Orateur:
Wei Xie (Tsinghua University, Beijing)
Genopolys Amphitheatre
Decoding the transcription circuitry in early mammalian development
Contact IGH Bernard DE MASSY
Méiose et recombinaison
Orateur:
John Diffley (Crick Institute, Londres)
Genopolys Amphitheatre
DNA Replication Forks and the DNA Damage CheckpointLe mardi 4 juin, à l'Amphithéâtre Genopolys, à 11h30, nous aurons un séminaire passionnant sur les dommages et la réplication de l'ADN par John Diffley (Crick Institute, Londres), « DNA Replication Forks and the DNA Damage Checkpoint ». John Diffley, directeur associé du Francis Crick Institute de Londres, est un pionnier dans le domaine de la réplication et des dommages causés à l'ADN. Ses recherches pionnières ont permis de caractériser la réplication de l'ADN et à reconstituer in vitro ses...
Contact IGH Marcel MECHALI
Réplication et Dynamique du Génome
Orateur:
Liesbeth Veenhoff (ERIBA, Groningen University, NL)
Genopolys Amphitheatre
The nuclear pore complex in ageing - A landmark structure at the crossroads of genome stability and protein homeostasis.
Contact IGH Charlene BOUMENDIL
Architecture nucléaire dans les contextes physiologiques et pathologiques
Orateur:
Dr. Sophie Zinn-Justin (Institute for Integrative Biology of the Cell, CEA, Paris)
Genopolys, Montpellier - France
BRCA2 interactome in meiosis and mitosis: the role of intrinsically disordered regionsTo mitigate the threat of DNA double strand breaks (DSBs), human cells rely on the activity of multiple DNA repair machineries, which are tightly regulated throughout the cell cycle. In G1-phase, DSBs are mainly repaired by non-homologous end joining (NHEJ), whereas in S-phase, when the cell duplicates its genome to get prepared for mitosis, DSBs are repaired by homologous recombination (HR). The Breast CAncer type 2 protein (BRCA2) is a central regulator of HR in most eukaryotes. During HR, BRCA2...
Contact IGH Jihane BASBOUS
Vous devez vous connecter pour accéder aux informations personnel IGH
Orateur:
Dr. Manuel Stucki (University of Zurich)
Genopolys, Montpellier - France
Mechanisms of genome stability maintenance during cell divisionThe accurate repair of DNA double-strand breaks (DSBs) is crucial for genome integrity and is tightly regulated during the cell cycle. In mitosis, cells inactivate canonical DSB repair pathways in favor of a DSB tethering mechanism that clusters acentric chromosome fragments in close spatial proximity to ensure their segregation in one of the daughter cells. A complex composed of the adaptor TOPBP1 and the CIP2A protein is critically implicated in chromosome stability maintenance and chromosome fragment...
Contact IGH Jihane BASBOUS
Vous devez vous connecter pour accéder aux informations personnel IGH
Seminar series Department "Molecular Bases of Human Diseases"
Contact IGH Domenico MAIORANO
Orateur:
Wolfgang J. MILLER (Medical University of Vienna, Austria)
IGH seminar room
Seminar Wolfgang Miller - March 5thWolfgang J. MILLER is an Assistant Professor and the group leader of the Laboratories of Genome Dynamics at the Medical University of Vienna, Austria. He has been working on the evolutionary dynamics of genomic parasites in Drosophila since more than 30 years, first on P element evolution in Drosophila and discovered the first case of “molecular domestication” of a TE, i.e., the functional transition from a selfish element in a new host gene now serving novel host functions. More recently, he has...
Contact IGH Severine CHAMBEYRON
ARN non codants, épigénétique et stabilité génomique
Orateur:
Dario Lupianez (Centro Andaluz de Biología del Desarrollo, Sevilla, Spain)
Genopolys amphitheater
Seminar of Dario Lupianez - March 1stDario Lupianez, whose laboratory is based in Seville, will be giving a seminar entitled "Genomes in 3D: implications for development and evolution". Dario did his thesis in Raphael Jimenez's laboratory on a very specific model of sex determination: the mole. In 2012, he joined Stefan Mundlos' laboratory for a post-doc where his main research topic was chromatin architecture and disease. In 2017-2023, he joined the Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Centre for Molecular...
Contact IGH Francis POULAT
Développement et Pathologie de la Gonade
Orateur:
Dominique Weil (IBPS, Paris)
IGH, Seminar room
What drives the dynamics of RNA storage in P-bodies?P-bodies (PBs) are cytoplasmic membraneless organelles containing untranslated mRNAs, whose functions are poorly understood. In two extreme scenarios, they could either ensure cellular functions by gathering together specific proteins and RNAs in a timely manner, or they could be an epiphenomenon due to intrinsic molecular features of their components. We tackled this issue by purifying human PBs at different phases of the cell cycle. We observed widespread changes in their RNA content: some were...
Contact IGH Edouard BERTRAND
Biologie cellulaire de l'ARN
Orateur:
Germano CECERE (Institut Pasteur, Paris, France)
Genopolys amphitheater
Small RNAs In Epigenetic InheritanceHeritable traits have long revolved around genomic DNA, yet emerging research redefines our understanding of inheritance. In our laboratory, we embark on a captivating journey into the world of small RNAs and their role in epigenetic inheritance, employing the model organism Caenorhabditis elegans. During my talk, I will unveil the profound influence of small RNAs in trait inheritance. I will present a compelling case study demonstrating how small RNAs gradually reduce fertility across successive...
Contact IGH Giacomo CAVALLI
Chromatine et Biologie Cellulaire
