IMGT® - the international ImMunoGeneTics information system®

Molecular bases of human diseases

The research activities of the Laboratoire d’ImmunoGénétique Moléculaire (LIGM), created in March 1983 at Montpellier by the Professors Marie-Paule Lefranc and Gérard Lefranc (University of Montpellier and CNRS) since 1998 at the Institute of Human Genetics (IGH), are focused on molecular immunogenetics, immunoinformatics, bioinformatics and rare genetic diseases. We are studying the genetics, structures, functions and repertoires of the immunoglobulins (IG) of B lymphocytes and plasmocytes, and of the T cell receptors (TR) on T lymphocytes, which are essential components of the adaptive immunity in humans and other vertebrates with jaws (Gnathostomata).

In 1989, IMGT®, the international ImMunoGeneTics information system®, which is at the birth of immunoinformatics, was created by Marie-Paule Lefranc (University of Montpellier and CNRS). Founded on the IMGT-ONTOLOGY concepts and IMGT Scientific chart rules developed by the LIGM team, IMGT® has become the global reference in immunogenetics and immunoinformatics and a pioneer in solving Immunoinformatic challenges. IMGT® is a CNRS registered trademark (EU, Canada and USA). IMGT® has been certified ISO 9001:2008 since 2010 and NFX 50-900 since 2014.

IMGT® is specialized in the IG, TR and major histocompatibility (MH) proteins of vertebrates, and in the immunoglobulin superfamily (IgSF), MH superfamily (MhSF) and related proteins of the immune system (RPI) of invertebrates and vertebrates. IMGT® is a high-quality integrated knowledge resource which provides a common access to expertly annotated genes, sequences and structures. IMGT® includes seven databases (IMGT/LIGM-DB, a biocurated database of 178,929 IG and TR nucleotide sequences with translation from 351 species in May 2017; IMGT/GENE-DB, IMGT/CLL-DB, IMGT/PRIMER-DB, IMGT/2Dstructure-DB, IMGT/3Dstructure-DB and IMGT/mAb-DB), seventeen interactive tools and more than 20,000 pages of Web resources. IMGT/DomainGapAlign is widely used for antibody engineering and design of humanized antibodies as it allows the precise definition of FR-IMGT and CDR-IMGT and the standardized comparison of the amino acid sequences between the nonhuman (mouse, rat…) V domains and the closest human germline genes. IMGT/HighV-QUEST, the first and so far the only online portal for IG and TR Next Generation Sequencing (NGS) data, has analysed to date (April 2017) more than 12.5 billions of IG and TR sequences, from 2043 users (45% USA, 35% Europe, 20% other countries).

Since July 1995, IMGT® is available on the Web. IMGT® is used by researchers and scientists, academic and from pharmaceutical and biotechnology companies, involved in fundamental research, medical research (autoimmune and infectious diseases, AIDS, leukemia, lymphoma, myeloma), veterinary research, genomics (genome diversity and evolution of the adaptive immune system), biotechnology related to antibody engineering for humanization of therapeutic antibodies, diagnostics (detection of minimal residual diseases) and therapeutic approaches (grafts, immunotherapy, vaccinology). The IMGT® Web server at Montpellier is accessed by more than 80,000 sites per year. IMGT® has an exceptional response with more than 150,000 requests per month.

Antibodies represent a large number of the pharmaceutical substances submitted to the World Health Organization International Nonproprietary Names (WHO INN) Programme. The INN definition of antibodies is based on the IMGT-ONTOLOGY concepts. Since 2008, amino acid sequences of monoclonal antibodies (mAb, INN suffix -mab), of fusion proteins for immune applications (FPIA) and composite proteins for clinical applications (CPCA) from WHO INN have been entered into IMGT®. These therapeutic applications emphasize the importance of the IMGT-ONTOLOGY concepts in bridging the gap between antibody sequences and 2D and 3D structures.

Another research interest, in collaboration mainly with the Unit of Medical Genetics, St-Joseph University, Beirut, and also with other teams in Tunisia and Algeria and the Children’s Hospital of Boston (Pr Raif GEHA) concerns rare Immuno Deficiencies and autosomal recessive genetic diseases in consanguineous families (there are as many as 25% of marriages between cousins, often first cousins and even double-first). The patients are autozygous (homozygous by descent) for very rare mutated genes and haplotypes, present in the common ancestor(s) of their parents. These exceptional genotypes are invaluable starting points to allow the identification more quickly of the yet unknown mutated genes. Their functions in the cell organization or in signaling pathways, including epigenetic and silencing by microARN, are unmasked and can be investigated. The genetic counselling can be performed in these families.

The better understanding of the molecular basis of the pathophysiology allows better choices in the development of diagnostic tools and innovative therapeutics. This research is beneficial not only for monogenic diseases, but also for complex ones. Indeed, the consanguinity, responsible also for homozygosity of large chromosomal regions, identical by descent, permits to discover more easily the genetic networks. This approach is also valid for the search of genetic susceptibility or protection against infectious diseases.

PUBLICATIONS OF THE TEAM

Inferred Allelic Variants of Immunoglobulin Receptor Genes: A System for Their Evaluation, Documentation, and Naming.

Ohlin M, Scheepers C, Corcoran M, Lees WD, Busse CE, Bagnara D, Thörnqvist L, Bürckert JP, Jackson KJL, Ralph D, Schramm CA, Marthandan N, Breden F, Scott J, Matsen Iv FA, Greiff V, Yaari G, Kleinstein SH, Christley S, Sherkow JS, Kossida S, Lefranc MP, van Zelm MC, Watson CT, Collins AM

Disease-biased and shared characteristics of the immunoglobulin gene repertoires in marginal zone B cell lymphoproliferations.

Xochelli A, Bikos V, Polychronidou E, Galigalidou C, Agathangelidis A, Charlotte F, Moschonas P, Davis Z, Colombo M, Roumelioti M, Sutton LA, Groenen P, van den Brand M, Boudjoghra M, Algara P, Traverse-Glehen A, Ferrer A, Stalika E, Karypidou M, Kanellis G, Kalpadakis C, Mollejo M, Pangalis G, Vlamos P, Amini RM, Pospisilova S, Gonzalez D, Ponzoni M, Anagnostopoulos A, Giudicelli V, Lefranc MP, Espinet B, Panagiotidis P, Piris MA, Du MQ, Rosenquist R, Papadaki T, Belessi C, Ferrarini M, Oscier D, Tzovaras D, Ghia P, Davi F, Hadzidimitriou A, Stamatopoulos K

Thymoquinone Potently Enhances the Activities of Classically Activated Macrophages Pulsed with Necrotic Jurkat Cell Lysates and the Production of Antitumor Th1-/M1-Related Cytokines.

Miliani M, Nouar M, Paris O, Lefranc G, Mennechet F, Aribi M

Use of IMGT® Databases and Tools for Antibody Engineering and Humanization.

Lefranc MP, Ehrenmann F, Kossida S, Giudicelli V, Duroux P

Coupling of Single Molecule, Long Read Sequencing with IMGT/HighV-QUEST Analysis Expedites Identification of SIV gp140-Specific Antibodies from scFv Phage Display Libraries.

Han SY, Antoine A, Howard D, Chang B, Chang WS, Slein M, Deikus G, Kossida S, Duroux P, Lefranc MP, Sebra RP, Smith ML, Fofana IBF

No improvement in long-term survival over time for chronic lymphocytic leukemia patients in stereotyped subsets #1 and #2 treated with chemo(immuno)therapy.

Baliakas P, Mattsson M, Hadzidimitriou A, Minga E, Agathangelidis A, Sutton LA, Scarfo L, Davis Z, Yan XJ, Plevova K, Sandberg Y, Vojdeman FJ, Tzenou T, Chu CC, Veronese S, Mansouri L, Smedby KE, Giudicelli V, Nguyen-Khac F, Panagiotidis P, Juliusson G, Anagnostopoulos A, Lefranc MP, Trentin L, Catherwood M, Montillo M, Niemann CU, Langerak AW, Pospisilova S, Stavroyianni N, Chiorazzi N, Oscier D, Jelinek DF, Shanafelt T, Darzentas N, Belessi C, Davi F, Ghia P, Rosenquist R, Stamatopoulos K

When monoclonal antibodies are not monospecific: Hybridomas frequently express additional functional variable regions.

Bradbury ARM, Trinklein ND, Thie H, Wilkinson IC, Tandon AK, Anderson S, Bladen CL, Jones B, Aldred SF, Bestagno M, Burrone O, Maynard J, Ferrara F, Trimmer JS, Görnemann J, Glanville J, Wolf P, Frenzel A, Wong J, Koh XY, Eng HY, Lane D, Lefranc MP, Clark M, Dübel S

Pacific Biosciences Sequencing and IMGT/HighV-QUEST Analysis of Full-Length Single Chain Fragment Variable from an In Vivo Selected Phage-Display Combinatorial Library.

Hemadou A, Giudicelli V, Smith ML, Lefranc MP, Duroux P, Kossida S, Heiner C, Hepler NL, Kuijpers J, Groppi A, Korlach J, Mondon P, Ottones F, Jacobin-Valat MJ, Laroche-Traineau J, Clofent-Sanchez G

Comprehensive annotation and evolutionary insights into the canine (Canis lupus familiaris) antigen receptor loci.

Martin J, Ponstingl H, Lefranc MP, Archer J, Sargan D, Bradley A

Epidermodysplasia verruciformis as a manifestation of ARTEMIS deficiency in a young adult.

Tahiat A, Badran YR, Chou J, Cangemi B, Lefranc G, Labgaa ZM, Oussalam S, Kaddouri-Slimani A, Belarbi A, Bendissari-Bouzid K, Gharnaout M, Geha RS, Djidjik R, Massaad MJ

Reproducibility and Reuse of Adaptive Immune Receptor Repertoire Data.

Breden F, Luning Prak ET, Peters B, Rubelt F, Schramm CA, Busse CE, Vander Heiden JA, Christley S, Bukhari SAC, Thorogood A, Matsen Iv FA, Wine Y, Laserson U, Klatzmann D, Douek DC, Lefranc MP, Collins AM, Bubela T, Kleinstein SH, Watson CT, Cowell LG, Scott JK, Kepler TB.

Adaptive Immune Receptor Repertoire Community recommendations for sharing immune-repertoire sequencing data

Rubelt F, Busse CE, Bukhari SAC, Bürckert JP, Mariotti-Ferrandiz E, Cowell LG, Watson CT, Marthandan N, Faison WJ, Hershberg U, Laserson U, Corrie BD, Davis MM, Peters B, Lefranc MP, Scott JK, Breden F; AIRR Community, Luning Prak ET, Kleinstein SH

Targeting the Wnt Pathway and Cancer Stem Cells with Anti-progastrin Humanized Antibodies as a Potential Treatment for K-RAS-Mutated Colorectal Cancer.

Prieur A, Cappellini M, Habif G, Lefranc MP, Mazard T, Morency E, Pascussi JM, Flacelière M, Cahuzac N, Vire B, Dubuc B, Durochat A, Liaud P, Ollier J, Pfeiffer C, Poupeau S, Saywell V, Planque C, Assenat E, Bibeau F, Bourgaux JF, Pujol P, Sézeur A, Ychou M, Joubert D.

Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes.

Xochelli A, Baliakas P, Kavakiotis I, Agathangelidis A, Sutton LA, Minga E, Ntoufa S, Tausch E, Yan XJ, Shanafelt T, Plevova K, Boudjogra M, Rossi D, Davis Z, Navarro A, Sandberg Y, Vojdeman FJ, Scarfo L, Stavroyianni N, Sudarikov A, Veronese S, Tzenou T, Karan-Djurasevic T, Catherwood M, Kienle D, Chatzouli M, Facco M, Bahlo J, Pott C, Pedersen LB, Mansouri L, Smedby KE, Chu CC, Giudicelli V, Lefranc MP, Panagiotidis P, Juliusson G, Anagnostopoulos A, Vlahavas I, Antic D, Trentin L, Montillo M, Niemann C, Döhner H, Langerak AW, Pospisilova S, Hallek M, Campo E, Chiorazzi N, Maglaveras N, Oscier D, Gaidano G, Jelinek DF, Stilgenbauer S, Chouvarda I, Darzentas N, Belessi C, Davi F, Hadzidimitriou A, Rosenquist R, Ghia P, Stamatopoulos K.

Immunoglobulin gene sequence analysis in chronic lymphocytic leukemia: updated ERIC recommendations

Rosenquist R, Ghia P, Hadzidimitriou A, Sutton LA, Agathangelidis A, Baliakas P, Darzentas N, Giudicelli V, Lefranc MP, Langerak AW, Belessi C, Davi F, Stamatopoulos K.

High-Throughput Immunogenetics for Clinical and Research Applications in Immunohematology: Potential and Challenges

Langerak AW, Brüggemann M, Davi F, Darzentas N, van Dongen JJM, Gonzalez D, Cazzaniga G, Giudicelli V, Lefranc MP, Giraud M, Macintyre EA, Hummel M, Pott C, Groenen PJTA, Stamatopoulos K; EuroClonality-NGS Consortium

Human Immunoglobulin Heavy Gamma Chain Polymorphisms: Molecular Confirmation Of Proteomic Assessment.

Dambrun M, Dechavanne C, Emmanuel A, Aussenac F, Leduc M, Giangrande C, Vinh J, Dugoujon JM, Lefranc MP, Guillonneau F, Migot-Nabias F.

Novel Structural Parameters of Ig-Ag Complexes Yield a Quantitative Description of Interaction Specificity and Binding Affinity.

Marillet S, Lefranc MP, Boudinot P, Cazals F.

Web Sites of Interest to Immunologists.

Lefranc M.P.

DOCK8 and STAT3 dependent inhibition of IgE isotype switching by TLR9 ligation in human B cells.

Massaad MJ, Cangemi B, Al-Herz W, LeFranc G, Freeman A, Baxi S, Keles S, Metin A, Dasouki M, Sobh A, Kanariou M, Al-Sukaiti N, Ozen A, Ochs H, Chatila TA, Manis JP, Geha R.

Detection of Sp110 by Flow Cytometry and Application to Screening Patients for Veno-occlusive Disease with Immunodeficiency.

Marquardsen FA, Baldin F, Wunderer F, Al-Herz W, Mikhael R, Lefranc G, Baz Z, Rezaee F, Hanna R, Kfir-Erenfeld S, Stepensky P, Meyer B, Jauch A, Bigler MB, Burgener AV, Higgins R, Navarini AA, Church JA, Chou J, Geha R, Notarangelo LD, Hess C, Berger CT, Bloch DB, Recher M.

Facial cutaneo-mucosal venous malformations can develop independently of mutation of TEK gene but may be associated with excessive expression of Src and p-Src

Brahami N, Subramaniam S, Al-Ddafari MS, Elkaim C, Harmand PO, Sari BE, Lefranc G, Aribi M.

TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin.

Khalifa O, Balandraud N, Lambert N, Auger I, Roudier J, Sénéchal A, Geneviève D, Picard C, Lefranc G, Touitou I, Mrenda BM, Benedito C, Pardoux E, Gagez AL, Pers YM, Jorgensen C, Mahjoub T, Apparailly F.

Immunogenetic factors driving formation of ultralong VH CDR3 in Bos taurus antibodies

Deiss TC, Vadnais M, Wang F, Chen PL, Torkamani A, Mwangi W, Lefranc MP, Criscitiello MF, Smider VV.

IG and TR single chain fragment variable (scFv) sequence analysis: a new advanced functionality of IMGT/V-QUEST and IMGT/HighV-QUEST

Giudicelli V, Duroux P, Kossida S, Lefranc MP.

12. Combined IKZF1 and IG markers as new tools for diagnosis and minimal residual disease assessment in Tunisian B-ALL

Besbes S, Hamadou WS, Boulland ML, Lefranc MP, Ben Youssef Y, Achour B, Khelif A, Fest T, Soua Z.

Erratum to: Genomic and expression analyses of Tursiops truncatus T cell receptor gamma (TRG) and alpha/delta (TRA/TRD) loci reveal a similar basic public γδ repertoire in dolphin and human.

Linguiti G, Antonacci R, Tasco G, Grande F, Casadio R, Massari S, Castelli V, Consiglio A, Lefranc MP, Ciccarese S.

Cynomolgus macaque (Macaca fascicularis) immunoglobulin heavy chain locus description.

Yu GY, Mate S, Garcia K, Ward MD, Brueggemann E, Hall M, Kenny T, Sanchez-Lockhart M, Lefranc MP, Palacios G.

Restricting nonclassical MHC genes coevolve with TRAV genes used by innate-like T cells in mammals.

Boudinot P, Mondot S, Jouneau L, Teyton L, Lefranc MP, Lantz O.

COPD characteristics in subjects carrying the rare alpha-1 antitrypsin variant PIMMmalton

Denden S, Bouden B, Boudawara Keskes N, Knani J, Hassine M, Lefranc G, Ben Chibani J, Haj Khelil A

Correction: IMGT/HighV-QUEST Statistical Significance of IMGT Clonotype (AA) Diversity per Gene for Standardized Comparisons of Next Generation Sequencing Immunoprofiles of Immunoglobulins and T Cell Receptors

Aouinti S, Malouche D, Giudicelli V, Kossida S, Lefranc MP.

Structuprint: a scalable and extensible tool for two-dimensional representation of protein surfaces

Kontopoulos DG, Vlachakis D, Tsiliki G, Kossida S.

IMGT/StatClonotype for Pairwise Evaluation and Visualization of NGS IG and TR IMGT Clonotype (AA) Diversity or Expression from IMGT/HighV-QUEST

Aouinti S, Giudicelli V, Duroux P, Malouche D, Kossida S, Lefranc MP

IMGT/HighV-QUEST statistical significance of IMGT clonotype (AA) diversity per gene for standardized comparisons of next generation sequencing immunoprofiles of immunoglobulins and T cell receptors

Aouinti, S., Malouche D, Giudicelli V, Kossida, S., Lefranc, M-P

Sheep (Ovis aries) T cell receptor alpha (TRA) and delta (TRD) genes and genomic organization of the TRA/TRD locus.

Piccinni B, Massari S, Caputi Jambrenghi A, Giannico F, Lefranc MP, Ciccarese S, Antonacci R

Antibody Informatics: IMGT, the International ImMunoGeneTics Information System

Lefranc MP.

From IMGT-ONTOLOGY to IMGT/HighV-QUEST for NGS immunoglobulin (IG) and T cell receptor (TR) repertoires in autoimmune and infectious diseases

Giudicelli V., Duroux P., Lavoie A, Aouinti S, Lefranc M-P, Kossida S

The Role of Recent Admixture in Forming the Contemporary West Eurasian Genomic Landscape

Busby GBJ, Hellenthal G, Montinaro F, Tofanelli S, Bulayeva K, Rudan I, Zemunik T, Hayward C, Toncheva D, Karachanak-Yankova S, Nesheva D, Anagnostou P, Cali F, Brisighelli F, Romano V, Lefranc G, Buresi C, Ben Chibani J, Haj-Khelil A, Denden S, Ploski R, Krajewski P, Hervig T, Moen T, Herrera RJ, Wilson JF, Myers S, Capelli C.

The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency.

Engelhardt KR, Gertz ME, Keles S, Schäffer AA, Sigmund EC, Glocker C, Saghafi S, Pourpak Z, Ceja R, Sassi A, Graham LE, Massaad MJ, Mellouli F, Ben-Mustapha I, Khemiri M, Kilic SS, Etzioni A, Freeman AF, Thiel J, Schulze I, Al-Herz W, Metin A, Sanal Ö, Tezcan I, Yeganeh M, Niehues T, Dueckers G, Weinspach S, Patiroglu T, Unal E, Dasouki M, Yilmaz M, Genel F, Aytekin C, Kutukculer N, Somer A, Kilic M, Reisli I, Camcioglu Y, Gennery AR, Cant AJ, Jones A, Gaspar BH, Arkwright PD, Pietrogrande MC, Baz Z, Al-Tamemi S, Lougaris V, Lefranc G, Megarbane A, Boutros J, Galal N, Bejaoui M, Barbouche MR, Geha RS, Chatila TA, Grimbacher B.

IMGT®, the international ImMunoGeneTics information system® 25 years on

Lefranc MP, Giudicelli V, Duroux P, Jabado-Michaloud J, Folch G, Aouinti S, Carillon E, Duvergey H, Houles A, Paysan-Lafosse T, Hadi-Saljoqi S, Sasorith S, Lefranc G, Kossida S.

Immunoglobulin heavy variable (IGHV) genes and alleles: new entities, new names and implications for research and prognostication in chronic lymphocytic leukaemia

Xochelli A, Agathangelidis A, Kavakiotis I, Minga E, Sutton LA, Baliakas P, Chouvarda I, Giudicelli V, Vlahavas I, Maglaveras N, Bonello L, Trentin L, Tedeschi A, Panagiotidis P, Geisler C, Langerak AW, Pospisilova S, Jelinek DF, Oscier D, Chiorazzi N, Darzentas N, Davi F, Ghia P, Rosenquist R, Hadzidimitriou A, Belessi C, Lefranc MP, Stamatopoulos K

Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations

Baliakas P, Agathangelidis A, Hadzidimitriou A, Sutton LA, Minga E, Tsanousa A, Scarfò L, Davis Z, Yan XJ, Shanafelt T, Plevova K, Sandberg Y, Vojdeman FJ, Boudjogra M, Tzenou T, Chatzouli M, Chu CC, Veronese S, Gardiner A, Mansouri L, Smedby KE, Pedersen LB, Moreno D, Van Lom K, Giudicelli V, Francova HS, Nguyen-Khac F, Panagiotidis P, Juliusson G, Angelis L, Anagnostopoulos A, Lefranc MP, Facco M, Trentin L, Catherwood M, Montillo M, Geisler CH, Langerak AW, Pospisilova S, Chiorazzi N, Oscier D, Jelinek DF, Darzentas N, Belessi C, Davi F, Ghia P, Rosenquist R, Stamatopoulos K

A broad range of mutations in HIV-1 neutralizing human monoclonal antibodies specific for V2, V3, and the CD4 binding site

Li L, Wang XH, Williams C, Volsky B, Steczko O, Seaman MS, Luthra K, Nyambi P, Nadas A, Giudicelli V, Lefranc MP, Zolla-Pazner S, Gorny MK

A Novel Mutation of the hGR Gene Causing Chrousos Syndrome

Nicolaides NC, Geer EB, Vlachakis D, Roberts ML, Psarra AM, Moutsatsou P, Sertedaki A, Kossida S, Charmandari E

DrugOn: a fully integrated pharmacophore modeling and structure optimization toolkit

Vlachakis D, Fakourelis P, Megalooikonomou V, Makris C, Kossida S

How to use IMGT® for therapeutic antibody engineering

Lefranc MP.

IMGT® immunoglobulin repertoire analysis and antibody humanization.

Lefranc MP.

Antibody informatics: IMGT®, the international ImMunoGeneTics information system®

Lefranc MP

Lack of TEK Gene Mutation in Patients with Cutaneomucosal Venous Malformations from the North-Western Region of Algeria.

Brahami N, Aribi M, Sari BE, Khau Van Kien P, Touitou I, Lefranc G, Barat-Houari M

Dedicator of cytokinesis 8-deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells.

Janssen E, Morbach H, Ullas S, Bannock JM, Massad C, Menard L, Barlan I, Lefranc G, Su H, Dasouki M, Al-Herz W, Keles S, Chatila T, Geha RS, Meffre E.

Plasmacytoid dendritic cell depletion in DOCK8 deficiency: rescue of severe herpetic infections with IFN-α 2b therapy.

Keles S, Jabara HH, Reisli I, McDonald DR, Barlan I, Hanna-Wakim R, Dbaibo G, Lefranc G, Al-Herz W, Geha RS, Chatila TA

Flow cytometry biomarkers distinguish DOCK8 deficiency from severe atopic dermatitis.

Janssen E, Tsitsikov E, Al-Herz W, Lefranc G, Megarbane A, Dasouki M, Bonilla FA, Chatila T, Schneider L, Geha RS.

Characterization of a new V gene replacement in the absence of activation-induced cytidine deaminase and its contribution to human B-cell receptor diversity

Ouled-Haddou H, Ghamlouch H, Regnier A, Trudel S, Herent D, Lefranc MP, Marolleau JP, Gubler B.

Antibody V and C Domain Sequence, Structure, and Interaction Analysis with Special Reference to IMGT(®).

Alamyar E, Giudicelli V, Duroux P, Lefranc MP.

Immunoglobulin and T Cell Receptor Genes: IMGT(®) and the Birth and Rise of Immunoinformatics

Lefranc MP.

Characteristics of the somatic hypermutation in the Camelus dromedarius T cell receptor gamma (TRG) and delta (TRD) variable domains.

Ciccarese S, Vaccarelli G, Lefranc MP, Tasco G, Consiglio A, Casadio R, Linguiti G, Antonacci R.

DBAASP: Database of Antimicrobial Activity and Structure of Peptides

Gogoladze G, Grigolava M, Vishnepolsky B, Chubinidze M, Duroux P, Lefranc MP, Pirtskhalava M.

2. Immunoinformatics of the V, C, and G Domains: IMGT(®) Definitive System for IG, TR and IgSF, MH, and MhSF.

Lefranc, MP.

Antibody informatics for drug discovery

Shirai H, Prades C, Vita R, Marcatili P, Popovic B, Xu J, Overington JP, Hirayama K, Soga S, Tsunoyama K, Clark D, Lefranc MP, Ikeda K.

Immunoglobulins: 25 years of immunoinformatics and IMGT-ONTOLOGY

Lefranc, MP.

IMGT® information system

Lefranc MP.

IMGT-ONTOLOGY

Giudicelli V and Lefranc M.-P

Deep dermatophytosis and inherited CARD9 deficiency.

Lanternier F, Pathan S, Vincent QB, Liu L, Cypowyj S, Prando C, Migaud M, Taibi L, Ammar-Khodja A, Stambouli OB, Guellil B, Jacobs F, Goffard JC, Schepers K, del Marmol V, Boussofara L, Denguezli M, Larif M, Bachelez H, Michel L, Lefranc G, Hay R, Jouvion G, Chretien F, Fraitag S, Bougnoux ME, Boudia M, Abel L, Lortholary O, Casanova JL, Picard C, Grimbacher B, Puel A.

Association Analysis of IL10, TNF-α, and IL23R-IL12RB2 SNPs with Behçet's Disease Risk in Western Algeria.

Khaib Dit Naib O, Aribi M, Idder A, Chiali A, Sairi H, Touitou I, Lefranc G, Barat-Houari M

IMGT unique numbering

Lefranc MP.

Deep dermatophytosis and inherited CARD9 deficiency.

Lanternier F, Pathan S, Vincent QB, Liu L, Cypowyj S, Prando C, Migaud M, Taibi L, Ammar-Khodja A, Stambouli OB, Guellil B, Jacobs F, Goffard JC, Schepers K, Del Marmol V, Boussofara L, Denguezli M, Larif M, Bachelez H, Michel L, Lefranc G, Hay R, Jouvion G, Chretien F, Fraitag S, Bougnoux ME, Boudia M, Abel L, Lortholary O, Casanova JL, Picard C, Grimbacher B, Puel A

IMGT Collier de Perles

Lefranc MP

A homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiency.

Jabara HH, Ohsumi T, Chou J, Massaad MJ, Benson H, Megarbane A, Chouery E, Mikhael R, Gorka O, Gewies A, Portales P, Nakayama T, Hosokawa H, Revy P, Herrod H, Le Deist F, Lefranc G, Ruland J, Geha RS

Consanguinity

Lefranc M.-P and Lefranc G.

The intellectual disability of trisomy 21: differences in gene expression in a case series of patients with lower and higher IQ.

Mégarbané A, Noguier F, Stora S, Manchon L, Mircher C, Bruno R, Dorison N, Pierrat F, Rethoré MO, Trentin B, Ravel A, Morent M, Lefranc G, Piquemal D

Homozygous stop mutation in the SNX10 gene in a consanguineous Iraqi boy with osteopetrosis and corpus callosum hypoplasia.

Mégarbané A, Pangrazio A, Villa A, Chouery E, Maarawi J, Sabbagh S, Lefranc G, Sobacchi C

Teleost Fish Mount Complex Clonal IgM and IgT Responses in Spleen upon Systemic Viral Infection

Castro R, Jouneau L, Pham HP, Bouchez O, Giudicelli V, Lefranc MP, Quillet E, Benmansour A, Cazals F, Six A, Fillatreau S, Sunyer O, Boudinot P.

IMGT/HighV QUEST paradigm for T cell receptor IMGT clonotype diversity and next generation repertoire immunoprofiling.

Li S, Lefranc MP, Miles JJ, Alamyar E, Giudicelli V, Duroux P, Freeman JD, Corbin VD, Scheerlinck JP, Frohman MA, Cameron PU, Plebanski M, Loveland B, Burrows SR, Papenfuss AT, Gowans EJ.

The Past, Present, and Future of Immune Repertoire Biology - The Rise of Next-Generation Repertoire Analysis

Six A, Mariotti-Ferrandiz ME, Chaara W, Magadan S, Pham HP, Lefranc MP, Mora T, Thomas-Vaslin V, Walczak AM, Boudinot P

A novel homozygous mutation in recombination activating gene 2 in 2 relatives with different clinical phenotypes: Omenn syndrome and hyper-IgM syndrome.

Chou J, Hanna-Wakim R, Tirosh I, Kane J, Fraulino D, Lee YN, Ghanem S, Mahfouz I, Mégarbané A, Lefranc G, Inati A, Dbaibo G, Giliani S, Notarangelo LD, Geha RS, Massaad MJ

Clinical, molecular, and cellular immunologic findings in patients with SP110-associated veno-occlusive disease with immunodeficiency syndrome.

Cliffe ST, Bloch DB, Suryani S, Kamsteeg EJ, Avery DT, Palendira U, Church JA, Wainstein BK, Trizzino A, Lefranc G, Akatcherian C, Megarbané A, Gilissen C, Moshous D, Reichenbach J, Misbah S, Salzer U, Abinun M, Ong PY, Stepensky P, Ruga E, Ziegler JB, Wong M, Tangye SG, Lindeman R, Buckley MF, Roscioli T

DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation.

Jabara HH, McDonald DR, Janssen E, Massaad MJ, Ramesh N, Borzutzky A, Rauter I, Benson H, Schneider L, Baxi S, Recher M, Notarangelo LD, Wakim R, Dbaibo G, Dasouki M, Al-Herz W, Barlan I, Baris S, Kutukculer N, Ochs HD, Plebani A, Kanariou M, Lefranc G, Reisli I, Fitzgerald KA, Golenbock D, Manis J, Keles S, Ceja R, Chatila TA, Geha RS

DNA replication is altered in Immunodeficiency Centromeric instability Facial anomalies (ICF) cells carrying DNMT3B mutations.

Lana E, Mégarbané A, Tourrière H, Sarda P, Lefranc G, Claustres M, De Sario A

A novel deletion in ZBTB24 in a Lebanese family with immunodeficiency, centromeric instability, and facial anomalies syndrome type 2.

Chouery E, Abou-Ghoch J, Corbani S, El Ali N, Korban R, Salem N, Castro C, Klayme S, Azoury-Abou Rjeily M, Khoury-Matar R, Debo G, Germanos-Haddad M, Delague V, Lefranc G, Mégarbané A

Use of IMGT(®) databases and tools for antibody engineering and humanization

Lefranc, MP., Ehrenmann, F., Ginestoux, C., Giudicelli, V., Duroux, P

Mass Spectrometry Detection of G3m and IGHG3 Alleles and Follow-Up of Differential Mother and Neonate IgG3.

Dechavanne C, Guillonneau F, Chiappetta G, Sago L, Lévy P, Salnot V, Guitard E, Ehrenmann F, Broussard C, Chafey P, Le Port A, Vinh J, Mayeux P, Dugoujon JM, Lefranc MP, Migot-Nabias F.

Diversity, Molecular Characterization and Expression of T Cell Receptor γ in a Teleost Fish, the Sea Bass (Dicentrarchus labrax, L)

Buonocore F, Castro R, Randelli E, Lefranc MP, Six A, Kuhl H, Reinhardt R, Facchiano A, Boudinot P, Scapigliati G.

Cytomegalovirus-specific CD8+ T cells targeting different peptide/HLA combinations demonstrate varying T-cell receptor diversity

Giest, S., McWhinnie, A., Lefranc, MP., Little, AM., Grace, S., Mackinnon, S., Madrigal, JA., Travers, PJ

Antigen receptor stereotypy across B-cell lymphoproliferations: the case of IGHV4-59/IGKV3-20 receptors with rheumatoid factor activity

Kostareli, E., Gounari, M., Janus, A., Murray, F., Brochet, X., Giudicelli, V., Pospisilova, S., Oscier, D., Foroni, L., di Celle, PF., Tichy, B., Pedersen, LB., Jurlander, J., Ponzoni, M., Kouvatsi, A., Anagnostopoulos, A., Thompson, K., Darzentas, N., Lefranc, MP., Belessi, C., Rosenquist, R., Davi, F., Ghia, P., Stamatopoulos, K

Evolution of the porcine (Sus scrofa domestica) immunoglobulin kappa locus through germline gene conversion

Schwartz, JC., Lefranc, MP., Murtaugh, MP

Organization, complexity and allelic diversity of the porcine (Sus scrofa domestica) immunoglobulin lambda locus

Schwartz, JC., Lefranc, MP., Murtaugh, MP

Human Gm, Km, and Am allotypes and their molecular characterization: a remarkable demonstration of polymorphism

Lefranc MP, Lefranc G

IMGT/DomainGapAlign: the IMGT® tool for the analysis of IG, TR, MH, IgSF, and MhSF domain amino acid polymorphism

Ehrenmann F, Lefranc MP

IMGT(®) tools for the nucleotide analysis of immunoglobulin (IG) and T cell receptor (TR) V-(D)-J repertoires, polymorphisms, and IG mutations: IMGT/V-QUEST and IMGT/HighV-QUEST for NGS

Alamyar E, Duroux P, Lefranc MP, Giudicelli V

IMGT-ONTOLOGY 2012

Giudicelli V, Lefranc MP.

IMGT/HighV-QUEST: the IMGT® web portal for immunoglobulin (IG) or antibody and T cell receptor (TR) analysis from NGS high throughput and deep sequencing

Alamyar E, Giudicelli V, Li S, Duroux P, Lefranc MP

Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies

Agathangelidis A, Darzentas N, Hadzidimitriou A, Brochet X, Murray F, Yan XJ, Davis Z, van Gastel-Mol EJ, Tresoldi C, Chu CC, Cahill N, Giudicelli V, Tichy B, Pedersen LB, Foroni L, Bonello L, Janus A, Smedby K, Anagnostopoulos A, Merle-Beral H, Laoutaris N, Juliusson G, di Celle PF, Pospisilova S, Jurlander J, Geisler C, Tsaftaris A, Lefranc MP, Langerak AW, Oscier DG, Chiorazzi N, Belessi C, Davi F, Rosenquist R, Ghia P, Stamatopoulos K.

Combined analysis of EPHX1, GSTP1, GSTM1 and GSTT1 gene polymorphisms in relation to chronic obstructive pulmonary disease risk and lung function impairment.

Lakhdar R, Denden S, Knani J, Leban N, Daimi H, Hassine M, Lefranc G, Chibani JB, Khelil AH

Update in chronic obstructive pulmonary disease: role of antioxidant and metabolizing gene polymorphisms.

Lakhdar R, Denden S, Kassab A, Leban N, Knani J, Lefranc G, Miled A, Chibani JB, Khelil AH

Heterochromatic genes undergo epigenetic changes and escape silencing in immunodeficiency, centromeric instability, facial anomalies (ICF) syndrome.

Brun ME, Lana E, Rivals I, Lefranc G, Sarda P, Claustres M, Mégarbané A, De Sario A

Correlation of EPHX1, GSTP1, GSTM1, and GSTT1 genetic polymorphisms with antioxidative stress markers in chronic obstructive pulmonary disease.

Lakhdar R, Denden S, Mouhamed MH, Chalgoum A, Leban N, Knani J, Lefranc G, Miled A, Ben Chibani J, Khelil AH

T cell diversity and TcR repertoires in teleost fish.

Castro R, Bernard D, Lefranc MP, Six A, Benmansour A, Boudinot P

Familial Mediterranean fever in a large Lebanese family: Multiple MEFV mutations and evidence for a Founder effect of the p.[M694I] mutation.

Medlej-Hashim, M., Chouery, E., Salem, N., Delague, V., Lefranc, G., Loiselet, J., Mégarbané, A.

Antibody nomenclature: From IMGT-ONTOLOGY to INN definition

Lefranc, MP.

Expression and genomic analyses of Camelus dromedarius T cell receptor delta (TRD) genes reveal a variable domain repertoire enlargement due to CDR3 diversification and somatic mutation

Antonacci, R., Mineccia, M., Lefranc, MP., Ashmaoui, HM., Lanave, C., Piccinni, B., Pesole, G., Hassanane, MS., Massari, S., Ciccarese, S.

Analysis of somatic hypermutations of immunoglobulin gene rearrangements in childhood acute lymphoblastic leukemia

Braoudaki, M., Katsibardi, K., Giudicelli, V., Karamolegou, K., Papathanassiou, Ch., Lefranc, MP., Tzortzatou-Stathopoulou, F

IMGT/DomainGapAlign: IMGT Standardized Analysis of Amino Acid Sequences of Variable, Constant, and Groove Domains (IG, TR, MH, IgSF, MhSF).

Ehrenmann, F., Lefranc, MP

IMGT/3Dstructure-DB: Querying the IMGT Database for 3D Structures in Immunology and Immunoinformatics (IG or Antibodies, TR, MH, RPI, and FPIA)

Ehrenmann, F., Lefranc, MP

IMGT/Collier de Perles: IMGT Standardized Representation of Domains (IG, TR, and IgSF Variable and Constant Domains, MH and MhSF Groove Domains).

Ehrenmann, F., Giudicelli, V., Duroux, P., Lefranc, MP

IMGT/V-QUEST: IMGT Standardized Analysis of the Immunoglobulin (IG) and T Cell Receptor (TR) Nucleotide Sequences

Giudicelli, V., Brochet, X., Lefranc, MP

) IMGT/JunctionAnalysis: IMGT Standardized Analysis of the V-J and V-D-J Junctions of the Rearranged Immunoglobulins (IG) and T Cell Receptors (TR).

Giudicelli, V., Lefranc, MP

From IMGT-ONTOLOGY IDENTIFICATION Axiom to IMGT Standardized Keywords: For Immunoglobulins (IG), T Cell Receptors (TR), and Conventional Genes.

Lefranc, MP

From IMGT-ONTOLOGY DESCRIPTION Axiom to IMGT Standardized Labels: For Immunoglobulin (IG) and T Cell Receptor (TR) Sequences and Structures.

Lefranc, MP

From IMGT-ONTOLOGY CLASSIFICATION Axiom to IMGT Standardized Gene and Allele Nomenclature: For Immunoglobulins (IG) and T Cell Receptors (TR).

Lefranc, MP

IMGT Unique Numbering for the Variable (V), Constant (C), and Groove (G) Domains of IG, TR, MH, IgSF, and MhSF

Lefranc, MP

IMGT Collier de Perles for the Variable (V), Constant (C), and Groove (G) Domains of IG, TR, MH, IgSF, and MhSF

Lefranc, MP

IMGT, the International ImMunoGeneTics Information System.

Lefranc, MP

Microsomal epoxide hydrolase gene polymorphisms and susceptibility to chronic obstructive pulmonary disease in the Tunisian population.

Lakhdar R, Denden S, Knani J, Leban N, Daimi H, Hassine M, Lefranc G, Chibani JB, Khelil AH

Standardized sequence and structure analysis of antibody using IMGT®

Ehrenmann F., Duroux P., Giudicelli V. and Lefranc M.-P.

A Mise au point: déficit en alpha 1 antitrypsine. A review: alpha1 antitrypsin deficiency

Denden S., Lakhdar R., Leban N., Daimi H., El Hayek D., Knani J., Perrin P., Lefranc G., Ben Chibani J. and Haj Khelil A.

A new familial sclerosing bone dysplasia.

Chouery, E., Pangrazio, A., Frattini, A., Villa, A., Van Wesenbeeck, L., Piters, E., Van Hul, W., Coxon, F., Schouten, T., Helfrich, M., Lefranc, G., Mégarbané, A.

IMGT/3D Structure-DB and IMGT/DomainGapAlign: a database and a tool for immunoglobulins or antibodies, T cell receptors, MHC, IgSF and MhcSF

Ehrenmann, F., Kaas, Q., Lefranc, MP.

Hemoglobinopathies in North Africa: a review.

Haj Khelil, A., Denden, S., Leban, N., Daimi, H., Lakhdhar, R., Lefranc, G., Ben Chibani, J., Perrin , P

Annotation and classification of the bovine T cell receptor delta genes

Herzig, CT., Lefranc, MP., Baldwin, CL.

A novel paradigm for cell and molecule interaction ontology: from the CMM model to IMGT-ONTOLOGY

Pappalardo, F., Lefranc, MP., Lollini, PL., Motta, S

From IMGT-ONTOLOGY to IMGT/LIGMotif: the IMGT(R) standardized approach for immunoglobulin and T cell receptor gene identification and description in large genomic sequences

Lane J, Duroux P, Lefranc MP.

Relationship between glutathione S-transferase P1 polymorphisms and chronic obstructive pulmonary disease in a Tunisian population

Lakhdar R, Denden S, Knani J, Leban N, Daimi H, Hassine M, Lefranc G, Ben Chibani J, Haj Khelil A.

ImmunoGrid: towards agent-based simulations of the human immune system at a natural scale.

Halling-Brown M, Pappalardo F, Rapin N, Zhang P, Alemani D, Emerson A, Castiglione F, Duroux P, Pennisi M, Miotto O, Churchill D, Rossi E, Moss DS, Sansom CE, Bernaschi M, Lefranc MP, Brunak S, Lund O, Motta S, Lollini PL, Murgo A, Palladini A, Basford KE, Brusic V, Shepherd AJ.

Association of GSTM1 and GSTT1 polymorphisms with chronic obstructive pulmonary disease in a Tunisian population

Lakhdar, R., Denden, S., Knani, J., Leban, N., Daimi, H., Hassine, M., Lefranc, G., Ben Chibani, J., Haj Khelil, A.

Restricted V gene usage and VH/VL pairing of mouse humoral response against the N-terminal immunodominant epitope of the amyloid β peptide

Robert, R., Lefranc, MP., Ghochikyan, A., Agadjanyan, MG., Cribbs, DH., Van Nostrand, WE., Wark, KL., Dolezal, O.

Atypical hemolytic uremic syndrome in the Tunisian population.

Leban, N., Aloui, S., Touati, D., Lakhdhar, R., Skhiri, H., Lefranc, G., Achour, A., Elmay, M., Lopez-Trascasa, M., Sanchez-Corral, P., Chibani, J., Haj Khelil, A.

Antibody databases and tools: The IMGT® experience.

Lefranc MP.

IMGT® standardized analysis of immunoglobulin rearranged sequences.

Giudicelli V. and Lefranc M.-P.

) IMGT(R), the international ImMunoGeneTics information system(R).

Lefranc, MP., Giudicelli, V., Ginestoux, C., Jabado-Michaloud, J., Folch, G., Bellahcene, F., Wu, Y., Gemrot, E., Brochet, X., Lane, J., Regnier, L., Ehrenmann, F., Lefranc, G., Duroux, P.

The B7 family of immunoregulatory receptors: A comparative and evolutionary perspective.

Hansen JD, Pasquier LD, Lefranc MP, Lopez V, Benmansour A, Boudinot P.

IgG1 heavy chain-coding gene polymorphism (G1m allotypes) and development of antibodies-to-infliximab.

Magdelaine-Beuzelin C, Vermeire S, Goodall M, Baert F, Noman M, Assche GV, Ohresser M, Degenne D, Dugoujon JM, Jefferis R, Rutgeerts P, Lefranc MP, Watier H.

ImmunoGrid, an integrative environment for large-scale simulation of the immune system for vaccine discovery, design and optimization.

Pappalardo, F., Halling-Brown, MD., Rapin, N., Zhang, P., Alemani, D., Emerson, A., Paci, P., Duroux, P., Pennisi, M., Palladini, A., Miotto, O., Churchill, D., Rossi, E., Shepherd, AJ., Moss, DS., Castiglione, F., Bernaschi, M., Lefranc, MP., Brunak, S., Motta, S., Lollini, PL., Basford, KE., Brusic, V.

The deduced structure of the T cell receptor gamma locus in Canis lupus familiaris

Massari, S., Bellahcene, F., Vaccarelli, G., Carelli, G., Mineccia, M., Lefranc, MP., Antonacci, R., Ciccarese, S.

Human Immunoglobulin Allotypes: Possible implications for immunogenicity

Jefferis, R and Lefranc, M.-P.

Isolation of a human-like antibody fragment (scFv) that neutralizes ricin biological activity

Pelat T., Hust M., Hale M., Lefranc M.-P., Dübel S and Thullier P

Alteration of sarcoplasmic reticulum ca release in skeletal muscle from calpain 3-deficient mice.

Dayanithi G, Richard I, Viero C, Mazuc E, Mallie S, Valmier J, Bourg N, Herasse M, Marty I, Lefranc G, Mangeat P, Baghdiguian S

Biochemical and molecular diagnosis of alpha 1 antitrypsin deficiency in a Tunisian family

Denden S, Braham W, Amri F, Lakhdar R, Lefranc G, Knani J, Ben Chibani J, Haj Khelil A.

Protective effect of diclofenac towards the oxidative stress induced by paracetamol toxicity in rats

Aouacheri, W., Saka, S., Djafer, R., Lefranc, G

Antibody databases: IMGT® a french platform of world-wide interest.

Lefranc, MP.

IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis.

Brochet X, Lefranc MP, Giudicelli V

IMGT, the International ImMunoGeneTics Information System for Immunoinformatics : methods for querying IMGT databases, tools, and web resources in the context of immunoinformatics.

Lefranc MP

IMGT standardization for molecular characterization of the T cell receptor/peptide/MHC complexes.

Kaas, Q., Duprat, E., Tourneur, G. and Lefranc M.P

Admixture and sexual bias in the population settlement of La Réunion Island (Indian Ocean).

Berniell-Lee G, Plaza S, Bosch E, Calafell F, Jourdan E, Césari M, Lefranc G, Comas D

NF-kappaB-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A.

Benayoun B, Baghdiguian S, Lajmanovich A, Bartoli M, Daniele N, Gicquel E, Bourg N, Raynaud F, Pasquier MA, Suel L, Lochmuller H, Lefranc G, Richard I

Recovering probabilities for nucleotide trimming processes for T cell receptor TRA and TRG V-J junctions analyzed with IMGT tools

Bleakley, K., Lefranc, MP., Biau, G.

Germline Humanization of a Non-human Primate Antibody that Neutralizes the Anthrax Toxin, by in Vitro and in Silico Engineering.

Pelat T, Bedouelle H, Rees AR, Crennell SJ, Lefranc MP, Thullier P.

IMGT, a system and an ontology that bridge biological and computational spheres in bioinformatics

Lefranc, MP., Giudicelli, V., Regnier, L., Duroux, P.

IMGT-Kaleidoscope, the formal IMGT-ONTOLOGY paradigm

Duroux, P., Kaas, Q., Brochet, X., Lane, J., Ginestoux, C., Lefranc, MP., Giudicelli, V.

Alpha 1 antitrypsin polymorphism in the tunisian population with special reference to pulmonary disease

Denden, S., Haj Khelil, A., Perrin, P., Daimi, H., Leban, N., Ouaja, A., Mahdouani, K., Hlioui, L., Lefranc, G., Ben Chibani, J.

WHO-IUIS Nomenclature Subcommittee for immunoglobulins and T cell receptors report August 2007, 13th International Congress of Immunology, Rio de Janeiro, Brazil.

Lefranc MP

IMGT-ONTOLOGY, IMGT® databases, tools and Web resources for Immunoinformatics.

Lefranc MP

Alpha 1 antitrypsin polymorphism associated to asthma and emphysema in a central Tunisian population.

Haj-Khelil, A., Denden, S., Hlioui, L., Hattab, N., Daimi, H., Leban, N., Perrin, P, Lefranc, G., Ben Chibani, J.

Novel and recurrent STAT3 mutations in hyper-IgE syndrome patients from different ethnic groups.

Jiao, H., Tóth, B., Erdős, M., Fransson, I., Rákóczi, E., Balogh, I., Magyarics, Z., Dérfalvi, B. Csorba, G., Szaflarska, A., Megarbane, A., Akatcherian, C., Dbaibo, G., Rajnavölgyi, E., Hammarström, L., Kere, J., Lefranc, G., Maródi, L

IMGT Colliers de Perles for IgSF domain standardization: The T cell costimulatory activatory (CD28, ICOS) and inhibitory (CTLA4, PDCD1 and BTLA) receptors

Garapati V.P. and Lefranc M.-P.

Genetic diseases in consanguineous families: Invaluable contribution to the fundamental research

Lefranc G

IMGT®, the international ImMunoGeneTics information system®, the reference in immunogenetics and immunoinformatics. In: Proceedings First International Congress on Macromolecular Biochemistry and Genetics. Gafsa, Tunisia, 12-16 April 2007.

Duroux P., Giudicelli V., Kaas Q., Jabado-Michaloud J., Folch G., Ginestoux C., Brochet X., Lane J., Régnier L. Wu Y., Garapati V.P., Bellahcene F., Servier E.-J., Ehrenmann F., Lefranc G and Lefranc M.-P.

Diversity in the Complementarity Determining Region 3 (CDR3) of Antibodies from mice with evolving anti-TSHR antibody responses.

Martinez O, Gangi E, Mordi D, Gupta S, Dorevitch S, Lefranc MP, Prabhakar BS.

The genomic sequence of the bovine T cell receptor gamma TRG loci and localization of the TRGC5 cassette.

Conrad, ML., Mawer, MA., Lefranc, MP., McKinnell, L., Whitehead, J., Davis, SK., Pettman, R., Koop, BF.

IMGT Colliers de Perles: standardized sequence-structure representations of the IgSF and MhcSF superfamily domains

Kaas, Q., Lefranc, MP.

Interactive IMGT on-line database and tool for the structural analysis of immunoglobulins, T cell receptors, MHC and related proteins of the immune system

Kaas, Q. and Lefranc, M.P.

IMGT®, the international ImMunoGeneTics information system® for immunoinformatics. Methods for querying IMGT® databases, tools and Web resources in the context of immunoinformatics.

Lefranc , M.P.

Structure-function relationships of the variable domains of monoclonal antibodies approved for cancer treatment

Magdelaine-Beuzelin, C., Kaas, Q., Wehbi, V., Ohresser, M., Jefferis, R., Lefranc, M.P., Watier, H.

Molecular study of six families originating from the Middle-East and presenting with autosomal recessive osteopetrosis.

Souraty N, Noun P, Djambas-Khayat C, Chouery E, Pangrazio A, Villa A, Lefranc G, Frattini A, Megarbane A.

IMGT Colliers de Perles and IgSF domain standardization for T cell costimulatory activatory (CD28, ICOS) and inhibitory (CTLA4, PDCD1 and BTLA) receptors

Garapati, VP., Lefranc, MP.

Costimulatory receptors in jawed vertebrates: conserved CD28, odd CTLA4 and multiple BTLAs

Bernard, D., Hansen, JD., Du Pasquier, L., Lefranc, MP., Benmansour, A., Boudinot, P.

C3 complement polymorphism in patients suffering from obstructive chronic bronchopneumopathy in Tunisia

Leban, N., Haj Khelil, A., Daimi, H., Denden, S., Slimene, F., Mehdouani, K., Abdennaji Guenounou, B., Lefranc, G., Perrin, P., Ben Chibani, J.

A high affinity, human-like antibody fragment (scFv) neutralising the lethal factor (LF) of Bacillus anthracis by inhibiting PA-LF complex formation

Pelat T., Hust M., Laffly E., Condemine F., Bottex C., Vidal D., Lefranc M.-P., Dubel S. and Thullier P.

Le paradigme IMGT-ONTOLOGY

Giudicelli V. and Lefranc M.-P.

Electron microscopic findings in skin biopsies from patients with infantile osteopetrosis and neuronal storage disease

Alroy, J., Pfannl, R., Ucci, A., Lefranc, G., Frattini, A., Mégarbané, A.

WHO-IUIS Nomenclature Subcommittee for immunoglobulins and T cell receptors report

Lefranc MP

IG, TR and IgSF, MHC and MhcSF: what do we learn from the IMGT Colliers de Perles?

Kaas, Q., Ehrenmann, F., Lefranc, MP.

HLA-C molecular characterization of a Lebanese population and genetic structure of 39 populations from Europe to India-Pakistan

Buhler, S., Mégarbané, A., Lefranc, G., Tiercy, J.M. and Sanchez-Mazas, A.

Population structure in the Mediterranean basin: a Y chromosome perspective

Capelli C, Redhead N, Romano V, Cali F, Lefranc G, Delague V, Megarbane A, Felice AE, Pascali VL, Neophytou PI, Poulli Z, Novelletto A, Malaspina P, Terrenato L, Berebbi A, Fellous M, Thomas MG, Goldstein DB.

A simple method to predict protein-binding from aligned sequences--application to MHC superfamily and beta2-microglobulin

Duprat, E, Lefranc, MP, Gascuel, O.

IMGT/LIGM-DB, the IMGT® comprehensive database of immunoglobulin and T cell receptor nucleotide sequences.

Giudicelli V., Duroux, P., Ginestoux C., Folch G., Jabado-Michaloud J., Chaume D. and Lefranc, M.-P.

PenBase, the shrimp antimicrobial peptide penaeidin database: sequence-based classification and recommended nomenclature.

Gueguen, Y., Garnier, J., Robert, L., Lefranc, M.-P., Mougenot, I., de Lorgeril, J., Janech, M., Gross, P., Warr, G., Cuthbertson, B., Barracco, M.A., Bulet, P., Aumela, A., Yang, Y., Bo, D., Xiang, J., Tassanakajon, A., Piquemal, D. and Bachère, E

Bovine T cell receptor gamma variable and constant genes: combinatorial usage by circulating T cells

Herzig C., Blumerman S., Lefranc M.-P. and Baldwin C.

Web sites of Interest to Immunologists.

Lefranc M.-P.

Using bioinformatics tools for the sequence analysis of the immunoglobulins and T cell receptors.

Lefranc M.-P.

Mutations in OSTM1 (Grey Lethal) define a particular severe form of autosomal recessive osteopetrosis with neural involvement.

Pangrazio A., Poliani P.L., Mégarbané A., Lefranc G., Lanino E., Di Rocco M., Rucci F., Lucchini F., Ravanini M., Facchetti F., Abinun M., Vezzoni P., Villa A. and Frattini A.

IMGT/GeneInfo: T cell receptor gamma TRG and delta TRD genes in database give access to all TR potential V(D)J recombinations

Baum T.P., Hierle V., Pascal N., Bellahcene F., Chaume D., Lefranc M.-P., Jouvin-Marche E., Marche P.N. and Demongeot J.

Chemiluminescent detection of clonal immunoglobulin and T cell receptor gene rearrangements in Tunisian lymphoid malignancies, leukemias and lymphomas.

Abed R.E., Khechine A.E., Omri H.E., Youssef S., Laatiri A., Lefranc M.-P., Khelif A., Soua Z

IMGT standardization for statistical analyses of T cell receptor junctions: the TRAV-TRAJ example

BLEAKLEY K., GIUDICELLI V., WU Y., LEFRANC M.-P. and BIAU G

Retrieving factual data and documents using IMGT-ML in the IMGT information system®

Chaume D. Combres K., Giudicelli V. and Lefranc M.-P.

IMGT-ONTOLOGY and IMGT databases, tools and Web resources for Immunoinformatics. From the IMGT genomics, genetics and structural approaches to IMGT-Choreography

Lefranc MP.

IMGT-Choreography: processing of complex immunogenetics knowledge.

Chaume, D., Giudicelli, V., Combres, K., Ginestoux, C. and Lefranc, M.P

Familial Mediterranean fever (FMF) in Lebanon and Jordan: a population genetics study and report of three novel mutations.

Medlej-Hashim M, Serre JL, Corbani S, Saab O, Jalkh N, Delague V, Chouery E, Salem N, Loiselet J, Lefranc G, Mégarbané A.

IMGT unique numbering for immunoglobulin and T cell receptor constant domains and Ig superfamily C-like domains

Lefranc, M.-P., Pommié, C., Kaas, Q., Duprat, E., Bosc, N., Guiraudou, D., Jean, C., Ruiz, M., Da Piedade, I., Rouard, M., Foulquier, E., Thouvenin, V. and Lefranc, G.

IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes

Giudicelli, V., Chaume, D. and Lefranc, M.-P.

IMGT, the international ImMunoGeneTics information system®

Lefranc, M.-P., Giudicelli, V., Kaas, Q., Duprat, E., Jabado-Michaloud, J., Scaviner, D., Ginestoux, C., Clément, O., Chaume, D., Lefranc, G.

IMGT-Choreography for Immunogenetics and Immunoinformatics

Lefranc, M.-P., Clément, O., Kaas, Q., Duprat, E., Chastellan, P., Coelho, I., Combres, K., Ginestoux, C., Giudicelli, V., Chaume, D. and Lefranc, G.

IMGT-Choreography: processing of complex immunogenetics knowledge

Chaume, D., Giudicelli, V., Combres, K., Ginestoux, C. and Lefranc, M.-P.

IMGT unique numbering for MHC groove G-DOMAIN and MHC superfamily (MhcSF) G-LIKE-DOMAIN

Lefranc, M.-P., Duprat, E., Kaas, Q., Tranne, M., Thiriot, A. and Lefranc, G.

Interactive IMGT on-line tools for the analysis of immunoglobulin and T cell receptor repertoires

Giudicelli, V. and Lefranc, M.-P.

Immunogenetics sequence annotation: the strategy of IMGT based on IMGT-ONTOLOGY

Giudicelli, V., Chaume, D., Jabado-Michaloud, J. and Lefranc, M.-P.

Selection of a macaque Fab with human-like framework regions, high affinity, and that neutralizes the protective antigen (PA) of Bacillus anthracis

Laffly, E., Danjou, L., Condemine, F., Vidal, D., Drouet, E., Lefranc, M.-P., Bottex, C. and Thullier, P.

MICA: standardized IMGT allele nomenclature, polymorphisms and diseases

Frigoul, A. and Lefranc, M.-P.

IMGT unique numbering for standardized contact analysis of immunoglobulin/antigen and T cell receptor/peptide/MHC complexes

Kaas, Q., Chiche, L. and Lefranc, M.-P.

T cell receptor/peptide/MHC molecular characterization and standardized pMHC contact sites in IMGT/3Dstructure-DB

Kaas, Q. and Lefranc, M.-P.

IMGT, the international ImMunoGeneTics information system®: a standardized approach for immunogenetics and immunoinformatics

Lefranc, M.-P.

[Familial Mediterranean Fever (FMF): from diagnosis to treatment].

Medlej-Hashim M, Loiselet J, Lefranc G, Mégarbané A

IMGT standardization for alleles and mutations of the V-LIKE-DOMAINs and C-LIKE-DOMAINs of the immunoglobulin superfamily

Duprat E., Kaas Q., Garelle V., Lefranc G. and Lefranc M.-P.

IMGT-ONTOLOGY for Immunogenetics and Immunoinformatics (http://imgt.cines.fr)

Lefranc, M.-P., Giudicelli, V., Ginestoux, C., Bosc, N., Folch, G., Guiraudou, D., Jabado-Michaloud, J., Magris, S., Scaviner, D., Thouvenin, V., Combres,K., Girod, D., Jeanjean, S., Protat, C., Yousfi-Monod, M., Duprat, E., Kaas, Q., Pommié, C., C

Amyloidosis in familial Mediterranean fever patients: correlation with MEFV genotype-phenotype correlation and SAA1 and MICA polymorphisms effects

Medlej-Hashim, M., Delague, V., Chouery, E., Salem, N., Rawashdeh, M., Lefranc, G., Loiselet, J., and Mégarbané, A.

IMGT standardized criteria for statistical analysis of immunoglobulin V-REGION amino acid properties

Pommié, C., Levadoux, S., Sabatier, R., Lefranc, G. and Lefranc, M.-P.

Ichthyosis Follicularis, Alopecia, and Photophobia (IFAP) syndrome: report of a new family with additional features and review

Mégarbané, H., Zablit, C., Waked, N., Lefranc, G., Tomb, R. and Mégarbané, A.

IMGT/3Dstructure-DB and IMGT/StructuralQuery, a database and a tool for immunoglobulin, t cell receptor and MHC structural data.

Kaas, Q., Ruiz, M. and Lefranc, M.-P.

IMGT-ONTOLOGY and IMGT databases, tools and web resources for immunogenetics and immunoinformatics

Lefranc, M.-P.

IMGT/GeneInfo: enhancing V(D)J recombination database accessibility

Baum, P., Pasqual, N., Thuderoz, F., Hierle, V., Chaume, D., Lefranc, M.-P., Jouvin-Marche, E., Marche, N., and Demongeot, J.

Immunoglobulin lambda (IGL) genes of human and mouse

Lefranc, M.-P. and Lefranc, G.

Characterization of human FCGR3B*02 (HNA-1b, NA2) cDNAs and IMGT standardized description of FCGR3B alleles

Bertrand, G., Duprat, E., Lefranc, M.-P., Marti, J. and Coste, J.

IMGT/V-QUEST, an integrated software for immunoglobulin and T cell receptor V-J and V-D-J rearrangement analysis.

Giudicelli V., Chaume D. and Lefranc M.-P.

A high affinity macaque antibody Fab with human-like framework regions obtained from a small immune phage display library.

Chassagne, S., Laffly, E., Drouet, E., Herodin, F., Lefranc, M.-P. and Thullier, P.

IMGT/JunctionAnalysis : the first tool for the analysis of the immunoglobulin and T cell receptor complex V-J and V-D-J JUNCTIONs

Yousfi Monod M., Giudicelli V., Chaume D. and Lefranc M.-P.

IMGT, the international ImMunoGeneTics information system®

Lefranc, M-P.

IMGT, the international ImMunoGeneTics database®, http://imgt.cines.fr

Lefranc, M.-P.

IMGT Locus in Focus: The mouse (Mus musculus) T cell receptor alpha (TRA) and delta (TRD) variable genes

Bosc, N. and Lefranc, M.-P.

IMGT-ONTOLOGY: gestion et découverte de connaissances au sein d'IMGT

Giudicelli, V. and Lefranc, M.-P.

IMGT/PhyloGene: an online software package for phylogenetic analysis of immunoglobulin and T cell receptor genes

Elemento, O and Lefranc, M.-P.

Editorial - The International ImMunoGeneTics database IMGT

Warr, G.W., Clem, L.W. and Söderhall, K.

Joining the pillars of Hercules: mtDNA sequences show multidirectional gene flow in the Western Mediterranean

Plaza, S., Calafell, F., Helal, A., Bouzerna, N., Lefranc, G., Bertranpetit, J. and Comas, D.

Local application of IGF1 on dental pulp mechanically exposed; in vivo study on rabbit

Haddad, M., Lefranc, G. and Aftimos, G.

IMGT, the international ImMunoGeneTics information system®, http://imgt.cines.fr -

Lefranc, M.-P.

IMGT, the international ImMunoGeneTics information system, http://imgt.cines.fr: the reference in immunoinformatics.

Lefranc, M.-P., Giudicelli, V., Ginestoux, C. and Chaume, D.

IMGT® databases, web resources and tools for immunoglobulin and T cell receptor sequence analysis, http://imgt.cines.fr

Lefranc, M.-P.

IMGT unique numbering for immunoglobulin and T cell receptor variable domains and Ig superfamily V-like domains

Lefranc, M.-P., Pommié, C., Ruiz, M., Giudicelli, V., Foulquier, E., Truong, L., Thouvenin-Contet, V. and Lefranc, G.

Familial mediterranean fever: the potential for misdiagnosis of E148V using the E148Q usual RFLP detection method

Medlej-Hashim, M., Salem, N., Chouery, E., Rawashdeh, M., Delague, V., Haffar, M., Mansour, I., Naman, R., Lefranc, G., Loiselet, J. and Megarbané A.

Consanguinity

Lefranc, M.-P. and Lefranc, G.

IMGT gene identification and Colliers de Perles of human immunoglobulin with know 3D structures

Ruiz, M. and Lefranc, M-P.

Reconstructing the duplication history of tandemly repeated genes

Elemento, O., Gascuel, O. and Lefranc, M-P.

The human anti-thyroid peroxidase autoantibody repertoire in Graves' and Hashimoto's autoimmune thyroid diseases

Chardes, T., Chapal, N., Bresson, D., Bes, C., Giudicelli, V., Lefranc, M-P and Peraldi-Roux, S.

IMGT, the international ImMunoGeneTics database : a high-quality information system for comparative immunogenetics and immunology

Lefranc, M-P

Asymptomatic deficiency in the peptide transporter associated to antigen processing (TAP)

De la Salle, H., Saulquin, X., Mansour, I., Klaymé, S., Fricker, D., Zimmer, J., Cazenave, J-P., Hanau, D., Bonneville, M., Houssaint, E., Lefranc, G. and Naman, R.

Evidence for Balancing Selection from Nucleotide Sequence Analyses of Human G6PD

Verrelli, B.C., McDonald, J.H., Argyropoulos, G., Destro-Bisol, G., Froment, A., Drousiotou, A., Lefranc, G., Helal, A.N., Loiselet, J. and Tishkoff, S.A.

An efficient and accurate distance based algorithm to reconstruct tandem duplication trees

Elemento, O. and Gascuel, O.

The Mouse (Mus musculus) T cell Receptor Delta Variable (TRDV), Diversity (TRDD), and Joining (TRDJ) Genes

Bosc, N., Contet, V. and Lefranc, M.-P.

A worldwide analysis of AG molecular diversity inferred from serology

Sanchez-Mazas, A., Bütler-Brunner, E., Bütler, R., Calderon, R., Chaventre, A., Dugoujon, J.-M.,Hammond, M., Lefranc, G., Matsumoto, H., Osipova, L., Politis, C., Pullman, R. and Langaney, A.

Familial Mediterranean Fever in Lebanon: mutation spectrum, evidence for cases in Maronites, Greek Orthodoxes, Greek Catholics, Syriacs and Chiites and for an association between Amyloidosis and M694V and M694I mutations

Mansour, I., Delague, V., Cazeneuve, C., Dode, C., Chouery, E., Pecheux, C., Medlej-Hachim, M., Salem, N., Al Zein, L., Levan-Petit, I., Lefranc, G., Goossens, M., Delpech, M., Amselem, S., Megarbane, A., Grateau, G., Loiselet, J. and Naman, R.

Nomenclature of the human immunoglobulin kappa (IGK) genes

Lefranc, M.-P.

Nomenclature of the human immunoglobulin heavy (IGH) genes

Lefranc, M.-P.

A study of GM allotypes and gamma immunoglobulins heavy chain genes in Berbers, Arabs and sub-Saharan Africans from the Jerba Island (Tunisia)

Yacoubi Loveslati, B., Sanchez-Mazas, A., Ennafaa, H., Marrakchi, R., Dugoujon, J.-M., Lefranc, M.-P., Ben Ammar Elgaaied, A.

IMGT, the International ImMunoGeneTics database.

Lefranc, M.-P.

Pathophysiology of limb girdle muscular dystrophy type 2A: hypothesis and new insights in the IkappaBalpha/NF-kappaB survival pathway

Baghdiguian, S., Richard, I., Martin, M., Coopman, P., Beckmann, J.S., Mangeat, P., Lefranc, G.

Nomenclature of the human immunoglobulin lambda (IGL) genes

Lefranc, M.-P.

IGHV3 associated restriction fragment length polymorphisms confer susceptibility to bullous pemphigoid

Raux, G., Gilbert, D., Joly, P., Martel, P., Roujeau, J.-C., Prost, C., Lefranc, M.-P., Tron, F.

The Immunoglobulin FactsBook

Lefranc, M.-P., and Lefranc, G.

The T cell Receptor FactsBook

Lefranc, M.-P., and Lefranc, G.

DNA sequence variability of IGHG3 genes associated to the main G3m haplotypes in human populations

Dard, P., Lefranc, M.-P., Osipova, L., Sanchez-Mazas, A.

IMGT-XML a XML language for IMGT-ONTOLOGY and IMGT/LIGM-DB data

Chaume, D., Giudicelli, V. and Lefranc, M.-P.

Haplotype diversity and linkage disequilibrium at human G6PD: recent origin of alleles that confer malarial resistance

Tishkoff, S.A., Varkonyi, R., Cahinhinan, N., Abbes, S., Argyropoulos, G., Destro-Bisol, G., Drousiotou, A;, Dangerfield, B., Lefranc, G., Loiselet, J., Piro, A., Stoneking, M., Tagarelli, A., Tagarelli, G., Touma, E.H., Williams, S.M. and Clark, A.G

Familial mediterranean fever: association of elevated IgD plasma levels with specific MEFV mutations

Medlej-Hashim, M., Petit, I., Adib, S., Chouery, E., Salem, N., Delague, V., Rawashdeh, M., Mansour, I., Lefranc, G., Naman, R., Loiselet, J., Lecron, J.-C., Serre, J.-L. and Megarbané A.

Nomenclature and overview of the mouse (Mus musculus and Mus sp.) immunoglobulin kappa (IGK) genes

Martinez-Jean C., Folch, G. and Lefranc, M.-P.

Alu insertion polymorphisms in Northwest Africa and the Iberian Peninsula: evidence for a strong genetic boundary through the Gilbraltar Straits

Comas, D., Calafell, F., Benchemsi, N., Helal, A., Lefranc, G., Stoneking, M., Batzer, M.A., Bertranpetit, J. and Sajantila, A.

IMGT ImMunoGeneTics Database

Lefranc, M.-P.

The Mouse (Mus musculus) T cell Receptor Beta Variable (TRBV), Diversity (TRBD), and Joining (TRBJ) Genes

Bosc, N. and Lefranc, M.-P.

Loss of calpain 3 proteolytic activity leads to muscular dystrophy and to apoptosis-associated IkappaBalpha/NF-kappaB pathway perturbation in mice

Richard, I., Roudaut, C., Marchand, S., Baghdiguian, S., Herasse, M., Stockholm, D., Ono, Y., Suel, L., Bourg, N., Sorimachi, H., Lefranc, G., Fardeau, M., Sebille, A. and Bexkmann, J.S.

IMGT sequence profile: a standardized visualization for the immunoglobulin and T cell receptor V-REGIONs applicable to other protein alignments

Ruiz, M. and Lefranc, M.-P.

The human T cell receptor beta variable (TRBV) genes.

Folch, G. and Lefranc, M.-P.

The human T cell Receptor Alpha Variable (TRAV) Genes.

Scaviner, D. and Lefranc, M.-P.

IMGT, the international ImMunoGeneTics database.

Ruiz, M., Giudicelli, V., Ginestoux, C., Stoehr, P., Robinson, J., Bodmer, J., Marsh, S.G., Bontrop, R., Lemaitre, M., Lefranc, G., Chaume, D. and Lefranc, M.-P.

IMGT (ImMunoGénéTique), base de données internationale spécialisée et intégrée en Immunogénétique

Giudicelli, V., Chaume, D. and Lefranc M-P.

Web sites of Interest to Immunologists

Lefranc, M.-P.

Nomenclature of the human immunoglobulin genes

Lefranc, M.-P.

Nomenclature of the human T cell Receptor genes

Lefranc, M.-P.

The Human T cell Receptor Alpha Joining (TRAJ) Genes

Scaviner, D. and Lefranc, M.-P.

The Human T cell Receptor Beta Diversity (TRBD) and Beta Joining (TRBJ) Genes

Folch, G. and Lefranc, M.-P.

The Teleostei Immunoglobulin Heavy IGH Genes

Artero, S. and Lefranc, M.-P.

The Teleostei Immunoglobulin Light IGL1 and IGL2 V, J and C Genes

Artero, S. and Lefranc, M.-P.

Locus Maps and Genomic Repertoire of the Human Immunoglobulin Genes

Lefranc, M.-P.

Locus Maps and Genomic Repertoire of the Human T cell Receptor Genes

Lefranc, M.-P.

Protein displays of the Human T cell Receptor Alpha, Beta, Gamma and Delta Variable and Joining Regions

Folch, G., Scaviner, D., Contet, V. and Lefranc, M.-P.

Genetic screening of fourteen mutations in jordanian familial mediterranean fever patients

Medlej-Hashim, M., Rawashdeh, M., Chouery, E., Mansour, I., Delague, V., Lefranc, G., Naman, R., Loiselet, J. and Mégarbané, A.

Characterisation and specificity of two single-chain Fv antibodies directed to the protein tyrosine kinase Syk

Péneff, C., Lefranc M.-P. and Dariavach, P.

Towards database interoperability, ontologies and biological data mining

Chaume, D.

Calpain 3 deficiency is associated with myonuclear apoptosis and profound perturbation of the IB/NF-B pathway in limb-girdle muscular dystrophy type 2A.

Baghdiguian, S., Martin, M., Richard, I., Pons, F., Astier, C., Bourg, N., Hay, R., Chemaly, R., Halaby, G., Loiselet, J., Anderson, L., Lopez de Munain, A., Fardeau, M., Mangeat, P., Beckmann, J. and Lefranc, G.

Towards database interoperability, ontologies and biological data mining.

Chaume, D.

Ontology for Immunogenetics : IMGT-ONTOLOGY.

Giudicelli, V. and Lefranc, M.-P.

The IMGT unique numbering for Immunoglobulins, T cell receptors and Ig-like domains.

Lefranc, M.-P.

Trends and challenges of Bioinformatics.

Lefranc, M.-P.

IMGT, the international ImMunoGeneTics database.

Lefranc, M.-P., Giudicelli, V., Ginestoux, C., Bodmer, J., Müller, W., Bontrop, R., Lemaître, M., Malik, A., Barbié, V. and Chaume, D.

Allelic polymorphisms and RFLP in the human immunoglobulin lambda light chain locus.

Lefranc, M.-P., Pallarès, N. and Frippiat, J.-P.

BamHI-SacI RFLP and Gm analysis of the immunoglobulin IGHG genes in the Northern Selkups (West Siberia) : new haplotypes with deletion, duplication and triplication.

Osipova, L.P., Posukh, O.L., Wiebe, V.P., Miyazaki, T., Matsumoto, H., Lefranc, G. and Lefranc, M.-P.

The human immunoglobulin heavy variable (IGHV) genes.

Pallarès, N., Lefebvre, S., Contet, V., Matsuda, F. and Lefranc, M.-P.

IMGT, base de données internationale en ImMunoGénétique, http://imgt.cnusc.fr:8104.

Ruiz, M., Giudicelli, V. and Lefranc, M.-P.

The Human Immunoglobulin Heavy Diversity (IGHD) and Joining (IGHJ) segments.

Ruiz, M., Pallarès, N., Contet, V., Barbie, V. and Lefranc, M.-P.

Protein displays of the human immunoglobulin heavy, kappa and lambda variable and joining regions.

Scaviner, D., Barbié, V., Ruiz, M. and Lefranc, M.-P.

Calpaïne 3 et dystrophie musculaire des ceintures de type 2A

Herasse, M., Baghdigian, S., Fougerousse, F., Martin, M., Stockhlom, D., Beckmann, J.S., Lefranc, G. and Richard, I.

The human immunoglobulin kappa variable (IGKV) genes and joining (IGKJ) segments.

Barbié, V. and Lefranc, M.-P.

IMGT/PRIMER-DB (http://imgt.cnusc.fr:8104) - Une base de données pour la construction de banques combinatoires de fragments d'anticorps et de peptides.

Barbié, V., Lemaitre, M. and Lefranc, M.-P.

Influence of Intron lenght and its influence on Alternative Splicing of CD44.

Bell, M.V., Cowper, A.E., Lefranc, M.-P., Bell, J.I. and Screaton, G.R.

Molecular and biochemical characterization of JAK3 deficiency in a patient with severe combined immunodeficiency over 20 years after bone marrow transplantation : implications for treatment.

Bozzi, F., Lefranc, G., Villa, A., Badolato, R., Schumacher, R.F., Khalil, G., Loiselet, J., Bresciani, S., O'Shea, J.J., Vezzoni, P., Notarangelo, L.D. and Candotti, F.

IMGT/LIGM-DB : a systematized approach for ImMunoGeneTics database coherence and data distribution improvement.

Giudicelli, V., Chaume, D. and Lefranc, M.-P.

IMGT, the international ImMunoGeneTics database: a new Design for Immunogenetics Data Access

Giudicelli, V., Chaume, D., Mennessier, G., Althaus, H.-H., Müller, W., Bodmer, J., Malik, A. and Lefranc, M.-P.

Role of JAK3 in CD40-mediated signaling.

Jabara, H.H., Buckley, R.H., Roberts, J.L., Lefranc, G., Loiselet, J., Khalil, G. and Geha, R.S.

Detection of antigen receptor gene rearrangements in lymphoproliferative malignancies by fluorescent polymerase chain reaction.

Kerlan-Candon, S., Soua, Z., Lefranc, M.-P., Clot, J. and Eliaou, J.-F.

IMGT Locus on Focus : a new section of Experimental and Clinical Immunogenetics.

Lefranc, M.-P.

IMGT, the international ImMunoGeneTics database, http://imgt.cnusc.fr:8104.

Lefranc, M.-P.

Quelle génétique demain

Lefranc, M.-P.

IMGT, the International ImMunoGeneTics database.

Lefranc, M.-P., Giudicelli, V., Busin, C., Bodmer, J., Muller, W., Bontrop, R., Lemaitre, M., Malik, A. and Chaume, D.

PreB1 (CD10-) acute lymphoblastic leukaemia : immunophenotypic and genomic characteristics, clinical features and outcome in 38 adults and 26 children.

Lenormand, B., Béné, M.C., Lesesve, J.F., Bastard, C., Tilly, H., Lefranc, M.-P., Faure, G.-C., Garand, R., Falkenrodt, A., Kandel, G., Solary, E., Maynadié, M., Callat, M.-P., Thouret, F., Monconduit, M., Vannier, J.-P. and The Groupe d'Etude Immuno

The mouse (Mus musculus) immunoglobulin kappa variable (IGKV) genes and joining (IGKJ) segments.

Martinez, C. and Lefranc, M.-P.

IMGT Locus on Focus - The human immunoglobulin lambda variable (IGLV) genes and joining (IGLJ) segments.

Pallares, N., Frippiat, J.P., Giudicelli, V. and Lefranc, M.-P.

A genetic study of the south Altaian population of the Mendur-Sokkon village, Altai Republic.

Posukh, O.L., Osipova, L.P., Kashinskaya, Y.O., Ivakin, E.A., Kryukov, Y.A., Karafet, T.M., Kazakovtseva, M.A., Skobel'Tsina, L.M., Crawford, M.G., Lefranc, M.-P. and Lefranc, G.

Présentation à la surface du phage filamenteux : les multiples applications du phage display.

Souriau, C., Hua, T.D., Lefranc, M.-P. and Weill, M.

PUBLICATIONS COMMUNES

Recruitment of ubiquitin-activating enzyme UBA1 to DNA by poly(ADP-ribose) promotes ATR signalling.

Kumbhar R, Vidal-Eychenié S, Kontopoulos DG, Larroque M, Larroque C, Basbous J, Kossida S, Ribeyre C, Constantinou A
2018 - Life Sci Alliance , 1(3):e201800096 30456359
Service porteur : Genetic Instability and Cancer

HADI-SALJOQI Saida
HADI-SALJOQI Saida

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SASORITH Souphatta
SASORITH Souphatta

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LAVOIE Arthur
LAVOIE Arthur

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AOUINTI Safa
AOUINTI Safa

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HOULES Amélie
HOULES Amélie
ISCOM

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KLEIN Valentin
KLEIN Valentin

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PICANDET Laurène
PICANDET Laurène

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LEBRE Marianne
LEBRE Marianne
genOway

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ABAD Johanne
ABAD Johanne

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ARTERO Sylvaine
ARTERO Sylvaine
CRLC Val d_Aurelle

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BELLAHCENE Fatena
BELLAHCENE Fatena

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BERANGER Sandrine
BERANGER Sandrine
Hopital St ELOI - Montpellier

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BROCHET Xavier
BROCHET Xavier
IGBMC

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LANE Jerome
LANE Jerome

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SERVIER Emmanuel jean
SERVIER Emmanuel jean

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BOUCOMONT Elodie
BOUCOMONT Elodie

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CHAUME Denys
CHAUME Denys

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COMBRES Kora
COMBRES Kora

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DANIS Sophie
DANIS Sophie

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DOUCHY Laurent
DOUCHY Laurent

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DUPRAT Elodie
DUPRAT Elodie

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FATTOUM Fadhel
FATTOUM Fadhel

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FIZAMES Cecile
FIZAMES Cecile

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FOULQUIER Elodie
FOULQUIER Elodie
UM2

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GUIRAUDOU Delphine
GUIRAUDOU Delphine

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JEAN Christele
JEAN Christele
MABGENE

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KAAS Quentin
KAAS Quentin

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MONNIER Bertrand
MONNIER Bertrand

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NEGRE Vincent
NEGRE Vincent
IGF

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ROZAS Nelly
ROZAS Nelly

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SAIDALI-BONNET Nora
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CIRAD

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LUCAS Odile
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GEMROT Elodie
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FRANCOIS Philippe
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OUARAY Zohra
OUARAY Zohra
Institut de Biologie Structurale Grenoble

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LACAN Amandine
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PROMSY Elsa
PROMSY Elsa

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LE ROY Christophe
LE ROY Christophe

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SALJOQI Mansour
Sopra Group

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iTK

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TOURNIER Caroline
TOURNIER Caroline

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Subject: Genomic and biocuration study of antigen receptor loci in jawed vertebrate species involved in biotechnology research
Thesis supervision of Mrs DEBBAGH CHAHRAZED (thesis 1A 2020-2023)
Thesis director: Sofia KOSSIDA 25% of the thesis
Supervisors: Veronique GIUDICELLI 25%, Geraldine FOLCH 25%, Joumana JABADO-MICHALOUD 25
Funding: Algerian excellence grant

Subject: Artificial intelligence applied to immunogenetics
Thesis direction of Mr ELAZAMI ELHASSANI Merouane (thesis 2A 2020-2023)
Thesis director: Sofia KOSSIDA 25%,
Supervisors: Loïc MAISONNASSE 50% (ATOS), Patrice Duroux 25%.
Funding: CIFRE grant with ATOS

Subject: Exploring and visualising the specific immune response after immunisation, VISIMMU
Thesis direction of Mrs GORET Agathe (thesis 1A 2020-2023)
Thesis director: Sofia KOSSIDA 25%,
Supervisors: Catherine PRADES 25% (SANOFI), Veronique GIUDICELLI 25%, Patrice DUROUX 25%.
Funding: CIFRE grant with SANOFI

Subject: IMGT approach for the prediction and analysis of epitope-paratope interaction
by Anjana Kushwaha
Thesis direction of Ms KUSHWAHA Anjana (thesis 1A 2020-2023)
Supervisors: Sofia KOSSIDA 25%, Konstantin TODOROV 25% (LIRMM),
Supervisors: Veronique GIUDICELLI 25%, Patrice DUROUX 25% (LIRMM)
Funding: co-financing by the Region

Subject: A knowledge base in immunogenetics for the discovery of new scientific knowledge within IMGT®.
Thesis direction of Mr SANOU Gaoussou (thesis 1A 2020-2023)
Thesis supervisors: Sofia KOSSIDA 25%, Konstantin TODOROV 25% (LIRMM),
Supervisors: Veronique GIUDICELLI 25%, Patrice DUROUX 25% (LIRMM)
Funding: CBS2 doctoral contract

Subject: In silico characterisation of immunoglobulin and T cell receptor gene repertoires in Mus musculus inbred strains
by Anna Tran
Thesis direction of Mrs TRAN Anna (thesis 2A 2020-2023)
Supervisor: Sofia KOSSIDA 25%,
Supervisors: Veronique GIUDICELLI 25%, Geraldine FOLCH 50%.
Funding: IMGT's own resources 

Theses directed by Marie-Paule Lefranc and Gérard Lefranc: http://www.imgt.org/about/aboutus.php#thesis