge
    Juge Francois
    Krzysztof Rogowski
    Rogowski Krzysztof
    Guillaume Marcellin
    Marcellin Guillaume
    Pierre Rome
    Rome Pierre
    Siem Van der laan
    Van der laan Siem
    Yoann Lannay
    Lannay Yoann


    Tubulin modifying enzymes as target for the treatment of tau-related diseases

    Krzysztof Rogowski, Khaled Hached, Carole Crozet, Siem Van Der Laan

    2020 - Pharmacology & Therapeutics

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    Evolutionary Divergence of Enzymatic Mechanisms for Tubulin Detyrosination.

    van der Laan S, Lévêque MF, Marcellin G, Vezenkov L, Lannay Y, Dubra G, Bompard G, Ovejero S, Urbach S, Burgess A, Amblard M, Sterkers Y, Bastien P, Rogowski K

    2019 - Cell Rep, 29(12):4159-4171.e6

    Request for full article31851940

    Vasohibins/SVBP are tubulin carboxypeptidases (TCP) that regulate neuron differentiation

    Aillaud, C., Bosc, C., Peris, L., Bosson, A., Heemeryck, P.,Van Dijk, J., Le Friec, J., Boulan, B., Vossier, F., Sanman, L.E., Syed, S., Amara, N., Couté, Y., Lafanechère, L., Denarier, E., Delphin, C., Pelletier, L., Humbert, S., Bogyo, M., Andrieux*, A., Rogowski*, K., Moutin*, M.J.

    2017 - SCIENCE, 358(6369):1448-1453

    Request for full article29146868

    CSAP acts as a regulator of TTLL-mediated microtubule glutamylation

    Bompard G, van Dijk J, Cau J, Marcellin G, Lannay Y, Lawera A, van der Laan S and Rogowski K.

    2018 - Cell Reports, 25, 1-12

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