Neurogenetics and memory

Genetics, cell biology and development

Drosophila adult brain developmental molecular genetics

Drosophila adult brain developmental molecular genetics is a youg science which is gaining momentum. We can raisonably foresee that the gene cascades at work during brain development will be conserved in mammals.

In Drosophila, recent techniques are now available and allow to work efficiently on this topic.

Mushroom bodies (MB) may be considered as the mamalian hippocampus analogue are an excellent model in order to study brain development. Each MB neuroblast generates, in a sequential fashion, three distinct classes of neurons.
First the γ then the α'β' and finally the αβ neurons appear during development.

MB are essential for several forms of learning and memory.

We have introduced in the laboratory a memory paradigm based on male courtship behavior (in collaboration with M.L. Parmentier and Y. Grau, IGF).
Therefore we are able to correlate a developing brain structure and its fonction.

Jean-Maurice DURA


Clarisse Perron
Clarisse PERRON

Daphné Cayron


Publications of the team

The Drosophila chemokine-like Orion bridges phosphatidylserine and Draper in phagocytosis of neurons

Hui Ji, Bei Wang, David Labib, Joyce Lei, Xinchen Chen, Maria Sapar, Ana Boulanger, Jean-Maurice Dura, Chun Han


Neuron-glia crosstalk in neuronal remodeling and degeneration: Neuronal signals inducing glial cell phagocytic transformation in Drosophila

Ana Boulanger, Jean-Maurice Dura


Axonal chemokine-like Orion induces astrocyte infiltration and engulfment during mushroom body neuronal remodeling

Ana Boulanger, Camille Thinat, Stephan Züchner, Lee G. Fradkin, Hugues Lortat-Jacob & Jean-Maurice Dura


Htt is a repressor of Abl activity required for APP-induced axonal growth

Claire Marquilly,Germain U. Busto,Brittany S. Leger,Ana Boulanger,Edward Giniger,James A. Walker,Lee G. Fradkin,Jean-Maurice Dura

read publication


Guidance of Drosophila Mushroom Body Axons Depends upon DRL-Wnt Receptor Cleavage in the Brain Dorsomedial Lineage Precursors

Reynaud E, Lahaye LL, Boulanger A, Petrova IM, Marquilly C, Flandre A, Martianez T, Privat M, Noordermeer JN, Fradkin LG, Dura JM

Nuclear receptors and Drosophila neuronal remodelling

Boulanger A, Dura JM.

Ecdysone signaling at metamorphosis triggers apoptosis of Drosophila abdominal muscles

Zirin J, Cheng D, Dhanyasi N, Cho J, Dura JM, Vijayraghavan K, Perrimon N.

The Drosophila Amyloid Precusor Protein is a conserved neuronal modulator of Wnt PCP signaling

Soldano A., Okray Z., Janovska P., Tmejova K., Reynaud E., Claeys A., Yan J., Atak Z. K., De Strooper B., Dura J.-M., Bryja V., Hasssan B. A.

Drosophila Motor Neuron Retraction during Metamorphosis Is Mediated by Inputs from TGF-β/BMP Signaling and Orphan Nuclear Receptors

Boulanger A, Farge M, Ramanoudjame C, Wharton K, Dura JM

Mushroom body neuronal remodelling is necessary for short-term but not for long-term courtship memory in Drosophila

Redt-Clouet C, Trannoy S, Boulanger A, Tokmatcheva E, Savvateeva-Popova E, Parmentier ML, Preat T, Dura JM

Parallel processing of appetitive short- and long-term memories in Drosophila.

Trannoy S, Redt-Clouet C, Dura JM, Preat T.

ftz-f1 and Hr39 opposing roles on EcR expression during Drosophila mushroom body neuron remodeling

Boulanger, A., Clouet-Redt, C., Farge, M., Flandre, A., Guignard, T., Fernando, C., Juge, F. & Dura, JM.

Ryks: new partners for Wnts in the developing and regenerating nervous system

Fradkin, LG., Dura, JM., Noordermeer, JN

Respective roles of the DRL receptor and its ligand WNT5 in Drosophila mushroom body development.

Grillenzoni, N., Flandre, A., Lasbleiz, C., Dura, JM

In vivo evidence for a regulatory role of the kinase activity of the linotte/derailed receptor tyrosine kinase : a Drosophila Ryk ortholog

Taillebourg E., Moreau-Fauvarque C., Delaval K. and Dura J.-M.

Molecular genetics of the Alhambra (Drosophila AF10) complex locus of Drosophila

Perrin L. and Dura J.-M.

Identification and characterization of polyhomeotic PREs and TREs.

Bloyer S, Cavalli G, Brock HW, Dura JM

Genome wide prediction of Polycomb/trithorax Response Elements in Drosophila melanogaster.

Ringrose L., Rehmsmeier M., Dura J.-M. and Paro R.

A gain of function screen identifies a role of the Src64 oncogene in Drosophila mushroom body development.

Nicolaï M., Lasbleiz C. and Dura J.-M.

The leucine zipper motif of the Drosophila AF10 homolog can inhibit PRE-mediated repression: implications for leukemogenic activity of human MLL-AF10 fusions.

Perrin L., Bloyer S., Ferraz C., Agrawal N., Sinha P., and Dura J.-M.

Mutation of linotte causes behavioral defects independently of pigeon in Drosophila.

Moreau-Fauvarque C., Taillebourg E., Préat T. and Dura J.-M.

Dominant modifiers of the polyhomeotic extra-sex-combs phenotype induced by marked P element insertional mutagenesis in Drosophila

Fauvarque M.-O., Laurenti P., Boivin A., Bloyer S., Griffin-Shea R., Bourbon H.-M. and Dura J.-M.

P element replacement at the linotte/derailed locus in Drosophila: presence of the wild-type region in the homologous chromosome increases the efficiency.

Taillebourg E. and Dura J.-M.

A novel mechanism for P element homing in drosophila.

Taillebourg, E. and Dura, J.M.

One-to-one correspondence between the two genetic units and the tandemly duplicated transcriptional units of the polyhomeotic locus of Drosphila.

Boivin, A., Fauvarque, M.O. and Dura, J.M.

White+ transgenes insertions presenting a dorso-ventral pattern define a single cluster of homeobox-genes that is silenced by the Polycomb-group proteins in Drosophila melanogaster.

Netter, S., Fauvarque, M.O., Diez del Corral, R., Dura, J.M. and Coen, D.

The receptor tyrosine kinase gene linotte is required for neuronal pathway selection in the Drosophila mushroom bodies.

Moreau, C., Taillebourg, E., Boissoneau, E., Mesnard, J. and Dura, J.M.

In vivo chromatin accessibility correlates with gene silencing in Drosophila.

Boivin, A. and Dura, J.M.

Thèses et hdr

Role of APPL protein in axonal growth of pedunculated bodies in Drosophila melanogaster 25/09/2017

Defended by Claire Marquilly on 25-09-2017

FARGE Morgane
FARGE Morgane
THINAT Camille
THINAT Camille