Roles and mechanisms of STAG1 and STAG2 cohesins in 3D genome organization

Presented by Ana Losada, Spanish National Cancer Research Centre, CNIO, Madrid

Contact IGH Bernard DE MASSY

The secret of safe sex: the role of chromosome cores in meiotic recombination control

Contact IGH Bernard DE MASSY

Epigenetics workshop-Seminar Serie 7th-15th Nov 2022

The Nuclear architecture in physiology - Charlène Boumendil - and the Chromatin and cell biology - Giacomo CAVALLI - are thrilled to announce our next workshop in Epigenetics, from November 07^th to November 15th.
We have a fantastic speakers line up (see below and attached flyer), all seminars will take place at 2pm in the Genopolys Amphitheatre.

7^th Nov, 2pm: Dr Petra Hajkova, MRC London Institute of Medical Sciences - UK
Stability and erasure of epigenetic information in vivo and in vitro

8^th Nov, 2pm: Dr Caroline Dean, John Innes Centre - UK
Cold-induced epigenetic silencing

9^th Nov, 2pm: Dr Jop Kind, Hubrecht Institute - Netherlands
The chromatin landscape during early embryo development at single-cell resolution

10^th Nov, 2pm: Dr Geneviève Almouzni, Institut Curie - France
Histone H3 variants and chaperones on the chromatin dance-floor

14th Nov, 2pm: Dr Remi Terranova, Novartis, Novartis Institutes for BioMedical Research - Switzerland
Basic Principles of Preclinical Safety Assessment- Therapeutic Modulation of the Epigenome

15th Nov, 2pm: Dr Maud Borensztein, Institute of Molecular Genetics of Montpellier - France
X-chromosome dynamics during female mouse development

Contact IGH Charlene BOUMENDIL | Giacomo Cavalli

Programmed DNA elimination in the ciliate Paramecium: from molecular mechanism to evolution

With its nuclear dimorphism, the ciliate Paramecium provides a powerful unicellular model to study how eukaryotic genomes cope with transposable elements (TEs). During evolution, the Paramecium germline genome, hosted in two transcriptionally silent micronuclei, has been continuously colonized by TEs, including in essential coding regions. Functional gene expression relies on the programmed elimination of parasitic sequences, which takes place at each sexual cycle in the transcription-prone somatic macronucleus. While most TEs are eliminated in a heterogeneous manner, excision of ~45,000 Tc1/mariner-related Internal Eliminated Sequences (IESs) is precise. It is carried out by a core machinery composed of domesticated PiggyBac transposases associated with double-strand break repair proteins. Except for a subset of IESs, which will be discussed during my talk, programmed DNA elimination is guided by non-coding RNAs (ncRNAs) and repressive chromatin marks.
More about Dr. Mireille Betermier ​https://www.i2bc.paris-saclay.fr/equipe-programmed-genome-rearrangements/

Contact IGH Salman SHEHZADA

Germline specific nucleome programming towards meiotic cell division in mice

Masahiro Nagano will present his work on nucleome programing https://doi.org/10.15252/embj.2022110600 as well as recent unpublished work.

Contact IGH Bernard DE MASSY

For  those who need to do analyses of DNA-seq (including de novo assembly), RNA-seq, ChIP seq (these are just examples), and who would be interested in a software to help you in these kinds of analyses (with intuitive tools, guides and tutorials), there will be a presentation of CLC Genomics Workbench from QIAGEN. The presentation of this software will be given by Elodie Dubus, a Qiagen software specialist, and for those who have already started to work with this software and want to go deeper in the comprehension of this tool and their databases there will be a workshop dedicated to what you want to do.

Specific analyses, the workshop session will be from 9:00 to 10:30, at Genopolys, room « Open ».

Introduction of the CLC Genomics Workbench tools will take place from 10:30 to 12:15, at Genopolys, room « Open » (2^nd floor).

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Biomolecular condensates as an organising principle in biology and disease

Contact IGH Martine SIMONELIG

Induction of telomerase in p21-positive cells counteracts capillaries rarefaction and preserves lung function of aging mice and much more…

Talk presented by Vincent Géli, DR CNRS at CRCM - Cancer Research Center of Marseille

Contact IGH Mathieu TARDAT | Vincent Géli, DR CNRS au CRCM (Centre de Recherche en Cancérologie de Marseille)

Decision-making during developmental progression

Jonathan Chubb (UCL Laboratory for Molecular Cell Biology, London, UK) did his post-doc with R. Singer ~15 years ago, where he discovered gene bursting using the MS2 system. Since then, he has done a lot of live cell transcription imaging and published many interesting stories.

Contact IGH Edouard BERTRAND | Jonathan Chubb (UCL Laboratory for Molecular Cell Biology, London, UK)

Identification of a novel and rare somatic lineage in the developing mouse gonad

Contact IGH Francis POULAT | Serge Nef