DNA N6-adenine methylation (6mA) is rediscovered as an important epigenetic mark in eukaryotes. It however remains unclear what the de novo methyltransferases (MTases) are and how they fulfill their biological functions. The binucleated Tetrahymena thermophila happens to possess a unique time window for the study of de novo methylation, when the 6mA-free zygotic nucleus develops into 6mA-positive new macronucleus (MAC). In this study, we found that the MT-A70 family members, AMT2 and AMT5, are not required for the maintenance 6mA in the vegetative MAC but for de novo 6mA in the new MAC. As a consequence loss of AMT2 and/or AMT5 reduces the fitness of sexual progeny.
de novo methylation of N6-methyladenine (6mA) showcased in the unicellular eukaryote Tetrahymena Epigenetic Chromatin Regulation
ORGANISÉ PAR L'IGH
International Summer-School on Epigenetics du 15/07/2024 jusqu'au 19/07/2024 Genopolys, Montpellier - France
Méiose et recombinaisonMBHD Dpt. Seminar Series
IGH Seminar Series of the Department “Molecular basis of Human Diseases” du 02/04/2024 jusqu'au 11/10/2024 11:30 - 14:00 Genopolys amphitheater
GCB&D Dpt. Seminar Series
IGH Seminar Series of the Department “Genetics, Cell Biology and Development” du 19/02/2024 jusqu'au 15/11/2024 Genopolys amphitheater
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Méiose et recombinaison 11/07/2024 11:30 Genopolys AmphitheatreCongrès
International Summer-School on Epigenetics
Méiose et recombinaison 15/07/2024 jusqu'au 19/07/2024 Genopolys, Montpellier - FranceTranscription and Genome maintenance
09/09/2024 jusqu'au 13/09/2024 Roscoff, France2024 RNase H meeting
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