Chromatine et Biologie Cellulaire

Dynamique du génome

Le génome est plus qu'une suite linéaire de gènes. Il est compacté dans l’espace tridimensionnel du noyau cellulaire en structures tertiaires et quaternaires d'ordre supérieur. Les gènes flanquants s'organisent dans des domaines chromosomiques qui sont caractérisés par de types différents de chromatine, actifs ou répressifs.
Dans l'espace 3D, chaque site à l’intérieur d’un domaine contacte les autres sites à l’intérieur du domaine plus fréquemment que les sites d’autres domaines.
Cette propriété permet de définir les domaines physiques ou topologiquement associés (TAD). Au niveau du chromosome, les TAD individuels forment des contacts avec d'autres TAD, préférentiellement du même type, afin de construire des architectures 3D ordonnées appelées territoires chromosomiques. Enfin, différents chromosomes s'organisent de manière non aléatoire dans l'espace nucléaire.
Par conséquent, le génome eucaryote est hautement organisé en 3D et cette régulation peut être transmise ou modulée pendant la vie des cellules et des organismes. Cette chorégraphie chromosomique sophistiquée implique des milliers de différents acteurs - séquences d'ADN, ARNs et protéines - mais plutôt que de se combiner en un nombre infini de formes, ces composantes organisent un nombre relativement limité de types de chromatine, soit actifs, soit répressifs.
En particulier, deux groupes principaux de facteurs régulateurs du génome sont constitués par les protéines Polycomb (PcG) et Trithorax (trxG). Les protéines PcG maintiennent la mémoire des états silencieux de l'expression de gènes à travers la physiologie cellulaire et les divisions cellulaires multiples, tandis que les membres du trxG maintiennent des états actifs de la chromatine.
Ces protéines sont capables de reconnaître les états chromatiniens de leurs gènes cibles et de maintenir ces états au fil des divisions cellulaires même après la disparition des régulateurs transcriptionnels qui les ont induits en premier lieu. Remarquablement, ces états peuvent également être transmis à une fraction de la descendance au cours de plusieurs générations.
Dans notre laboratoire, nous visons à comprendre le principe régissant l'organisation du génome en 3D, ses implications fonctionnelles et les mécanismes moléculaires par lesquels les protéines PcG et trxG régulent leurs gènes cibles, transmettent l'héritage des états chromatiniens et orchestrent le développement.
Pour atteindre cet objectif, nous utilisons une variété d'approches et de techniques complémentaires dans les domaines de la biologie moléculaire, cellulaire et de développement, de la génomique et de la bioinformatique.

Frederic Bantignies
Frederic BANTIGNIES
Responsable de Projet
Chercheur

0434359997
Giacomo CAVALLI
Chercheur

0434359970
Thierry Cheutin
Thierry CHEUTIN
Chercheur

0434359997
Jacques Drouin
Jacques DROUIN
Chercheur invité
Chercheur

0434359997
Anne-Marie MARTINEZ
Responsable de Projet
Chercheur

0434359969
Bernd Schuttengruber
Bernd SCHUTTENGRUBER
Chercheur

0434359997
Axelle Donjon
Axelle DONJON
Lab Manager
IT

0434359997
Lauriane Fritsch
Lauriane FRITSCH
IT

0434359997
Davide Normanno
Davide NORMANNO
IT

0434359662
Marco Di Stefano
Marco DI STEFANO
Postdoc

0434359968
Max Fitz-James
Max FITZ-JAMES
Postdoc

0434359968
Ivana JERKOVIC
Postdoc

0434359997
Flora Paldi
Flora PALDI
Postdoc

0434359968
Gonzalo Sabaris
Gonzalo SABARIS
Postdoc

0434359968
Nazli Akilli
Nazli AKILLI
Doctorant

0434359997
Sandrine Denaud
Sandrine DENAUD
Doctorant

0434359997
Victoria Parreno
Victoria PARRENO
Doctorant

0434359968
Ana-Maria Popmihaylova
Ana-Maria POPMIHAYLOVA
Doctorant

0434359968
Hadrien Reboul
Hadrien REBOUL
Doctorant

0434359997
Michael Szalay
Michael SZALAY
Doctorant

0434359997

PUBLICATIONS DE L'ÉQUIPE

A shared ancient enhancer element differentially regulates the bric-a-brac tandem gene duplicates in the developing Drosophila leg.

Bourbon HG, Benetah MH, Guillou E, Mojica-Vazquez LH, Baanannou A, Bernat-Fabre S, Loubiere V, Bantignies F, Cavalli G, Boube M

Comprehensive characterization of the epigenetic landscape in Multiple Myeloma.

Alaterre E, Ovejero S, Herviou L, de Boussac H, Papadopoulos G, Kulis M, Boireau S, Robert N, Requirand G, Bruyer A, Cartron G, Vincent L, Martinez AM, Martin-Subero JI, Cavalli G, Moreaux J

HiCmapTools: a tool to access HiC contact maps.

Chang JM, Weng YF, Chang WT, Lin FA, Cavalli G

SETDB1/NSD-dependent H3K9me3/H3K36me3 dual heterochromatin maintains gene expression profiles by bookmarking poised enhancers.

Barral A, Pozo G, Ducrot L, Papadopoulos GL, Sauzet S, Oldfield AJ, Cavalli G, Déjardin J

Mechanisms of Polycomb group protein function in cancer.

Parreno V, Martinez AM, Cavalli G

Molecular mechanisms of transgenerational epigenetic inheritance.

Fitz-James MH, Cavalli G

Clinical Correlations of Polycomb Repressive Complex 2 in Different Tumor Types.

Erokhin M, Chetverina O, Győrffy B, Tatarskiy VV, Mogila V, Shtil AA, Roninson IB, Moreaux J, Georgiev P, Cavalli G, Chetverina D

Understanding 3D genome organization by multidisciplinary methods

Ivana Jerkovic´ & Giacomo Cavalli

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Regulation of single-cell genome organization into TADs and chromatin nanodomains

Szabo, Q., Donjon, A., Jerkovic, I., Papadopoulos, G.L., Cheutin, T., Bonev, B., Nora, E., Bruneau, B.G., Bantignies, F., and Cavalli, G.

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4D Genome Rewiring during Oncogene-Induced and Replicative Senescence

Sati, S., Bonev, B., Szabo, Q., Jost, D., Bensadoun, P., Serra, F., Loubiere...

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Widespread activation of developmental gene expression characterized by PRC1-dependent chromatin looping.

Loubiere V, Papadopoulos GL, Szabo Q, Martinez AM, Cavalli G


+ Chromatine et Biologie Cellulaire

Widespread activation of developmental gene expression characterized by PRC1-dependent chromatin looping.

Loubiere V, Papadopoulos GL, Szabo Q, Martinez AM, Cavalli G


+ Chromatine et Biologie Cellulaire

Global chromatin conformation differences in the Drosophila dosage compensated chromosome X.

Pal K, Forcato M, Jost D, Sexton T, Vaillant C, Salviato E, Mazza EMC, Lugli E, Cavalli G, Ferrari F


+ Chromatine et Biologie Cellulaire

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Global chromatin conformation differences in the Drosophila dosage compensated chromosome X.

Pal K, Forcato M, Jost D, Sexton T, Vaillant C, Salviato E, Mazza EMC, Lugli E, Cavalli G, Ferrari F


+ Chromatine et Biologie Cellulaire

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Advances in epigenetics link genetics to the environment and disease

Giacomo Cavalli and Edith Heard


+ Chromatine et Biologie Cellulaire

Advances in epigenetics link genetics to the environment and disease

Giacomo Cavalli and Edith Heard


+ Chromatine et Biologie Cellulaire

Principles of genome folding into topologically associating domains.

Szabo Q, Bantignies F, Cavalli G

Microscopy-Based Chromosome Conformation Capture Enables Simultaneous Visualization of Genome Organization and Transcription in Intact Organisms.

Cardozo Gizzi AM, Cattoni DI, Fiche JB, Espinola SM, Gurgo J, Messina O, Houbron C, Ogiyama Y, Papadopoulos GL, Cavalli G, Lagha M, Nollmann M

Cell Fate and Developmental Regulation Dynamics by Polycomb Proteins and 3D Genome Architecture.

Loubiere V, Martinez AM, Cavalli G

PRC2 targeting is a therapeutic strategy for EZ score defined high-risk multiple myeloma patients and overcome resistance to IMiDs.

Herviou L, Kassambara A, Boireau S, Robert N, Requirand G, Müller-Tidow C, Vincent L, Seckinger A, Goldschmidt H, Cartron G, Hose D, Cavalli G, Moreaux J


+ Maintien de l'intégrité du génome au cours de la réplication

Challenges and guidelines toward 4D nucleome data and model standards.

Marti-Renom MA, Almouzni G, Bickmore WA, Bystricky K, Cavalli G, Fraser P, Gasser SM, Giorgetti L, Heard E, Nicodemi M, Nollmann M, Orozco M, Pombo A, Torres-Padilla ME

Loss of PRC1 induces higher-order opening of Hox loci independently of transcription during Drosophila embryogenesis.

Cheutin T, Cavalli G

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Polycomb-Dependent Chromatin Looping Contributes to Gene Silencing during Drosophila Development.

Ogiyama Y, Schuettengruber B, Papadopoulos GL, Chang JM, Cavalli G

TADs are 3D structural units of higher-order chromosome organization in Drosophila.

Szabo Q, Jost D, Chang JM, Cattoni DI, Papadopoulos GL, Bonev B, Sexton T, Gurgo J, Jacquier C, Nollmann M, Bantignies F, Cavalli G

Technical Review: A Hitchhiker's Guide to Chromosome Conformation Capture.

Grob S, Cavalli G

Genome Regulation by Polycomb and Trithorax: 70 Years and Counting

Schuettengruber, B., Bourbon, HM., Di Croce, L., Cavalli, G.

Multi-scale 3D genome rewiring during mouse neural development.

Bonev, B., Mendelson Cohen, N., Szabo, Q., Fritsch, L., Papadopoulos, G., Lubling, Y., Xu, X., Hugnot, JP., Tanay, A., Cavalli, G.

Stable Polycomb-dependent transgenerational inheritance of chromatin states in Drosophila

Ciabrelli F, Comoglio F, Fellous S, Bonev B, Ninova M, Szabo Q, Xuéreb A, Klopp C, Aravin A, Paro R, Bantignies F, Cavalli G

Three-Dimensional Genome Organization and Function in Drosophila

Schwartz YB, Cavalli G.

Chromosome topology guides the Drosophila Dosage Compensation Complex for target gene activation

Schauer T, Ghavi-Helm Y, Sexton T, Albig C, Regnard C, Cavalli G, Furlong EE, Becker PB.

Single-cell absolute contact probability detection reveals chromosomes are organized by multiple low-frequency yet specific interactions

Cattoni DI, Gizzi AMC, Georgieva M, Di Stefano M, Valeri A, Chamousset D, Houbron C, Déjardin S, Fiche JB, González I, Chang JM, Sexton T, Marti-Renom MA, Bantignies F, Cavalli G, Nollmann M.

Chromosome conformation capture technologies and their impact in understanding genome function

Sati S, Cavalli G.

Chromosome Conformation Capture on Chip (4C): Data Processing

Leblanc B, Comet I, Bantignies F, Cavalli G.

Regulation of Genome Architecture and Function by Polycomb Proteins

Entrevan M, Schuettengruber B, Cavalli G

Coordinate redeployment of PRC1 proteins suppresses tumor formation during Drosophila development

Loubière, V., Delest, A., Thomas, A., Bonev, B., Schuettengruber, B., Sati, S., Martinez AM., Cavalli, G.

Following the Motion of Polycomb Bodies in Living Drosophila Embryos

Cheutin T, Cavalli G.

Organization and function of the 3D genome

Bonev B, Cavalli G.

PRC1 proteins orchestrate three-dimensional genome architecture

Cavalli, G.

Distinct polymer physics principles govern chromatin dynamics in mouse and Drosophila topological domains

Ea V, Sexton T, Gostan T, Herviou L, Baudement MO, Zhang Y, Berlivet S, Le Lay-Taha MN, Cathala G, Lesne A, Victor JM, Fan Y, Cavalli G, Forné T.

Enhancer of zeste acts as a major developmental regulator of Ciona intestinalis embryogenesis

Le Goff E, Martinand-Mari C, Martin M, Feuillard J, Boublik Y, Godefroy N, Mangeat P, Baghdiguian S, Cavalli G

Histone H3 Serine 28 Is Essential for Efficient Polycomb-Mediated Gene Repression in Drosophila

Yung PY, Stuetzer A, Fischle W, Martinez AM, Cavalli G

Chromatin driven behavior of topologically associating domains

Ciabrelli F, Cavalli G.

Developmental determinants in non-communicable chronic diseases and ageing

Bousquet J, Anto JM, Berkouk K, Gergen P, Pinto Antunes J, Augé P, Camuzat T, Bringer J, Mercier J, Best N, Bourret R, Akdis M, Arshad SH, Bedbrook A, Berr C, Bush A, Cavalli G, Charles MA, Clavel-Chapelon F, Gillman M, Gold DR, Goldberg M, Holloway JW, Iozzo P, Jacquemin S, Jeandel C, Kauffmann F, Keil T, Koppelman GH, Krauss-Etschmann S, Kuh D, Lehmann S, Lodrup Carlsen KC, Maier D, Méchali M, Melén E, Moatti JP, Momas I, Nérin P, Postma DS, Ritchie K, Robine JM, Samolinski B, Siroux V, Slagboom PE, Smit HA, Sunyer J, Valenta R, Van de Perre P, Verdier JM, Vrijheid M, Wickman M, Yiallouros P, Zins M.

+ Réplication et Dynamique du Génome

The Role of Chromosome Domains in Shaping the Functional Genome

Sexton, T., Cavalli, G.

Chromosomes: now in 3D!

Cavalli, G.

Polycomb silencing: from linear chromatin domains to 3D chromosome folding

Cheutin T, Cavalli G

A RING to Rule Them All: RING1 as Silencer and Activator

Cavalli, G.

Identification of Regulators of the Three-Dimensional Polycomb Organization by a Microscopy-Based Genome-wide RNAi Screen

Gonzalez I, Mateos-Langerak J, Thomas A, Cheutin T, Cavalli G.

Modeling epigenome folding: formation and dynamics of topologically associated chromatin domains

Jost D, Carrivain P, Cavalli G, Vaillant C.

Topological organization of Drosophila hox genes using DNA fluorescent in situ hybridization

Bantignies, F., Cavalli, G.

Cooperativity, Specificity, and Evolutionary Stability of Polycomb Targeting in Drosophila

Schuettengruber B, Oded Elkayam N, Sexton T, Entrevan M, Stern S, Thomas A, Yaffe E, Parrinello H, Tanay A, Cavalli G.

Chromosomal domains: epigenetic contexts and functional implications of genomic compartmentalization.

Tanay A, Cavalli G.

Three-dimensional genome organization: a lesson from the Polycomb-Group proteins

Bantignies, F.

PRC2 Controls Drosophila Oocyte Cell Fate by Repressing Cell Cycle Genes.

Iovino N, Ciabrelli F, Cavalli G.

The 3D Genome Shapes Up For Pluripotency.

Sexton T, Cavalli G.

Functional implications of genome topology

Cavalli, G., Mistelli, T.

Polycomb domain formation depends on short and long distance regulatory cues.

Schuettengruber B, Cavalli G.

Molecular biology. EZH2 goes solo

Cavalli, G.

Three-Dimensional Folding and Functional Organization Principles of the Drosophila Genome.

Sexton T, Yaffe E, Kenigsberg E, Bantignies F, Leblanc B, Hoichman M, Parrinello H, Tanay A, Cavalli G.

Polycomb: a paradigm for genome organization from one to three dimensions.

Delest A, Sexton T, Cavalli G.

Progressive polycomb assembly on H3K27me3 compartments generates polycomb bodies with developmentally regulated motion

Cheutin T, Cavalli G.

Rolling ES Cells Down the Waddington Landscape with Oct4 and Sox2

Iovino, N., Cavalli, G.

Polycomb group proteins: repression in 3D.

Bantignies F, Cavalli G.

Editorial Review

Hetzer, M., Cavalli, G

Chromatin folding : from linear chromosomes to the 4D nucleus.

Cheutin, T., Bantignies, F., Leblanc, B., Cavalli, G.

Trithorax group proteins: switching genes on and keeping them active.

Schuettengruber B, Martinez AM, Iovino N, Cavalli G.

From linear genes to Epigenetic inheritance of three dimensional Epigenomes.

Cavalli, G.

A chromatin insulator driving three-dimensional Polycomb response element (PRE) contacts and Polycomb association with the chromatin fiber.

Comet, I., Schuettengruber, B., Sexton, T., Cavalli, G

Polycomb-dependent Regulatory Contacts between Distant Hox Loci in Drosophila,

Bantignies, F., Roure, V., Comet, I., Leblanc, B., Schuttengruber, B., Bonnet, J., Tixier, V., Mas, A., Cavalli, G.

Uncovering a tumor-suppressor function for Drosophila polycomb group genes.

Martinez, AM., Cavalli, G

The DUBle life of polycomb complexes

Schuettengruber, B., Cavalli, G

Epigenetics and the control of multicellularity. Workshop on Chromatin at the Nexus of Cell Division and Differentiation.

Reuter G, Cavalli G.

Functional Anatomy of Polycomb and Trithorax Chromatin Landscapes in Drosophila Embryos

Schuettengruber B, Ganapathi M, Leblanc B, Portoso M, Jaschek R, Tolhuis B, van Lohuizen M, Tanay A, Cavalli G.

Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling

Martinez, AM., Schuettengruber, B., Sakr, S., Janic, A., Gonzalez, C., and Cavalli, G.

Genomic interactions: Chromatin loops and gene meeting points in transcriptional regulation

Sexton, T., Bantignies, F., Cavalli, G.

Recruitment of polycomb group complexes and their role in the dynamic regulation of cell fate choice.

Schuettengruber B, Cavalli G.

The Role of RNAi and Noncoding RNAs in Polycomb Mediated Control of Gene Expression and Genomic Programming.

Portoso, M, and Cavalli, G.

Chapter 2 polycomb group proteins and long-range gene regulation.

Mateos-Langerak J, Cavalli G

Visualizing macromolecules with fluoronanogold: from photon microscopy to electron tomography.

Cheutin, T., Sauvage, C., Tchélidzé, P., O

Idefix insulator activity can be modulated by nearby regulatory elements.

Brasset E, Bantignies F, Court F, Cheresiz S, Conte C, Vaury C.

Chromosome kissing

Cavalli, G.

Polycomb response elements mediate the formation of chromosome higher-order structures in the bithorax complex.

Lanzuolo C, Roure V, Dekker J, Bantignies F, Orlando V.

Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions.

Lanctot C, Cheutin T, Cremer M, Cavalli G, Cremer T

Genome Regulation by Polycomb and Trithorax Proteins.

Schuettengruber B, Chourrout D, Vervoort M, Leblanc B, Cavalli G.

Polycomb controls the cell fate.

Negre N, Cavalli G.

Mapping the distribution of chromatin proteins by ChIP on chip.

Negre N, Lavrov S, Hennetin J, Bellis M, Cavalli G.

From genetics to epigenetics: the tale of Polycomb group and trithorax group genes.

Grimaud C, Negre N, Cavalli G.

PRE-Mediated Bypass of Two Su(Hw) Insulators Targets PcG Proteins to a Downstream Promoter.

Comet I, Savitskaya E, Schuettengruber B, Negre N, Lavrov S, Parshikov A, Juge F, Gracheva E, Georgiev P, Cavalli G.

Chromatin and epigenetics in development: blending cellular memory with cell fate plasticity.

Cavalli G.

The role of polycomb group proteins in cell cycle regulation during development.

Martinez AM, Cavalli G.

Cellular memory and dynamic regulation of polycomb group proteins.

Bantignies F, Cavalli G.

RNAi components are required for nuclear clustering of Polycomb group response elements.

Grimaud C, Bantignies F, Pal-Bhadra M, Ghana P, Bhadra U, Cavalli G.

Chromosomal Distribution of PcG Proteins during Drosophila Development.

Negre N, Hennetin J, Sun LV, Lavrov S, Bellis M, White KP, Cavalli G.

Polycomb group-dependent Cyclin A repression in Drosophila.

Martinez AM, Colomb S, Dejardin J, Bantignies F, Cavalli G.

Recruitment of Drosophila Polycomb Group proteins to chromatin by DSP1

Déjardin, J., Rappailles, A., Cuvier, O., Grimaud, C., Decoville, M., Locker, D., and Cavalli, G.

+ Réplication et Dynamique du Génome

Epigenetic inheritance of chromatin states mediated by Polycomb- and trithorax group proteins in Drosophila

Déjardin, J., and Cavalli, G.

The epigenome network of excellence.

Akhtar A, Cavalli G

Recruitment of Drosophila Polycomb group proteins to chromatin by DSP1

Dejardin J, Cavalli G.

Combined immunostaining and FISH analysis of polytene chromosomes

Lavrov, S., Déjardin, J., and Cavalli, G.

Interaction between GAF and Mod(mdg4) proteins promotes insulator bypass in Drosophila

Melnikova, L., Juge, F., Gruzdeva, N., Mazur, A., Cavalli, G., and Georgiev, P.

Chromatin inheritance upon Zeste-mediated Brahma recruitment at a minimal cellular memory module

Déjardin, J., and Cavalli, G.

Dissection of a natural RNA silencing process in the Drosophila melanogaster germ line

Aravin, A. A., Klenov, M. S., Vagin, V. V., Bantignies, F., Cavalli, G., and Gvozdev, V. A.

Inheritance of Polycomb-dependent chromosomal interactions in Drosophila

Bantignies, F., Grimaud, C., Lavrov, S., Gabut, M., and Cavalli, G.

Protein-DNA interaction mapping using genomic tiling path microarrays in Drosophila

Sun, L. V., Chen, L., Greil, F., Nègre, N., Li, T. R., Cavalli, G., Zhao, H., Van Steensel, B., and White, K.

SNR1 is an essential subunit in a subset of drosophila brm complexes, targeting specific functions during development

Zraly, C. B., Marenda, D. R., Nanchal, R., Cavalli, G., Muchardt, C., and Dingwal, A.K.

The MYST Domain Acetyltransferase Chameau Functions in Epigenetic Mechanisms of Transcriptional Repression

Grienenberger, A., Miotto, B., Sagnier, T., Cavalli, G., Schramke, V., Geli, V., Mariol, M. C., Berenger, H., Graba, Y., and Pradel, J.

Chromatin as a eukaryotic template of genetic information

Cavalli, G.

Mapping DNA target sites of chromatin-associated proteins by formaldehyde cross-linking in Drosophila embryos.

Cavalli, G., Orlando, V., and Paro, R.

Epigenetic Inheritance of active chromatin after removal of the main transactivator

Cavalli, G., Paro, R.

The Drosophila Fab-7 chromosomal element conveys epigenetic inheritance during mitosis and meiosis

11) Cavalli, G., and Paro, R.

CARRIVAIN Pascal
CARRIVAIN Pascal
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ROUX Solène
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CARRON Léopold
CARRON Léopold
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SZABO Quentin
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BAECKER Volker
BAECKER Volker
CRBM
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BARRO Marietta
BARRO Marietta
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PORTOSO Manuela
PORTOSO Manuela
Institut Curie Paris
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ROURE Virginie
ROURE Virginie
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CHIORINO Ornella
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FERNANDO Celine
FERNANDO Celine
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NAUMOVA Natasha
NAUMOVA Natasha
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NEGRE Nicolas
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ROCHE Julia
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DELEST Anna
DELEST Anna
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FALLET Chloé
FALLET Chloé
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SEXTON Thomas
SEXTON Thomas
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LEDJEMEL Nabil
LEDJEMEL Nabil
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SIMON Mylene
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YUNG Philip yuk kwong
YUNG Philip yuk kwong
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VOCADLO David
VOCADLO David
Simon Fraser University, Canada
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CRUZ SANCHEZ Teresita
IGF
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LOGEAY Remi
LOGEAY Remi
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JACQUIER-LABROCHE Caroline
JACQUIER-LABROCHE Caroline
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RUBERT-CASTRO Francesc
RUBERT-CASTRO Francesc
University of York
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Hadrien REBOUL, depuis Janvier 2021, titre : Etude des mécanismes de repliement du génome des nucléosomes aux domaines chromosomiques
Encadrant : Frédéric Bantignies

Nazli AKILLI, depuis Octobre 2020, titre : Functional dissection of mechanisms involved in the formation of H3K27me3 domain
Encadrants : Giacomo Cavalli et Thierry Cheutin à 50%

Victoria PARRENO, depuis Octobre 2019, titre : Régulation épigénétique de la tumorigenèse par le complexe Polycomb PRC1 chez la Drosophile
Encadrante : Anne-Marie MARTINEZ

Michael SZALAY, depuis Septembre 2019, Role of transcription and Polycomb proteins in 3D genome organization and cell differentiation
Encadrant : Giacomo Cavalli

Sandrine DENAUD, depuis Octobre 2018, titre : Importance of PRE interactions for the regulation of polycomb domains in Drosophila melanogaster
Encadrants : Giacomo Cavalli et Bernd Schüttengruber à 50%